midazolam has been researched along with Motor Neuron Disease in 4 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
Excerpt | Relevance | Reference |
---|---|---|
"Midazolam is a sedative used by patients with mechanical ventilation." | 1.48 | Midazolam prevents motor neuronal death from oxidative stress attack mediated by JNK-ERK pathway. ( Li, GZ; Peng, CB; Tao, HL; Wang, DD; Zhou, C, 2018) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (25.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (50.00) | 24.3611 |
2020's | 1 (25.00) | 2.80 |
Authors | Studies |
---|---|
Faull, C | 1 |
Wenzel, D | 1 |
Li, GZ | 1 |
Tao, HL | 1 |
Zhou, C | 1 |
Wang, DD | 1 |
Peng, CB | 1 |
Oliver, DJ | 1 |
Campbell, C | 1 |
O'brien, T | 1 |
Sloan, R | 1 |
Sykes, N | 1 |
Tallon, C | 1 |
Taylor-Horan, J | 1 |
Udoma, M | 1 |
Thal, GD | 1 |
Szabo, MD | 1 |
Lopez-Bresnahan, M | 1 |
Crosby, G | 1 |
4 other studies available for midazolam and Motor Neuron Disease
Article | Year |
---|---|
Mechanical ventilation withdrawal in motor neuron disease: an evaluation of practice.
Topics: Analgesics, Opioid; Humans; Hypnotics and Sedatives; Midazolam; Motor Neuron Disease; Respiration, A | 2022 |
Midazolam prevents motor neuronal death from oxidative stress attack mediated by JNK-ERK pathway.
Topics: Cell Death; Cell Line; Humans; Hypnotics and Sedatives; MAP Kinase Signaling System; Midazolam; Moto | 2018 |
Medication in the last days of life for motor neuron disease/amyotrophic lateral sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Analgesics, Opioid; Anti-Anxiety Agen | 2010 |
Exacerbation or unmasking of focal neurologic deficits by sedatives.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Brain Neoplasms; Endarterectomy, Carotid; | 1996 |