midazolam has been researched along with Liver Cirrhosis in 33 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Reference: YingHao Cao, Ping Chi, Chen Zhou, WenFei Lv, ZheFen Quan, Fu Shan Xue: Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing Gastroscopy: A Randomized Controlled Study." | 9.51 | Errate: Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing Gastroscopy: A Randomized Controlled Study. ( Cao, Y; Chi, P; Lv, W; Quan, Z; Xue, FS; Zhou, C, 2022) |
| "Propofol-based sedation exacerbated MHE after EIS similarly to midazolam-based sedation in patients with liver cirrhosis." | 9.27 | Propofol is a more effective and safer sedative agent than midazolam in endoscopic injection sclerotherapy for esophageal varices in patients with liver cirrhosis: a randomized controlled trial. ( Hashimoto, M; Hikichi, T; Irie, H; Kikuchi, H; Konno, N; Nakamura, J; Obara, K; Ohira, H; Sato, Y; Sugimoto, M; Suzuki, R; Takagi, T; Takasumi, M; Watanabe, K, 2018) |
| "Sedation with propofol has a shorter time recovery and a shorter time to discharge than midazolam and does not exacerbate sub-clinical hepatic encephalopathy in patients with compensated liver cirrhosis." | 9.15 | Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study. ( Alex, I; Kamal, D; Khamaysi, I; Nimer, A; Olga, A; Vladimir, M; William, N, 2011) |
| "Midazolam sedation for upper gastrointestinal (GI) endoscopy exacerbates minimal hepatic encephalopathy (HE) in patients with liver cirrhosis, therefore an alternative drug regimen for these patients is warranted." | 9.14 | Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study. ( Frenz, MB; Lechowicz, I; Riphaus, A; Wehrmann, T, 2009) |
| "BACKGROUND The aim of the present study was to evaluate the effects of different doses of oxycodone during endoscopic injection sclerotherapy (EIS) for esophageal varices with painless sclerosing agents." | 8.02 | Different Doses of Oxycodone for Endoscopic Injection Sclerotherapy of Esophageal Varices. ( He, H; Quan, Z; Song, C; Yao, J; Zhou, C, 2021) |
| "Grapefruit juice inhibits CYP3A4 in the intestinal wall leading to a reduced intestinal first pass metabolism and thereby an increased oral bioavailability of certain drugs." | 6.70 | Intestinal first pass metabolism of midazolam in liver cirrhosis --effect of grapefruit juice. ( Andersen, V; Larsen, NE; Larsen, S; Pedersen, N; Sonne, J, 2002) |
| " Reference: YingHao Cao, Ping Chi, Chen Zhou, WenFei Lv, ZheFen Quan, Fu Shan Xue: Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing Gastroscopy: A Randomized Controlled Study." | 5.51 | Errate: Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing Gastroscopy: A Randomized Controlled Study. ( Cao, Y; Chi, P; Lv, W; Quan, Z; Xue, FS; Zhou, C, 2022) |
| "Propofol-based sedation exacerbated MHE after EIS similarly to midazolam-based sedation in patients with liver cirrhosis." | 5.27 | Propofol is a more effective and safer sedative agent than midazolam in endoscopic injection sclerotherapy for esophageal varices in patients with liver cirrhosis: a randomized controlled trial. ( Hashimoto, M; Hikichi, T; Irie, H; Kikuchi, H; Konno, N; Nakamura, J; Obara, K; Ohira, H; Sato, Y; Sugimoto, M; Suzuki, R; Takagi, T; Takasumi, M; Watanabe, K, 2018) |
