midazolam has been researched along with Learning Disabilities in 10 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Learning Disabilities: Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This paper demonstrates how oral midazolam can be employed as an alternative method of behaviour management to general anaesthesia for the dental treatment of people with learning disabilities." | 7.70 | Oral midazolam for adults with learning disabilities. ( Boyle, CA; Fleming, GJ; Manley, MC, 2000) |
| "This paper demonstrates how oral midazolam can be employed as an alternative method of behaviour management to general anaesthesia for the dental treatment of people with learning disabilities." | 3.70 | Oral midazolam for adults with learning disabilities. ( Boyle, CA; Fleming, GJ; Manley, MC, 2000) |
| " This paper proposes that the technique described is safe and effective in providing a good standard of dental care for adults with severe learning disability." | 1.35 | Retrospective audit of the efficacy and safety of the combined intranasal/intravenous midazolam sedation technique for the dental treatment of adults with learning disability. ( Forbes, M; Lewis, DA; Manley, MC; Ransford, NJ; Thompson, SA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Niquet, J | 1 |
| Baldwin, R | 1 |
| Norman, K | 1 |
| Suchomelova, L | 1 |
| Lumley, L | 1 |
| Wasterlain, CG | 1 |
| Manley, MC | 2 |
| Ransford, NJ | 1 |
| Lewis, DA | 1 |
| Thompson, SA | 1 |
| Forbes, M | 1 |
| Hart, G | 1 |
| Harris, JA | 1 |
| Westbrook, RF | 1 |
| Jevtovic-Todorovic, V | 1 |
| Hartman, RE | 1 |
| Izumi, Y | 1 |
| Benshoff, ND | 1 |
| Dikranian, K | 1 |
| Zorumski, CF | 1 |
| Olney, JW | 1 |
| Wozniak, DF | 1 |
| Bailie, RK | 1 |
| Michalek, P | 2 |
| Doherty, JT | 1 |
| Hodgkinson, P | 1 |
| Donaldson, W | 1 |
| Scheepers, M | 1 |
| Scheepers, B | 1 |
| Clough, P | 1 |
| Boyle, CA | 1 |
| Fleming, GJ | 1 |
| McCloskey, MI | 1 |
| Tiffin, PA | 1 |
| Perini, AF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Combined Ketamine and Midazolam for Treatment of Generalized Convulsive Status Epilepticus in Children .[NCT05779657] | Phase 2/Phase 3 | 144 participants (Anticipated) | Interventional | 2023-03-21 | Recruiting | ||
| The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA) - A Randomised, Feasibility Trial[NCT05936853] | 16 participants (Anticipated) | Interventional | 2023-07-31 | Not yet recruiting | |||
| Anesthesia Exposure and Neurodevelopment in Infants and Children: Pediatric Anesthesia & NeuroDevelopment (PANDA) Study[NCT00881764] | 369 participants (Actual) | Observational | 2009-05-31 | Completed | |||
| Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery on Peri-operative Outcomes and Neurocognitive Development in Infants: A Randomized Controlled Trial[NCT02559102] | Phase 3 | 104 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Randomized Controlled Trial of Nitrous Oxide Analgesia in External Cephalic Version (ECV)[NCT03502915] | Phase 3 | 48 participants (Actual) | Interventional | 2017-01-30 | Completed | ||
| Appendectomy During Pregnancy in General Anesthesia With Perioperative Management Does Not Influence Normal Child Development: 10-year Study[NCT05759351] | 30 participants (Actual) | Observational | 2006-01-01 | Completed | |||
| A Comparison of Functional Magnetic Resonance Imaging (fMRI) Findings in Children With and Without a History of Early Exposure to General Anesthetics[NCT01229514] | 30 participants (Actual) | Observational | 2008-10-31 | Completed | |||
| Position of Supraglottic Airway as a Conduit for Tracheal Intubation - A Comparison of CTrach, Intubating LMA and I-gel Supraglottic Airway[NCT00983229] | 120 participants (Actual) | Interventional | 2009-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Anxiety scores will be collected following each version attempt using an 11 point scale (0 being not at all anxious; 10 being extremely anxious), ranging from 0 to 10. Higher scores indicate more anxiety, lower scores indicate less anxiety. If more than one attempt, anxiety scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 4.696 |
