midazolam and Nausea
midazolam has been researched along with Nausea in 27 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Midazolam dose, nausea, vomiting, and anxiety did not differ between groups." | 9.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| "Remifentanil enhanced the degree of bradycardia due to OCR as compared with sevoflurane during paediatric strabismus surgery." | 9.13 | Effect of remifentanil on oculocardiac reflex in paediatric strabismus surgery. ( Choi, SR; Chung, CJ; Lee, JH; Lee, JM; Lee, SC, 2008) |
| "To assess whether the addition of midazolam to dexamethasone and granisetron could ameliorate the refractory acute nausea and/or vomiting caused by a highly emetogenic platinum-based chemotherapy." | 9.11 | Midazolam for acute emesis refractory to dexamethasone and granisetron after highly emetogenic chemotherapy: a phase II study. ( Barni, S; Cabiddu, M; Cazzaniga, M; Cremonesi, M; Di Cosimo, S; Ferretti, G; Ghilardi, M; Mandalà, M; Rocca, A, 2005) |
| "To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children." | 7.81 | Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. ( Barcelos, A; Branco, R; Bruno, F; Garcia, PC; Piva, JP; Portela, JL; Tasker, RC, 2015) |
| "Forty-five breast cancer patients were randomized into three groups: Group I--chemotherapy, control, Group II--midazolam+chemotherapy, and Group III--propofol+chemotherapy." | 6.71 | Effect of sedation with midazolam or propofol on patient's comfort during cancer chemotherapy infusion: a prospective, randomized, double-blind study in breast cancer patients. ( Argun, G; Baran, O; Dikmen Mentes, S; Ertunc, FN; Unsal, D, 2005) |
| " Midazolam dose, nausea, vomiting, and anxiety did not differ between groups." | 5.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| "Remifentanil enhanced the degree of bradycardia due to OCR as compared with sevoflurane during paediatric strabismus surgery." | 5.13 | Effect of remifentanil on oculocardiac reflex in paediatric strabismus surgery. ( Choi, SR; Chung, CJ; Lee, JH; Lee, JM; Lee, SC, 2008) |
| "To assess whether the addition of midazolam to dexamethasone and granisetron could ameliorate the refractory acute nausea and/or vomiting caused by a highly emetogenic platinum-based chemotherapy." | 5.11 | Midazolam for acute emesis refractory to dexamethasone and granisetron after highly emetogenic chemotherapy: a phase II study. ( Barni, S; Cabiddu, M; Cazzaniga, M; Cremonesi, M; Di Cosimo, S; Ferretti, G; Ghilardi, M; Mandalà, M; Rocca, A, 2005) |
| "To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children." | 3.81 | Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. ( Barcelos, A; Branco, R; Bruno, F; Garcia, PC; Piva, JP; Portela, JL; Tasker, RC, 2015) |
| " For management of postoperative muscle spasm, an intravenous benzodiazepine was used (diazepam 0." | 3.69 | Pain management for children following selective dorsal rhizotomy. ( Geiduschek, JM; Haberkern, CM; Hays, RM; Jacobson, LE; McLaughlin, JF; Roberts, TS, 1994) |
| "We report difficulty with conscious sedation of a child taking methylphenidate for attention deficit disorder and possible delayed adverse interaction of ketamine and methylphenidate resulting in severe nausea, vomiting and dehydration." | 3.69 | Unexpected interaction of methylphenidate (Ritalin) with anaesthetic agents. ( Fox, L; Ririe, DG; Ririe, KL; Sethna, NF, 1997) |
| "Metoclopramide was administered as a 2-minute bolus infusion." | 2.77 | A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia. ( Aydin, B; Erdur, B; Ergin, A; Kabay, B; Ozen, M; Parlak, I; Tura, P, 2012) |
| "Dizziness was greater in the modafinil/remifentanil/propofol group 1." | 2.75 | Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. ( Boesjes, H; Galvin, E; Hol, J; Klein, J; Ubben, JF; Verbrugge, SJ, 2010) |
| " Blood samples were collected predose and at selected time points up to 24 hours after dosing with midazolam for measurement of midazolam pharmacokinetic parameters." | 2.73 | Cinacalcet does not affect the activity of cytochrome P450 3A enzymes, a metabolic pathway for common immunosuppressive agents : a randomized, open-label, crossover, single-centre study in healthy volunteers. ( Emery, M; Padhi, D; Salfi, M, 2008) |
