midazolam has been researched along with Miosis in 4 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Miosis: Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This investigation determined the ability of alfentanil miosis and single-point concentrations to detect various degrees of CYP3A inhibition." | 9.11 | Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. ( Hoffer, C; Kharasch, ED; Sheffels, P; Walker, A, 2005) |
| "Alfentanil effect (miosis) may be a sensitive and reliable surrogate for plasma alfentanil concentrations." | 9.09 | A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans. ( Kharasch, ED; Phimmasone, S, 2001) |
| "This investigation determined the ability of alfentanil miosis and single-point concentrations to detect various degrees of CYP3A inhibition." | 5.11 | Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. ( Hoffer, C; Kharasch, ED; Sheffels, P; Walker, A, 2005) |
| "Alfentanil effect (miosis) may be a sensitive and reliable surrogate for plasma alfentanil concentrations." | 5.09 | A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans. ( Kharasch, ED; Phimmasone, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kharasch, ED | 4 |
| Francis, A | 1 |
| London, A | 1 |
| Frey, K | 1 |
| Kim, T | 1 |
| Blood, J | 1 |
| Walker, A | 2 |
| Hoffer, C | 2 |
| Sheffels, P | 2 |
| Isoherranen, N | 1 |
| Thummel, K | 1 |
| Whittington, D | 1 |
| Ensign, D | 1 |
| Phimmasone, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Hydromorphone High Resolution Pharmacokinetic-Pharmacodynamic Fingerprint as the Basis for Identifying Sex Differences in Opioid Pharmacokinetics and Pharmacodynamics[NCT01123486] | 0 participants (Actual) | Interventional | 2015-01-31 | Withdrawn (stopped due to PI relocated to new university) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for midazolam and Miosis
| Article | Year |
|---|---|
Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity.
Topics: Administration, Oral; Adult; Alfentanil; Analgesics, Opioid; Area Under Curve; Cross-Over Studies; C | 2005 |
Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam.
Topics: Administration, Oral; Adult; Alfentanil; Biomarkers; Black or African American; Cytochrome P-450 CYP | 2007 |
A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans.
Topics: Adult; Alfentanil; Analgesics, Opioid; Antibiotics, Antitubercular; Area Under Curve; Cross-Over Stu | 2001 |
1 other study available for midazolam and Miosis
| Article | Year |
|---|---|
Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.
Topics: Administration, Oral; Adolescent; Adult; Alfentanil; Analgesics, Opioid; Area Under Curve; Biologica | 2011 |