midazolam has been researched along with Lacerations in 19 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Lacerations: Torn, ragged, mangled wounds.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intranasal dexmedetomidine is an alternative anxiolytic medication to intranasal midazolam for pediatric laceration repairs, performing similarly in our study, except that patients who received dexmedetomidine had less anxiety at the time of positioning for procedure." | 5.22 | Double-blind Randomized Controlled Trial of Intranasal Dexmedetomidine Versus Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair in the Emergency Department. ( Hayes, KR; Ivan, Y; McDowell, ER; Neville, DN; Pitetti, RD, 2016) |
| "No difference was found in pain assessment during local anaesthetic injection between the group treated with midazolam and ketamine, and the group treated with midazolam alone." | 5.19 | A double-blind, randomised, placebo-controlled trial of oral midazolam plus oral ketamine for sedation of children during laceration repair. ( Assa, A; Barkan, S; Berkovitch, S; Breitbart, R; Brenner-Zada, G; Feldon, M; Kozer, E; Shavit, I; Toledano, M, 2014) |
| "The authors performed a prospective, double-blinded, randomized trial with emergency department (ED) patients requiring procedural sedation and analgesia (PSA) for repair of deep traumatic lacerations and reduction of bone fractures, to compare the ketamine/propofol (ketofol) combination with the midazolam/fentanyl (MF) combination." | 5.15 | Ketamine/propofol versus midazolam/fentanyl for procedural sedation and analgesia in the emergency department: a randomized, prospective, double-blind trial. ( Ashraf, H; Golshani, K; Labaf, A; Moharari, RS; Nejati, A, 2011) |
| "Pediatric lacerations are frequently encountered by plastic surgeons in the emergency room." | 1.72 | Effect of sedation using Ketamine for primary closure of pediatric facial laceration. ( Kim, HJ; Kim, JH; Kim, SH; Lee, JH; Shin, SH; Suh, IS; Woo, SS, 2022) |
| " Having safe and fast means of providing sedation and anxiolysis to children is important for the child's tolerance of the procedure, parent satisfaction and efficient patient flow in the ED." | 1.51 | Adverse events and satisfaction with use of intranasal midazolam for emergency department procedures in children. ( Laurich, VM; Malia, L; Sturm, JJ, 2019) |
| " The primary outcome measures were adverse events and failed laceration repair." | 1.51 | Safety and effectiveness of intranasal midazolam and fentanyl used in combination in the pediatric emergency department. ( Cosgrove, P; Kienstra, AJ; Ryan, PM; Vezzetti, R; Wilkinson, M, 2019) |
| " There are no previous studies of validated anxiety scores with pharmacokinetic data to support optimal procedure timing." | 1.46 | Evaluating Clinical Effectiveness and Pharmacokinetic Profile of Atomized Intranasal Midazolam in Children Undergoing Laceration Repair. ( Adelgais, K; Bourne, D; Brent, A; Brou, L; Galinkin, J; Mellion, SA; Wathen, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, JH | 1 |
| Woo, SS | 1 |
| Shin, SH | 1 |
| Kim, HJ | 1 |
| Kim, JH | 1 |
| Kim, SH | 1 |
| Suh, IS | 1 |
| Chang, H | 1 |
| Yuan, Y | 1 |
| Yang, G | 1 |
| Liao, X | 1 |
| Chen, C | 1 |
| Ding, G | 1 |
| Mellion, SA | 1 |
| Bourne, D | 1 |
| Brou, L | 1 |
| Brent, A | 1 |
| Adelgais, K | 1 |
| Galinkin, J | 1 |
| Wathen, J | 1 |
| Malia, L | 1 |
| Laurich, VM | 1 |
| Sturm, JJ | 1 |
| Ryan, PM | 1 |
| Kienstra, AJ | 1 |
| Cosgrove, P | 1 |
| Vezzetti, R | 1 |
| Wilkinson, M | 1 |
| Barkan, S | 2 |
| Breitbart, R | 2 |
| Brenner-Zada, G | 1 |
| Feldon, M | 1 |
| Assa, A | 1 |