| "The authors studied the pharmacokinetic behaviour of a new benzodiazepine, midazolam, after a single oral administration in a group of five patients of both sexes, suffering from compensated alcoholic cirrhosis." | 5.27 | A pharmacokinetic study on midazolam in compensated liver cirrhosis. ( Ascalone, V; Cisternino, M; Colombi Zinelli, L; Rinetti, M, 1985) |
| "Midazolam was used as a CYP3A probe and its pharmacokinetics were analyzed in 24 patients with mild to severe liver cirrhosis (n = 4, 10 and 10 with CP class A, B and C, respectively) and six patients without liver disease." | 5.19 | CYP3A activity in severe liver cirrhosis correlates with Child-Pugh and model for end-stage liver disease (MELD) scores. ( Albarmawi, A; Burhenne, J; Czock, D; Ehehalt, R; Ganten, TM; Gauss, A; Haefeli, WE; Lorenzo Bermejo, J; Sauer, P, 2014) |
| "Sedation with propofol has a shorter time recovery and a shorter time to discharge than midazolam and does not exacerbate sub-clinical hepatic encephalopathy in patients with compensated liver cirrhosis." | 5.15 | Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study. ( Alex, I; Kamal, D; Khamaysi, I; Nimer, A; Olga, A; Vladimir, M; William, N, 2011) |
| "Midazolam sedation for upper gastrointestinal (GI) endoscopy exacerbates minimal hepatic encephalopathy (HE) in patients with liver cirrhosis, therefore an alternative drug regimen for these patients is warranted." | 5.14 | Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study. ( Frenz, MB; Lechowicz, I; Riphaus, A; Wehrmann, T, 2009) |
| "The results of this study indicate that (1) the majority of patients with cirrhosis and suspected portal hypertension have evidence of subclinical hepatic encephalopathy, (2) the extent of encephalopathy correlates with the Child Pugh's score, (3) sedation with midazolam for upper GI endoscopy exacerbates the encephalopathy, and (4) this adverse effect is still evident 2 hours after the procedure." | 5.09 | Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis. ( Assy, N; Grahame, GR; Minuk, GY; Rosser, BG, 1999) |
| "We assessed the pharmacokinetics of the six compounds and their CYP-specific metabolites of the Basel phenotyping cocktail (CYP1A2: caffeine, CYP2B6: efavirenz, CYP2C9: flurbiprofen, CYP2C19: omeprazole, CYP2D6: metoprolol, CYP3A: midazolam) in patients with liver cirrhosis (n = 16 Child A cirrhosis, n = 15 Child B cirrhosis, n = 5 Child C cirrhosis) and matched control subjects (n = 12)." | 4.12 | Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently. ( Bachmann, F; Bouitbir, J; Duthaler, U; Grandinetti, T; Haschke, M; Hruz, P; Krähenbühl, S; Pfefferkorn, F; Suenderhauf, C, 2022) |
| "BACKGROUND The aim of the present study was to evaluate the effects of different doses of oxycodone during endoscopic injection sclerotherapy (EIS) for esophageal varices with painless sclerosing agents." | 4.02 | Different Doses of Oxycodone for Endoscopic Injection Sclerotherapy of Esophageal Varices. ( He, H; Quan, Z; Song, C; Yao, J; Zhou, C, 2021) |