| "Forty-five breast cancer patients were randomized into three groups: Group I--chemotherapy, control, Group II--midazolam+chemotherapy, and Group III--propofol+chemotherapy." | 2.71 | Effect of sedation with midazolam or propofol on patient's comfort during cancer chemotherapy infusion: a prospective, randomized, double-blind study in breast cancer patients. ( Argun, G; Baran, O; Dikmen Mentes, S; Ertunc, FN; Unsal, D, 2005) |
| " Pharmacokinetic variables were determined by noncompartmental analysis." | 2.70 | The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam. ( Feldman, J; Ibrahim, A; Karim, A; Kharasch, E, 2002) |
| "Midazolam is a relatively short-acting water-soluble benzodiazepine that provides anxiolysis and anterograde amnesia and can be given orally with few adverse effects." | 2.68 | Premedication with oral midazolam for voiding cystourethrography in children: safety and efficacy. ( Elder, JS; Longenecker, R, 1995) |
| "Midazolam was associated with impairment of performance on the TDT and DSST after premedication administration and 15 (TDT and DSST) and 30 (DSST) min after postanesthesia care unit (PACU) arrival." | 2.68 | Midazolam premedication increases sedation but does not prolong discharge times after brief outpatient general anesthesia for laparoscopic tubal sterilization. ( Hussain, A; Richardson, MG; Wu, CL, 1997) |
| "Midazolam was found to be more effective than ketobemidone in reducing anxiety among more tense patients--those with a VAS grading before premedication of 2 or more (P less than 0." | 2.67 | Premedication before elective breast surgery, a comparison between ketobemidone and midazolam. ( Andersson, L; Askergren, J; Davidson, S; Jakobsson, J; Nilsson, A, 1991) |
| "Volatile-based sedation demonstrates a reduction in time to extubation, with no increase in short-term adverse outcomes." | 2.55 | Safety and Efficacy of Volatile Anesthetic Agents Compared With Standard Intravenous Midazolam/Propofol Sedation in Ventilated Critical Care Patients: A Meta-analysis and Systematic Review of Prospective Trials. ( Beattie, WS; Ferguson, ND; Jerath, A; Lightfoot, N; Panckhurst, J; Parotto, M; Steel, A; Wasowicz, M, 2017) |
| "Midazolam is an imidazobenzodiazepine with unique properties when compared with other benzodiazepines." | 2.37 | Midazolam: pharmacology and uses. ( Fragen, RJ; Greenblatt, DJ; Reves, JG; Vinik, HR, 1985) |
| "The study investigated patient discharge parameters and postdischarge adverse events after discharge among children who received oral conscious sedation for dental treatment." | 1.42 | Oral Sedation Postdischarge Adverse Events in Pediatric Dental Patients. ( Huang, A; Tanbonliong, T, 2015) |
| "Midazolam was the most common medication prescribed to achieve sedation." | 1.31 | A multicentre international study of sedation for uncontrolled symptoms in terminally ill patients. ( Bengtson, K; Bercovici, M; deMoissac, D; Fainsinger, RL; Hosking, M; Landman, W; Nunez-Olarte, JM; Waller, A, 2000) |
Research
Studies (27)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.41) | 18.7374 |
| 1990's | 9 (33.33) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Brant, AR | 1 |
| Reeves, MF | 1 |
| Ye, PP | 1 |
| Scott, RK | 1 |
| Floyd, S | 1 |
| Tefera, E | 1 |
| Lotke, PS | 1 |
| Weichselbaumer, E | 1 |
| Weixler, D | 1 |
| Portela, JL | 1 |
| Garcia, PC | 1 |
| Piva, JP | 1 |
| Barcelos, A | 1 |
| Bruno, F | 1 |
| Branco, R | 1 |
| Tasker, RC | 1 |
| Huang, A | 1 |
| Tanbonliong, T | 1 |
| Breuer, L | 1 |
| Kasper, BS | 1 |
| Schwarze, B | 1 |
| Gschossmann, JM | 1 |
| Kornhuber, J | 1 |
| Müller, HH | 1 |
| Jerath, A | 1 |
| Panckhurst, J | 1 |
| Parotto, M | 1 |
| Lightfoot, N | 1 |
| Wasowicz, M | 1 |
| Ferguson, ND | 1 |
| Steel, A | 1 |
| Beattie, WS | 1 |
| Padhi, D | 1 |
| Salfi, M | 1 |
| Emery, M | 1 |
| Chung, CJ | 1 |
