midazolam has been researched along with Injuries, Multiple in 12 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An open, prospective study was carried out on 45 patients with multiple injuries to compare the mortality and incidence of sepsis between those given early total enteral nutrition (TEN) when sedated with propofol and historical controls who had been given total parenteral nutrition (TPN) and sedated with midazolam." | 5.07 | Long-term sedation in the ICU: enteral versus parenteral feeding. ( Bataillie, K; Baute, L; Demeyer, I, 1994) |
| "Sixty-five critical ill children with multiple trauma admitted to pediatric intensive care unit (PICU) of Anhui Province Children's Hospital from January 2014 to September 2016 were enrolled, who were randomly divided into dexmedetomidine group (33 cases) and midazolam group (32 cases)." | 2.84 | [Effects of different sedation regimens on sedation and inflammatory response in critically ill children with multiple trauma]. ( Jin, D; Song, C; Sun, J; Tong, W; Wang, Y; Xu, D, 2017) |
| "Thirty patients with multiple trauma were randomly assigned to either breathe spontaneously with APRV (APRV Group) (n = 15) or to receive pressure-controlled, time-cycled mechanical ventilation (PCV) for 72 h followed by weaning with APRV (PCV Group) (n = 15)." | 2.70 | Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. ( Mutz, N; Putensen, C; Stüber, F; Von Spiegel, T; Wrigge, H; Zech, S; Zinserling, J, 2001) |
| "Midazolam was found to be a safe and viable alternative to muscle relaxants, allowing endotracheal intubation and ventilation, in addition to other invasive procedures, to be carried out with minimal distress to the patient." | 2.67 | The use of midazolam in trauma resuscitation. ( Deo, S; Knottenbelt, JD, 1994) |
| "Measurements included plasma concentration time profiles of midazolam and pharmacokinetic parameters, such as elimination half-life, clearance, and volume of distribution." | 1.28 | Pharmacokinetics of midazolam administered by continuous intravenous infusion to intensive care patients. ( Crevoisier, C; Fritz, ME; Malacrida, R; Suter, PM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ramin, S | 2 |
| Bringuier, S | 2 |
| Martinez, O | 2 |
| Sadek, M | 2 |
| Manzanera, J | 2 |
| Deras, P | 2 |
| Choquet, O | 2 |
| Charbit, J | 2 |
| Capdevila, X | 2 |
| Tong, W | 1 |
| Song, C | 1 |
| Jin, D | 1 |
| Sun, J | 1 |
| Wang, Y | 2 |
| Xu, D | 1 |
| Selbst, SM | 1 |
| Wang, WJ | 1 |
| Lu, HQ | 1 |
| Shao, RD | 1 |
| Melamed, E | 1 |
| Oron, Y | 1 |
| Ben-Avraham, R | 1 |
| Blumenfeld, A | 1 |
| Lin, G | 1 |
| Fowler, SB | 1 |
| Hertzog, J | 1 |
| Wagner, BK | 1 |
| Deo, S | 1 |
| Knottenbelt, JD | 1 |
| De Deyne, C | 1 |
| Struys, M | 1 |
| Decruyenaere, J | 1 |
| Creupelandt, J | 1 |
| Hoste, E | 1 |
| Colardyn, F | 1 |
| Demeyer, I | 1 |
| Bataillie, K | 1 |
| Baute, L | 1 |
| Putensen, C | 1 |
| Zech, S | 1 |
| Wrigge, H | 1 |
| Zinserling, J | 1 |
| Stüber, F | 1 |
| Von Spiegel, T | 1 |
| Mutz, N | 1 |
| Malacrida, R | 1 |
| Fritz, ME | 1 |
| Suter, PM | 1 |
| Crevoisier, C | 1 |
| Ledingham, IM | 1 |
| Bion, JF | 1 |
| Newman, LH | 1 |
| McDonald, JC | 1 |
| Wallace, PG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ketamine Versus Midazolam for Prehospital Agitation[NCT03554915] | 314 participants (Actual) | Observational | 2017-08-01 | Completed | |||
| Bispectral Index Monitoring To Guide Sedation In Patients With Non-Neurological Pathology Over 65 Years, Admitted To Intensive Care Unit: Randomized Control Trial[NCT02909010] | 150 participants (Anticipated) | Interventional | 2015-05-31 | Active, not recruiting | |||
| Impact of Proportional Assisted Ventilation on Dyspnea and Asynchrony in Mechanically Ventilated Patients[NCT02801994] | 34 participants (Actual) | Interventional | 2016-02-24 | Completed | |||
| Driving Pressure Variation During Proportional Assisted Ventilation: Comparison Between NAVA and PSV[NCT03719365] | 20 participants (Anticipated) | Interventional | 2018-11-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for midazolam and Injuries, Multiple
| Article | Year |
|---|---|
Pharmacological interventions for agitation in head-injured patients in the acute care setting.
