midazolam has been researched along with Muscle Relaxation in 24 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dosage of propofol needed for induction, consumption during maintenance and recovery time were recorded." | 5.40 | Impact of malnutrition on propofol consumption and recovery time among patients undergoing laparoscopic gastrointestinal surgery. ( Bu, H; Fan, Y; Gao, F; Manyande, A; Tian, X; Tian, Y; Xiang, Y; Yang, H, 2014) |
| " We examined the actions of Ro5-4684 (parachlorodiazepam) and midazolam on guinea pig tracheal smooth muscle contraction." | 3.67 | Peripheral type benzodiazepine receptor and airway smooth muscle relaxation. ( Miller, LG; Raeburn, D; Summer, WR, 1988) |
| " The dosage of propofol needed for induction, consumption during maintenance and recovery time were recorded." | 1.40 | Impact of malnutrition on propofol consumption and recovery time among patients undergoing laparoscopic gastrointestinal surgery. ( Bu, H; Fan, Y; Gao, F; Manyande, A; Tian, X; Tian, Y; Xiang, Y; Yang, H, 2014) |
| " Optimal length was determined, a dose-response curve to acetylcholine was established, and the 50% effective dose (ED50) of acetylcholine was calculated." | 1.29 | Direct relaxant effects of intravenous anesthetics on airway smooth muscle. ( Bosnjak, ZJ; Cheng, EY; Coon, RL; Kampine, JP; Mazzeo, AJ, 1996) |
| "Pretreatment with propranolol 10(-6) mol litre-1, flumazenil 10(-7) and 10(-6) mol litre-1 or PK11195 10(-6) mol litre-1 had no effect on diazepam- or midazolam-induced relaxation." | 1.28 | Comparison of the relaxant effects of diazepam, flunitrazepam and midazolam on airway smooth muscle. ( Hashimoto, Y; Iwatsuki, N; Kato, M; Koga, Y; Sato, S; Sodeyama, N; Takahashi, M, 1992) |
| "tizanidine was antagonized by co-administration of prazosin but not by yohimbine." | 1.28 | Myorelaxant effect after intrathecal injection of antispastic drugs in rats. ( Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Wüllner, U, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.50) | 18.7374 |
| 1990's | 11 (45.83) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tian, X | 1 |
| Xiang, Y | 1 |
| Fan, Y | 1 |
| Bu, H | 1 |
| Yang, H | 1 |
| Manyande, A | 1 |
| Gao, F | 1 |
| Tian, Y | 1 |
| Lee, CH | 1 |
| Kim, DK | 1 |
| Kim, SY | 1 |
| Rhee, CS | 1 |
| Won, TB | 1 |
| Diao, HX | 1 |
| Zhang, S | 1 |
| Hu, XY | 1 |
| Guan, W | 1 |
| Luan, L | 1 |
| Liu, HY | 1 |
| Fan, HG | 1 |
| Narayanaswamy, M | 1 |
| Alves-Júnior, JR | 1 |
| Bosso, AC | 1 |
| Andrade, MB | 1 |
| Werther, K | 1 |
| Santos, AL | 1 |
| Kohjitani, A | 1 |
| Miyawaki, T | 1 |
| Funahashi, M | 1 |
| Higuchi, H | 1 |
| Matsuo, R | 1 |
| Shimada, M | 1 |
| Vivien, B | 1 |
| Di Maria, S | 1 |
| Ouattara, A | 1 |
| Langeron, O | 1 |
| Coriat, P | 1 |
| Riou, B | 1 |
| Fodale, V | 1 |
| Praticò, C | 1 |
| Santamaria, LB | 1 |
| Klockgether-Radke, AP | 1 |
| Pawlowski, P | 1 |
| Neumann, P | 1 |
| Hellige, G | 1 |
| Bissinger, U | 1 |
| Miyawaki, I | 1 |
| Nakamura, K | 1 |
| Terasako, K | 1 |
| Toda, H | 1 |
| Kakuyama, M | 1 |
| Mori, K | 1 |
| Verstegen, J | 1 |
| Petcho, A | 1 |
| Smeulers, NJ | 1 |
| Wierda, JM | 1 |
| van den Broek, L | 1 |
| Gallandat Huet, RC | 1 |
| Hennis, PJ | 1 |
| Cheng, EY | 1 |
| Mazzeo, AJ | 1 |
| Bosnjak, ZJ | 1 |
| Coon, RL | 1 |
