midazolam has been researched along with Hypothermia in 19 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conclude that forced-air warming can effectively prevent midazolam-induced redistribution hypothermia." | 9.14 | Forced-air warming effectively prevents midazolam-induced core hypothermia in volunteers. ( Imai, Y; Ishiyama, T; Iwashita, H; Matsukawa, T; Okuyama, K; Sato, H; Yamakage, M, 2009) |
| "Inadvertent perioperative hypothermia is common during spinal anesthesia and after midazolam administration." | 9.12 | Preoperative warming combined with intraoperative skin-surface warming does not avoid hypothermia caused by spinal anesthesia in patients with midazolam premedication. ( Amorim, RB; Braz, JR; Braz, LG; Castiglia, YM; D'Angelo Vanni, SM; Ferrari, F; Ganem, EM; Rodrigues Júnior, GR, 2007) |
| "The effect of hypothermia on the in vivo pharmacokinetics of midazolam was evaluated, with a focus on altered metabolism in the liver and binding to serum proteins." | 7.81 | Evaluation of hypothermia on the in vitro metabolism and binding and in vivo disposition of midazolam in rats. ( Fumoto, S; Hirata, H; Matsueda, S; Miyamoto, H; Moritsuka, A; Nakashima, M; Nishida, K; Sasaki, H; Shimokawa, K, 2015) |
| " Population pharmacokinetic modeling identified a significant relationship between temperature and clearance and intercompartmental clearance for midazolam." | 6.75 | Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers. ( Bies, RR; Callaway, CW; Empey, PE; Hostler, D; Kochanek, PM; Poloyac, SM; Rittenberger, JC; Tortorici, MA; Zhou, J, 2010) |
| " Cardiopulmonary instability was more common, and hypothermia was less common in the sedation groups of pentazocine/midazolam and fentanyl/midazolam, compared to the general anesthesia group of air/oxygen/sevoflurane (AOS)." | 5.41 | Safety profile of anesthetic modalities during laser treatment for retinopathy of prematurity: a systematic review. ( Arvanitaki, Z; Gavriilidou, A; Haidich, AB; Mataftsi, A; Seliniotaki, AK; Ziakas, N, 2023) |
| "We conclude that forced-air warming can effectively prevent midazolam-induced redistribution hypothermia." | 5.14 | Forced-air warming effectively prevents midazolam-induced core hypothermia in volunteers. ( Imai, Y; Ishiyama, T; Iwashita, H; Matsukawa, T; Okuyama, K; Sato, H; Yamakage, M, 2009) |
| "Inadvertent perioperative hypothermia is common during spinal anesthesia and after midazolam administration." | 5.12 | Preoperative warming combined with intraoperative skin-surface warming does not avoid hypothermia caused by spinal anesthesia in patients with midazolam premedication. ( Amorim, RB; Braz, JR; Braz, LG; Castiglia, YM; D'Angelo Vanni, SM; Ferrari, F; Ganem, EM; Rodrigues Júnior, GR, 2007) |
| "The effect of hypothermia on the in vivo pharmacokinetics of midazolam was evaluated, with a focus on altered metabolism in the liver and binding to serum proteins." | 3.81 | Evaluation of hypothermia on the in vitro metabolism and binding and in vivo disposition of midazolam in rats. ( Fumoto, S; Hirata, H; Matsueda, S; Miyamoto, H; Moritsuka, A; Nakashima, M; Nishida, K; Sasaki, H; Shimokawa, K, 2015) |