| Toledano, M | 2 |
| Berkovitch, S | 2 |
| Shavit, I | 1 |
| Kozer, E | 2 |
| Neville, DN | 1 |
| Hayes, KR | 1 |
| Ivan, Y | 1 |
| McDowell, ER | 1 |
| Pitetti, RD | 1 |
| Rubinstein, O | 1 |
| Weiser, G | 1 |
| Karadi, N | 1 |
| Nassi, A | 1 |
| Jameson, E | 1 |
| Lusthof, KJ | 1 |
| Oosting, R | 1 |
| Maes, A | 1 |
| Verschraagen, M | 1 |
| Dijkhuizen, A | 1 |
| Sprong, AG | 1 |
| Klein, EJ | 2 |
| Brown, JC | 1 |
| Kobayashi, A | 1 |
| Osincup, D | 1 |
| Seidel, K | 1 |
| Nejati, A | 1 |
| Moharari, RS | 1 |
| Ashraf, H | 1 |
| Labaf, A | 1 |
| Golshani, K | 1 |
| Kanegaye, JT | 1 |
| Favela, JL | 1 |
| Acosta, M | 1 |
| Bank, DE | 1 |
| Asensio Martín, MJ | 1 |
| Pavón Benito, A | 1 |
| Salvador Bravo, M | 1 |
| García Pérez, G | 1 |
| Luhmann, JD | 1 |
| Kennedy, RM | 1 |
| Porter, FL | 1 |
| Miller, JP | 1 |
| Jaffe, DM | 1 |
| Krauss, B | 1 |
| Carley, S | 1 |
| Martin, B | 1 |
| Everitt, IJ | 1 |
| Barnett, P | 1 |
| Diekema, DS | 1 |
| Paris, CA | 1 |
| Quan, L | 1 |
| Cohen, M | 1 |
| Seidel, KD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dose-Finding Study of Intranasal Midazolam for Procedural Sedation in Children[NCT04586504] | Phase 1/Phase 2 | 150 participants (Anticipated) | Interventional | 2021-09-08 | Recruiting | ||
| A Randomized Controlled Trial of Intranasal Fentanyl in Combination With Midazolam Versus Midazolam Alone for Analgesia and Anxiolysis During Pediatric Facial Laceration Repair[NCT04745260] | 100 participants (Anticipated) | Interventional | 2021-03-01 | Not yet recruiting | |||
| A Randomized, Clinical Trial of Oral Midazolam Plus Placebo Versus Oral Midazolam Plus Oral Ketamine for Sedation During Laceration Repair[NCT01470157] | Phase 4 | 60 participants (Anticipated) | Interventional | 2011-07-31 | Recruiting | ||
| Exploring the Effects of an Informative Animated Video on Preoperative Anxiety in Children Undergoing Elective Otoplasty and Their Parents[NCT05894187] | 40 participants (Anticipated) | Interventional | 2023-06-30 | Not yet recruiting | |||
| Randomized Controlled Trial of IN Midazolam vs IN Dexmedetomidine vs IN Ketamine Evaluating Length of Stay After Medication Administration and Anxiolysis During Minimal Procedures in Pediatric Population in Pediatric Emergency Department[NCT05934669] | Phase 4 | 90 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Improving Sedation of Children Undergoing Procedures in the Emergency Department: Evaluation of Different Dosages and Routes of Administration of the Sedative Midazolam[NCT00675909] | 180 participants (Actual) | Interventional | 2006-11-30 | Completed | |||
| Comparing Intranasal Dexmedetomidine With Oral Midazolam as Premedication for Older Children Undergoing General Anesthesia for Dental Rehabilitation[NCT02250703] | Phase 3 | 75 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| The Effects of Single-dose Rectal Midazolam Application on Post-operative Recovery, Sedation, and Analgesia in Children Given Caudal Anesthesia Plus Bupivacaine[NCT02127489] | Phase 4 | 40 participants (Actual) | Interventional | 2005-06-30 | Completed | ||
| iPad as a Distraction Tool During Facial Laceration Repair[NCT02217436] | 80 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Modified CHEOPS (Children's Hospital of Eastern Ontario Pain Scale)assessment used to score sedation.~Scale range is 0-10 with 0 meaning no pain and 4 or greater meaning pain. Scale is determined by assessing Facial Expression (0-2), Cry (0-3), Child Verbal (0-2) and Movements (0-3)." (NCT00675909)
Timeframe: Baseline (presentation, before sedation) in ED to start of procedure (laceration repair).