| Kampine, JP | 1 |
| Tsujita, T | 1 |
| Shibata, O | 1 |
| Makita, T | 1 |
| Iwanaga, S | 1 |
| Nakamura, H | 1 |
| Fukusaki, M | 1 |
| Sumikawa, K | 1 |
| Kelicen, P | 1 |
| Ismailoglu, UB | 1 |
| Erdemli, O | 1 |
| Sahin-Erdemli, I | 1 |
| Shiraishi, Y | 1 |
| Ohashi, M | 1 |
| Kanmura, Y | 1 |
| Yamaguchi, S | 1 |
| Yoshimura, N | 1 |
| Itoh, T | 1 |
| Kojima, K | 1 |
| Nishimura, R | 1 |
| Mutoh, T | 1 |
| Takao, K | 1 |
| Matsunaga, S | 1 |
| Mochizuki, M | 1 |
| Sasaki, N | 1 |
| Hanazaki, M | 1 |
| Jones, KA | 1 |
| Warner, DO | 1 |
| Koga, Y | 1 |
| Sato, S | 1 |
| Sodeyama, N | 1 |
| Takahashi, M | 1 |
| Kato, M | 1 |
| Iwatsuki, N | 1 |
| Hashimoto, Y | 1 |
| Stefański, R | 1 |
| Plaznik, A | 1 |
| Pałejko, W | 1 |
| Kostowski, W | 1 |
| Raeburn, D | 1 |
| Miller, LG | 1 |
| Summer, WR | 1 |
| Haxhiu, MA | 1 |
| van Lunteren, E | 1 |
| Cherniack, NS | 1 |
| Deal, EC | 1 |
| Klockgether, T | 1 |
| Schwarz, M | 1 |
| Wüllner, U | 1 |
| Turski, L | 1 |
| Sontag, KH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Bispectral Index: A Comparison of Bifrontal Montage Agreement[NCT04062240] | 15 participants (Actual) | Observational | 2019-11-27 | Completed | |||
| Bispectral Index Monitoring In Pediatric Cataract Surgery: A Comparative Study Using Propofol- Midazolam Versus Sevoflurane Anesthesia[NCT05262205] | 100 participants (Anticipated) | Interventional | 2021-11-15 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Degree of variability between the values produced by the BIS sensors in a bifrontal montage when monitored simultaneously by use of a Bland-Altmann plot. The average value of each timed pair was plotted against the difference between the pairs.~The BIS monitor outputs data on a scale of 0-100 in arbitrary units; 0 = an isoelectric state on EEG, 100 = fully awake patient. BIS values of 40-60 are thought to reduce the chance of patient recall during general anesthesia.~For the purpose of this study, a smaller confidence interval is better as it indicates a higher level of agreement between the two BIS sensors." (NCT04062240)
Timeframe: 10 minutes where both sensors are recording concurrently
| Intervention | units on a scale (Mean) |
|---|---|
| Additional BIS Sensor | 0.01 |
3 trials available for midazolam and Muscle Relaxation
| Article | Year |
|---|---|
Behavioral and cardiopulmonary effects of dexmedetomidine-midazolam and dexmedetomidine-midazolam-butorphanol in the silver fox (Vulpes vulpes).
Topics: Anesthetics, Combined; Animals; Arterial Pressure; Behavior, Animal; Body Temperature; Butorphanol; | 2017 |
Overestimation of Bispectral Index in sedated intensive care unit patients revealed by administration of muscle relaxant.
Topics: Anesthetics, Intravenous; Conscious Sedation; Critical Care; Echocardiography; Electroencephalograph | 2003 |
Hypothermic cardiopulmonary bypass influences the concentration-response relationship and the biodisposition of rocuronium.
Topics: Adjuvants, Anesthesia; Adult; Aged; Androstanols; Anesthesia; Cardiopulmonary Bypass; Chromatography | 1995 |
21 other studies available for midazolam and Muscle Relaxation
| Article | Year |
|---|---|
Impact of malnutrition on propofol consumption and recovery time among patients undergoing laparoscopic gastrointestinal surgery.
