midazolam has been researched along with Low Back Ache in 8 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate pain relief in patients with chronic low back pain and failed back surgery syndrome after a single-shot intrathecal administration of midazolam." | 5.15 | Intrathecal midazolam as supplementary analgesia for chronic lumbar pain--15 years' experience. ( Hejcl, A; Prochazka, J; Prochazkova, L, 2011) |
| "To determine the clinical usefulness of the long-term intrathecal administration of midazolam and clonidine in patients with refractory neurogenic and musculoskeletal pain." | 3.69 | Long-term intrathecal administration of midazolam and clonidine. ( Borg, PA; Krijnen, HJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cohen, SP | 2 |
| Hameed, H | 2 |
| Kurihara, C | 1 |
| Pasquina, PF | 2 |
| Patel, AM | 1 |
| Babade, M | 1 |
| Griffith, SR | 1 |
| Erdek, ME | 1 |
| Jamison, DE | 1 |
| Hurley, RW | 2 |
| Wasan, AD | 1 |
| Manchikanti, L | 1 |
| Benyamin, RM | 1 |
| Candido, KD | 1 |
| Hirsch, JA | 1 |
| Kennedy, DJ | 1 |
| Schneider, B | 1 |
| Smuck, M | 1 |
| Plastaras, CT | 1 |
| Bogduk, N | 1 |
| Prochazka, J | 1 |
| Hejcl, A | 1 |
| Prochazkova, L | 1 |
| Borg, PA | 1 |
| Krijnen, HJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Cross-over Study Evaluating the Effect of Sedation on Pain Relief After Diagnostic Injections[NCT01472835] | 73 participants (Actual) | Interventional | 2011-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Measure of functional capacity on a scale ranging from 0% to 100%, with 0% signifying no disability (NCT01472835)
Timeframe: 1-month
| Intervention | units on a scale (Mean) |
|---|---|
| Sedation | 34.8 |
| Control | 40.6 |
0-10 numerical rating scale (NRS) pain scale. 0 being no pain and 10 being the worst possible pain. (NCT01472835)
Timeframe: 1-month
| Intervention | units on a scale (Mean) |
|---|---|
| Sedation | 5.1 |
| Control | 5.6 |
pain diary using 0-10 scale, with 0 being no pain and 10 being the worst pain imaginable (NCT01472835)
Timeframe: through 6 hours after injection
| Intervention | units on a scale (Mean) |
|---|---|
| Sedation | 2.2 |
| Control | 3.4 |
0-10 pain scale, with 0 being no pain and 10 being the worst pain imaginable (NCT01472835)
Timeframe: 1 day
| Intervention | units on a scale (Mean) |
|---|---|
| Sedation | 3.1 |
| Control | 5.5 |
5-point Likert scale. The scale is from 1-5. 1 being very unsatisfied and 5 being very satisfied. (NCT01472835)
Timeframe: 1 day
| Intervention | units on a scale (Mean) |
|---|---|
| Sedation | 4.0 |
| Control | 3.6 |
2 trials available for midazolam and Low Back Ache
| Article | Year |
|---|---|
The effect of sedation on the accuracy and treatment outcomes for diagnostic injections: a randomized, controlled, crossover study.
Topics: Adult; Aged; Anesthetics, Intravenous; Autonomic Nerve Block; Complex Regional Pain Syndromes; Consc | 2014 |
Intrathecal midazolam as supplementary analgesia for chronic lumbar pain--15 years' experience.
Topics: Adjuvants, Anesthesia; Adult; Aged; Aged, 80 and over; Chronic Pain; Dose-Response Relationship, Dru | 2011 |
6 other studies available for midazolam and Low Back Ache
| Article | Year |
|---|---|
Efficacy vs effectiveness and explanatory vs pragmatic: where is the balance point in pain medicine research?
Topics: Anesthetics, Intravenous; Autonomic Nerve Block; Complex Regional Pain Syndromes; Conscious Sedation | 2014 |
Sedation for diagnostic injections: prioritizing patient interests.
Topics: Anesthetics, Intravenous; Autonomic Nerve Block; Complex Regional Pain Syndromes; Conscious Sedation | 2014 |
Cohen et al. Reach inappropriate conclusions on the effect of sedation on the accuracy and treatment outcomes for diagnostic injections.
Topics: Anesthetics, Intravenous; Autonomic Nerve Block; Complex Regional Pain Syndromes; Conscious Sedation | 2014 |
The use of moderate sedation for the secondary prevention of adverse vasovagal reactions.
Topics: Conscious Sedation; Fentanyl; Humans; Hypnotics and Sedatives; Injections, Spinal; Low Back Pain; Mi | 2015 |
When data are not proof.
Topics: Adjuvants, Anesthesia; Chronic Pain; Failed Back Surgery Syndrome; Female; Humans; Low Back Pain; Ma | 2011 |
Long-term intrathecal administration of midazolam and clonidine.
Topics: Activities of Daily Living; Adolescent; Adult; Analgesics, Non-Narcotic; Clonidine; Female; Humans; | 1996 |