midazolam has been researched along with Laryngismus in 13 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Laryngismus: A disorder in which the adductor muscles of the VOCAL CORDS exhibit increased activity leading to laryngeal spasm. Laryngismus causes closure of the VOCAL FOLDS and airflow obstruction during inspiration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intranasal dexmedetomidine and midazolam are equally effective in decreasing anxiety upon separation from parents; however, midazolam is superior in providing satisfactory conditions during mask induction." | 5.16 | Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia. ( Akin, A; Aksu, R; Altuntas, R; Bayram, A; Boyaci, A; Esmaoglu, A; Tosun, Z, 2012) |
| "Laryngospasm was observed in 6 patients without statistical difference between the 2 groups." | 2.77 | Ketamine with and without midazolam for gastrointestinal endoscopies in children. ( Brecelj, J; Orel, R; Trop, TK, 2012) |
| "Isoflurane was compared with sevoflurane in terms of rapidity, efficacy, safety and acceptability of induction." | 2.69 | Single vital capacity inhalational anaesthetic induction in adults--isoflurane vs sevoflurane. ( Lee, TL; Pua, HL; Ti, LK, 1998) |
| "The incidence of gagging (P = 0." | 2.68 | Comparison of propofol versus thiopentone with midazolam or lidocaine to facilitate laryngeal mask insertion. ( Bapat, P; Jago, RH; Joshi, RN; Young, E, 1996) |
| "Flumazenil is a competitive inhibitor of the benzodiazepines that is available for reversal at the end of such a procedure or when too much sedation has been achieved." | 2.40 | Reversal of midazolam-induced laryngospasm with flumazenil. ( Davis, DP; Hamilton, RS; Webster, TH, 1998) |
| "The incidence of laryngospasm was not reduced when up to two successive doses of 1." | 1.36 | Fentanyl does not reduce the incidence of laryngospasm in children anesthetized with sevoflurane. ( Craig, D; Erb, TO; Frei, FJ; Keller, K; Rosner, GL; von Ungern-Sternberg, BS, 2010) |
| "To compare the incidence of laryngospasm by using halothane-fentanyl anaesthesia and midazolam-remifentanil anaesthesia in paediatric patients undergoing eye surgery." | 1.35 | Reduced incidence of laryngospasm with remifentanil-midazolam anaesthesia compared to halothane-fentanyl. ( Ali, S, 2008) |
| "Desaturation was attributed to laryngospasm, which was managed with positive pressure ventilation and oxygen." | 1.35 | Intranasal flumazenil and naloxone to reverse over-sedation in a child undergoing dental restorations. ( Creighton, P; Heard, C; Lerman, J, 2009) |
| " We characterize the fasting status of patients receiving procedural sedation and analgesia in a pediatric ED and assess the relationship between fasting status and adverse events." | 1.32 | Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department. ( Agrawal, D; Gupta, R; Krauss, B; Manzi, SF, 2003) |
| "In no case was laryngospasm or total airway obstruction observed." | 1.31 | Additional clinical observations utilizing bispectral analysis. ( Sandler, NA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, S | 1 |
| Heard, C | 1 |
| Creighton, P | 1 |
| Lerman, J | 1 |
| Erb, TO | 1 |
| von Ungern-Sternberg, BS | 1 |
| Keller, K | 1 |
| Rosner, GL | 1 |
| Craig, D | 1 |
| Frei, FJ | 1 |
| Brecelj, J | 1 |
| Trop, TK | 1 |
| Orel, R | 1 |
| Akin, A | 1 |
| Bayram, A | 1 |
| Esmaoglu, A | 1 |
| Tosun, Z | 1 |
| Aksu, R | 1 |
| Altuntas, R | 1 |
| Boyaci, A | 1 |
| Agrawal, D | 1 |
| Manzi, SF | 1 |
| Gupta, R | 1 |
| Krauss, B | 1 |
| Cay, DL | 1 |
| Bapat, P | 1 |
| Joshi, RN | 1 |
| Young, E | 1 |
| Jago, RH | 1 |
| Davis, DP | 1 |
| Hamilton, RS | 1 |
| Webster, TH | 1 |
| Ti, LK | 1 |
| Pua, HL | 1 |
| Lee, TL | 1 |
| D'Eramo, EM | 1 |
| Sandler, NA | 1 |
| Raine, J | 1 |
| Warner, JO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluating Stress Response and Anxiety Score in Paediatric Patients Sedated With Intranasal Dexmedetomidine[NCT04526652] | Phase 2 | 60 participants (Actual) | Interventional | 2020-12-01 | Completed | ||