| Lee, JM | 1 |
| Choi, SR | 1 |
| Lee, SC | 1 |
| Lee, JH | 1 |
| Dilli, D | 1 |
| Dallar, Y | 1 |
| Sorgui, NH | 1 |
| Galvin, E | 1 |
| Boesjes, H | 1 |
| Hol, J | 1 |
| Ubben, JF | 1 |
| Klein, J | 1 |
| Verbrugge, SJ | 1 |
| Erdur, B | 1 |
| Tura, P | 1 |
| Aydin, B | 1 |
| Ozen, M | 1 |
| Ergin, A | 1 |
| Parlak, I | 1 |
| Kabay, B | 1 |
| Ibrahim, A | 1 |
| Karim, A | 1 |
| Feldman, J | 1 |
| Kharasch, E | 1 |
| Mandalà, M | 1 |
| Cremonesi, M | 1 |
| Rocca, A | 1 |
| Cazzaniga, M | 1 |
| Ferretti, G | 1 |
| Di Cosimo, S | 1 |
| Ghilardi, M | 1 |
| Cabiddu, M | 1 |
| Barni, S | 1 |
| Dikmen Mentes, S | 1 |
| Unsal, D | 1 |
| Baran, O | 1 |
| Argun, G | 1 |
| Ertunc, FN | 1 |
| Lu, DP | 1 |
| Lu, WI | 1 |
| Elder, JS | 1 |
| Longenecker, R | 1 |
| Donnelly, MB | 1 |
| Scott, WA | 1 |
| Daly, DS | 1 |
| Geiduschek, JM | 1 |
| Haberkern, CM | 1 |
| McLaughlin, JF | 1 |
| Jacobson, LE | 1 |
| Hays, RM | 1 |
| Roberts, TS | 1 |
| Ririe, DG | 1 |
| Ririe, KL | 1 |
| Sethna, NF | 1 |
| Fox, L | 1 |
| Mainwaring, CJ | 1 |
| Wong, C | 1 |
| Lush, RJ | 1 |
| Smith, JG | 1 |
| Singer, CR | 1 |
| Richardson, MG | 1 |
| Wu, CL | 1 |
| Hussain, A | 1 |
| Fainsinger, RL | 1 |
| Waller, A | 1 |
| Bercovici, M | 1 |
| Bengtson, K | 1 |
| Landman, W | 1 |
| Hosking, M | 1 |
| Nunez-Olarte, JM | 1 |
| deMoissac, D | 1 |
| Di Florio, T | 1 |
| Jakobsson, J | 1 |
| Andersson, L | 1 |
| Nilsson, A | 1 |
| Davidson, S | 1 |
| Askergren, J | 1 |
| Jakobbson, J | 1 |
| Andreen, M | 1 |
| Westgren, M | 1 |
| Thomasson, K | 1 |
| Olynyk, JK | 1 |
| Cullen, SR | 1 |
| Leahy, MF | 1 |
| Reves, JG | 1 |
| Fragen, RJ | 1 |
| Vinik, HR | 1 |
| Greenblatt, DJ | 1 |
Clinical Trials (5)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gabapentin as an Adjunct for Pain Management During Dilation and Evacuation: A Double-blind Randomized Controlled Trial[NCT03635905] | Phase 4 | 130 participants (Actual) | Interventional | 2017-05-26 | Completed | ||
| Effect of Inhalational Sedation on Mechanical Power in Mechanically Ventilated Patients: a Pilot Open-label Randomized Controlled Study[NCT05559970] | 40 participants (Anticipated) | Interventional | 2022-11-15 | Recruiting | |||
| A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102] | Phase 4 | 105 participants (Actual) | Interventional | 2016-02-29 | Terminated | ||
| Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227] | Phase 4 | 748 participants | Interventional | 2001-09-30 | Completed | ||
| Effects of Premedication by Midazolam on Preoperative Anxiety for Emergency Surgery[NCT02213302] | Phase 4 | 59 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit
Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Placebo | 53.5 |
| Modafinil | 61.0 |
Postanesthesia Quality Recovery Scale Score
Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -5.67 |
| Modafinil | -8.91 |
Reviews
2 reviews available for midazolam and Nausea
| Article | Year |
|---|---|
Safety and Efficacy of Volatile Anesthetic Agents Compared With Standard Intravenous Midazolam/Propofol Sedation in Ventilated Critical Care Patients: A Meta-analysis and Systematic Review of Prospective Trials.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Clinical Trials as Topic; Critical Care; Humans; | 2017 |
Midazolam: pharmacology and uses.
Topics: Adult; Aged; Aging; Ambulatory Surgical Procedures; Anesthetics; Animals; Benzodiazepines; Benzodiaz | 1985 |
Trials
14 trials available for midazolam and Nausea
| Article | Year |
|---|---|
Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial.
Topics: Dilatation; Double-Blind Method; Female; Fentanyl; Gabapentin; Humans; Midazolam; Nausea; Pain; Pain | 2023 |
Cinacalcet does not affect the activity of cytochrome P450 3A enzymes, a metabolic pathway for common immunosuppressive agents : a randomized, open-label, crossover, single-centre study in healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Calcium; Calcium Channel Agonists; Cinaca | 2008 |
Effect of remifentanil on oculocardiac reflex in paediatric strabismus surgery.
