midazolam has been researched along with Hypotension in 84 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypotension is common during propofol sedation for colonoscopy and of a magnitude and duration associated with harm in surgical patients." | 9.22 | Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis. ( Absalom, AR; Barends, CRM; Jones, JB; Sneyd, JR, 2022) |
| "Continuous midazolam infusion is commonly used for the management of status epilepticus (SE)." | 9.11 | Efficacy of continuous midazolam infusion and mortality in childhood refractory generalized convulsive status epilepticus. ( Aydin, A; Gulez, P; Kavakli, T; Ozdemir, D; Uran, N; Yendur, G, 2005) |
| "To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children." | 7.81 | Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. ( Barcelos, A; Branco, R; Bruno, F; Garcia, PC; Piva, JP; Portela, JL; Tasker, RC, 2015) |
| "Midazolam, even in low dose, was more likely than etomidate to cause significant hypotension when used as an induction agent for rapid sequence intubation." | 7.72 | Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubation. ( Choi, YF; Lau, CC; Wong, TW, 2004) |
| " The investigators studied a patient with a nortriptyline HCI level of 1,205 ng/mL who had four generalized grand mal seizures, each lasting between 60 and 90 seconds that were immediately followed by hypotension requiring norepinephrine support." | 7.69 | Recurrent hypotension immediately after seizures in nortriptyline overdose. ( Bell, A; Gaynor, B; Lipper, B, 1994) |
| "The effectiveness and side effects of dexmedetomidine (DEX) in combination with midazolam and propofol have not been comparatively studied in a single clinical trial as sedative agents to general anesthesia before." | 5.51 | Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery. ( Gao, Y; Yan, F, 2022) |
| "Propofol was commenced in all patients at a mean infusion rate of 18." | 5.38 | Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation. ( Drewitz, I; Heitmann, K; Hoffmann, BA; Rostock, T; Salukhe, TV; Steven, D; Willems, S, 2012) |
| "Midazolam is a licensed medication, but the buccal formulation is currently used off-licence." | 5.36 | Significant hypotension following buccal midazolam administration. ( Kensche, M; Sander, JW; Sisodiya, SM, 2010) |
| "Etiology and management of neonatal seizures was retrospectively studied in 39 patients, who were admitted in our neonatal intensive care unit." | 5.33 | [Etiology and management of neonatal seizures--successful treatment by midazolam]. ( Imataka, G; Kawaguchi, N; Suzumura, H; Yamanouchi, H, 2006) |
| "Diazepam has been shown to decrease the catecholamine response to perioperative stress." | 5.27 | Investigation of midazolam's influence on physiological and hormonal responses to hypotension. ( Glisson, SN, 1987) |
| "Hypotension is common during propofol sedation for colonoscopy and of a magnitude and duration associated with harm in surgical patients." | 5.22 | Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis. ( Absalom, AR; Barends, CRM; Jones, JB; Sneyd, JR, 2022) |