| "The objective of this study was to determine the frequency of clinically overt hepatic encephalopathy (HE) in cirrhotic patients undergoing diagnostic or therapeutic upper gastrointestinal endoscopy (UGE) who received midazolam for sedation." | 3.78 | Midazolam for sedation during diagnostic or therapeutic upper gastrointestinal endoscopy in cirrhotic patients. ( Arain, N; Faisal, N; Haq, MM; Haqqi, SA; Khalil, A; Shaikh, H, 2012) |
| "Patients with liver cirrhosis frequently undergo diagnostic or therapeutic upper GI endoscopy (UGIE), and the liver disease might impair the metabolism of drugs usually administered for sedation." | 2.76 | Sedation during upper GI endoscopy in cirrhotic outpatients: a randomized, controlled trial comparing propofol and fentanyl with midazolam and fentanyl. ( Bonilha, DQ; Brito, JR; Correia, LM; Ferrari, AP; Gomes, GF; Lenz, L; Libera, ED; Nakao, FS; Rohr, MR, 2011) |
| "Grapefruit juice inhibits CYP3A4 in the intestinal wall leading to a reduced intestinal first pass metabolism and thereby an increased oral bioavailability of certain drugs." | 2.70 | Intestinal first pass metabolism of midazolam in liver cirrhosis --effect of grapefruit juice. ( Andersen, V; Larsen, NE; Larsen, S; Pedersen, N; Sonne, J, 2002) |
| " Using this dosage regime, midazolam caused significantly greater impairment in psychomotor function in both cirrhotic and non cirrhotic subjects, and the time taken for recovery of normal function was also significantly prolonged." | 2.66 | Sedation for gastroscopy: a comparative study of midazolam and Diazemuls in patients with and without cirrhosis. ( Hamdy, NA; Kennedy, HJ; Nicholl, J; Triger, DR, 1986) |
| "Patho-physiological changes in liver cirrhosis create portacaval shunts that allow blood flow to bypass the hepatic portal vein into the systemic circulation affecting drug pharmacokinetics (PKs)." | 1.91 | Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis. ( Gardner, I; Hatley, O; Jamei, M; Johnson, TN; Small, BG, 2023) |
| "Sedation for upper gastrointestinal endoscopy (UGIE) in patients with cirrhosis is theoretically associated with high incidence of adverse events due to low levels of binding proteins and decreased hepatic clearance of drugs." | 1.62 | Safety of balanced propofol and midazolam in upper gastrointestinal endoscopy for sedation in cirrhotic patients. ( Alam, L; Alam, M; Khattak, MA, 2021) |
| "This retrospective cohort study of cirrhotic patients undergoing endoscopy from a large academic medical center between 2010 and 2014 examined extensive clinical data including the following: past history, physical findings, laboratory results, and procedural adverse events." | 1.56 | Sedation During Endoscopy in Patients with Cirrhosis: Safety and Predictors of Adverse Events. ( Edelson, J; Rockey, DC; Suarez, AL; Zhang, J, 2020) |
| " However, adverse events (AEs) may occur more frequently in patients with cirrhosis due to altered MDZ metabolism." | 1.48 | Safety and effectiveness of midazolam for cirrhotic patients undergoing endoscopic variceal ligation. ( Jang, DK; Jo, HB; Kang, HW; Kim, JH; Koh, MS; Lee, JH; Lee, JK; Lim, YJ, 2018) |
