Page last updated: 2024-10-31

midazolam and Nausea

midazolam has been researched along with Nausea in 27 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Research Excerpts

ExcerptRelevanceReference
" Midazolam dose, nausea, vomiting, and anxiety did not differ between groups."9.69Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023)
"Remifentanil enhanced the degree of bradycardia due to OCR as compared with sevoflurane during paediatric strabismus surgery."9.13Effect of remifentanil on oculocardiac reflex in paediatric strabismus surgery. ( Choi, SR; Chung, CJ; Lee, JH; Lee, JM; Lee, SC, 2008)
"To assess whether the addition of midazolam to dexamethasone and granisetron could ameliorate the refractory acute nausea and/or vomiting caused by a highly emetogenic platinum-based chemotherapy."9.11Midazolam for acute emesis refractory to dexamethasone and granisetron after highly emetogenic chemotherapy: a phase II study. ( Barni, S; Cabiddu, M; Cazzaniga, M; Cremonesi, M; Di Cosimo, S; Ferretti, G; Ghilardi, M; Mandalà, M; Rocca, A, 2005)
"To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children."7.81Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. ( Barcelos, A; Branco, R; Bruno, F; Garcia, PC; Piva, JP; Portela, JL; Tasker, RC, 2015)
"Forty-five breast cancer patients were randomized into three groups: Group I--chemotherapy, control, Group II--midazolam+chemotherapy, and Group III--propofol+chemotherapy."6.71Effect of sedation with midazolam or propofol on patient's comfort during cancer chemotherapy infusion: a prospective, randomized, double-blind study in breast cancer patients. ( Argun, G; Baran, O; Dikmen Mentes, S; Ertunc, FN; Unsal, D, 2005)
" Midazolam dose, nausea, vomiting, and anxiety did not differ between groups."5.69Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023)
"Remifentanil enhanced the degree of bradycardia due to OCR as compared with sevoflurane during paediatric strabismus surgery."5.13Effect of remifentanil on oculocardiac reflex in paediatric strabismus surgery. ( Choi, SR; Chung, CJ; Lee, JH; Lee, JM; Lee, SC, 2008)
"To assess whether the addition of midazolam to dexamethasone and granisetron could ameliorate the refractory acute nausea and/or vomiting caused by a highly emetogenic platinum-based chemotherapy."5.11Midazolam for acute emesis refractory to dexamethasone and granisetron after highly emetogenic chemotherapy: a phase II study. ( Barni, S; Cabiddu, M; Cazzaniga, M; Cremonesi, M; Di Cosimo, S; Ferretti, G; Ghilardi, M; Mandalà, M; Rocca, A, 2005)
"To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children."3.81Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. ( Barcelos, A; Branco, R; Bruno, F; Garcia, PC; Piva, JP; Portela, JL; Tasker, RC, 2015)
" For management of postoperative muscle spasm, an intravenous benzodiazepine was used (diazepam 0."3.69Pain management for children following selective dorsal rhizotomy. ( Geiduschek, JM; Haberkern, CM; Hays, RM; Jacobson, LE; McLaughlin, JF; Roberts, TS, 1994)
"We report difficulty with conscious sedation of a child taking methylphenidate for attention deficit disorder and possible delayed adverse interaction of ketamine and methylphenidate resulting in severe nausea, vomiting and dehydration."3.69Unexpected interaction of methylphenidate (Ritalin) with anaesthetic agents. ( Fox, L; Ririe, DG; Ririe, KL; Sethna, NF, 1997)
"Metoclopramide was administered as a 2-minute bolus infusion."2.77A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia. ( Aydin, B; Erdur, B; Ergin, A; Kabay, B; Ozen, M; Parlak, I; Tura, P, 2012)
"Dizziness was greater in the modafinil/remifentanil/propofol group 1."2.75Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. ( Boesjes, H; Galvin, E; Hol, J; Klein, J; Ubben, JF; Verbrugge, SJ, 2010)
" Blood samples were collected predose and at selected time points up to 24 hours after dosing with midazolam for measurement of midazolam pharmacokinetic parameters."2.73Cinacalcet does not affect the activity of cytochrome P450 3A enzymes, a metabolic pathway for common immunosuppressive agents : a randomized, open-label, crossover, single-centre study in healthy volunteers. ( Emery, M; Padhi, D; Salfi, M, 2008)
"Forty-five breast cancer patients were randomized into three groups: Group I--chemotherapy, control, Group II--midazolam+chemotherapy, and Group III--propofol+chemotherapy."2.71Effect of sedation with midazolam or propofol on patient's comfort during cancer chemotherapy infusion: a prospective, randomized, double-blind study in breast cancer patients. ( Argun, G; Baran, O; Dikmen Mentes, S; Ertunc, FN; Unsal, D, 2005)
" Pharmacokinetic variables were determined by noncompartmental analysis."2.70The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam. ( Feldman, J; Ibrahim, A; Karim, A; Kharasch, E, 2002)