| "BACKGROUND Despite the high frequency of hypotension during spinal anesthesia with proper sedation, no previous report has compared the hemodynamic effects of dexmedetomidine and midazolam sedation during spinal anesthesia." | 5.22 | Comparison of Intravenous Dexmedetomidine and Midazolam for Bispectral Index-Guided Sedation During Spinal Anesthesia. ( Cho, NR; Jo, YY; Jung, WS; Kwak, HJ; Lee, D, 2016) |
| "Patients scheduled to undergo ESD for early gastric cancer or adenoma were randomly assigned to sedation with midazolam or propofol, and consciousness level was evaluated by bispectral index (BIS) monitoring." | 5.16 | Propofol sedation with bispectral index monitoring is useful for endoscopic submucosal dissection: a randomized prospective phase II clinical trial. ( Azuma, M; Higuchi, K; Ishido, K; Katada, C; Koizumi, W; Naruke, A; Sasaki, T; Sato, A; Tanabe, S, 2012) |
| " Midazolam with bupivacaine prolongs the duration of analgesia when administered intrathecally but does not prevent hypotension." | 5.13 | Combination of low doses of intrathecal ketamine and midazolam with bupivacaine improves postoperative analgesia in orthopaedic surgery. ( Batra, YK; Murali Krishna, T; Panda, NB; Rajeev, S, 2008) |
| "The routine use of fentanyl and midazolam prior to sheath removal leads to a reduction in pain perception and vasovagal incidence, whilst the routine use of local infiltration during sheath removal should be discouraged as it leads to more pain and a trend to more vasovagal reactions." | 5.12 | Effect of local anesthesia and intravenous sedation on pain perception and vasovagal reactions during femoral arterial sheath removal after percutaneous coronary intervention. ( French, JK; Juergens, CP; Kiat Ang, C; Leung, DY; Lo, S, 2007) |
| "Continuous midazolam infusion is commonly used for the management of status epilepticus (SE)." | 5.11 | Efficacy of continuous midazolam infusion and mortality in childhood refractory generalized convulsive status epilepticus. ( Aydin, A; Gulez, P; Kavakli, T; Ozdemir, D; Uran, N; Yendur, G, 2005) |
| "Oral midazolam significantly reduces anxiety and pain during flexible sigmoidoscopy as assessed by both patients and physicians." | 5.09 | A double-blind placebo controlled trial of oral midazolam as premedication before flexible sigmoidoscopy. ( Chen, ST; Clarkston, WK; Cuddy, PG; Dierenfeldt, WT; Jonnalagadda, SS; Kuganeswaran, E; Pandya, PK; Quiason, SG; Smith, OJ, 1999) |
| "min-1), (2) the incidence of apnea and desaturation of oxygen (< 80%), (3) the degree of sedation, and (4) the serum levels of bilirubin and unbound bilirubin after surgery." | 5.08 | [Midazolam for anesthetic induction in neonates]. ( Iwasawa, K; Kadosaki, M; Kawakami, K; Mitono, H; Ohata, J; Saito, I, 1998) |
| " This review of refractory and super-refractory status epilepticus summarizes recent pediatric case series regarding definitions, the second-tier AED therapies once initial anticonvulsants have failed, and the experience of high-dose midazolam, barbiturate anesthesia, and volatile anesthetics for uncontrolled status epilepticus." | 4.89 | Pediatric intensive care treatment of uncontrolled status epilepticus. ( Tasker, RC; Wilkes, R, 2013) |