| "Shock was more common in patients with variceal bleeding compared to those with non-variceal bleeding (12." | 1.43 | Outcomes of Propofol Sedation During Emergency Endoscopy Performed for Upper Gastrointestinal Bleeding. ( Eun, CS; Han, DS; Jeon, YC; Jeong, JY; Park, CH; Sohn, JH; Yoo, KS, 2016) |
| " Therefore, patients with advanced cirrhosis may have greater drug exposure following oral dosing as a result of both impaired liver function and decreased intestinal CYP3A expression and activity." | 1.35 | Reduced duodenal cytochrome P450 3A protein expression and catalytic activity in patients with cirrhosis. ( Blough, DK; Hashizume, T; Lin, YS; Mathisen, TL; McConn, DJ; Shuhart, MC; Taylor, SL; Thummel, KE; Xu, Y, 2009) |
| " The bioavailability of midazolam was significantly higher (P <." | 1.31 | Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: effects of transjugular intrahepatic portosystemic shunts. ( Chalasani, N; Galinsky, RE; Gorski, JC; Hall, SD; Patel, NH, 2001) |
| "The antipyrine-half-life was 32." | 1.28 | Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects. ( Crevoisier, C; Himberg, JJ; Pentikäinen, PJ; Välisalmi, L, 1989) |
| "The authors studied the pharmacokinetic behaviour of a new benzodiazepine, midazolam, after a single oral administration in a group of five patients of both sexes, suffering from compensated alcoholic cirrhosis." | 1.27 | A pharmacokinetic study on midazolam in compensated liver cirrhosis. ( Ascalone, V; Cisternino, M; Colombi Zinelli, L; Rinetti, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.12) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 7 (21.21) | 29.6817 |
| 2010's | 12 (36.36) | 24.3611 |
| 2020's | 8 (24.24) | 2.80 |
| Authors | Studies |
|---|---|
| Duthaler, U | 1 |
| Bachmann, F | 1 |
| Suenderhauf, C | 1 |
| Grandinetti, T | 1 |
| Pfefferkorn, F | 1 |
| Haschke, M | 1 |
| Hruz, P | 1 |
| Bouitbir, J | 1 |
| Krähenbühl, S | 1 |
| Cao, Y | 1 |
| Chi, P | 1 |
| Zhou, C | 2 |
| Lv, W | 1 |
| Quan, Z | 2 |
| Xue, FS | 1 |
| Small, BG | 1 |
| Hatley, O | 1 |
| Jamei, M | 1 |
| Gardner, I | 1 |
| Johnson, TN | 1 |
| Edelson, J | 1 |
| Suarez, AL | 1 |
| Zhang, J | 1 |
| Rockey, DC | 1 |
| Yoo, JJ | 1 |
| Goong, HJ | 1 |
| Moon, JE | 1 |
| Kim, SG | 1 |
| Kim, YS | 1 |
| Jeong, J | 1 |
| Jung, K | 1 |
| Seo, KI | 1 |
| Yun, BC | 1 |
| Han, BH | 1 |
| Lee, SU | 1 |
| Moon, W | 1 |
| Alam, L | 1 |
| Khattak, MA | 1 |
| Alam, M | 1 |
| Yao, J | 1 |
| Song, C | 1 |
| He, H | 1 |
| Jo, HB | 1 |
| Lee, JK | 1 |
| Jang, DK | 1 |
| Kang, HW | 1 |
| Kim, JH | 1 |
| Lim, YJ | 1 |
| Koh, MS | 1 |
| Lee, JH | 1 |
| Watanabe, K | 1 |
| Hikichi, T | 1 |
| Takagi, T | 1 |
| Suzuki, R | 1 |
| Nakamura, J | 1 |
| Sugimoto, M | 1 |
| Kikuchi, H | 1 |
| Konno, N | 1 |
| Takasumi, M | 1 |
| Sato, Y | 1 |
| Hashimoto, M | 1 |
| Irie, H | 1 |
| Obara, K | 1 |
| Ohira, H | 1 |
| Ünal, HÜ | 1 |
| Saruç, M | 1 |
| Albarmawi, A | 1 |
| Czock, D | 1 |
| Gauss, A | 1 |
| Ehehalt, R | 1 |
| Lorenzo Bermejo, J | 1 |
| Burhenne, J | 1 |
| Ganten, TM | 1 |
| Sauer, P | 1 |
| Haefeli, WE | 1 |
| Kim, SI | 1 |
| Jin, YJ | 1 |
| Lee, SH | 1 |
| Lee, JW | 1 |
| Lee, DH | 1 |
| Lee, D | 1 |