Topics: Adult; Brain Injuries; Critical Care; Dose-Response Relationship, Drug; Drug Administration Schedule | 1995 |
7 trials available for midazolam and Injuries, Multiple
| Article | Year |
|---|---|
Continuous peripheral nerve blocks for analgesia of ventilated critically ill patients with multiple trauma: a prospective randomized study.
Topics: Analgesia; Analgesics, Opioid; Critical Illness; Female; Humans; Hypnotics and Sedatives; Intensive | 2023 |
Continuous peripheral nerve blocks for analgesia of ventilated critically ill patients with multiple trauma: a prospective randomized study.
Topics: Analgesia; Analgesics, Opioid; Critical Illness; Female; Humans; Hypnotics and Sedatives; Intensive | 2023 |
Continuous peripheral nerve blocks for analgesia of ventilated critically ill patients with multiple trauma: a prospective randomized study.
Topics: Analgesia; Analgesics, Opioid; Critical Illness; Female; Humans; Hypnotics and Sedatives; Intensive | 2023 |
Continuous peripheral nerve blocks for analgesia of ventilated critically ill patients with multiple trauma: a prospective randomized study.
Topics: Analgesia; Analgesics, Opioid; Critical Illness; Female; Humans; Hypnotics and Sedatives; Intensive | 2023 |
[Effects of different sedation regimens on sedation and inflammatory response in critically ill children with multiple trauma].
Topics: Child; Critical Illness; Humans; Intensive Care Units; Midazolam; Multiple Trauma; Prospective Studi | 2017 |
[Hemodynamic effects of midazolam and fentanyl combination in multiple trauma patients].
Topics: Adolescent; Adult; Aged, 80 and over; Female; Fentanyl; Hemodynamics; Humans; Male; Midazolam; Middl | 2012 |
The use of midazolam in trauma resuscitation.
Topics: Adolescent; Adult; Conscious Sedation; Female; Humans; Hypnotics and Sedatives; Injury Severity Scor | 1994 |
Long-term sedation in the ICU: enteral versus parenteral feeding.
Topics: Adult; APACHE; Enteral Nutrition; Female; Humans; Injury Severity Score; Male; Midazolam; Multiple T | 1994 |
Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Female; Humans; Injury Severity Score; Length | 2001 |
Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Female; Humans; Injury Severity Score; Length | 2001 |
Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Female; Humans; Injury Severity Score; Length | 2001 |
Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Female; Humans; Injury Severity Score; Length | 2001 |
Mortality and morbidity amongst sedated intensive care patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Critical Care; Drug Therapy, C | 1988 |
4 other studies available for midazolam and Injuries, Multiple
| Article | Year |
|---|---|
Pediatric emergency medicine: legal briefs.
Topics: Accidents, Traffic; Amputation, Surgical; Baseball; Brain Damage, Chronic; Child; Colon; Commitment | 2013 |
The combative multitrauma patient: a protocol for prehospital management.
Topics: Adolescent; Adult; Anesthetics, Dissociative; Behavior Control; Clinical Protocols; Drug Therapy, Co | 2007 |
Use of continuous bispectral EEG monitoring to assess depth of sedation in ICU patients.
Topics: Analgesics, Opioid; Conscious Sedation; Critical Illness; Dose-Response Relationship, Drug; Drug Mon | 1998 |
Pharmacokinetics of midazolam administered by continuous intravenous infusion to intensive care patients.
Topics: Adult; Critical Care; Half-Life; Humans; Infusions, Intravenous; Linear Models; Metabolic Clearance | 1992 |