midazolam has been researched along with Myoclonic Jerk in 24 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "While occasional myoclonic jerks are prevalent in cancer patients receiving opioids, severe myoclonic jerks and seizures due to opioids are uncommon." | 5.30 | Strychnine-like multifocal myoclonus and seizures in extremely high-dose opioid administration: treatment strategies. ( Hagen, N; Swanson, R, 1997) |
| "CSH (200 mg/kg, i." | 5.27 | Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures. ( Cottrell, GA; Robertson, HA, 1987) |
| "The results of this study suggest that (a) etomidate is much safer than propofol for first-trimester surgical abortions and (b) using a lower dose of etomidate, supplemented with fentanyl and midazolam, is more beneficial than the use of etomidate with or without fentanyl in reducing adverse effects like myoclonus and postoperative nausea and vomiting." | 5.17 | A comparison of anesthetic regimens using etomidate and propofol in patients undergoing first-trimester abortions: double-blind, randomized clinical trial of safety and efficacy. ( Chu, S; Deng, F; Wu, J; Wu, Z; Xia, G; Yao, S, 2013) |
| "To determine the frequency, severity and duration of adverse events including myoclonus, pain on injection, hypersalivation, regurgitation and apnoea after administration of midazolam or saline followed by etomidate in hydromorphone premedicated dogs." | 3.01 | Descriptive assessment of adverse events associated with midazolam-etomidate versus saline-etomidate in healthy hydromorphone premedicated dogs. ( Calbay, R; da Cunha, AF; Hofmeister, EH; Jones, TL, 2021) |
| "Recent studies have shown that etomidate is associated with fewer serious adverse events than propofol and has a noninferior sedative effect." | 2.87 | Efficacy and safety of etomidate-midazolam for screening colonoscopy in the elderly: A prospective double-blinded randomized controlled study. ( Choi, HS; Choi, SJ; Chun, HJ; Jeen, YT; Keum, B; Kim, CD; Kim, ES; Kim, SH; Kim, W; Lee, BJ; Lee, HS; Lee, JM; Min, G; Park, JJ, 2018) |
| " The dosage of anesthetic medications administered was also recorded for each patient." | 2.73 | Metoclopramide does not influence the frequency of propofol-induced spontaneous movements. ( Ahmed, SA; Herazo, L; Iyer, C; Joshi, GP; Lenkovsky, F; Markin, V; Robertson, BD; Ross, L, 2007) |
| " In this study, pretreatment with a small dosage of etomidate or midazolam was compared with placebo for the prevention of myoclonic muscle movements." | 2.71 | Midazolam pretreatment reduces etomidate-induced myoclonic movements. ( Fritz, HG; Hueter, L; Schwarzkopf, KR; Simon, M, 2003) |
| "Propofol was well tolerated and lacked the myoclonus, prolonged sedation, and resedation noted with the latter 3 respective groups." | 2.71 | Sedation for cardioversion in the emergency department: analysis of effectiveness in four protocols. ( Bragulat, E; Coll-Vinent, B; Espinosa, G; Fernández, C; Millá, J; Miró, O; Sala, X; Sánchez, M, 2003) |
| " Midazolam concentrations were also measured and pharmacokinetic parameters determined using a population modelling package." | 2.68 | Haemodynamic responses and population pharmacokinetics of midazolam following administration to ventilated, preterm neonates. ( Charles, BG; Gray, PH; Harte, GJ; Lee, TC; Steer, PA, 1997) |
