midazolam has been researched along with Malaria, Falciparum in 2 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Plasma concentration-time data were fitted using pharmacokinetic models." | 2.73 | Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions. ( Edwards, G; Kokwaro, GO; Muchohi, SN; Newton, CR; Ogutu, BR; Ward, SA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Muchohi, SN | 2 |
| Kokwaro, GO | 2 |
| Ogutu, BR | 1 |
| Edwards, G | 2 |
| Ward, SA | 2 |
| Newton, CR | 2 |
| Preston, L | 1 |
1 trial available for midazolam and Malaria, Falciparum
| Article | Year |
|---|---|
Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions.
Topics: Administration, Buccal; Adolescent; Africa; Anticonvulsants; Child; Child, Preschool; Drug Administr | 2008 |
1 other study available for midazolam and Malaria, Falciparum
| Article | Year |
|---|---|
Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children.
Topics: Anticonvulsants; Child; Chromatography, High Pressure Liquid; Humans; Kenya; Malaria, Falciparum; Mi | 2005 |