| Intervention | Scores on a scale (Median) |
|---|---|
| Oral Midazolam | 2 |
| Intranasal Midazolam | 2 |
| Buccal Midazolam | 1 |
(NCT00675909)
Timeframe: Duration of procedure up to 40 minutes
| Intervention | minutes (Median) |
|---|---|
| Oral Midazolam | 12 |
| Intranasal Midazolam | 12 |
| Buccal Midazolam | 10 |
Range is 0-10. Higher is associated with nurse impression that sedation is better. (NCT00675909)
Timeframe: After the procedure nurse was asked about their impression of the level of sedation.
| Intervention | units on a scale (Median) |
|---|---|
| Oral Midazolam | 6.8 |
| Intranasal Midazolam | 7.7 |
| Buccal Midazolam | 7.6 |
Range is 0-10. Higher is associated with physician impression that sedation is better. (NCT00675909)
Timeframe: Physician was asked after the procedure was done about their impression of sedation.
| Intervention | units on a scale (Median) |
|---|---|
| Oral Midazolam | 6.7 |
| Intranasal Midazolam | 8.1 |
| Buccal Midazolam | 7.1 |
(NCT00675909)
Timeframe: Time from study drug administration to start of procedure up to 68 minutes
| Intervention | minutes (Median) |
|---|---|
| Oral Midazolam | 34 |
| Intranasal Midazolam | 28 |
| Buccal Midazolam | 32 |
"Level of sedation at separation from parents and at the time of mask induction will be measured on a scale of 0 to 4 (University of Michigan Sedation Scale)~University of Michigan Sedation Scale:~0 -Awake/Alert~1 -Minimally Sedated: Tired/sleepy, appropriate response to verbal conversation and/or sounds.~2- Moderately Sedated: Somnolent/sleeping, easily aroused with light tactile stimulation.~3 - Deeply Sedated: Deep sleep, arousable only with significant physical stimulation.~4 - Unarousable~Moderately and Deeply sedated: Satisfactory Awake, minimally sedate, unarousable: Unsatisfactory" (NCT02250703)
Timeframe: Day 0:Just before the patient will be brought to the operating room
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Satisfactory sedation on separation from parents | Unsatisfactory sedation on separation from parents | Satisfactory sedation on transfer to OR table | Unsatisfactory sedation on transfer to OR table | |
| Dexmedetomidine | 25 | 11 | 22 | 14 |
| Midazolam | 15 | 22 | 12 | 25 |
Weighted average Observational Score Behavioral Distress Revised (OSBD-R) scored from videotapes of the entire laceration repair procedure Scale 0-23.5 (0 low/better, 23.5 high/worse) (NCT02217436)
Timeframe: Entire laceration repair procedure
| Intervention | units on a scale (Median) |
|---|---|
| iPad | 2.3 |
| Standard Care | 0.8 |
Parent rating of own anxiety during the procedure Likert-based scale 1-5 (1 low/better, 5 high/worse) (NCT02217436)
Timeframe: Survey administered immediately following the laceration repair
| Intervention | score on a scale (Median) |
|---|---|
| iPad | 2 |
| Standard Care | 4 |
1 review available for midazolam and Lacerations
| Article | Year |
|---|---|
Question 3 Ketamine or midazolam: does it matter which?