| "Outcome measures comprised overall myoclonus incidence rate and incidence rate classified by degree of myoclonus following etomidate injection." | 2.55 | Effect of pretreatment with midazolam on etomidate-induced myoclonus: A meta-analysis. ( Liu, Z; Ruan, L; Zhou, C; Zhu, Y, 2017) |
| "Spinal myoclonus following neuraxial anesthesia is rare." | 1.43 | Myoclonus-like involuntary movements following cesarean delivery epidural anesthesia. ( Hong, EP; Kang, HY; Kang, JM; Lee, SM; Lee, SW; Park, SW; Sim, YH, 2016) |
| "Study results showed that myoclonus incidence was 85%, 40%, 70%, and 25% in Group NP, Group F, Group M, and Group FM, respectively, and were significantly lower in Group F and Group FM." | 1.40 | Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? A Retrospective comparative study. ( Akkoc, I; Gül, YG; Inal, FY; Isitemiz, I; Toptaş, M; Uzman, S; Vahapoglu, A, 2014) |
| "Because of acute renal failure resulting from rhabdomyolysis hemodialysis was necessary three times." | 1.35 | ["Liquid ecstasy": gamma-butyrolactone withdrawal delirium with rhabdomyolysis and dialysis dependent renal failure]. ( Busch, HJ; Schwab, T; Supady, A, 2009) |
| "Flumazenil is a potent benzodiazepine antagonist that competitively blocks the central effects of benzodiazepines." | 1.31 | Flumazenil's reversal of myoclonic-like movements associated with midazolam in term newborns. ( da Silva, O; Knoppert, DC; Zaw, W, 2001) |
| "While occasional myoclonic jerks are prevalent in cancer patients receiving opioids, severe myoclonic jerks and seizures due to opioids are uncommon." | 1.30 | Strychnine-like multifocal myoclonus and seizures in extremely high-dose opioid administration: treatment strategies. ( Hagen, N; Swanson, R, 1997) |
| "As morphine dosages were further escalated, it was also necessary to increase the midazolam infusion to control additional myoclonic spasms." | 1.29 | Continuous midazolam infusion for the management of morphine-induced myoclonus. ( Adams, VR; Chavez, CM; Duncan, MH; Holdsworth, MT; Vaughan, LJ, 1995) |
| "Life-threatening myoclonus developed in a patient following inadvertent intrathecal usage of 60% diatrizoate meglumine." | 1.29 | Spinal myoclonus following intrathecal administration of diatrizoate meglumine. ( Gutmann, L; Sam, MC, 1996) |
| "CSH (200 mg/kg, i." | 1.27 | Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures. ( Cottrell, GA; Robertson, HA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Jones, TL | 1 |
| Calbay, R | 1 |
| da Cunha, AF | 1 |
| Hofmeister, EH | 1 |
| Zhou, C | 1 |
| Zhu, Y | 1 |
| Liu, Z | 1 |
| Ruan, L | 1 |
| Lee, JM | 2 |
| Min, G | 1 |
| Kim, SH | 1 |
| Choi, HS | 1 |
| Kim, ES | 1 |
| Keum, B | 1 |
| Jeen, YT | 1 |
| Chun, HJ | 1 |
| Lee, HS | 1 |
| Kim, CD | 1 |
| Park, JJ | 1 |
| Lee, BJ | 1 |
| Choi, SJ | 1 |
| Kim, W | 1 |
| Yamaguchi, S | 1 |
| Isitemiz, I | 1 |
| Uzman, S | 1 |
| Toptaş, M | 1 |
| Vahapoglu, A | 1 |
| Gül, YG | 1 |
| Inal, FY | 1 |
| Akkoc, I | 1 |
| Ozcan, B | 1 |
| Kavurt, S | 1 |
| Yucel, H | 1 |
| Bas, AY | 1 |
| Demirel, N | 1 |
| Kang, HY | 1 |
| Lee, SW | 1 |
| Hong, EP | 1 |
| Sim, YH | 1 |
| Lee, SM | 1 |
| Park, SW | 1 |
| Kang, JM | 1 |
| Supady, A | 1 |
| Schwab, T | 1 |
| Busch, HJ | 1 |
| Wu, J | 1 |
| Yao, S | 1 |
| Wu, Z | 2 |
| Chu, S | 1 |
| Xia, G | 1 |
| Deng, F | 1 |
| Chu, YC | 1 |
| Tsai, SK | 1 |
| Chan, KH | 1 |
| Kao, SC | 1 |
| Liang, CH | 1 |
| Lin, SM | 1 |
| Schwarzkopf, KR | 1 |
