midazolam has been researched along with Mental Disorders in 23 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Records of children with autism or neurobehavioral disorders sedated with dexmedetomidine at Chris Evert Children's Hospital and Kosair Children's Hospital were reviewed." | 5.35 | Dexmedetomidine for procedural sedation in children with autism and other behavior disorders. ( Berkenbosch, JW; Lubisch, N; Roskos, R, 2009) |
| " Midazolam was more rapidly sedating than haloperidol-promethazine, reducing the time people are exposed to aggression." | 5.10 | Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine. ( , 2003) |
| "The assessment of modifications in the tetanus treatment, which included using metronidazol and midazolam instead penicillin and diazepam, was presented." | 3.70 | [Modifications in treatment of tetanus and prognosis--observations from the Cracow Department of Infectious Diseases]. ( Bociaga-Jasik, M; Caban, J; Garlicki, A; Kluba-Wojewoda, U; Krukowiecki, J, 1999) |
| "Midazolam was used in approximately 47% in the MC group." | 1.40 | Survey on choice of intravenous sedative agent at department of dental anesthesiology, Tokyo Dental College Chiba Hospital between 2010 and 2011. ( Ichinohe, T; Kasahara, M; Matsuki, Y; Matsuura, N; Okamura, T; Shiozaki, K, 2014) |
| "Oral ketamine is an effective premedication for major ambulatory surgery and does not increase the incidence of side effects." | 1.36 | [Oral ketamine-midazolam premedication of uncooperative patients in major outpatient surgery]. ( Cano, G; Caparros, P; Cortiñas, M; Ibarra, M; Martínez, L; Oya, B, 2010) |
| "Records of children with autism or neurobehavioral disorders sedated with dexmedetomidine at Chris Evert Children's Hospital and Kosair Children's Hospital were reviewed." | 1.35 | Dexmedetomidine for procedural sedation in children with autism and other behavior disorders. ( Berkenbosch, JW; Lubisch, N; Roskos, R, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, LY | 1 |
| Zhang, YH | 1 |
| Shen, J | 1 |
| Luo, Y | 1 |
| Huebinger, RM | 1 |
| Zaidi, HQ | 1 |
| Tataris, KL | 1 |
| Weber, JM | 1 |
| Pearlman, KS | 1 |
| Markul, E | 1 |
| Stein-Spencer, L | 1 |
| Richards, CT | 1 |
| Calver, L | 1 |
| Drinkwater, V | 1 |
| Isbister, GK | 2 |
| Matsuki, Y | 1 |
| Okamura, T | 1 |
| Shiozaki, K | 1 |
| Matsuura, N | 1 |
| Kasahara, M | 1 |
| Ichinohe, T | 1 |
| Lubisch, N | 1 |
| Roskos, R | 1 |
| Berkenbosch, JW | 1 |
| Brakoulias, V | 1 |
| Mandali, R | 1 |
| Seymour, J | 1 |
| Sammut, P | 1 |
| Starcevic, V | 1 |
| Calver, LA | 1 |
| Page, CB | 1 |
| Stokes, B | 1 |
| Bryant, JL | 1 |
| Downes, MA | 1 |
| Cortiñas, M | 1 |
| Oya, B | 1 |
| Caparros, P | 1 |
| Cano, G | 1 |
| Ibarra, M | 1 |
| Martínez, L | 1 |
| Sharshar, T | 1 |
| Porcher, R | 1 |
| Siami, S | 1 |
| Rohaut, B | 1 |
| Bailly-Salin, J | 1 |
| Hopkinson, NS | 1 |
| Clair, B | 1 |
| Guidoux, C | 1 |
| Iacobone, E | 1 |
| Sonneville, R | 1 |
| Polito, A | 1 |
| Aboab, J | 1 |
| Gaudry, S | 1 |
| Morla, O | 1 |
| Amouyal, G | 1 |
| Azuar, J | 1 |
| Allary, J | 1 |
| Vieillard-Baron, A | 1 |
| Wolff, M | 1 |
| Cariou, A | 1 |
| Annane, D | 1 |
| Huf, G | 1 |
| Coutinho, ES | 1 |
| Adams, CE | 1 |
| Chan, WP | 1 |
| Chilvers, CR | 1 |
| Ng, B | 1 |
| Malesu, RR | 1 |
| Pojda-Wilczek, D | 1 |
| Stołtny, LG | 1 |
| Pojda, SM | 1 |
| Pojda, G | 1 |
| Bleiberg, AH | 1 |
