midazolam has been researched along with Myocardial Infarction in 17 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this retrospective study, the effect on ventricular arrhythmia incidence during ligation and infarct size following in vivo reperfusion of two anaesthetic regimens, sufentanil-medetomidine (SM) and fentanyl/fluanisone-midazolam (FFM) was evaluated in rats." | 7.88 | Sufentanil-medetomidine anaesthesia compared with fentanyl/fluanisone-midazolam is associated with fewer ventricular arrhythmias and death during experimental myocardial infarction in rats and limits infarct size following reperfusion. ( Flecknell, P; Kramer, K; Krijnen, PAJ; Meyer, KW; Niessen, HWM; Piek, JJ; Ter Horst, EN; van der Laan, AM, 2018) |
| "To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats." | 7.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "Myocardial infarction is a rare and lethal event during pregnancy with an incidence of 1 in 10,000 pregnancies." | 5.28 | Anaesthetic management of a parturient with myocardial infarction related to cocaine use. ( Chen, K; Forrester, RM; Glassenberg, R; Liu, SS; Murphy, GS, 1992) |
| " Cardiac morbidity (postoperative myocardial ischemia, postoperative myocardial infarction, and perioperative sympathoadrenal stress response), respiratory morbidity (postextubation apnea, alveolar-arterial oxygen gradient, pulmonary shunting, oxygen consumption, atelectasis, and reintubation), hemodynamic values and vasoactive medication requirements, intraoperative awareness, postoperative cognitive function, 30 day mortality, and intensive care unit and hospital lengths of stay were compared between the two groups." | 5.08 | Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial. ( Asokumar, B; Carroll, J; Cheng, DC; David, T; Karski, J; Mickle, D; Nierenberg, H; Peniston, C; Raveendran, G; Roger, S; Sandler, A; Tong, J; Zelovitsky, J, 1996) |
| " Thirty-day complication rates were compared with EGD under sedation or not, type of sedation drugs (midazolam only vs midazolam/propofol) and age groups (18-64 year vs ≥65 year) for GI (bleeding and perforation) and non-GI complications (pneumonia, acute myocardial infarction, congestive heart failure and cerebral stroke)." | 4.12 | Gastrointestinal and non-gastrointestinal complication rates associated with diagnostic esophagogastroduodenoscopy under sedation. ( Cha, JM; Jang, JM; Kwak, MS; Park, SB; Yoon, JY, 2022) |
| " In this retrospective study, the effect on ventricular arrhythmia incidence during ligation and infarct size following in vivo reperfusion of two anaesthetic regimens, sufentanil-medetomidine (SM) and fentanyl/fluanisone-midazolam (FFM) was evaluated in rats." | 3.88 | Sufentanil-medetomidine anaesthesia compared with fentanyl/fluanisone-midazolam is associated with fewer ventricular arrhythmias and death during experimental myocardial infarction in rats and limits infarct size following reperfusion. ( Flecknell, P; Kramer, K; Krijnen, PAJ; Meyer, KW; Niessen, HWM; Piek, JJ; Ter Horst, EN; van der Laan, AM, 2018) |
| "To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats." | 3.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "Midazolam is a benzodiazepine commonly utilized in anesthesia and intensive care." | 1.72 | Midazolam suppresses ischemia/reperfusion-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway. ( Cai, D; Zhou, W, 2022) |
| "Patients with unstable angina pectoris or who have just had a myocardial infarction underwent full treatment for pain-induced dental problems, with the use of an incremental three-level antiangina and antianxiety medication: before dental treatment; in the waiting room, and c) during dental treatment." | 1.29 | Dental treatment in very high risk patients with active ischemic heart disease. ( Findler, M; Galili, D; Garfunkel, AA; Meidan, Z; Yakirevitch, V, 1993) |
| "Myocardial infarction is a rare and lethal event during pregnancy with an incidence of 1 in 10,000 pregnancies." | 1.28 | Anaesthetic management of a parturient with myocardial infarction related to cocaine use. ( Chen, K; Forrester, RM; Glassenberg, R; Liu, SS; Murphy, GS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 4 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, W | 1 |
| Cai, D | 1 |
| Jiang, X | 1 |
| Yan, M | 1 |
| Jang, JM | 1 |
| Park, SB | 1 |
| Yoon, JY | 1 |
| Kwak, MS | 1 |
| Cha, JM | 1 |
| Heybati, K | 1 |
| Zhou, F | 1 |
| Baltazar, M | 1 |
| Poudel, K | 1 |
| Ochal, D | 1 |
| Ellythy, L | 1 |
| Deng, J | 1 |
| Chelf, CJ | 1 |
| Welker, C | 1 |
| Ramakrishna, H | 1 |
| Ter Horst, EN | 1 |
| Krijnen, PAJ | 1 |
| Flecknell, P | 1 |
| Meyer, KW | 1 |
| Kramer, K | 1 |
| van der Laan, AM | 1 |
| Piek, JJ | 1 |
| Niessen, HWM | 1 |
| Chen, L | 1 |
| Gong, Q | 1 |
| Xiao, C | 1 |
| Chen, Q | 1 |
| Scott, BH | 1 |
| Bilfinger, TV | 1 |
| Petrie, J | 1 |
| Glass, PS | 1 |
| Higuchi, H | 1 |
| Maeda, S | 1 |
| Miyawaki, T | 1 |