| Park, CH | 1 |
| Han, DS | 1 |
| Jeong, JY | 1 |
| Eun, CS | 1 |
| Yoo, KS | 1 |
| Jeon, YC | 1 |
| Sohn, JH | 1 |
| McConn, DJ | 1 |
| Lin, YS | 1 |
| Mathisen, TL | 1 |
| Blough, DK | 1 |
| Xu, Y | 1 |
| Hashizume, T | 1 |
| Taylor, SL | 1 |
| Thummel, KE | 1 |
| Shuhart, MC | 1 |
| Riphaus, A | 1 |
| Lechowicz, I | 1 |
| Frenz, MB | 1 |
| Wehrmann, T | 1 |
| Lee, KH | 1 |
| Nam, SH | 1 |
| Yoo, SY | 1 |
| Jung, CW | 1 |
| Bae, SS | 1 |
| Lee, JR | 1 |
| Khamaysi, I | 1 |
| William, N | 1 |
| Olga, A | 1 |
| Alex, I | 1 |
| Vladimir, M | 1 |
| Kamal, D | 1 |
| Nimer, A | 1 |
| Sharma, P | 2 |
| Singh, S | 1 |
| Sharma, BC | 2 |
| Correia, LM | 1 |
| Bonilha, DQ | 1 |
| Gomes, GF | 1 |
| Brito, JR | 1 |
| Nakao, FS | 1 |
| Lenz, L | 1 |
| Rohr, MR | 1 |
| Ferrari, AP | 1 |
| Libera, ED | 1 |
| Haq, MM | 1 |
| Faisal, N | 1 |
| Khalil, A | 1 |
| Haqqi, SA | 1 |
| Shaikh, H | 1 |
| Arain, N | 1 |
| Agrawal, A | 1 |
| Uppal, R | 1 |
| Sarin, SK | 1 |
| Andersen, V | 1 |
| Pedersen, N | 1 |
| Larsen, NE | 1 |
| Sonne, J | 1 |
| Larsen, S | 1 |
| Hourmand-Ollivier, I | 1 |
| Dao, T | 1 |
| Weston, BR | 1 |
| Chadalawada, V | 1 |
| Chalasani, N | 2 |
| Kwo, P | 1 |
| Overley, CA | 1 |
| Symms, M | 1 |
| Strahl, E | 1 |
| Rex, DK | 1 |
| Assy, N | 1 |
| Rosser, BG | 1 |
| Grahame, GR | 1 |
| Minuk, GY | 1 |
| Lluch Fernández, M | 1 |
| Vallejo Uclés, A | 1 |
| Vallejo Cantarero, F | 1 |
| Zurita Castro, F | 1 |
| Huelva Ramírez, E | 1 |
| Moreno Carmona, C | 1 |
| Gorski, JC | 1 |
| Patel, NH | 1 |
| Hall, SD | 1 |
| Galinsky, RE | 1 |
| Ferencz, S | 1 |
| Batey, R | 1 |
| Pentikäinen, PJ | 1 |
| Välisalmi, L | 1 |
| Himberg, JJ | 1 |
| Crevoisier, C | 1 |
| Rinetti, M | 1 |
| Ascalone, V | 1 |
| Colombi Zinelli, L | 1 |
| Cisternino, M | 1 |
| Hamdy, NA | 1 |
| Kennedy, HJ | 1 |
| Nicholl, J | 1 |
| Triger, DR | 1 |
| Bryssine, B | 1 |
| Bouletreau, P | 1 |
| Balay, C | 1 |
| Raupp, C | 1 |
| Seranne, C | 1 |
| Guiraud, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| In Vivo Determination of Cytochrome P450 Activities in Patients With Liver Cirrhosis[NCT03337945] | 48 participants (Actual) | Interventional | 2018-04-04 | Completed | |||
| Randomized Controlled Trial Comparing Effects of Sedation for Upper Gastrointestinal Endoscopy With Propofol Versus Midazolam on Psychometric Tests and Critical Flicker Frequency in Cirrhotics[NCT01356121] | Phase 4 | 120 participants (Anticipated) | Interventional | 2010-11-30 | Recruiting | ||
| Evaluation of Gastroesophageal Varices in Cirrhotic and Non-cirrhotic Patients With Portal Hypertension by Transnasal Endoscopy.[NCT02767206] | 50 participants (Actual) | Observational | 2016-03-31 | Enrolling by invitation | |||
| A New Technique to Enhance Detection of Small Esophageal Varices by PillCam ESO Capsule Endoscopy[NCT00911131] | Phase 3 | 0 participants (Actual) | Interventional | Withdrawn (stopped due to Loss of funding) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 trials available for midazolam and Liver Cirrhosis
| Article | Year |
|---|---|
Errate: Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing Gastroscopy: A Randomized Controlled Study.