| Comparing Intranasal Dexmedetomidine With Oral Midazolam as Premedication for Older Children Undergoing General Anesthesia for Dental Rehabilitation[NCT02250703] | Phase 3 | 75 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| Do Patients Need Pre-Procedural Fasting for Coronary Artery Procedures?[NCT02562638] | 240 participants (Anticipated) | Interventional | 2015-10-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Level of sedation at separation from parents and at the time of mask induction will be measured on a scale of 0 to 4 (University of Michigan Sedation Scale)~University of Michigan Sedation Scale:~0 -Awake/Alert~1 -Minimally Sedated: Tired/sleepy, appropriate response to verbal conversation and/or sounds.~2- Moderately Sedated: Somnolent/sleeping, easily aroused with light tactile stimulation.~3 - Deeply Sedated: Deep sleep, arousable only with significant physical stimulation.~4 - Unarousable~Moderately and Deeply sedated: Satisfactory Awake, minimally sedate, unarousable: Unsatisfactory" (NCT02250703)
Timeframe: Day 0:Just before the patient will be brought to the operating room
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Satisfactory sedation on separation from parents | Unsatisfactory sedation on separation from parents | Satisfactory sedation on transfer to OR table | Unsatisfactory sedation on transfer to OR table | |
| Dexmedetomidine | 25 | 11 | 22 | 14 |
| Midazolam | 15 | 22 | 12 | 25 |
1 review available for midazolam and Laryngismus
| Article | Year |
|---|---|
Reversal of midazolam-induced laryngospasm with flumazenil.
Topics: Anti-Anxiety Agents; Antidotes; Conscious Sedation; Electric Countershock; Flumazenil; GABA Modulato | 1998 |
4 trials available for midazolam and Laryngismus
| Article | Year |
|---|---|
Ketamine with and without midazolam for gastrointestinal endoscopies in children.
Topics: Adolescent; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Drug Administrat | 2012 |
Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Dexmedetomidine; | 2012 |
Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Dexmedetomidine; | 2012 |
Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Dexmedetomidine; | 2012 |
Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anxiety; Child; Child, Preschool; Dexmedetomidine; | 2012 |
Comparison of propofol versus thiopentone with midazolam or lidocaine to facilitate laryngeal mask insertion.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Cough; Drug Costs; Elective Surgical Procedures | 1996 |
Single vital capacity inhalational anaesthetic induction in adults--isoflurane vs sevoflurane.
Topics: Adolescent; Adult; Anesthesia, Closed-Circuit; Anesthesia, Inhalation; Anesthetics, Inhalation; Coug | 1998 |
8 other studies available for midazolam and Laryngismus
| Article | Year |
|---|---|
Reduced incidence of laryngospasm with remifentanil-midazolam anaesthesia compared to halothane-fentanyl.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Drug Therapy, Combination; F | 2008 |
Intranasal flumazenil and naloxone to reverse over-sedation in a child undergoing dental restorations.
Topics: Adjuvants, Anesthesia; Administration, Intranasal; Anesthesia, Dental; Antidotes; Child, Preschool; | 2009 |
Fentanyl does not reduce the incidence of laryngospasm in children anesthetized with sevoflurane.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Preschool; Dose-Response Relationsh | 2010 |
Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department.
Topics: Adjuvants, Anesthesia; Analgesia; Anesthetics, Combined; Child; Child, Preschool; Chloral Hydrate; C | 2003 |
Midazolam-opioid combination and postoperative upper airway obstruction in children.
Topics: Airway Obstruction; Analgesics, Opioid; Anti-Anxiety Agents; Child; Humans; Laryngismus; Midazolam; | 1994 |
Mortality and morbidity with outpatient anesthesia: the Massachusetts experience.
Topics: Aged; Ambulatory Care; Analgesics, Opioid; Anesthesia, Dental; Anesthesia, General; Anesthesia, Loca | 1999 |
Additional clinical observations utilizing bispectral analysis.
Topics: Airway Obstruction; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, General; Anesthe | 2000 |
Fibreoptic bronchoscopy without general anaesthetic.
Topics: Adolescent; Adult; Anesthesia, Local; Bronchoscopes; Bronchoscopy; Child; Child, Preschool; Consciou | 1991 |