midazolam has been researched along with Liver Failure in 3 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Midazolam and metabolites were dosed in plasma and ultratiltration liquid by chromatography." | 6.70 | [Use of midazolam in postoperative sedation of patients with multiple organ failure treated with hemodiafiltration. Clinical study and pharmacokinetics]. ( Bastien, O; Bolon, M; Boulieu, R; Flamens, C; Lehot, JJ, 2002) |
| "Midazolam and metabolites were dosed in plasma and ultratiltration liquid by chromatography." | 2.70 | [Use of midazolam in postoperative sedation of patients with multiple organ failure treated with hemodiafiltration. Clinical study and pharmacokinetics]. ( Bastien, O; Bolon, M; Boulieu, R; Flamens, C; Lehot, JJ, 2002) |
| "Midazolam is a commonly used sedative in critically ill, mechanically ventilated patients in intensive care unit (ICU) settings worldwide." | 2.44 | Clinical pharmacokinetic monitoring of midazolam in critically ill patients. ( Ensom, MH; Spina, SP, 2007) |
| "Prospective population pharmacokinetic study." | 1.32 | Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients. ( de Hoog, M; de Wildt, SN; van den Anker, JN; van der Giesen, E; Vinks, AA, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bastien, O | 1 |
| Bolon, M | 1 |
| Flamens, C | 1 |
| Lehot, JJ | 1 |
| Boulieu, R | 1 |
| de Wildt, SN | 1 |
| de Hoog, M | 1 |
| Vinks, AA | 1 |
| van der Giesen, E | 1 |
| van den Anker, JN | 1 |
| Spina, SP | 1 |
| Ensom, MH | 1 |
1 review available for midazolam and Liver Failure
| Article | Year |
|---|---|
Clinical pharmacokinetic monitoring of midazolam in critically ill patients.
Topics: Critical Care; Drug Monitoring; Humans; Hypnotics and Sedatives; Intensive Care Units; Liver Failure | 2007 |
1 trial available for midazolam and Liver Failure
| Article | Year |
|---|---|
[Use of midazolam in postoperative sedation of patients with multiple organ failure treated with hemodiafiltration. Clinical study and pharmacokinetics].
Topics: Adjuvants, Anesthesia; Aged; Biotransformation; Chromatography, Liquid; Female; Half-Life; Hemofiltr | 2002 |
1 other study available for midazolam and Liver Failure
| Article | Year |
|---|---|
Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients.
Topics: Adolescent; Aryl Hydrocarbon Hydroxylases; Bayes Theorem; Child; Child, Preschool; Conscious Sedatio | 2003 |