| Hueter, L | 1 |
| Simon, M | 1 |
| Fritz, HG | 1 |
| Coll-Vinent, B | 1 |
| Sala, X | 1 |
| Fernández, C | 1 |
| Bragulat, E | 1 |
| Espinosa, G | 1 |
| Miró, O | 1 |
| Millá, J | 1 |
| Sánchez, M | 1 |
| Di Liddo, L | 1 |
| D'Angelo, A | 1 |
| Nguyen, B | 1 |
| Bailey, B | 1 |
| Amre, D | 1 |
| Stanciu, C | 1 |
| Hüter, L | 1 |
| Schreiber, T | 1 |
| Gugel, M | 1 |
| Schwarzkopf, K | 1 |
| Lenkovsky, F | 1 |
| Robertson, BD | 1 |
| Iyer, C | 1 |
| Ross, L | 1 |
| Ahmed, SA | 1 |
| Herazo, L | 1 |
| Markin, V | 1 |
| Joshi, GP | 1 |
| Alfa, JA | 1 |
| Bamgbade, OA | 1 |
| Schneider, R | 1 |
| Reebye, U | 1 |
| Choi, C | 1 |
| Kalman, D | 1 |
| Holdsworth, MT | 1 |
| Adams, VR | 1 |
| Chavez, CM | 1 |
| Vaughan, LJ | 1 |
| Duncan, MH | 1 |
| Magny, JF | 1 |
| d'Allest, AM | 1 |
| Nedelcoux, H | 1 |
| Zupan, V | 1 |
| Dehan, M | 1 |
| Sam, MC | 1 |
| Gutmann, L | 1 |
| Hagen, N | 1 |
| Swanson, R | 1 |
| Harte, GJ | 1 |
| Gray, PH | 1 |
| Lee, TC | 1 |
| Steer, PA | 1 |
| Charles, BG | 1 |
| Zaw, W | 1 |
| Knoppert, DC | 1 |
| da Silva, O | 1 |
| Cottrell, GA | 1 |
| Robertson, HA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Pretreatment of Lignocaine Versus Midazolam in the Prevention of Etomidate Induced Myoclonus[NCT04921046] | Phase 4 | 224 participants (Actual) | Interventional | 2015-01-01 | Completed | ||
| Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus During General Anesthesia Induction Period[NCT02518789] | Phase 4 | 132 participants (Anticipated) | Interventional | 2015-09-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for midazolam and Myoclonic Jerk
| Article | Year |
|---|---|
Effect of pretreatment with midazolam on etomidate-induced myoclonus: A meta-analysis.
Topics: Anesthesia, General; Anesthetics, Intravenous; Etomidate; Humans; Injections, Intravenous; Midazolam | 2017 |
9 trials available for midazolam and Myoclonic Jerk
| Article | Year |
|---|---|
Descriptive assessment of adverse events associated with midazolam-etomidate versus saline-etomidate in healthy hydromorphone premedicated dogs.
Topics: Anesthetics, Intravenous; Animals; Dog Diseases; Dogs; Etomidate; Hydromorphone; Midazolam; Myoclonu | 2021 |
Efficacy and safety of etomidate-midazolam for screening colonoscopy in the elderly: A prospective double-blinded randomized controlled study.
Topics: Aged; Anesthetics, Intravenous; Cardiovascular Diseases; Colonoscopy; Double-Blind Method; Etomidate | 2018 |
A comparison of anesthetic regimens using etomidate and propofol in patients undergoing first-trimester abortions: double-blind, randomized clinical trial of safety and efficacy.
Topics: Abortion, Induced; Adult; Analysis of Variance; Anesthesia Recovery Period; Anesthesia, General; Ane | 2013 |
Midazolam pretreatment reduces etomidate-induced myoclonic movements.
Topics: Anesthetics, Intravenous; Double-Blind Method; Etomidate; Female; Humans; Male; Midazolam; Middle Ag | 2003 |
Midazolam pretreatment reduces etomidate-induced myoclonic movements.
Topics: Anesthetics, Intravenous; Double-Blind Method; Etomidate; Female; Humans; Male; Midazolam; Middle Ag | 2003 |
Midazolam pretreatment reduces etomidate-induced myoclonic movements.
Topics: Anesthetics, Intravenous; Double-Blind Method; Etomidate; Female; Humans; Male; Midazolam; Middle Ag | 2003 |
Midazolam pretreatment reduces etomidate-induced myoclonic movements.