Topics: Accelerometry; Aged; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Intravenous; Anest | 2014 |
Changes in site of obstruction in obstructive sleep apnea patients according to sleep position: a DISE study.
Topics: Adult; Anesthesia, Intravenous; Endoscopy; Female; Gravitation; Humans; Larynx; Male; Midazolam; Mid | 2015 |
Decrease in Bispectral Index while correcting hyperglycemia and an increase in Bispectral Index with correction of hypoglycemia.
Topics: Aged; Anesthesia; Anesthesiology; Blood Glucose; Electroencephalography; Female; Fentanyl; Humans; H | 2009 |
Association of midazolam with ketamine in giant Amazon river turtles Podocnemis expansa breed in captivity.
Topics: Analgesics; Anesthesia; Anesthetics, Combined; Animals; Female; Heart Rate; Ketamine; Locomotion; Ma | 2012 |
Ketamine and midazolam differentially inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation in rabbits: role of superoxide anion and nitric oxide synthase.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Autonomic Nervous System; Esophagogast | 2003 |
Coadministration of propofol and midazolam decreases bispectral index value as a result of synergic muscle relaxant action on the motor system.
Topics: Anesthetics, Intravenous; Drug Synergism; Electroencephalography; Humans; Midazolam; Muscle Relaxati | 2004 |
Mechanisms involved in the relaxing effect of midazolam on coronary arteries.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coronary Vessels; Dinoprostone; Dose-Response Rela | 2005 |
Different onset times of succinylcholine-induced neuromuscular blockade at the adductor pollicis and stapedius muscles.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Humans; Ketamin | 1995 |
Modification of endothelium-dependent relaxation by propofol, ketamine, and midazolam.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Binding Sites; Cyclic GMP; Endothelium, Vascular; | 1995 |
Medetomidine-butorphanol-midazolam for anaesthesia in dogs and its reversal by atipamezole.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics; Animals; Butorphanol; Dogs; Drug Combinations | 1993 |
Direct relaxant effects of intravenous anesthetics on airway smooth muscle.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Bronchi; Calcium; Dogs; Dose-Response Relationship | 1996 |
Effects of intravenous anesthetics on the contraction and response of rat trachea to phosphatidylinositol.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Carbachol; Fentanyl; Ketamine; Male; Midazo | 1997 |
The effect of propofol and thiopentone on impairment by reactive oxygen species of endothelium-dependent relaxation in rat aortic rings.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Aorta, Thoracic; Endothelium, Vascular; Etomidate; | 1997 |
Possible mechanisms underlying the midazolam-induced relaxation of the noradrenaline-contraction in rabbit mesenteric resistance artery.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; In Vitro Techniques; Male; Membrane Potentials | 1997 |
Comparison of sedative effects of medetomidine-midazolam, acepromazine-butorphanol and midazolam-butorphanol in dogs.
Topics: Acepromazine; Analgesia; Animals; Butorphanol; Dogs; Drug Therapy, Combination; Female; Hypnotics an | 1999 |
Effects of intravenous anesthetics on Ca2+ sensitivity in canine tracheal smooth muscle.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Calcium; Dogs; Female; Halothane; Ketami | 2000 |
Comparison of the relaxant effects of diazepam, flunitrazepam and midazolam on airway smooth muscle.
Topics: Animals; Atropine; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Guine | 1992 |
Myorelaxant effect of baclofen injected to the nucleus accumbens septi.
Topics: Animals; Baclofen; Behavior, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Halo | 1990 |
Peripheral type benzodiazepine receptor and airway smooth muscle relaxation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzodiazepinones; Calcium; Convulsants; Guinea Pigs; | 1988 |
Benzodiazepines acting on ventral surface of medulla cause airway dilation.
Topics: Animals; Atropine; Blood Pressure; Cats; Diazepam; Female; Flumazenil; Lung; Male; Medulla Oblongata | 1989 |
Myorelaxant effect after intrathecal injection of antispastic drugs in rats.
Topics: Animals; Baclofen; Clonidine; Dose-Response Relationship, Drug; Female; H-Reflex; Injections, Spinal | 1989 |