Page last updated: 2024-10-31

midazolam and Nerve Pain

midazolam has been researched along with Nerve Pain in 6 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Research Excerpts

ExcerptRelevanceReference
"Furthermore, the mechanical allodynia was significantly attenuated after PUR administration."5.48Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats. ( Chen, J; Li, H; Li, N; Lim, G; Ma, W; McCabe, MF; Yang, Y; Zhao, W, 2018)
" Here, we show that inhibition of spinal CA activity with acetazolamide (ACT) reduces neuropathic allodynia."3.76Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. ( Asiedu, M; Kaila, K; Ossipov, MH; Price, TJ, 2010)
"The results showed that CCI-ION induced hyperalgesia, which was attenuated by lidocaine or carbamazepine, developed anxiety-like behavior, which was reduced only by midazolam, and displayed a reduced number of 50-kHz calls, compared to sham."1.72Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs. ( Araya, EI; Baggio, DF; Chichorro, JG; Koren, LO; Schwarting, RKW, 2022)
"Furthermore, the mechanical allodynia was significantly attenuated after PUR administration."1.48Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats. ( Chen, J; Li, H; Li, N; Lim, G; Ma, W; McCabe, MF; Yang, Y; Zhao, W, 2018)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Peng, Y1
Zhang, Q1
Welsh, WJ1
Araya, EI1
Baggio, DF1
Koren, LO1
Schwarting, RKW1
Chichorro, JG1
Chen, J1
Li, H1
Lim, G1
McCabe, MF1
Zhao, W1
Yang, Y1
Ma, W1
Li, N1
Asiedu, M1
Ossipov, MH1
Kaila, K1
Price, TJ1
Canavero, S1
Bonicalzi, V1
Clemente, M1
Orliaguet, G1
Nguyen, JP1
Abay, K1
Berberich, E1
Melon, E1
Duvaldestin, P1

Other Studies

6 other studies available for midazolam and Nerve Pain

ArticleYear
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.
    Journal of medicinal chemistry, 2021, 01-14, Volume: 64, Issue:1

    Topics: Animals; Binding Sites; Blood-Brain Barrier; Drug Design; Guinea Pigs; Half-Life; Humans; Microsomes

2021
Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs.
    European journal of pharmacology, 2022, May-05, Volume: 922

    Topics: Analgesics; Animals; Carbamazepine; Hyperalgesia; Lidocaine; Male; Midazolam; Neuralgia; Rats; Trige

2022
Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats.
    IUBMB life, 2018, Volume: 70, Issue:2

    Topics: Animals; Dexmedetomidine; Disease Models, Animal; Hedgehog Proteins; Hyperalgesia; Male; Midazolam;

2018
Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.
    Pain, 2010, Volume: 148, Issue:2

    Topics: Acetazolamide; Anesthetics, Intravenous; Animals; Carbonic Anhydrase Inhibitors; Disease Models, Ani

2010
No neurotoxicity from long-term (>5 years) intrathecal infusion of midazolam in humans.
    Journal of pain and symptom management, 2006, Volume: 32, Issue:1

    Topics: Analgesics; Drug Administration Schedule; Female; Humans; Infusion Pumps, Implantable; Infusions, Pa

2006
[Anesthesia for thalamic stimulations: value of flumazenil].
    Annales francaises d'anesthesie et de reanimation, 1991, Volume: 10, Issue:3

    Topics: Adult; Aged; Anesthesia, General; Electric Stimulation; Flumazenil; Humans; Intraoperative Period; M

1991