| Salvaggio, CA | 1 |
| Roy, LC | 1 |
| Kassutto, Z | 1 |
| Fukuta, O | 2 |
| Braham, RL | 2 |
| Yanase, H | 2 |
| Kurosu, K | 2 |
| Atsumi, N | 1 |
| Thakker, P | 1 |
| Gallagher, TM | 1 |
| Nielssen, O | 1 |
| Buhrich, N | 1 |
| Finlay-Jones, R | 1 |
| McCall, WV | 1 |
| Garlicki, A | 1 |
| Caban, J | 1 |
| Bociaga-Jasik, M | 1 |
| Kluba-Wojewoda, U | 1 |
| Krukowiecki, J | 1 |
| Wroblewski, BA | 1 |
| Joseph, AB | 1 |
| Knaack-Steinegger, R | 1 |
| Schou, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sedation to Electroencephalography With Dexmedetomidine or Chloral Hydrate: a Comparative Study of the Qualitative and Quantitative Electroencephalogram Pattern[NCT01083797] | Phase 3 | 25 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| The Use of Dexmedetomidine for Procedural Sedation During EEG in Children Affected by Behavioural Disorders[NCT03799783] | Phase 2 | 19 participants (Actual) | Interventional | 2018-03-01 | Completed | ||
| Ketamine Versus Midazolam for Prehospital Agitation[NCT03554915] | 314 participants (Actual) | Observational | 2017-08-01 | Completed | |||
| Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612] | Phase 2 | 358 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
the PSSS is a validated scale for assessing the level of procedural sedation. It is a 6 items scale , from 0 to 5, where 5 is an alert patient and 0 is a deep sedation with abnormal vital signs. We evaluate patients 10 minutes after the infusion of dexmedetomidine. (NCT03799783)
Timeframe: 10 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Dexmedetomidine | 13 |
any adverse event potentially related with DEX-administration (NCT03799783)
Timeframe: during and immediately after DEX infusion, up to 150 minutes after DEX infusion (time to first awakening)
| Intervention | Participants (Count of Participants) |
|---|---|
| Dexmedetomidine | 10 |
Length of seizure. (NCT00326612)
Timeframe: 24 hours
| Intervention | Minutes (Median) |
|---|---|
| Intranasal Midazolam | 3.0 |
| Rectal Diazepam | 4.3 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 21 |
| Rectal Diazepam | 17 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 4 |
| Rectal Diazepam | 3 |
(NCT00326612)
Timeframe: 12 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 1 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 5 |
| Rectal Diazepam | 5 |
Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 0 |
Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 3 |
| Rectal Diazepam | 1 |
5 trials available for midazolam and Mental Disorders
| Article | Year |
|---|---|
Effects of dexmedetomidine on post-operative recovery and mental status in patients receiving robotic-assisted thoracic surgery.
Topics: Adjuvants, Anesthesia; Adult; Aged; Dexmedetomidine; Female; Health Status; Humans; Hypnotics and Se | 2019 |
Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study.
Topics: Acute Disease; Adult; Aggression; Double-Blind Method; Droperidol; Drug Therapy, Combination; Emerge | 2010 |
Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine.
Topics: Adult; Aggression; Drug Therapy, Combination; Emergency Service, Hospital; Emergency Services, Psych | 2003 |
The sedative effects of intranasal midazolam administration in the dental treatment of patients with mental disabilities. Part 2: optimal concentration of intranasal midazolam.