| " The following 4 cardiopulmonary complications were assessed: hypoxia, hypotension, arrhythmias, and apnea." | 4.82 | Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis. ( Khandwala, F; Lopez, R; Qadeer, MA; Vargo, JJ; Zuccaro, G, 2005) |
| " There was no demonstrable difference in post-induction hypotension between ketamine-based and midazolam-based PHEA." | 4.12 | Cardiovascular complications of prehospital emergency anaesthesia in patients with return of spontaneous circulation following medical cardiac arrest: a retrospective comparison of ketamine-based and midazolam-based induction protocols. ( Keeliher, C; Khan-Cheema, H; King, C; Lewinsohn, A; McLachlan, S; Sherren, P; Sherrin, J, 2022) |
| " Bradycardia with dexmedetomidine, unplanned extubation rates, and morphine dosage were monitored as balancing measures." | 4.02 | Reducing Benzodiazepine Exposure by Instituting a Guideline for Dexmedetomidine Usage in the NICU. ( Hansen, A; Labrecque, M; Leeman, K; Moline, M; Morton, SU, 2021) |
| "To compare the therapeutic efficacy of intramuscular midazolam (MDZ-IM) with that of intravenous diazepam (DZP-IV) for seizures in children." | 3.81 | Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. ( Barcelos, A; Branco, R; Bruno, F; Garcia, PC; Piva, JP; Portela, JL; Tasker, RC, 2015) |
| "In this large, pediatric multicenter registry, fentanyl, midazolam, and ketamine were the most commonly used induction agents, and the majority of tracheal intubations involved neuromuscular blockade." | 3.81 | Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study. ( Brown, CA; Howell, JD; Hsing, DD; Montgomery, V; Nadkarni, VM; Nishisaki, A; Parker, MM; Tarquinio, KM; Turner, DA; Walls, RM, 2015) |
| "We experienced a case of life-threatening hypotension and bronchoconstriction associated with edema in a patient undergoing resection of a tumor of the right mandible following intravenous midazolam for induction of general anesthesia." | 3.81 | Anaphylactoid-like Reaction to Midazolam During Oral and Maxillofacial Surgery. ( Ayuse, T; Kurata, S, 2015) |
| " The adverse event (AE) rate was 18% and included apnea (10%), inadequate sedation (3%), bradycardia (2%), desaturation (1%), hypotension (1%) and bag-valve-mask use (1%)." | 3.73 | Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS). ( Mensour, M; Michaud, J; Pineau, R; Sahai, V, 2006) |
| "Midazolam, even in low dose, was more likely than etomidate to cause significant hypotension when used as an induction agent for rapid sequence intubation." | 3.72 | Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubation. ( Choi, YF; Lau, CC; Wong, TW, 2004) |
| " The investigators studied a patient with a nortriptyline HCI level of 1,205 ng/mL who had four generalized grand mal seizures, each lasting between 60 and 90 seconds that were immediately followed by hypotension requiring norepinephrine support." | 3.69 | Recurrent hypotension immediately after seizures in nortriptyline overdose. ( Bell, A; Gaynor, B; Lipper, B, 1994) |
| "Remimazolam is an ultrashort-acting benzodiazepine that is potentially a practical option for procedural sedation in colonoscopy." | 3.11 | Discharge readiness after remimazolam versus propofol for colonoscopy: A randomised, double-blind trial. ( Chen, L; Fu, B; Guan, J; Liu, L; Yao, Y; Zheng, X, 2022) |
