midazolam has been researched along with Morbid Obesity in 12 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to better understand the drug-drug interaction (DDI) potential of CYP3A and P-gp inhibitors." | 1.56 | PBPK modeling of CYP3A and P-gp substrates to predict drug-drug interactions in patients undergoing Roux-en-Y gastric bypass surgery. ( Chan, LN; Chen, KF; Lin, YS, 2020) |
| " In a semiphysiologically based pharmacokinetic (semi-PBPK) model in which different blood flow scenarios were evaluated, intrinsic hepatic clearance of midazolam (CLint,H) was 2 (95% CI 1." | 1.43 | Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1-OH-midazolam in morbidly obese and weight loss surgery patients. ( Brill, MJ; Danhof, M; Darwich, AS; Knibbe, CA; Rostami-Hodjegan, A; Välitalo, PA; van Dongen, HP; van Ramshorst, B, 2016) |
| " Midazolam concentrations were analyzed using population pharmacokinetic modeling." | 1.42 | The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery. ( Brill, MJ; Darwich, AS; Hazebroek, EJ; Knibbe, CA; Rostami-Hodjegan, A; van Dongen, EP; van Ramshorst, B; van Rongen, A, 2015) |
| " Data from 12 healthy volunteers were available for a population pharmacokinetic analysis using NONMEM(®)." | 1.40 | Midazolam pharmacokinetics in morbidly obese patients following semi-simultaneous oral and intravenous administration: a comparison with healthy volunteers. ( Brill, MJ; Burggraaf, J; Houwink, AP; Knibbe, CA; van Dongen, EP; van Ramshorst, B; van Rongen, A; Wiezer, RJ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, KF | 1 |
| Chan, LN | 1 |
| Lin, YS | 1 |
| Yamamoto, T | 1 |
| Miyazawa, N | 1 |
| Yamamoto, S | 1 |
| Kawahara, H | 1 |
| van Rongen, A | 3 |
| van den Anker, JN | 1 |
| Knibbe, CAJ | 1 |
| Reith, DM | 1 |
| Al-Sallami, HS | 1 |
| Brill, MJ | 3 |
| Houwink, AP | 1 |
| Burggraaf, J | 1 |
| van Ramshorst, B | 3 |
| Wiezer, RJ | 1 |
| van Dongen, EP | 2 |
| Knibbe, CA | 3 |
| Hazebroek, EJ | 1 |
| Darwich, AS | 2 |
| Rostami-Hodjegan, A | 2 |
| Välitalo, PA | 1 |
| van Dongen, HP | 1 |
| Danhof, M | 1 |
| Yildiz, TS | 1 |
| Ozdamar, D | 1 |
| Arslan, I | 1 |
| Solak, M | 1 |
| Toker, K | 1 |
| Salihoglu, T | 1 |
| Salihoglu, Z | 1 |
| Zengin, AK | 1 |
| Taskin, M | 1 |
| Colakoglu, N | 1 |
| Babazade, R | 1 |
| Fernández Meré, LA | 1 |
| García, VF | 1 |
| Blanco, MA | 1 |
| Wieczorek, PM | 1 |
| Schricker, T | 1 |
| Vinet, B | 1 |
| Backman, SB | 1 |
| Alvarez, AO | 1 |
| Cascardo, A | 1 |
| Albarracin Menendez, S | 1 |
| Capria, JJ | 1 |
| Cordero, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Timing of Intravenous Paracetamol Administration on Post-surgical Pain and Cytokines Levels Following Laparoscopic Sleeve Gastrectomy[NCT03221998] | Early Phase 1 | 126 participants (Anticipated) | Interventional | 2017-07-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for midazolam and Morbid Obesity
| Article | Year |
|---|---|
The LMA CTrach™ in morbidly obese and lean patients undergoing gynecological procedures: a comparative study.
Topics: Adult; Body Mass Index; Female; Gynecologic Surgical Procedures; Humans; Hypnotics and Sedatives; In | 2010 |
Airway topicalisation in morbidly obese patients using atomised lidocaine: 2% compared with 4%.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Blood Pressure; Dose-Response Relationship, Drug; Dru | 2007 |
10 other studies available for midazolam and Morbid Obesity
| Article | Year |
|---|---|
PBPK modeling of CYP3A and P-gp substrates to predict drug-drug interactions in patients undergoing Roux-en-Y gastric bypass surgery.
Topics: Acetaminophen; Administration, Oral; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B | 2020 |
Anesthetic Management in Mitochondrial Encephalomyopathy: A Case Report.
Topics: Adjuvants, Anesthesia; Adolescent; Anesthesia, General; Dental Caries; Entropion; Humans; Male; Mida | 2017 |
Author's Reply to Reith: "Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults".
Topics: Adolescent; Adult; Humans; Hypnotics and Sedatives; Midazolam; Models, Biological; Obesity, Morbid | 2018 |
Comment on van Rongen et al., "Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults".
Topics: Adolescent; Adult; Humans; Midazolam; Models, Biological; Obesity, Morbid | 2018 |
Midazolam pharmacokinetics in morbidly obese patients following semi-simultaneous oral and intravenous administration: a comparison with healthy volunteers.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Biological Availability; Case- | 2014 |
The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery.
Topics: Administration, Intravenous; Administration, Oral; Adult; Anti-Anxiety Agents; Bariatric Surgery; Co | 2015 |
Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1-OH-midazolam in morbidly obese and weight loss surgery patients.
Topics: Administration, Oral; Algorithms; Cytochrome P-450 CYP3A; Gastrointestinal Tract; Humans; Injections | 2016 |
The impacts of super obesity versus morbid obesity on respiratory mechanics and simple hemodynamic parameters during bariatric surgery.
Topics: Anesthetics, Intravenous; Arterial Pressure; Bariatric Surgery; Blood Gas Analysis; Female; Hemodyna | 2013 |
Positioning of intragastric balloon under sedation in super-super-obese patients.
Topics: Bariatric Surgery; Conscious Sedation; Gastric Balloon; Humans; Hypnotics and Sedatives; Midazolam; | 2006 |
Total intravenous anesthesia with midazolam, remifentanil, propofol and cistracurium in morbid obesity.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Atracurium; Fe | 2000 |