"Midazolam is a relatively short-acting water-soluble benzodiazepine that provides anxiolysis and anterograde amnesia and can be given orally with few adverse effects."2.68Premedication with oral midazolam for voiding cystourethrography in children: safety and efficacy. ( Elder, JS; Longenecker, R, 1995)
"Midazolam was associated with impairment of performance on the TDT and DSST after premedication administration and 15 (TDT and DSST) and 30 (DSST) min after postanesthesia care unit (PACU) arrival."2.68Midazolam premedication increases sedation but does not prolong discharge times after brief outpatient general anesthesia for laparoscopic tubal sterilization. ( Hussain, A; Richardson, MG; Wu, CL, 1997)
"Midazolam was found to be more effective than ketobemidone in reducing anxiety among more tense patients--those with a VAS grading before premedication of 2 or more (P less than 0."2.67Premedication before elective breast surgery, a comparison between ketobemidone and midazolam. ( Andersson, L; Askergren, J; Davidson, S; Jakobsson, J; Nilsson, A, 1991)
"Volatile-based sedation demonstrates a reduction in time to extubation, with no increase in short-term adverse outcomes."2.55Safety and Efficacy of Volatile Anesthetic Agents Compared With Standard Intravenous Midazolam/Propofol Sedation in Ventilated Critical Care Patients: A Meta-analysis and Systematic Review of Prospective Trials. ( Beattie, WS; Ferguson, ND; Jerath, A; Lightfoot, N; Panckhurst, J; Parotto, M; Steel, A; Wasowicz, M, 2017)
"Midazolam is an imidazobenzodiazepine with unique properties when compared with other benzodiazepines."2.37Midazolam: pharmacology and uses. ( Fragen, RJ; Greenblatt, DJ; Reves, JG; Vinik, HR, 1985)
"The study investigated patient discharge parameters and postdischarge adverse events after discharge among children who received oral conscious sedation for dental treatment."1.42Oral Sedation Postdischarge Adverse Events in Pediatric Dental Patients. ( Huang, A; Tanbonliong, T, 2015)
"Midazolam was the most common medication prescribed to achieve sedation."1.31A multicentre international study of sedation for uncontrolled symptoms in terminally ill patients. ( Bengtson, K; Bercovici, M; deMoissac, D; Fainsinger, RL; Hosking, M; Landman, W; Nunez-Olarte, JM; Waller, A, 2000)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.41)18.7374
1990's9 (33.33)18.2507
2000's8 (29.63)29.6817
2010's7 (25.93)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Brant, AR1
Reeves, MF1
Ye, PP1
Scott, RK1
Floyd, S1
Tefera, E1
Lotke, PS1
Weichselbaumer, E1
Weixler, D1
Portela, JL1
Garcia, PC1
Piva, JP1
Barcelos, A1
Bruno, F1
Branco, R1
Tasker, RC1
Huang, A1
Tanbonliong, T1
Breuer, L1
Kasper, BS1
Schwarze, B1
Gschossmann, JM1
Kornhuber, J1
Müller, HH1
Jerath, A1
Panckhurst, J1
Parotto, M1
Lightfoot, N1
Wasowicz, M1
Ferguson, ND1
Steel, A1
Beattie, WS1
Padhi, D1
Salfi, M1
Emery, M1
Chung, CJ1
Lee, JM1
Choi, SR1
Lee, SC1
Lee, JH1
Dilli, D1
Dallar, Y1
Sorgui, NH1
Galvin, E1
Boesjes, H1
Hol, J1
Ubben, JF1
Klein, J1
Verbrugge, SJ1
Erdur, B1
Tura, P1
Aydin, B1
Ozen, M1
Ergin, A1
Parlak, I1
Kabay, B1
Ibrahim, A1
Karim, A1
Feldman, J1
Kharasch, E1
Mandalà, M1
Cremonesi, M1
Rocca, A1
Cazzaniga, M1
Ferretti, G1
Di Cosimo, S1
Ghilardi, M1
Cabiddu, M1
Barni, S1
Dikmen Mentes, S1
Unsal, D1
Baran, O1
Argun, G1
Ertunc, FN1
Lu, DP1
Lu, WI1
Elder, JS1
Longenecker, R1
Donnelly, MB1
Scott, WA1
Daly, DS1
Geiduschek, JM1
Haberkern, CM1
McLaughlin, JF1
Jacobson, LE1
Hays, RM1
Roberts, TS1
Ririe, DG1
Ririe, KL1
Sethna, NF1
Fox, L1
Mainwaring, CJ1
Wong, C1
Lush, RJ1
Smith, JG1
Singer, CR1
Richardson, MG1
Wu, CL1
Hussain, A1
Fainsinger, RL1
Waller, A1
Bercovici, M1
Bengtson, K1
Landman, W1
Hosking, M1
Nunez-Olarte, JM1
deMoissac, D1
Di Florio, T1
Jakobsson, J1
Andersson, L1
Nilsson, A1
Davidson, S1
Askergren, J1
Jakobbson, J1
Andreen, M1
Westgren, M1
Thomasson, K1
Olynyk, JK1
Cullen, SR1
Leahy, MF1
Reves, JG1
Fragen, RJ1
Vinik, HR1
Greenblatt, DJ1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Gabapentin as an Adjunct for Pain Management During Dilation and Evacuation: A Double-blind Randomized Controlled Trial[NCT03635905]Phase 4130 participants (Actual)Interventional2017-05-26Completed
Effect of Inhalational Sedation on Mechanical Power in Mechanically Ventilated Patients: a Pilot Open-label Randomized Controlled Study[NCT05559970]40 participants (Anticipated)Interventional2022-11-15Recruiting
A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102]Phase 4105 participants (Actual)Interventional2016-02-29Terminated
Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227]Phase 4748 participants Interventional2001-09-30Completed
Effects of Premedication by Midazolam on Preoperative Anxiety for Emergency Surgery[NCT02213302]Phase 459 participants (Actual)Interventional2014-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit

Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours

Interventionminutes (Mean)
Placebo53.5
Modafinil61.0

Postanesthesia Quality Recovery Scale Score

Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery

Interventionunits on a scale (Mean)
Placebo-5.67
Modafinil-8.91

Reviews

2 reviews available for midazolam and Nausea

ArticleYear
Safety and Efficacy of Volatile Anesthetic Agents Compared With Standard Intravenous Midazolam/Propofol Sedation in Ventilated Critical Care Patients: A Meta-analysis and Systematic Review of Prospective Trials.
    Anesthesia and analgesia, 2017, Volume: 124, Issue:4

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Clinical Trials as Topic; Critical Care; Humans;

2017
Midazolam: pharmacology and uses.
    Anesthesiology, 1985, Volume: 62, Issue:3

    Topics: Adult; Aged; Aging; Ambulatory Surgical Procedures; Anesthetics; Animals; Benzodiazepines; Benzodiaz

1985

Trials

14 trials available for midazolam and Nausea

ArticleYear
Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial.
    Contraception, 2023, Volume: 118

    Topics: Dilatation; Double-Blind Method; Female; Fentanyl; Gabapentin; Humans; Midazolam; Nausea; Pain; Pain

2023
Cinacalcet does not affect the activity of cytochrome P450 3A enzymes, a metabolic pathway for common immunosuppressive agents : a randomized, open-label, crossover, single-centre study in healthy volunteers.
    Drugs in R&D, 2008, Volume: 9, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Calcium; Calcium Channel Agonists; Cinaca

2008
Effect of remifentanil on oculocardiac reflex in paediatric strabismus surgery.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:9

    Topics: Anesthesia; Blood Pressure; Child; Child, Preschool; Female; Heart Rate; Humans; Infant; Male; Midaz

2008
Intravenous ketamine plus midazolam vs. intravenous ketamine for sedation in lumbar puncture: a randomized controlled trial.
    Indian pediatrics, 2008, Volume: 45, Issue:11

    Topics: Adolescent; Anesthetics, Dissociative; Anesthetics, Intravenous; Child; Confidence Intervals; Dizzin

2008
Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia Recovery Period; Anesthetics, Inha

2010
A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:1

    Topics: Adult; Akathisia, Drug-Induced; Antiemetics; Diphenhydramine; Double-Blind Method; Female; Humans; H

2012
The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:3

    Topics: Adult; Area Under Curve; Biotransformation; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP3A; Cytoc

