midazolam has been researched along with Muscle Contraction in 37 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate in vitro effects of propofol, midazolam and dexmedetomidine, which are commonly used anaesthesic or sedatives, on spontaneous contractions of the ileum both in normal rats and those exposed to hyperdynamic peritonitis." | 3.75 | Altered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitis. ( Altun, A; Aydin, C; Bagcivan, I; Gursoy, S; Koyuncu, A; Topcu, O, 2009) |
| "To investigate the relationship between total body weight (TBW) or body mass index (BMI) and atracurium reversal time." | 3.70 | Antagonism of atracurium-induced block in obese patients. ( Kirkegaard-Nielsen, H; Lindholm, P; Petersen, HS; Severinsen, IK, 1998) |
| " Neuromuscular blockade was induced and maintained with atracurium." | 3.70 | New equipment for neuromuscular transmission monitoring: a comparison of the TOF-Guard with the Myograph 2000. ( Helbo-Hansen, HS; Kirkegaard-Nielsen, H; Lindholm, P; Pedersen, HS; Schmidt, MB; Severinsen, IK, 1998) |
| " We examined the actions of Ro5-4684 (parachlorodiazepam) and midazolam on guinea pig tracheal smooth muscle contraction." | 3.67 | Peripheral type benzodiazepine receptor and airway smooth muscle relaxation. ( Miller, LG; Raeburn, D; Summer, WR, 1988) |
| " Concomitant medication use, such as benzodiazepines, could alter responses to neuromodulation, and so before the development of a clinical trial to confirm translation of this potential therapy, the potential interactions between acute and chronic use of benzodiazepines and bPNS were examined in a preclinical model." | 1.56 | Benzodiazepines Suppress Neuromodulatory Effects of Pudendal Nerve Stimulation on Rat Bladder Nociception. ( Clodfelder-Miller, B; McNaught, J; Nelson, DE; Ness, TJ; Su, X, 2020) |
| "Propofol pretreatment greatly attenuated the impairment in comparison with midazolam, which agrees with the concept of antioxidant activity in the presence of membranes." | 1.31 | Propofol versus midazolam regarding their antioxidant activities. ( Asada, A; Inoue, M; Maeda, K; Sato, EF; Shindo, M; Tsuchiya, M; Ueda, Y, 2001) |
| " We studied the dose-response characteristics of midazolam for reducing the diaphragmatic contractility in dogs." | 1.31 | Dose-response characteristics of midazolam for reducing diaphragmatic contractility. ( Fujii, Y; Hoshi, T; Toyooka, H; Uemura, A, 2001) |
| "Midazolam has no effect on the release of stored Ca2+." | 1.29 | Effects of midazolam on intracellular Ca2+ and tension in airway smooth muscles. ( Kai, T; Kanaide, H; Kobayashi, S; Nishimura, J; Takahashi, S; Yoshimura, H, 1995) |
| "tizanidine was antagonized by co-administration of prazosin but not by yohimbine." | 1.28 | Myorelaxant effect after intrathecal injection of antispastic drugs in rats. ( Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Wüllner, U, 1989) |
| "Midazolam is a water soluble benzodiazepine of interest to the anaesthetist for use as a premedicant and for induction of anaesthesia." | 1.27 | Effects of midazolam on directly stimulated muscle biopsies from control and malignant hyperthermia positive patients. ( Fletcher, JE; Hilf, M; Rosenberg, H, 1984) |
| "Midazolam (0." | 1.27 | Comparison of thiopental and midazolam on the neuromuscular responses to succinylcholine or pancuronium in humans. ( Cronnelly, R; Miller, RD; Morris, RB, 1983) |