| "However, adverse events such as hypoxemia often occur clinically." | 3.11 | Effects of intravenous lidocaine on hypoxemia induced by propofol-based sedation for gastrointestinal endoscopy procedures: study protocol for a prospective, randomized, controlled trial. ( An, LX; Qi, XR; Sun, JY; Xue, FS; Zhang, K, 2022) |
| "The occurrences of hypoxemia in groups Cs, Cc, Ns, and Nc were 4 (9." | 2.78 | Stepwise sedation for elderly patients with mild/moderate COPD during upper gastrointestinal endoscopy. ( Cao, K; Chen, X; Guo, Q; Jia, Y; Liu, XM; Shen, SR; Tong, LL; Wang, F; Wang, XY; Xiao, DH; Xu, CX; Zou, HF, 2013) |
| "Patients with liver cirrhosis frequently undergo diagnostic or therapeutic upper GI endoscopy (UGIE), and the liver disease might impair the metabolism of drugs usually administered for sedation." | 2.76 | Sedation during upper GI endoscopy in cirrhotic outpatients: a randomized, controlled trial comparing propofol and fentanyl with midazolam and fentanyl. ( Bonilha, DQ; Brito, JR; Correia, LM; Ferrari, AP; Gomes, GF; Lenz, L; Libera, ED; Nakao, FS; Rohr, MR, 2011) |
| "To determine the safety, effectiveness, and dosing of dexmedetomidine in intensive care infants and children who require sedation, and the rationale for patient selection." | 2.73 | Use of dexmedetomidine in the pediatric intensive care unit. ( Buck, ML; Willson, DF, 2008) |
| "Patients receiving propofol reached full recovery sooner (16." | 2.71 | Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists. ( Chadalawada, V; Hansen, JJ; Liangpunsakul, S; Mendel, AM; Overley, CA; Rex, DK; Strahl, E; Symms, MR; Ulmer, BJ, 2003) |
| "Hypotension was documented in two patients in the propofol group and one patient receiving midazolam/meperidine." | 2.71 | Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study. ( Riphaus, A; Stergiou, N; Wehrmann, T, 2005) |
| "Ephedrine has adrenergic effects on the circulation." | 2.68 | The effects of midazolam and ephedrine on post-exercise autonomic chronotropic control of the heart in normal subjects. ( Jalonen, J; Laitinen, LA; Lindqvist, A; Seppälä, T; Strömberg, C, 1996) |
| "Midazolam was associated with the deterioration of psychometric scores for a longer period than propofol." | 2.52 | Propofol versus midazolam for upper gastrointestinal endoscopy in cirrhotic patients: a meta-analysis of randomized controlled trials. ( Chen, CY; Chen, TL; Ko, CL; Lin, YC; Lou, HY; Tam, KW; Tsai, HC, 2015) |
| "Propofol was commonly used and is potentially associated with poorer clinical outcomes." | 1.56 | Comparison of drugs used for intubation of pediatric trauma patients. ( Davidson, J; Merritt, N; Mudri, M; Priestap, F; Williams, A, 2020) |
| " There were no other serious adverse events." | 1.51 | Computer-Assisted Propofol Sedation for Esophagogastroduodenoscopy Is Effective, Efficient, and Safe. ( Beecher, R; Chiorean, M; Drennan, F; Gluck, M; Koch, J; Kozarek, RA; La Selva, D; Larsen, M; Lin, OS; McCormick, S; Ross, A; Tombs, D; Venu, N; Weigel, W, 2019) |
| "The sevoflurane flow rate was 7±3 mL/h in INSP group, and 3." | 1.51 | Sevoflurane sedation for weaning from mechanical ventilation in pediatric intensive care unit. ( Groselj Grenc, M; Pavcnik, M, 2019) |