Topics: Child; Conscious Sedation; Evidence-Based Medicine; Forearm Injuries; Humans; Hypnotics and Sedative | 2011 |
10 trials available for midazolam and Lacerations
| Article | Year |
|---|---|
Comparison of sedative effects of intramuscular and intranasal midazolam for pediatric laceration repair in dental emergency department: A randomized controlled study.
Topics: Administration, Intranasal; Child; Emergency Service, Hospital; Humans; Hypnotics and Sedatives; Lac | 2023 |
A double-blind, randomised, placebo-controlled trial of oral midazolam plus oral ketamine for sedation of children during laceration repair.
Topics: Administration, Oral; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Double | 2014 |
Double-blind Randomized Controlled Trial of Intranasal Dexmedetomidine Versus Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair in the Emergency Department.
Topics: Administration, Intranasal; Anesthesia; Anti-Anxiety Agents; Anxiety; Child, Preschool; Dexmedetomid | 2016 |
Double-blind Randomized Controlled Trial of Intranasal Dexmedetomidine Versus Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair in the Emergency Department.
Topics: Administration, Intranasal; Anesthesia; Anti-Anxiety Agents; Anxiety; Child, Preschool; Dexmedetomid | 2016 |
Double-blind Randomized Controlled Trial of Intranasal Dexmedetomidine Versus Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair in the Emergency Department.
Topics: Administration, Intranasal; Anesthesia; Anti-Anxiety Agents; Anxiety; Child, Preschool; Dexmedetomid | 2016 |
Double-blind Randomized Controlled Trial of Intranasal Dexmedetomidine Versus Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair in the Emergency Department.
Topics: Administration, Intranasal; Anesthesia; Anti-Anxiety Agents; Anxiety; Child, Preschool; Dexmedetomid | 2016 |
Double-blind Randomized Controlled Trial of Intranasal Dexmedetomidine Versus Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair in the Emergency Department.
Topics: Administration, Intranasal; Anesthesia; Anti-Anxiety Agents; Anxiety; Child, Preschool; Dexmedetomid | 2016 |
Double-blind Randomized Controlled Trial of Intranasal Dexmedetomidine Versus Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair in the Emergency Department.
Topics: Administration, Intranasal; Anesthesia; Anti-Anxiety Agents; Anxiety; Child, Preschool; Dexmedetomid | 2016 |
Double-blind Randomized Controlled Trial of Intranasal Dexmedetomidine Versus Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair in the Emergency Department.
Topics: Administration, Intranasal; Anesthesia; Anti-Anxiety Agents; Anxiety; Child, Preschool; Dexmedetomid | 2016 |
Double-blind Randomized Controlled Trial of Intranasal Dexmedetomidine Versus Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair in the Emergency Department.
Topics: Administration, Intranasal; Anesthesia; Anti-Anxiety Agents; Anxiety; Child, Preschool; Dexmedetomid | 2016 |
Double-blind Randomized Controlled Trial of Intranasal Dexmedetomidine Versus Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair in the Emergency Department.
Topics: Administration, Intranasal; Anesthesia; Anti-Anxiety Agents; Anxiety; Child, Preschool; Dexmedetomid | 2016 |
Efficacy of oral ketamine compared to midazolam for sedation of children undergoing laceration repair: A double-blind, randomized, controlled trial.
Topics: Administration, Oral; Analgesics; Child; Child, Preschool; Conscious Sedation; Double-Blind Method; | 2016 |
A randomized clinical trial comparing oral, aerosolized intranasal, and aerosolized buccal midazolam.
Topics: Administration, Buccal; Administration, Intranasal; Administration, Oral; Aerosols; Child; Child, Pr | 2011 |
Ketamine/propofol versus midazolam/fentanyl for procedural sedation and analgesia in the emergency department: a randomized, prospective, double-blind trial.