| " Midazolam 5 mg kg-1 caused a shift to the left of the cumulative dose-response curves of vecuronium." | 1.27 | Interaction of midazolam with two non-depolarizing neuromuscular blocking drugs in the rat in vivo sciatic nerve-tibialis anterior muscle preparation. ( Booij, LH; Crul, JF; Driessen, JJ; van Egmond, J; Vree, TB, 1985) |
| " This situation demonstrates the difficulties of assessing the level of sedation as well as the dosage requirements in this type of patient." | 1.27 | Detection of overdosage of sedation in a patient with renal failure by the absence of lower oesophageal motility. ( Sinclair, ME; Suter, PM, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (24.32) | 18.7374 |
| 1990's | 14 (37.84) | 18.2507 |
| 2000's | 10 (27.03) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Ness, TJ | 1 |
| McNaught, J | 1 |
| Clodfelder-Miller, B | 1 |
| Nelson, DE | 1 |
| Su, X | 1 |
| Li, SP | 1 |
| Zhou, XL | 1 |
| Zhao, Y | 1 |
| Aydin, C | 1 |
| Bagcivan, I | 1 |
| Gursoy, S | 1 |
| Altun, A | 1 |
| Topcu, O | 1 |
| Koyuncu, A | 1 |
| Moriyama, T | 1 |
| Tsuneyoshi, I | 1 |
| Kanmura, Y | 3 |
| Toyosato, A | 1 |
| Begum, M | 1 |
| Sugiyama, K | 1 |
| Someya, G | 1 |
| Fujii, Y | 5 |
| Uemura, A | 3 |
| Toyooka, H | 5 |
| Klockgether-Radke, AP | 1 |
| Thudium, A | 1 |
| Frerichs, A | 1 |
| Kettler, D | 1 |
| Hellige, G | 1 |
| Pandya, AB | 1 |
| O'Leary, CE | 1 |
| Bhalla, RK | 1 |
| Wallis, J | 1 |
| Kaushik, V | 1 |
| Carpentier, JP | 1 |
| Fletcher, JE | 1 |
| Rosenberg, H | 1 |
| Hilf, M | 1 |
| Morel, DR | 1 |
| Forster, A | 1 |
| Bachmann, M | 1 |
| Suter, PM | 2 |
| Tassonyi, E | 1 |
| Cronnelly, R | 1 |
| Morris, RB | 1 |
| Miller, RD | 1 |
| Eukushima, K | 1 |
| Aoki, T | 1 |
| Yoshimura, H | 1 |
| Kai, T | 1 |
| Nishimura, J | 1 |
| Kobayashi, S | 1 |
| Takahashi, S | 2 |
| Kanaide, H | 1 |
| Miyawaki, I | 1 |
| Nakamura, K | 1 |
| Terasako, K | 1 |
| Toda, H | 1 |
| Kakuyama, M | 1 |
| Mori, K | 1 |
| Iwasaki, H | 1 |
| Igarashi, M | 1 |
| Kawana, S | 1 |
| Namiki, A | 1 |
| Kaplan, RF | 1 |
| Garcia, M | 1 |
| Hannallah, RS | 1 |
| Lepage, JY | 1 |
| Malinovsky, JM | 1 |
| Malinge, M | 1 |
| Lechevalier, T | 1 |
| Dupuch, C | 1 |
| Cozian, A | 1 |
| Pinaud, M | 1 |
| Souron, R | 1 |
| Yamaguchi, S | 2 |
| Yoshimura, N | 2 |
| Tsujita, T | 1 |
| Shibata, O | 1 |
| Makita, T | 1 |
| Iwanaga, S | 1 |
| Nakamura, H | 1 |
| Fukusaki, M | 1 |
| Sumikawa, K | 1 |
| Lang, CJ | 1 |
| Sittl, H | 1 |
| Erbguth, F | 1 |
| Shiraishi, Y | 1 |
| Ohashi, M | 1 |
| Itoh, T | 1 |
| Kirkegaard-Nielsen, H | 2 |
| Lindholm, P | 2 |
| Petersen, HS | 1 |
| Severinsen, IK | 2 |
| Helbo-Hansen, HS | 1 |
| Pedersen, HS | 1 |
| Schmidt, MB | 1 |
| Dhonneur, G | 1 |
| Combes, X | 1 |
| Leroux, B | 1 |
| Duvaldestin, P | 1 |
| Hoshi, T | 2 |
| Tsuchiya, M | 1 |
| Asada, A | 1 |
| Maeda, K | 1 |
| Ueda, Y | 1 |
| Sato, EF | 1 |
| Shindo, M | 1 |
| Inoue, M | 1 |
| Parker, CJ | 1 |
| Hunter, JM | 1 |
| Roewer, N | 1 |
| Proske, O | 1 |
| Schulte am Esch, J | 1 |
| Raeburn, D | 1 |
| Miller, LG | 1 |
| Summer, WR | 1 |
| Klockgether, T | 1 |
| Schwarz, M | 1 |
| Wüllner, U | 1 |
| Turski, L | 1 |
| Sontag, KH | 1 |
| Driessen, JJ | 1 |
| Vree, TB | 1 |
| van Egmond, J | 1 |
| Booij, LH | 1 |
| Crul, JF | 1 |
| Sinclair, ME | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TAP) Block in Morbid Obese Patients Undergoing Laparoscopic Gastric Bypass Surgery: A Prospective,Randomized, Blinded Study[NCT01075087] | 19 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 Hour total opioid consumption translated into IV morphine equivalents. (NCT01075087)
Timeframe: 24 hours
| Intervention | miligram IV morphine equivalents (Median) |
|---|---|
| Placebo | 13 |
| Active Comparator | 7.5 |