Topics: Anesthetics, Intravenous; Double-Blind Method; Etomidate; Female; Humans; Male; Midazolam; Middle Ag | 2003 |
Sedation for cardioversion in the emergency department: analysis of effectiveness in four protocols.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia Recovery Period; Clinical Protocols; Consciou | 2003 |
Etomidate versus midazolam for procedural sedation in pediatric outpatients: a randomized controlled trial.
Topics: Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Consumer Behavior | 2006 |
Low-dose intravenous midazolam reduces etomidate-induced myoclonus: a prospective, randomized study in patients undergoing elective cardioversion.
Topics: Aged; Anesthetics, Intravenous; Double-Blind Method; Electric Countershock; Etomidate; Female; Human | 2007 |
Metoclopramide does not influence the frequency of propofol-induced spontaneous movements.
Topics: Aged; Anesthesia, General; Anesthetics, Intravenous; Antiemetics; Double-Blind Method; Drug Interact | 2007 |
Haemodynamic responses and population pharmacokinetics of midazolam following administration to ventilated, preterm neonates.
Topics: Analysis of Variance; Anesthetics, Intravenous; Blood Flow Velocity; Blood Pressure; Cerebrovascular | 1997 |
14 other studies available for midazolam and Myoclonic Jerk
| Article | Year |
|---|---|
[Efficacy of Dexmedetomidine in Monitored Anesthesia Care (MAC) for a Woman with Mitochondrial Encephalomyopathy Associated with Myoclonus].
Topics: Adult; Anesthesia Recovery Period; Anesthetics, Intravenous; Dexmedetomidine; Female; Humans; Midazo | 2017 |
Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? A Retrospective comparative study.
Topics: Anesthetics, Intravenous; Blood Pressure; Drug Therapy, Combination; Etomidate; Fentanyl; Heart Rate | 2014 |
Rhythmic myoclonic jerking induced by midazolam in a preterm infant.
Topics: Anesthetics, Intravenous; Female; Humans; Infant, Newborn; Infant, Premature; Laser Coagulation; Mid | 2015 |
Myoclonus-like involuntary movements following cesarean delivery epidural anesthesia.
Topics: Administration, Intravenous; Adult; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, Ob | 2016 |
["Liquid ecstasy": gamma-butyrolactone withdrawal delirium with rhabdomyolysis and dialysis dependent renal failure].
Topics: 4-Butyrolactone; Acute Kidney Injury; Adrenergic alpha-Agonists; Benzodiazepines; Clonidine; GABA Mo | 2009 |
Lateral medullary syndrome after prone position for general surgery.
Topics: Adult; Brain Diseases; Cerebral Arteries; Functional Laterality; GABA Modulators; Humans; Magnetic R | 2002 |
Acute myoclonus following spinal anaesthesia.
Topics: Acute Disease; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, Intr | 2008 |
Seizure-like activity and prolonged central nervous system side effects after intravenous sedation.
Topics: Adult; Anesthesia, Dental; Anesthetics, Intravenous; Conscious Sedation; Drug Interactions; Fentanyl | 2008 |
Continuous midazolam infusion for the management of morphine-induced myoclonus.
Topics: Adolescent; Humans; Infusions, Intravenous; Male; Midazolam; Morphine; Myoclonus | 1995 |
Midazolam and myoclonus in neonate.
Topics: Electroencephalography; Humans; Infant, Newborn; Midazolam; Myoclonus; Respiratory Distress Syndrome | 1994 |
Spinal myoclonus following intrathecal administration of diatrizoate meglumine.
Topics: Aged; Contrast Media; Diatrizoate Meglumine; Humans; Hypnotics and Sedatives; Injections, Spinal; Ma | 1996 |
Strychnine-like multifocal myoclonus and seizures in extremely high-dose opioid administration: treatment strategies.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Intravenous; Drug Administration Sc | 1997 |
Flumazenil's reversal of myoclonic-like movements associated with midazolam in term newborns.
Topics: Female; Flumazenil; GABA Modulators; Humans; Hypnotics and Sedatives; Infant, Newborn; Male; Midazol | 2001 |
Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures.
Topics: Animals; Cysteamine; Kindling, Neurologic; Male; Midazolam; Myoclonus; Neural Inhibition; Rats; Rats | 1987 |