Topics: Anesthesia; Blood Pressure; Child; Child, Preschool; Female; Heart Rate; Humans; Infant; Male; Midaz | 2008 |
Intravenous ketamine plus midazolam vs. intravenous ketamine for sedation in lumbar puncture: a randomized controlled trial.
Topics: Adolescent; Anesthetics, Dissociative; Anesthetics, Intravenous; Child; Confidence Intervals; Dizzin | 2008 |
Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia Recovery Period; Anesthetics, Inha | 2010 |
A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia.
Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Diphenhydramine; Double-Blind Method; Female; Humans; H | 2012 |
The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam.
Topics: Adult; Area Under Curve; Biotransformation; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP3A; Cytoc | 2002 |
Midazolam for acute emesis refractory to dexamethasone and granisetron after highly emetogenic chemotherapy: a phase II study.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents; Cisplatin; Dexamethasone; Female; Graniset | 2005 |
Effect of sedation with midazolam or propofol on patient's comfort during cancer chemotherapy infusion: a prospective, randomized, double-blind study in breast cancer patients.
Topics: Adult; Anesthetics, Intravenous; Antineoplastic Agents; Anxiety; Breast Neoplasms; Double-Blind Meth | 2005 |
Premedication with oral midazolam for voiding cystourethrography in children: safety and efficacy.
Topics: Administration, Oral; Affect; Aggression; Anger; Child; Child, Preschool; Female; Humans; Infant; Ma | 1995 |
Sedation for upper gastrointestinal endoscopy: a comparison of alfentanil-midazolam and meperidine-diazepam.
Topics: Age Factors; Alfentanil; Anesthesia Recovery Period; Apnea; Conscious Sedation; Diazepam; Dizziness; | 1994 |
Midazolam premedication increases sedation but does not prolong discharge times after brief outpatient general anesthesia for laparoscopic tubal sterilization.
Topics: Adult; Age Factors; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; | 1997 |
Premedication before elective breast surgery, a comparison between ketobemidone and midazolam.
Topics: Aged; Analgesics, Opioid; Anxiety; Breast; Female; Humans; Injections, Intramuscular; Meperidine; Mi | 1991 |
Discomfort after outpatient abortion using paracervical block: a comparison between two opioids and one non-opioid drug for premedication.
Topics: Abortion, Induced; Adult; Ambulatory Care; Anesthesia, Local; Anxiety; Female; Humans; Meperidine; M | 1990 |
Other Studies
11 other studies available for midazolam and Nausea
| Article | Year |
|---|---|
[Palliative sedation for psycho-existential suffering].
Topics: Attitude to Death; Austria; Caregivers; Conscious Sedation; Ethics, Medical; Existentialism; Female; | 2014 |
Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Service, Hospital; Female; | 2015 |
Oral Sedation Postdischarge Adverse Events in Pediatric Dental Patients.
Topics: Administration, Oral; Analgesics, Opioid; Anesthesia, Dental; Anesthetics, Inhalation; Child; Child | 2015 |
"Herbal seizures"--atypical symptoms after ibogaine intoxication: a case report.
Topics: Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Hallucinogens; Humans; Hypnotics and Sedatives; Ibog | 2015 |
Practical oral sedation in dentistry. Part II--Clinical application of various oral sedatives and discussion.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, Dental; Child; Child, | 2006 |
Pain management for children following selective dorsal rhizotomy.
Topics: Adolescent; Adult; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Bupiva | 1994 |
Unexpected interaction of methylphenidate (Ritalin) with anaesthetic agents.
Topics: Anesthetics, Dissociative; Attention Deficit Disorder with Hyperactivity; Central Nervous System Sti | 1997 |
The role of midazolam-induced sedation in bone marrow aspiration/trephine biopsies.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Antidotes; Awareness; Bone Marrow; Conscious Sedation; | 1996 |
A multicentre international study of sedation for uncontrolled symptoms in terminally ill patients.
Topics: Aged; Analgesics, Opioid; Anti-Anxiety Agents; Consciousness; Delirium; Drug Therapy, Combination; D | 2000 |
The use of midazolam for persistent postoperative nausea and vomiting.
Topics: Adult; Aged; Female; Humans; Male; Midazolam; Nausea; Postoperative Complications; Vomiting | 1992 |
Midazolam: an effective antiemetic agent for cytotoxic chemotherapy.
Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Humans; Midazolam; Nausea; Vomiting | 1989 |