Quality of Recovery 40 Score at 24 hours postoperative. (NCT01075087)
Timeframe: 24 hours post operatively
| Intervention | units on scale 40 (low) - 200 (high) (Median) |
|---|---|
| Placebo | 170 |
| Active Comparator | 175.5 |
5 trials available for midazolam and Muscle Contraction
| Article | Year |
|---|---|
Modulation of exteroceptive suppression periods in human jaw-closing muscles by subanaesthetic dose of propofol.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Bite Force; Dose-Response Relationship, Drug; | 2011 |
Effect of intravenous midazolam on breathing pattern and chest wall mechanics in human.
Topics: Abdominal Muscles; Adult; Benzodiazepines; Functional Residual Capacity; Humans; Male; Midazolam; Mu | 1984 |
Effects of midazolam (Ro 21-3981) on neuromuscular block.
Topics: Abdomen; Adult; Anesthesia, General; Benzodiazepines; Drug Interactions; Electric Stimulation; Human | 1984 |
Accelerated onset of vecuronium neuromuscular block with pulmonary arterial administration.
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Cardiac Catheterization; Catheterization, Peripher | 1994 |
Postoperative obstructive apnea.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Diaphragm; Electromyography; Flumazenil; GABA | 1999 |
32 other studies available for midazolam and Muscle Contraction
| Article | Year |
|---|---|
Benzodiazepines Suppress Neuromodulatory Effects of Pudendal Nerve Stimulation on Rat Bladder Nociception.
Topics: Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Female; | 2020 |
Sedation with midazolam worsens the diaphragm function than dexmedetomidine and propofol during mechanical ventilation in rats.
Topics: Anesthesia; Animals; Antioxidants; Autophagy; Biomechanical Phenomena; Cell Line; Dexmedetomidine; D | 2020 |
Altered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitis.
Topics: Anesthetics, Intravenous; Animals; Dexmedetomidine; Gastrointestinal Motility; Ileum; Male; Midazola | 2009 |
Effects of a novel benzodiazepine derivative, JM-1232(-), on human gastroepiploic artery in vitro.
Topics: Dose-Response Relationship, Drug; Endothelium, Vascular; Flumazenil; GABA Modulators; Gastroepiploic | 2011 |
Flumazenil recovers diaphragm muscle dysfunction caused by midazolam in dogs.
Topics: Anesthetics, Intravenous; Animals; Antidotes; Dogs; Dose-Response Relationship, Drug; Electric Stimu | 2002 |
High-dose midazolam and the attenuation of the contractile response to vasoconstrictors in coronary artery segments.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Endothelium, Vascular; Flu | 2003 |
Midazolam-induced muscle dysfunction and its recovery in fatigued diaphragm in dogs.
Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Diaphragm; Dogs; Dose-Response Relationship, Drug | 2003 |
Development of malignant hyperthermia post-cardiopulmonary bypass during surgery for mitral valve replacement.
Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Cardiopulmonary Bypas | 2003 |
How we do it: adjunctive intravenous midazolam: diagnosis and treatment of therapy-resistant muscle tension dysphonia.
Topics: Anti-Anxiety Agents; Humans; Infusions, Intravenous; Laryngeal Muscles; Midazolam; Muscle Contractio | 2005 |
Effects of midazolam on directly stimulated muscle biopsies from control and malignant hyperthermia positive patients.
Topics: Anti-Anxiety Agents; Benzodiazepines; Caffeine; Halothane; Humans; In Vitro Techniques; Malignant Hy | 1984 |
Comparison of thiopental and midazolam on the neuromuscular responses to succinylcholine or pancuronium in humans.
