Page last updated: 2024-10-31

midazolam and Motor Neuron Disease

midazolam has been researched along with Motor Neuron Disease in 4 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)

Research Excerpts

ExcerptRelevanceReference
"Midazolam is a sedative used by patients with mechanical ventilation."1.48Midazolam prevents motor neuronal death from oxidative stress attack mediated by JNK-ERK pathway. ( Li, GZ; Peng, CB; Tao, HL; Wang, DD; Zhou, C, 2018)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Faull, C1
Wenzel, D1
Li, GZ1
Tao, HL1
Zhou, C1
Wang, DD1
Peng, CB1
Oliver, DJ1
Campbell, C1
O'brien, T1
Sloan, R1
Sykes, N1
Tallon, C1
Taylor-Horan, J1
Udoma, M1
Thal, GD1
Szabo, MD1
Lopez-Bresnahan, M1
Crosby, G1

Other Studies

4 other studies available for midazolam and Motor Neuron Disease

ArticleYear
Mechanical ventilation withdrawal in motor neuron disease: an evaluation of practice.
    BMJ supportive & palliative care, 2022, Volume: 12, Issue:e6

    Topics: Analgesics, Opioid; Humans; Hypnotics and Sedatives; Midazolam; Motor Neuron Disease; Respiration, A

2022
Midazolam prevents motor neuronal death from oxidative stress attack mediated by JNK-ERK pathway.
    Human cell, 2018, Volume: 31, Issue:1

    Topics: Cell Death; Cell Line; Humans; Hypnotics and Sedatives; MAP Kinase Signaling System; Midazolam; Moto

2018
Medication in the last days of life for motor neuron disease/amyotrophic lateral sclerosis.
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases, 2010, Volume: 11, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Analgesics, Opioid; Anti-Anxiety Agen

2010
Exacerbation or unmasking of focal neurologic deficits by sedatives.
    Anesthesiology, 1996, Volume: 85, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Brain Neoplasms; Endarterectomy, Carotid;

1996