Topics: Adjuvants, Anesthesia; Adult; Analgesics; Anesthetics, Intravenous; Attitude of Health Personnel; Do | 2011 |
High-dose rectal midazolam for pediatric procedures: a randomized trial of sedative efficacy and agitation.
Topics: Administration, Rectal; Anxiety; Child, Preschool; Conscious Sedation; Dose-Response Relationship, D | 2003 |
High-dose rectal midazolam for pediatric procedures: a randomized trial of sedative efficacy and agitation.
Topics: Administration, Rectal; Anxiety; Child, Preschool; Conscious Sedation; Dose-Response Relationship, D | 2003 |
High-dose rectal midazolam for pediatric procedures: a randomized trial of sedative efficacy and agitation.
Topics: Administration, Rectal; Anxiety; Child, Preschool; Conscious Sedation; Dose-Response Relationship, D | 2003 |
High-dose rectal midazolam for pediatric procedures: a randomized trial of sedative efficacy and agitation.
Topics: Administration, Rectal; Anxiety; Child, Preschool; Conscious Sedation; Dose-Response Relationship, D | 2003 |
A randomized clinical trial of continuous-flow nitrous oxide and midazolam for sedation of young children during laceration repair.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Child; Child, Preschool; Conscious Sedation; Emergen | 2001 |
Comparison of two benzodiazepines used for sedation of children undergoing suturing of a laceration in an emergency department.
Topics: Child, Preschool; Conscious Sedation; Diazepam; Emergency Service, Hospital; Humans; Hypnotics and S | 2002 |
A randomized, clinical trial of oral midazolam plus placebo versus oral midazolam plus oral transmucosal fentanyl for sedation during laceration repair.
Topics: Adjuvants, Anesthesia; Administration, Oral; Anesthesia; Child; Child, Preschool; Conscious Sedation | 2002 |
8 other studies available for midazolam and Lacerations
| Article | Year |
|---|---|
Effect of sedation using Ketamine for primary closure of pediatric facial laceration.
Topics: Child; Conscious Sedation; Facial Injuries; Humans; Hypnotics and Sedatives; Infant; Ketamine; Lacer | 2022 |
Evaluating Clinical Effectiveness and Pharmacokinetic Profile of Atomized Intranasal Midazolam in Children Undergoing Laceration Repair.
Topics: Adjuvants, Anesthesia; Administration, Intranasal; Anxiety; Child; Child, Preschool; Conscious Sedat | 2017 |
Adverse events and satisfaction with use of intranasal midazolam for emergency department procedures in children.
Topics: Administration, Intranasal; Child; Child, Preschool; Conscious Sedation; Emergency Service, Hospital | 2019 |
Safety and effectiveness of intranasal midazolam and fentanyl used in combination in the pediatric emergency department.
Topics: Administration, Intranasal; Analgesics, Opioid; Anxiety; Child; Child, Preschool; Drug Therapy, Comb | 2019 |
A case of extreme agitation and death after the use of mephedrone in The Netherlands.
Topics: Adult; Brain Edema; Central Nervous System Stimulants; Cocaine; Contusions; Delirium; Designer Drugs | 2011 |
[Burst suppression entropy response to moderate hypothermia in a patient receiving a massive transfusion].
Topics: Abdominal Injuries; Adjustment Disorders; Adult; Anesthesia, Inhalation; Blood Component Transfusion | 2006 |
Continuous-flow nitrous oxide: searching for the ideal procedural anxiolytic for toddlers.
Topics: Analgesics, Non-Narcotic; Anti-Anxiety Agents; Child; Child, Preschool; Emergency Service, Hospital; | 2001 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Midazolam and emergence phenomena in children undergoing ketamine sedation.
Topics: Adolescent; Analgesics; Anti-Anxiety Agents; Child; Child, Preschool; Drug Therapy, Combination; Eme | 2001 |