Topics: Anesthesia, Intravenous; Anesthetics; Benzodiazepines; Drug Interactions; Humans; Midazolam; Muscle | 1983 |
[Effect of midazolam on the neuromuscular junction--in vitro study (author's transl)].
Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Technique | 1981 |
Effects of midazolam on intracellular Ca2+ and tension in airway smooth muscles.
Topics: Animals; Anti-Anxiety Agents; Calcium; Drug Interactions; Flumazenil; Fluorometry; GABA Modulators; | 1995 |
Modification of endothelium-dependent relaxation by propofol, ketamine, and midazolam.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Binding Sites; Cyclic GMP; Endothelium, Vascular; | 1995 |
Mivacurium-induced neuromuscular blockade during sevoflurane and halothane anaesthesia in children.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Child; Child, Preschool | 1995 |
Pharmacodynamic dose-response and safety study of cisatracurium (51W89) in adult surgical patients during N2O-O2-opioid anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; A | 1996 |
Effects of midazolam on contractions in smooth muscle of the rabbit mesenteric artery.
Topics: Adrenergic alpha-Agonists; Anesthetics, Intravenous; Animals; Caffeine; Calcium Channel Blockers; Do | 1997 |
Effects of intravenous anesthetics on the contraction and response of rat trachea to phosphatidylinositol.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Carbachol; Fentanyl; Ketamine; Male; Midazo | 1997 |
Autonomous stump movements in brain death.
Topics: Aged; Aged, 80 and over; Amputation Stumps; Anti-Anxiety Agents; Brain Death; Female; Humans; Inject | 1997 |
Possible mechanisms underlying the midazolam-induced relaxation of the noradrenaline-contraction in rabbit mesenteric resistance artery.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; In Vitro Techniques; Male; Membrane Potentials | 1997 |
Antagonism of atracurium-induced block in obese patients.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Atracurium; Body Mass Index; Body Weight; | 1998 |
New equipment for neuromuscular transmission monitoring: a comparison of the TOF-Guard with the Myograph 2000.
Topics: Acceleration; Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhal | 1998 |
The effect of sedative drugs on diaphragmatic contractility in dogs: propofol versus midazolam.
Topics: Analysis of Variance; Animals; Blood Pressure; Diaphragm; Dogs; Electric Stimulation; Heart Rate; Hy | 2000 |
Propofol versus midazolam regarding their antioxidant activities.
Topics: Antioxidants; Aorta; Endothelium, Vascular; Erythrocyte Membrane; Humans; In Vitro Techniques; Lipid | 2001 |
Dose-response characteristics of midazolam for reducing diaphragmatic contractility.
Topics: Anesthetics, Intravenous; Animals; Diaphragm; Dogs; Dose-Response Relationship, Drug; Female; Hemody | 2001 |
Midazolam versus propofol for reducing contractility of fatigued canine diaphragm.
Topics: Adjuvants, Anesthesia; Animals; Diaphragm; Dogs; Electric Stimulation; Midazolam; Muscle Contraction | 2001 |
Dependence of the neuromuscular blocking effect of atracurium upon its disposition.
Topics: Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Atracurium; Depression, Chemical; Female; | 1992 |
[The effects of midazolam on the mechanical and electrical properties of the isolated ventricular myocardium].
Topics: Action Potentials; Animals; Depression, Chemical; Guinea Pigs; In Vitro Techniques; Midazolam; Muscl | 1990 |
Peripheral type benzodiazepine receptor and airway smooth muscle relaxation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzodiazepinones; Calcium; Convulsants; Guinea Pigs; | 1988 |
Myorelaxant effect after intrathecal injection of antispastic drugs in rats.
Topics: Animals; Baclofen; Clonidine; Dose-Response Relationship, Drug; Female; H-Reflex; Injections, Spinal | 1989 |
Interaction of midazolam with two non-depolarizing neuromuscular blocking drugs in the rat in vivo sciatic nerve-tibialis anterior muscle preparation.
Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Drug Interactions; Midazolam; Muscle Con | 1985 |
Detection of overdosage of sedation in a patient with renal failure by the absence of lower oesophageal motility.
Topics: Acute Kidney Injury; Adult; Esophagus; Hemofiltration; Humans; Hypnotics and Sedatives; Male; Midazo | 1988 |