| Oxygen | 4.253 |
Pain scores will be collected following each version attempt using an 11 point scale (with 0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. If more than one attempt, pain scores will be averaged to obtain a single score for the entire procedure. (NCT03502915)
Timeframe: During each version procedure, a total average of up to approximately 30 minutes
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 5.486 |
| Oxygen | 5.433 |
Pain scores will be collected following completion of the version using an 11 point scale (0 being no pain at all; 10 being worst pain imaginable), ranging from 0 to 10. Higher scores indicate more pain, lower scores indicate less pain. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 1 |
| Oxygen | 0.88 |
Satisfaction will be assessed following the procedure using an 11 point scale (0 being not at all satisfied; 10 being extremely satisfied), ranging from 0 to 10. Higher scores indicate more satisfaction, lower scores indicate less satisfaction. (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 4.286 |
| Oxygen | 6.920 |
Following the procedure, the obstetric provider performing the procedure will rate the ease of procedure on a 1-10 scale (1 being very easy and 10 being extremely difficult), ranging from 1 to 10. Higher scores indicate more difficulty, lower scores indicate less difficulty. A 10 point scale was used for this outcome, while an 11 point scale was used for the other 4 outcome measures (pain, anxiety, post-procedure pain and satisfaction). (NCT03502915)
Timeframe: Immediately Post-procedure, within approximately 15 minutes of final version attempt
| Intervention | score on a scale (Mean) |
|---|---|
| Nitrous Oxide | 6.136 |
| Oxygen | 6.080 |
10 other studies available for midazolam and Learning Disabilities
| Article | Year |
|---|---|
Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits.
Topics: Animals; Anticonvulsants; Brain; Cholinergic Agents; Disease Models, Animal; Drug Synergism; Drug Th | 2016 |
Retrospective audit of the efficacy and safety of the combined intranasal/intravenous midazolam sedation technique for the dental treatment of adults with learning disability.
Topics: Administration, Intranasal; Adult; Aerosols; Anesthesia, Dental; Anesthesia, Intravenous; Conscious | 2008 |
Systemic or intra-amygdala infusion of the benzodiazepine, midazolam, impairs learning, but facilitates re-learning to inhibit fear responses in extinction.
Topics: Amygdala; Animals; Behavior, Animal; Benzodiazepines; Conditioning, Classical; Extinction, Psycholog | 2010 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits.
Topics: Anesthetics; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Drug Co | 2003 |
Premedication with buccal midazolam in children and in adults with learning disabilities.
Topics: Administration, Buccal; Adult; Child; Child, Preschool; Humans; Hypnotics and Sedatives; Learning Di | 2007 |
Fiberoptic intubation through an I-gel supraglottic airway in two patients with predicted difficult airway and intellectual disability.
Topics: Administration, Buccal; Adult; Anesthesia, General; Equipment Design; Female; Fiber Optic Technology | 2008 |
Midazolam via the intranasal route: an effective rescue medication for severe epilepsy in adults with learning disability.
Topics: Administration, Intranasal; Adult; Epilepsy; Female; GABA Modulators; Humans; Learning Disabilities; | 1998 |
Oral midazolam for adults with learning disabilities.
Topics: Administration, Oral; Adult; Anesthesia, Dental; Behavior Therapy; Conscious Sedation; Dental Calcul | 2000 |
Caution with oral midazolam.
Topics: Anesthesia, Dental; Dental Care for Disabled; Equipment Contamination; Filtration; Glass; Humans; Hy | 2000 |
The use of antiepileptic drugs in learning disabled people with epilepsy: an audit of adult in-patients in a treatment and continuing care service.
Topics: Adult; Anticonvulsants; Brain; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Learning | 2001 |