| " Vital signs before and after dosing were not significantly different." | 1.51 | Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit. ( Bidegain, M; Cotten, CM; Fisher, K; Goldberg, RN; Greenberg, RG; Hornik, CD; Ku, LC; Simmons, C; Smith, PB, 2019) |
| "Propofol sedation has been shown to be safe for atrial fibrillation ablation and internal cardioverter-defibrillator implantation but its use for catheter ablation (CA) of ventricular tachycardia (VT) has yet to be evaluated." | 1.43 | Propofol sedation administered by cardiologists for patients undergoing catheter ablation for ventricular tachycardia. ( Höfeler, T; Hoffmann, BA; Lüker, J; Schäffer, B; Servatius, H; Steven, D; Sultan, A; Willems, S, 2016) |
| "Weight-adjusted anesthetic induction dosing, age-associated differences in dosing by ASA-PS (American Society of Anesthesiology-Physical Status), and hemodynamic outcomes between younger (18-64 years, n = 537) and older (≥65 years, n = 231) female patients were analyzed." | 1.43 | A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients? ( Akhtar, S; Burg, MM; Dai, F; Heng, J; Schonberger, RB, 2016) |
| "For propofol, there was a significantly lower dosing for older patients: 17% for patients aged 65-79 and 29% for those aged >80, which was still in less than the recommendations." | 1.43 | Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice. ( Akhtar, S; Burg, MM; Dai, F; Heng, J; Liu, J; Schonberger, RB, 2016) |
| "Add-on seizure control with midazolam was limited (23% seizure control)." | 1.42 | Anticonvulsant effectiveness and hemodynamic safety of midazolam in full-term infants treated with hypothermia. ( de Vries, LS; Egberts, T; Groenendaal, F; Huitema, AD; Rademaker, K; Toet, MC; van den Broek, MP; van Straaten, HL, 2015) |
| " Primary outcomes are sedation-related adverse events and predictors of sedation requirement." | 1.40 | Conscious sedation for upper endoscopy in the gastric bypass patient: prevalence of cardiopulmonary adverse events and predictors of sedation requirement. ( Abu Dayyeh, BK; Jirapinyo, P; Thompson, CC, 2014) |
| " Compared with the control group, a higher dosage of midazolam was administered (P = 0." | 1.39 | Risk of sedation for diagnostic esophagogastroduodenoscopy in obstructive sleep apnea patients. ( Cha, JM; Jeun, JW; Joo, KR; Lee, JI; Pack, KM; Shin, HP; Shin, WC, 2013) |
| "Propofol was commenced in all patients at a mean infusion rate of 18." | 1.38 | Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation. ( Drewitz, I; Heitmann, K; Hoffmann, BA; Rostock, T; Salukhe, TV; Steven, D; Willems, S, 2012) |
| "Deep sedation during endoscopic procedures is safe in both adults and children." | 1.37 | Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience. ( Agostoni, M; Beretta, L; Fanti, L; Gemma, M; Pasculli, N; Testoni, PA, 2011) |
| "Midazolam is a licensed medication, but the buccal formulation is currently used off-licence." | 1.36 | Significant hypotension following buccal midazolam administration. ( Kensche, M; Sander, JW; Sisodiya, SM, 2010) |