| " Population pharmacokinetic modeling identified a significant relationship between temperature and clearance and intercompartmental clearance for midazolam." | 2.75 | Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers. ( Bies, RR; Callaway, CW; Empey, PE; Hostler, D; Kochanek, PM; Poloyac, SM; Rittenberger, JC; Tortorici, MA; Zhou, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 5 (26.32) | 2.80 |
| Authors | Studies |
|---|---|
| Tashiro, M | 2 |
| Tohei, A | 2 |
| Ikonomidou, C | 1 |
| Wang, SH | 1 |
| Fuhler, NA | 1 |
| Larson, S | 1 |
| Capuano, S | 1 |
| Brunner, KR | 1 |
| Crosno, K | 1 |
| Simmons, HA | 1 |
| Mejia, AF | 1 |
| Noguchi, KK | 1 |
| Gavriilidou, A | 1 |
| Seliniotaki, AK | 1 |
| Arvanitaki, Z | 1 |
| Ziakas, N | 1 |
| Haidich, AB | 1 |
| Mataftsi, A | 1 |
| Eshar, D | 1 |
| Beaufrère, H | 1 |
| Hosokawa, Y | 1 |
| Amao, H | 1 |
| Rufiange, M | 1 |
| Leung, VSY | 1 |
| Simpson, K | 1 |
| Pang, DSJ | 1 |
| Tsukamoto, A | 2 |
| Konishi, Y | 1 |
| Kawakami, T | 1 |
| Koibuchi, C | 1 |
| Sato, R | 1 |
| Kanai, E | 1 |
| Inomata, T | 2 |
| Radhakrishnan, A | 1 |
| Jayakumari, N | 1 |
| Kumar, VM | 1 |
| Gulia, KK | 1 |
| Niino, N | 1 |
| Sakamoto, M | 1 |
| Ohtani, R | 1 |
| Miyamoto, H | 1 |
| Matsueda, S | 1 |
| Moritsuka, A | 1 |
| Shimokawa, K | 1 |
| Hirata, H | 1 |
| Nakashima, M | 1 |
| Sasaki, H | 1 |
| Fumoto, S | 1 |
| Nishida, K | 1 |
| Sato, H | 1 |
| Yamakage, M | 1 |
| Okuyama, K | 1 |
| Imai, Y | 1 |
| Iwashita, H | 1 |
| Ishiyama, T | 1 |
| Matsukawa, T | 2 |
| Hostler, D | 1 |
| Zhou, J | 1 |
| Tortorici, MA | 1 |
| Bies, RR | 1 |
| Rittenberger, JC | 1 |
| Empey, PE | 1 |
| Kochanek, PM | 1 |
| Callaway, CW | 1 |
| Poloyac, SM | 1 |
| Toyota, K | 1 |
| Sakura, S | 1 |
| Saito, Y | 1 |
| Ozasa, H | 1 |
| Uchida, H | 1 |
| Stegmann, GF | 1 |
| Preisman, S | 1 |
| Marks, R | 1 |
| Nahtomi-Shick, O | 1 |
| Sidi, A | 1 |
| D'Angelo Vanni, SM | 1 |
| Castiglia, YM | 1 |
| Ganem, EM | 1 |
| Rodrigues Júnior, GR | 1 |
| Amorim, RB | 1 |
| Ferrari, F | 1 |
| Braz, LG | 1 |
| Braz, JR | 1 |
| Verstegen, J | 1 |
| Petcho, A | 1 |
| Ben-David, B | 1 |
| Solomon, E | 1 |
| Levin, H | 1 |
| Ozaki, M | 1 |
| Nishiyama, T | 1 |
| Imamura, M | 1 |
| Iwamoto, R | 1 |
| Iijima, T | 1 |
| Kumazawa, T | 1 |
1 review available for midazolam and Hypothermia
| Article | Year |
|---|---|
Safety profile of anesthetic modalities during laser treatment for retinopathy of prematurity: a systematic review.
Topics: Anesthetics; Child; Fentanyl; Humans; Hypothermia; Infant; Infant, Newborn; Ketamine; Lasers; Midazo | 2023 |
5 trials available for midazolam and Hypothermia
| Article | Year |
|---|---|
Forced-air warming effectively prevents midazolam-induced core hypothermia in volunteers.
Topics: Adjuvants, Anesthesia; Adult; Body Temperature; Body Temperature Regulation; Humans; Hypothermia; In | 2009 |
Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers.
Topics: Adult; Area Under Curve; Body Temperature; Computer Simulation; Cross-Over Studies; Cytochrome P-450 | 2010 |
The effect of pre-operative administration of midazolam on the development of intra-operative hypothermia.