Topics: Benzodiazepines; China; Double-Blind Method; Gastroscopy; Humans; Hypnotics and Sedatives; Liver Cir | 2022 |
Safety profile of sedative endoscopy including cognitive performance in liver cirrhosis: A double-blind randomized controlled trial.
Topics: Adult; Aged; Cognition; Double-Blind Method; Endoscopy, Gastrointestinal; Female; Humans; Hypnotics | 2019 |
Propofol is a more effective and safer sedative agent than midazolam in endoscopic injection sclerotherapy for esophageal varices in patients with liver cirrhosis: a randomized controlled trial.
Topics: Aged; Esophageal and Gastric Varices; Female; Hepatic Encephalopathy; Humans; Hypnotics and Sedative | 2018 |
CYP3A activity in severe liver cirrhosis correlates with Child-Pugh and model for end-stage liver disease (MELD) scores.
Topics: Adult; Aged; Aged, 80 and over; Animals; Biomarkers, Pharmacological; Cytochrome P-450 CYP3A; Female | 2014 |
Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study.
Topics: Aged; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Female; Hepatic Encephalopathy; H | 2009 |
Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study.
Topics: Adult; Aged; Anesthesia Recovery Period; Cognition; Conscious Sedation; Endoscopy, Gastrointestinal; | 2011 |
Propofol in patients with cirrhosis and minimal hepatic encephalopathy.
Topics: Anesthetics, Intravenous; Endoscopy, Gastrointestinal; Hepatic Encephalopathy; Humans; Liver Cirrhos | 2011 |
Sedation during upper GI endoscopy in cirrhotic outpatients: a randomized, controlled trial comparing propofol and fentanyl with midazolam and fentanyl.
Topics: Analgesics, Opioid; Anesthesia Recovery Period; Bradycardia; Conscious Sedation; Deep Sedation; Endo | 2011 |
Randomized controlled trial for endoscopy with propofol versus midazolam on psychometric tests and critical flicker frequency in people with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthesia Recovery Period; Deep Sedation; Endoscopy, Gastrointestinal; | 2012 |
Intestinal first pass metabolism of midazolam in liver cirrhosis --effect of grapefruit juice.
Topics: Adult; Aged; Biological Availability; Citrus; Cross-Over Studies; Cytochrome P-450 Enzyme System; Fe | 2002 |
Nurse-administered propofol versus midazolam and meperidine for upper endoscopy in cirrhotic patients.
Topics: Aged; Ambulatory Care; Chronic Disease; Conscious Sedation; Dose-Response Relationship, Drug; Drug A | 2003 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |
Sedation for gastroscopy: a comparative study of midazolam and Diazemuls in patients with and without cirrhosis.
Topics: Adult; Aged; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Gastroscopy; Humans; L | 1986 |
20 other studies available for midazolam and Liver Cirrhosis
| Article | Year |
|---|---|
Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently.
Topics: Caffeine; Child; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochr | 2022 |
Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis.
Topics: Buspirone; Humans; Liver Cirrhosis; Midazolam; Models, Biological; Propranolol; Simvastatin | 2023 |
Sedation During Endoscopy in Patients with Cirrhosis: Safety and Predictors of Adverse Events.
Topics: Adjuvants, Anesthesia; Aged; Analgesics, Opioid; Cohort Studies; Conscious Sedation; Endoscopy; Fema | 2020 |
Propofol alone prevents worsening hepatic encephalopathy rather than midazolam alone or combined sedation after esophagogastroduodenoscopy in compensated or decompensated cirrhotic patients.
