Page last updated: 2024-10-31

midazolam and Lassitude

midazolam has been researched along with Lassitude in 3 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Research Excerpts

ExcerptRelevanceReference
"The proposed study is a single-center, phase II, randomized, double-blind, parallel-group, active-placebo-controlled trial of intravenous low-dose ketamine in patients with MS fatigue."9.69Low-dose ketamine infusion for the treatment of multiple sclerosis fatigue (INKLING-MS): Study protocol for a randomized, double-blind, active placebo-controlled phase II trial. ( Ghajarzadeh, M; Nourbakhsh, B; Roman, S; Vega, L, 2023)
"The proposed study is a single-center, phase II, randomized, double-blind, parallel-group, active-placebo-controlled trial of intravenous low-dose ketamine in patients with MS fatigue."5.69Low-dose ketamine infusion for the treatment of multiple sclerosis fatigue (INKLING-MS): Study protocol for a randomized, double-blind, active placebo-controlled phase II trial. ( Ghajarzadeh, M; Nourbakhsh, B; Roman, S; Vega, L, 2023)
"Modafinil 200 mg was administered to the treatment group patients 1 h before sedation/analgesia."2.75Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. ( Boesjes, H; Galvin, E; Hol, J; Klein, J; Ubben, JF; Verbrugge, SJ, 2010)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Ghajarzadeh, M1
Roman, S1
Vega, L1
Nourbakhsh, B1
Galvin, E1
Boesjes, H1
Hol, J1
Ubben, JF1
Klein, J1
Verbrugge, SJ1
Chung, F1
Kayumov, L1
Sinclair, DR1
Edward, R1
Moller, HJ1
Shapiro, CM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102]Phase 4105 participants (Actual)Interventional2016-02-29Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit

Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours

Interventionminutes (Mean)
Placebo53.5
Modafinil61.0

Postanesthesia Quality Recovery Scale Score

Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery

Interventionunits on a scale (Mean)
Placebo-5.67
Modafinil-8.91

Trials

2 trials available for midazolam and Lassitude

ArticleYear
Low-dose ketamine infusion for the treatment of multiple sclerosis fatigue (INKLING-MS): Study protocol for a randomized, double-blind, active placebo-controlled phase II trial.
    Contemporary clinical trials, 2023, Volume: 126

    Topics: Adult; Clinical Trials, Phase II as Topic; Double-Blind Method; Fatigue; Humans; Ketamine; Midazolam

2023
Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia Recovery Period; Anesthetics, Inha

2010

Other Studies

1 other study available for midazolam and Lassitude

ArticleYear
What is the driving performance of ambulatory surgical patients after general anesthesia?
    Anesthesiology, 2005, Volume: 103, Issue:5

    Topics: Adjuvants, Anesthesia; Adult; Ambulatory Surgical Procedures; Anesthesia, General; Anesthetics, Intr

2005