midazolam has been researched along with Nerve Degeneration in 6 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Exposure to chemical warfare nerve agents (CWNAs), such as soman (GD), can induce status epilepticus (SE) that becomes refractory to benzodiazepines when treatment is delayed, leading to increased risk of epileptogenesis, severe neuropathology, and long-term behavioral and cognitive deficits." | 7.88 | Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam. ( de Araujo Furtado, M; Du, F; Kundrick, E; Lumley, LA; Marrero-Rosado, B; O'Brien, S; Schultz, CR; Stone, M; Walker, K, 2018) |
| "Exposure to chemical warfare nerve agents (CWNAs), such as soman (GD), can induce status epilepticus (SE) that becomes refractory to benzodiazepines when treatment is delayed, leading to increased risk of epileptogenesis, severe neuropathology, and long-term behavioral and cognitive deficits." | 3.88 | Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam. ( de Araujo Furtado, M; Du, F; Kundrick, E; Lumley, LA; Marrero-Rosado, B; O'Brien, S; Schultz, CR; Stone, M; Walker, K, 2018) |
| "We hypothesized that seizures, during limited substrate availability, aggravate hypoglycemia-induced brain damage." | 1.34 | Hypoglycemic seizures during transient hypoglycemia exacerbate hippocampal dysfunction. ( Abdelmalik, PA; Adamchik, Y; Burnham, WM; Carlen, PL; Liang, P; Samoilova, M; Shannon, P; Weisspapir, M; Yiu, A, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marrero-Rosado, B | 1 |
| de Araujo Furtado, M | 1 |
| Schultz, CR | 1 |
| Stone, M | 1 |
| Kundrick, E | 1 |
| Walker, K | 1 |
| O'Brien, S | 1 |
| Du, F | 1 |
| Lumley, LA | 1 |
| Joksovic, PM | 1 |
| Lunardi, N | 1 |
| Jevtovic-Todorovic, V | 2 |
| Todorovic, SM | 1 |
| Sankar, R | 1 |
| Painter, MJ | 1 |
| Young, C | 1 |
| Qin, YQ | 1 |
| Tenkova, T | 1 |
| Wang, H | 1 |
| Labruyere, J | 1 |
| Olney, JW | 1 |
| Abdelmalik, PA | 1 |
| Shannon, P | 1 |
| Yiu, A | 1 |
| Liang, P | 1 |
| Adamchik, Y | 1 |
| Weisspapir, M | 1 |
| Samoilova, M | 1 |
| Burnham, WM | 1 |
| Carlen, PL | 1 |
| Erdine, S | 1 |
| Yücel, A | 1 |
| Ozyalçin, S | 1 |
| Ozyuvaci, E | 1 |
| Talu, GK | 1 |
| Ahiskali, B | 1 |
| Apak, H | 1 |
| Savci, N | 1 |
6 other studies available for midazolam and Nerve Degeneration
| Article | Year |
|---|---|
Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam.
Topics: Animals; Anticonvulsants; Carboxylesterase; Cell Count; Chemical Warfare Agents; Cholinesterase Reac | 2018 |
Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Biological Transport; Cell Membrane; Drug | 2015 |
Neonatal seizures: after all these years we still love what doesn't work.
Topics: Animals; Anticonvulsants; Brain; Clinical Trials as Topic; Drug Resistance; Electroencephalography; | 2005 |
Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain.
Topics: Animals; Apoptosis; Blood Gas Analysis; Brain; Caspase 3; Caspases; Cell Count; Cell Death; Drug Int | 2005 |
Hypoglycemic seizures during transient hypoglycemia exacerbate hippocampal dysfunction.
Topics: Action Potentials; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Cortical Spreading D | 2007 |
Neurotoxicity of midazolam in the rabbit.
Topics: Animals; Heart Rate; Injections, Spinal; Male; Microscopy, Electron; Midazolam; Necrosis; Nerve Dege | 1999 |