midazolam has been researched along with Methemoglobinemia in 2 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methemoglobinemia (MetHb) after exposure to benzocaine (BZC) has been reported for more than 50 years, however the pathophysiologic mechanism has not been previously established." | 3.80 | Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure. ( Casavant, MJ; Gerona, RR; Ho, RY; Russell, JL; Spiller, HA, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spiller, HA | 1 |
| Russell, JL | 1 |
| Casavant, MJ | 1 |
| Ho, RY | 1 |
| Gerona, RR | 1 |
| Chalfa, R | 1 |
| Elliott, CG | 1 |
| Mathewson, HS | 1 |
2 other studies available for midazolam and Methemoglobinemia
| Article | Year |
|---|---|
Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure.
Topics: 4-Aminobenzoic Acid; Acetaminophen; Administration, Topical; Benzocaine; Bupivacaine; Child; Cyanosi | 2014 |
Drug-induced methemoglobinemia in a healthy 20-year-old soldier undergoing shoulder surgery.
Topics: Adult; Arthroscopy; Fentanyl; Humans; Male; Methemoglobinemia; Methylene Blue; Midazolam; Pain; Prop | 1993 |