| Kohjitani, A | 1 |
| Mori, T | 1 |
| Ishida, R | 1 |
| Egusa, M | 1 |
| Shimada, M | 1 |
| Findler, M | 1 |
| Galili, D | 1 |
| Meidan, Z | 1 |
| Yakirevitch, V | 1 |
| Garfunkel, AA | 1 |
| Achar, MN | 1 |
| Achar, KN | 1 |
| Cheng, DC | 1 |
| Karski, J | 1 |
| Peniston, C | 1 |
| Asokumar, B | 1 |
| Raveendran, G | 1 |
| Carroll, J | 1 |
| Nierenberg, H | 1 |
| Roger, S | 1 |
| Mickle, D | 1 |
| Tong, J | 1 |
| Zelovitsky, J | 1 |
| David, T | 1 |
| Sandler, A | 1 |
| Liu, SS | 1 |
| Forrester, RM | 1 |
| Murphy, GS | 1 |
| Chen, K | 1 |
| Glassenberg, R | 1 |
| Noble, WH | 1 |
| Baker, A | 1 |
| Tuman, KJ | 1 |
| McCarthy, RJ | 1 |
| el-Ganzouri, AR | 1 |
| Spiess, BD | 1 |
| Ivankovich, AD | 1 |
| Hess, L | 3 |
| Vrána, M | 3 |
| Vránová, Z | 3 |
| Fejfar, Z | 3 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Study Comparing the Efficacy and Safety of 100 mcg and 200 mcg of Intranasal Fentanyl Pectin Spray as an Analgesic in Adult Males Undergoing Outpatient Cystoscopic Procedures[NCT01756651] | Phase 1 | 20 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for midazolam and Myocardial Infarction
| Article | Year |
|---|---|
Appraisal of Postoperative Outcomes of Volatile and Intravenous Anesthetics: A Network Meta-Analysis of Patients Undergoing Cardiac Surgery.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Cardiac Surgical Procedures; Humans; Midaz | 2023 |
2 trials available for midazolam and Myocardial Infarction
| Article | Year |
|---|---|
Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial.
Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Apnea; Catecholamines; | 1996 |
An experimental contribution to the treatment of acute myocardial infarction.
Topics: Adult; Analgesics; Animals; Benzodiazepines; Clinical Trials as Topic; Dogs; Drug Evaluation; Electr | 1987 |
14 other studies available for midazolam and Myocardial Infarction
| Article | Year |
|---|---|
Midazolam suppresses ischemia/reperfusion-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway.
Topics: Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; JNK Mitogen-Activated Protein Kinases; | 2022 |
Comparing the impact on the prognosis of acute myocardial infarction critical patients of using midazolam, propofol, and dexmedetomidine for sedation.
Topics: Aged; Aged, 80 and over; Coronary Care Units; Critical Illness; Databases, Factual; Dexmedetomidine; | 2021 |
Gastrointestinal and non-gastrointestinal complication rates associated with diagnostic esophagogastroduodenoscopy under sedation.
Topics: Aged; Conscious Sedation; Endoscopy, Digestive System; Humans; Hypnotics and Sedatives; Midazolam; M | 2022 |
Sufentanil-medetomidine anaesthesia compared with fentanyl/fluanisone-midazolam is associated with fewer ventricular arrhythmias and death during experimental myocardial infarction in rats and limits infarct size following reperfusion.
Topics: Anesthetics, Combined; Animals; Arrhythmias, Cardiac; Butyrophenones; Fentanyl; Male; Medetomidine; | 2018 |
Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Edema; Brain Ischemia; Excitatory Amino Acids; Male; M | 2003 |
Pulseless electrical activity after induction of anesthesia: a witnessed cardiac rupture.
Topics: Anesthesia; Anesthetics, Intravenous; Blood Gas Analysis; Blood Pressure; Cardiopulmonary Bypass; Ca | 2004 |
Dental management of a patient with takotsubo cardiomyopathy: a case report.
Topics: Adult; Anesthesia, Dental; Anesthetics, Intravenous; Cardiomyopathies; Conscious Sedation; Dental Ca | 2007 |
Dental treatment in very high risk patients with active ischemic heart disease.
Topics: Aged; Anesthesia, Dental; Anesthesia, Local; Angina, Unstable; Conscious Sedation; Dental Care for D | 1993 |
Efficacy of ketamine infusion in refractory asthma complicated by acute myocardial infarction.
Topics: Asthma; Bronchial Spasm; Conscious Sedation; Female; Humans; Infusions, Intravenous; Ketamine; Midaz | 1993 |
Anaesthetic management of a parturient with myocardial infarction related to cocaine use.
Topics: Adult; Anesthesia, Intravenous; Anesthesia, Obstetrical; Crack Cocaine; Female; Fentanyl; Humans; La | 1992 |
MAO inhibitors and coronary artery surgery: a patient death.
Topics: Acidosis; Anesthesia, Intravenous; Angina, Unstable; Cause of Death; Coronary Artery Bypass; Fentany | 1992 |
Sufentanil-midazolam anesthesia for coronary artery surgery.
Topics: Adrenergic beta-Antagonists; Anesthesia, Intravenous; Anesthetics; Blood Pressure; Cardiac Output; C | 1990 |
The electrostabilizing effect of a combination of midazolam and fentanyl: an experimental study in the dog.
Topics: Animals; Blood Pressure; Dogs; Drug Combinations; Electrocardiography; Fentanyl; Heart Conduction Sy | 1989 |
A comparison of the antifibrillatory effect of midazolam and flunitrazepam in acute myocardial ischaemia in the dog.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Vessels; Dogs; Flunitrazepam; Heart Ventricles; Ligation; | 1987 |