2002
Midazolam for acute emesis refractory to dexamethasone and granisetron after highly emetogenic chemotherapy: a phase II study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2005, Volume: 13, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents; Cisplatin; Dexamethasone; Female; Graniset

2005
Effect of sedation with midazolam or propofol on patient's comfort during cancer chemotherapy infusion: a prospective, randomized, double-blind study in breast cancer patients.
    Journal of chemotherapy (Florence, Italy), 2005, Volume: 17, Issue:3

    Topics: Adult; Anesthetics, Intravenous; Antineoplastic Agents; Anxiety; Breast Neoplasms; Double-Blind Meth

2005
Premedication with oral midazolam for voiding cystourethrography in children: safety and efficacy.
    AJR. American journal of roentgenology, 1995, Volume: 164, Issue:5

    Topics: Administration, Oral; Affect; Aggression; Anger; Child; Child, Preschool; Female; Humans; Infant; Ma

1995
Sedation for upper gastrointestinal endoscopy: a comparison of alfentanil-midazolam and meperidine-diazepam.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:12

    Topics: Age Factors; Alfentanil; Anesthesia Recovery Period; Apnea; Conscious Sedation; Diazepam; Dizziness;

1994
Midazolam premedication increases sedation but does not prolong discharge times after brief outpatient general anesthesia for laparoscopic tubal sterilization.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Age Factors; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period;

1997
Premedication before elective breast surgery, a comparison between ketobemidone and midazolam.
    Acta anaesthesiologica Scandinavica, 1991, Volume: 35, Issue:6

    Topics: Aged; Analgesics, Opioid; Anxiety; Breast; Female; Humans; Injections, Intramuscular; Meperidine; Mi

1991
Discomfort after outpatient abortion using paracervical block: a comparison between two opioids and one non-opioid drug for premedication.
    Gynecologic and obstetric investigation, 1990, Volume: 30, Issue:2

    Topics: Abortion, Induced; Adult; Ambulatory Care; Anesthesia, Local; Anxiety; Female; Humans; Meperidine; M

1990

Other Studies

11 other studies available for midazolam and Nausea

ArticleYear
[Palliative sedation for psycho-existential suffering].
    Wiener medizinische Wochenschrift (1946), 2014, Volume: 164, Issue:9-10

    Topics: Attitude to Death; Austria; Caregivers; Conscious Sedation; Ethics, Medical; Existentialism; Female;

2014
Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial.
    Medicina intensiva, 2015, Volume: 39, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Service, Hospital; Female;

2015
Oral Sedation Postdischarge Adverse Events in Pediatric Dental Patients.
    Anesthesia progress, 2015,Fall, Volume: 62, Issue:3

    Topics: Administration, Oral; Analgesics, Opioid; Anesthesia, Dental; Anesthetics, Inhalation; Child; Child

2015
"Herbal seizures"--atypical symptoms after ibogaine intoxication: a case report.
    Journal of medical case reports, 2015, Oct-31, Volume: 9

    Topics: Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Hallucinogens; Humans; Hypnotics and Sedatives; Ibog

2015
Practical oral sedation in dentistry. Part II--Clinical application of various oral sedatives and discussion.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2006, Volume: 27, Issue:9

    Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, Dental; Child; Child,

2006
Pain management for children following selective dorsal rhizotomy.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Bupiva

1994
Unexpected interaction of methylphenidate (Ritalin) with anaesthetic agents.
    Paediatric anaesthesia, 1997, Volume: 7, Issue:1

    Topics: Anesthetics, Dissociative; Attention Deficit Disorder with Hyperactivity; Central Nervous System Sti

1997
The role of midazolam-induced sedation in bone marrow aspiration/trephine biopsies.
    Clinical and laboratory haematology, 1996, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Aged; Anesthetics, Local; Antidotes; Awareness; Bone Marrow; Conscious Sedation;

1996
A multicentre international study of sedation for uncontrolled symptoms in terminally ill patients.
    Palliative medicine, 2000, Volume: 14, Issue:4

    Topics: Aged; Analgesics, Opioid; Anti-Anxiety Agents; Consciousness; Delirium; Drug Therapy, Combination; D

2000
The use of midazolam for persistent postoperative nausea and vomiting.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:3

    Topics: Adult; Aged; Female; Humans; Male; Midazolam; Nausea; Postoperative Complications; Vomiting

1992
Midazolam: an effective antiemetic agent for cytotoxic chemotherapy.
    The Medical journal of Australia, 1989, Apr-17, Volume: 150, Issue:8

    Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Humans; Midazolam; Nausea; Vomiting

1989