Topics: Administration, Intranasal; Adolescent; Adult; Analysis of Variance; Anesthesia, Dental; Chi-Square | 1994 |
Intravenous sedation of involuntary psychiatric patients in New South Wales.
Topics: Adult; Benztropine; Commitment of Mentally Ill; Diazepam; Drug Utilization; Emergency Services, Psyc | 1997 |
18 other studies available for midazolam and Mental Disorders
| Article | Year |
|---|---|
Retrospective Study of Midazolam Protocol for Prehospital Behavioral Emergencies.
Topics: Administration, Intranasal; Administration, Intravenous; Adult; Allied Health Personnel; Clinical Pr | 2020 |
A prospective study of high dose sedation for rapid tranquilisation of acute behavioural disturbance in an acute mental health unit.
Topics: Adult; Droperidol; Drug Therapy, Combination; Female; Haloperidol; Humans; Hypnotics and Sedatives; | 2013 |
Survey on choice of intravenous sedative agent at department of dental anesthesiology, Tokyo Dental College Chiba Hospital between 2010 and 2011.
Topics: Administration, Intravenous; Adult; Aged; Anesthesia, Dental; Anesthetics, Intravenous; Cerebral Pal | 2014 |
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi | 2009 |
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi | 2009 |
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi | 2009 |
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi | 2009 |
Characteristics of admissions to a recently opened Psychiatric Emergency Care Centre.
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Antipsychotic Agents; Australia; Drug Prescriptions; | 2010 |
[Oral ketamine-midazolam premedication of uncooperative patients in major outpatient surgery].
Topics: Adjuvants, Anesthesia; Administration, Oral; Ambulatory Surgical Procedures; Anesthetics, Dissociati | 2010 |
Brainstem responses can predict death and delirium in sedated patients in intensive care unit.
Topics: Aged; Aged, 80 and over; Cause of Death; Cohort Studies; Conscious Sedation; Critical Care; Critical | 2011 |
TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243].
Topics: Brazil; Clinical Protocols; Drug Combinations; Emergency Services, Psychiatric; Ethics, Research; Ha | 2002 |
Induction of anaesthesia in the home.
Topics: Adult; Aggression; Anesthesia; Anesthetics, Dissociative; Home Care Services, Hospital-Based; Humans | 2002 |
The use of intramuscular midazolam in an acute psychiatric unit.
Topics: Adult; Female; GABA Modulators; Hospitalization; Hospitals, General; Humans; Injections, Intramuscul | 2003 |
[Flash visual evoked potentials (FVEP) examination under midazolam sedation of non-cooperating children].
Topics: Anxiety; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; Child; Child, Preschool; Evoked Po | 2002 |
Low-dose ketamine: efficacy in pediatric sedation.
Topics: Adolescent; Atropine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Evaluation; Dr | 2007 |
The sedative effect of intranasal midazolam administration in the dental treatment of patients with mental disabilities. Part 1. The effect of a 0.2 mg/kg dose.
Topics: Administration, Intranasal; Adolescent; Adult; Analysis of Variance; Anesthesia, Dental; Autistic Di | 1993 |
Flumazenil reverses paradoxical reaction to midazolam in a child.
Topics: Antidotes; Child; Flumazenil; Humans; Hypnotics and Sedatives; Male; Mental Disorders; Midazolam | 1996 |
Safety of amobarbital.
Topics: Amobarbital; Humans; Mental Disorders; Midazolam | 1997 |
[Modifications in treatment of tetanus and prognosis--observations from the Cracow Department of Infectious Diseases].
Topics: Aged; Aged, 80 and over; Diazepam; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; | 1999 |
The use of intramuscular midazolam for acute seizure cessation or behavioral emergencies in patients with traumatic brain injury.
Topics: Adult; Brain Injuries; Child; Emergencies; Female; Humans; Injections, Intramuscular; Male; Mental D | 1992 |
[Therapy of paradoxical reactions to midazolam in regional anesthesia].
Topics: Adult; Anesthesia, Conduction; Female; Humans; Male; Mental Disorders; Midazolam; Middle Aged; Prean | 1987 |