Topics: Adolescent; Adult; Arthroscopy; Body Temperature; Conscious Sedation; Dose-Response Relationship, Dr | 2004 |
Preoperative warming combined with intraoperative skin-surface warming does not avoid hypothermia caused by spinal anesthesia in patients with midazolam premedication.
Topics: Adult; Analysis of Variance; Anesthesia, Spinal; Anti-Anxiety Agents; Body Temperature; Female; Heat | 2007 |
Atropine prevents midazolam-induced core hypothermia in elderly patients.
Topics: Aged; Atropine; Body Temperature Regulation; Female; Hemodynamics; Humans; Hypothermia; Male; Midazo | 2001 |
13 other studies available for midazolam and Hypothermia
| Article | Year |
|---|---|
Recommended doses of medetomidine-midazolam-butorphanol with atipamezole for preventing hypothermia in mice.
Topics: Animals; Butorphanol; Hypnotics and Sedatives; Hypothermia; Imidazoles; Medetomidine; Mice; Midazola | 2022 |
Mild hypothermia fails to protect infant macaques from brain injury caused by prolonged exposure to Antiseizure drugs.
Topics: Animals; Brain; Brain Injuries; Humans; Hypothermia; Hypothermia, Induced; Infant; Infant, Newborn; | 2022 |
Anesthetic effects of dexmedetomidine-ketamine-midazolam administered intramuscularly in five-striped palm squirrels (
Topics: Anesthesia; Anesthetics; Animals; Dexmedetomidine; Female; Heart Rate; Hypothermia; Ketamine; Male; | 2019 |
Duration of thermal support for preventing hypothermia induced by anesthesia with medetomidine-midazolam-butorphanol in mice.
Topics: Anesthesia; Anesthetics, Combined; Animals; Butorphanol; Hypothermia; Male; Medetomidine; Mice; Mice | 2020 |
Pre-warming following premedication limits hypothermia before and during anesthesia in Sprague-Dawley rats
Topics: Adjuvants, Anesthesia; Analgesics; Analgesics, Opioid; Anesthesia; Anesthetics, Inhalation; Animals; | 2021 |
Pharmacological properties of various anesthetic protocols in 10-day-old neonatal rats.
Topics: Anesthesia; Anesthetics, Combined; Animals; Animals, Newborn; Butorphanol; Dose-Response Relationshi | 2017 |
Sleep promoting potential of low dose α-Asarone in rat model.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Body Temperature; Brain; Dose-Response Relationship, Dr | 2017 |
The validity of anesthetic protocols for the surgical procedure of castration in rats.
Topics: Administration, Inhalation; Anesthesia; Anesthetics; Animal Experimentation; Animals; Bradycardia; B | 2018 |
Evaluation of hypothermia on the in vitro metabolism and binding and in vivo disposition of midazolam in rats.
Topics: Animals; Brain; Cells, Cultured; Cytochrome P-450 CYP3A; Drug Evaluation, Preclinical; Hypothermia; | 2015 |
Midazolam/ketamine induction and isoflurane maintenance of anaesthesia in a 2-month-old, hand-raised African buffalo (Syncerus caffer).
Topics: Anesthetics, Combined; Anesthetics, Inhalation; Animals; Buffaloes; Hypnotics and Sedatives; Hypoten | 2004 |
Preservation of static and dynamic cerebral autoregulation after mild hypothermic cardiopulmonary bypass.
Topics: Aged; Anesthetics, Combined; Blood Flow Velocity; Cardiopulmonary Bypass; Cerebral Arteries; Female; | 2005 |
Medetomidine-butorphanol-midazolam for anaesthesia in dogs and its reversal by atipamezole.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics; Animals; Butorphanol; Dogs; Drug Combinations | 1993 |
Spinal anesthesia, hypothermia, and sedation: a case of resedation with forced-air warming.
Topics: Anesthesia, Spinal; Arousal; Body Temperature Regulation; Conscious Sedation; Humans; Hypnotics and | 1997 |