| "Etiology and management of neonatal seizures was retrospectively studied in 39 patients, who were admitted in our neonatal intensive care unit." | 1.33 | [Etiology and management of neonatal seizures--successful treatment by midazolam]. ( Imataka, G; Kawaguchi, N; Suzumura, H; Yamanouchi, H, 2006) |
| " There was no association between preprocedural fasting state and adverse events." | 1.32 | Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department. ( Agrawal, D; Gupta, R; Krauss, B; Manzi, SF, 2003) |
| "Adverse effects were common; however, serious adverse effects rarely occurred after 25 minutes from the final medication administration." | 1.32 | When is a patient safe for discharge after procedural sedation? The timing of adverse effect events in 1367 pediatric procedural sedations. ( Azer, MM; Newman, DH; Pitetti, RD; Singh, S, 2003) |
| "The GP sedationists encountered a low incidence of adverse events, which they managed effectively." | 1.31 | Sedation for endoscopy: the safe use of propofol by general practitioner sedationists. ( Chiragakis, L; Clarke, AC; Hillman, LC; Kaye, GL, 2002) |
| " Deep sedation was induced in 260 patients using midazolam, phenergan, and meperidine, then maintained with intermittent dosing of meperidine at the following mean doses: midazolam 0." | 1.30 | Evaluation of the safety and efficacy of deep sedation for electrophysiology procedures administered in the absence of an anesthetist. ( Brandon, MJ; Geiger, MJ; Kearney, MM; Kent, V; Natale, A; Newby, KH; Wase, A, 1997) |
| "Midazolam is a water soluble benzodiazepine, with a short elimination half-life in adults and children." | 1.28 | Pharmacokinetics of midazolam during continuous infusion in critically ill neonates. ( Beaufils, F; Burtin, P; Daoud, P; Jacqz-Aigrain, E; Maherzi, S, 1992) |
| "Diazepam has been shown to decrease the catecholamine response to perioperative stress." | 1.27 | Investigation of midazolam's influence on physiological and hormonal responses to hypotension. ( Glisson, SN, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (5.95) | 18.7374 |
| 1990's | 14 (16.67) | 18.2507 |
| 2000's | 22 (26.19) | 29.6817 |
| 2010's | 35 (41.67) | 24.3611 |
| 2020's | 8 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| King, C | 1 |
| Lewinsohn, A | 1 |
| Keeliher, C | 1 |
| McLachlan, S | 1 |
| Sherrin, J | 1 |
| Khan-Cheema, H | 1 |
| Sherren, P | 1 |
| Morton, SU | 1 |
| Labrecque, M | 1 |
| Moline, M | 1 |
| Hansen, A | 1 |
| Leeman, K | 1 |
| Gao, Y | 1 |
| Yan, F | 1 |
| Sneyd, JR | 1 |
| Absalom, AR | 1 |
| Barends, CRM | 1 |
| Jones, JB | 1 |
| Yao, Y | 1 |
| Guan, J | 1 |
| Liu, L | 1 |
| Fu, B | 1 |
| Chen, L | 1 |
| Zheng, X | 1 |
| Qi, XR | 1 |
| Sun, JY | 1 |
| An, LX | 1 |
| Zhang, K | 1 |
| Xue, FS | 1 |
| Mudri, M | 1 |
| Williams, A | 1 |
| Priestap, F | 1 |
| Davidson, J | 1 |
| Merritt, N | 1 |
| Wang, L | 1 |
| Zhang, T | 1 |
| Huang, L | 1 |
| Peng, W | 1 |
| Park, CH | 1 |
| Park, SW | 1 |
| Hyun, B | 1 |
| Lee, J | 1 |
| Kae, SH | 1 |
| Jang, HJ | 1 |
| Koh, DH | 1 |
| Choi, MH | 1 |
| Cabadas Avión, R | 1 |
| Leal Ruiloba, MS | 1 |
| Vázquez López, S | 1 |
| Ojea Cendón, M | 1 |
| Wi Hijazi, I | 1 |
| Baluja González, MA | 1 |
| Álvarez-Escudero, J | 1 |
| Ku, LC | 1 |
| Simmons, C | 1 |
| Smith, PB | 1 |
| Greenberg, RG | 1 |
| Fisher, K | 1 |
| Hornik, CD | 1 |