Topics: Conscious Sedation; Endoscopy, Digestive System; Hepatic Encephalopathy; Humans; Hypnotics and Sedat | 2020 |
Safety of balanced propofol and midazolam in upper gastrointestinal endoscopy for sedation in cirrhotic patients.
Topics: Conscious Sedation; Endoscopy, Gastrointestinal; Humans; Hypnotics and Sedatives; Liver Cirrhosis; M | 2021 |
Different Doses of Oxycodone for Endoscopic Injection Sclerotherapy of Esophageal Varices.
Topics: Adult; China; Dose-Response Relationship, Drug; Endoscopy; Esophageal and Gastric Varices; Female; G | 2021 |
Safety and effectiveness of midazolam for cirrhotic patients undergoing endoscopic variceal ligation.
Topics: Aged; Esophageal and Gastric Varices; Esophagoscopy; Female; Gastrointestinal Hemorrhage; Humans; Hy | 2018 |
Is midazolam safe for sedation in cirrhotic patients?
Topics: Conscious Sedation; Humans; Hypnotics and Sedatives; Liver Cirrhosis; Midazolam | 2020 |
Conscious Sedation Using Midazolam and Sequential Flumazenil in Cirrhotic Patients for Prophylactic Endoscopic Variceal Ligation.
Topics: Adult; Aged; Aged, 80 and over; Antidotes; Conscious Sedation; Esophageal and Gastric Varices; Esoph | 2015 |
Outcomes of Propofol Sedation During Emergency Endoscopy Performed for Upper Gastrointestinal Bleeding.
Topics: Adult; Age Factors; Aged; Anticoagulants; Cerebrovascular Disorders; Cohort Studies; Comorbidity; Di | 2016 |
Reduced duodenal cytochrome P450 3A protein expression and catalytic activity in patients with cirrhosis.
Topics: Adult; Aged; Catalysis; Cytochrome P-450 CYP3A; Duodenum; Enzyme Activation; Female; Gene Expression | 2009 |
Vecuronium requirement during liver transplantation under sevoflurane anesthesia.
Topics: Aged; Analysis of Variance; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2010 |
Midazolam for sedation during diagnostic or therapeutic upper gastrointestinal endoscopy in cirrhotic patients.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Conscious Sedation; Endoscopy, Gastrointestinal | 2012 |
Subclinical encephalopathy after conscious sedation with midazolam in cirrhotic patients?
Topics: Anesthetics, Intravenous; Conscious Sedation; Humans; Liver Cirrhosis; Midazolam; Neurotoxicity Synd | 2003 |
[Anesthesia and intraoperative treatment in 2 cases of simultaneous liver, pancreas, and kidney transplantation].
Topics: Adult; Anesthesia, General; Cardiomyopathy, Hypertrophic; Diabetes Mellitus, Type 1; Diabetic Nephro | 1999 |
Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: effects of transjugular intrahepatic portosystemic shunts.
Topics: Administration, Oral; Adult; Aryl Hydrocarbon Hydroxylases; Biological Availability; Cytochrome P-45 | 2001 |
Can pre-emptive analgesia reduce pain experienced after liver biopsy?
Topics: Analgesia; Biopsy, Needle; Bupivacaine; Hepatitis C, Chronic; Humans; Infusions, Intravenous; Liver | 2002 |
Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects.
Topics: Administration, Oral; Adult; Aged; Antipyrine; Half-Life; Humans; Injections, Intravenous; Liver Cir | 1989 |
A pharmacokinetic study on midazolam in compensated liver cirrhosis.
Topics: Aged; Benzodiazepines; Biotransformation; Female; Half-Life; Humans; Kinetics; Liver Cirrhosis; Live | 1985 |
[Use of midazolam in the cirrhotic patient candidate for visceral surgery. Clinical study apropos of 22 cases].
Topics: Abdomen; Anesthesia Recovery Period; Anesthesia, General; Humans; Liver Cirrhosis; Midazolam | 1987 |