| Cotten, CM | 1 |
| Goldberg, RN | 1 |
| Bidegain, M | 1 |
| Pavcnik, M | 1 |
| Groselj Grenc, M | 1 |
| Bode, K | 1 |
| Whittaker, P | 1 |
| Lucas, J | 1 |
| Müssigbrodt, A | 1 |
| Hindricks, G | 1 |
| Richter, S | 1 |
| Doering, M | 1 |
| Shehabi, Y | 1 |
| Howe, BD | 1 |
| Bellomo, R | 1 |
| Arabi, YM | 1 |
| Bailey, M | 1 |
| Bass, FE | 1 |
| Bin Kadiman, S | 1 |
| McArthur, CJ | 1 |
| Murray, L | 1 |
| Reade, MC | 1 |
| Seppelt, IM | 1 |
| Takala, J | 1 |
| Wise, MP | 1 |
| Webb, SA | 1 |
| Lin, OS | 1 |
| La Selva, D | 1 |
| Kozarek, RA | 1 |
| Tombs, D | 1 |
| Weigel, W | 1 |
| Beecher, R | 1 |
| Koch, J | 1 |
| McCormick, S | 1 |
| Chiorean, M | 1 |
| Drennan, F | 1 |
| Gluck, M | 1 |
| Venu, N | 1 |
| Larsen, M | 1 |
| Ross, A | 1 |
| Wilkes, R | 1 |
| Tasker, RC | 2 |
| Cha, JM | 1 |
| Jeun, JW | 1 |
| Pack, KM | 1 |
| Lee, JI | 1 |
| Joo, KR | 1 |
| Shin, HP | 1 |
| Shin, WC | 1 |
| Xu, CX | 1 |
| Chen, X | 1 |
| Jia, Y | 1 |
| Xiao, DH | 1 |
| Zou, HF | 1 |
| Guo, Q | 1 |
| Wang, F | 1 |
| Wang, XY | 1 |
| Shen, SR | 1 |
| Tong, LL | 1 |
| Cao, K | 1 |
| Liu, XM | 1 |
| Jirapinyo, P | 1 |
| Abu Dayyeh, BK | 1 |
| Thompson, CC | 1 |
| Portela, JL | 1 |
| Garcia, PC | 1 |
| Piva, JP | 1 |
| Barcelos, A | 1 |
| Bruno, F | 1 |
| Branco, R | 1 |
| Zhou, Y | 1 |
| Jin, X | 1 |
| Kang, Y | 1 |
| Liang, G | 1 |
| Liu, T | 1 |
| Deng, N | 1 |
| van den Broek, MP | 1 |
| van Straaten, HL | 1 |
| Huitema, AD | 1 |
| Egberts, T | 1 |
| Toet, MC | 1 |
| de Vries, LS | 1 |
| Rademaker, K | 1 |
| Groenendaal, F | 1 |
| Tarquinio, KM | 1 |
| Howell, JD | 1 |
| Montgomery, V | 1 |
| Turner, DA | 1 |
| Hsing, DD | 1 |
| Parker, MM | 1 |
| Brown, CA | 1 |
| Walls, RM | 1 |
| Nadkarni, VM | 1 |
| Nishisaki, A | 1 |
| Hung, A | 1 |
| Marshall, J | 1 |
| Barnett, S | 1 |
| Falchuk, ZM | 1 |
| Sawhney, M | 1 |
| Leffler, DA | 1 |
| Tsai, HC | 1 |
| Lin, YC | 1 |
| Ko, CL | 1 |
| Lou, HY | 1 |
| Chen, TL | 1 |
| Tam, KW | 1 |
| Chen, CY | 1 |
| Lewis, SR | 1 |
| Nicholson, A | 1 |
| Reed, SS | 1 |
| Kenth, JJ | 1 |
| Alderson, P | 1 |
| Smith, AF | 1 |
| Ayuse, T | 2 |
| Kurata, S | 1 |
| Servatius, H | 1 |
| Höfeler, T | 1 |
| Hoffmann, BA | 2 |
| Sultan, A | 1 |
| Lüker, J | 1 |
| Schäffer, B | 1 |
| Willems, S | 2 |
| Steven, D | 2 |
| Akhtar, S | 2 |
| Liu, J | 1 |
| Heng, J | 2 |
| Dai, F | 2 |
| Schonberger, RB | 2 |
| Burg, MM | 2 |
| Jo, YY | 1 |
| Lee, D | 1 |
| Jung, WS | 1 |
| Cho, NR | 1 |
| Kwak, HJ | 1 |
| Miller, M | 1 |
| Groombridge, CJ | 1 |
| Lyon, R | 1 |
| Correia, LM | 1 |
| Bonilha, DQ | 1 |
| Gomes, GF | 1 |
| Brito, JR | 1 |
| Nakao, FS | 1 |
| Lenz, L | 1 |
| Rohr, MR | 1 |
| Ferrari, AP | 1 |
| Libera, ED | 1 |
| Hasani, A | 1 |
| Maloku, H | 1 |
| Sallahu, F | 1 |
| Gashi, V | 1 |
| Ozgen, SU | 1 |
| Agostoni, M | 1 |
| Fanti, L | 1 |
| Gemma, M | 1 |
| Pasculli, N | 1 |
| Beretta, L | 1 |
| Testoni, PA | 1 |
| Salukhe, TV | 1 |
| Drewitz, I | 1 |
| Heitmann, K | 1 |
| Rostock, T | 1 |
| Levitzky, BE | 1 |
| Lopez, R | 2 |
| Dumot, JA | 1 |
| Vargo, JJ | 2 |
| von Delius, S | 1 |
| Salletmaier, H | 1 |
| Meining, A | 1 |
| Wagenpfeil, S | 1 |
| Saur, D | 1 |
| Bajbouj, M | 1 |
| Schneider, G | 1 |
| Schmid, RM | 1 |
| Huber, W | 1 |
| Fujimoto, Y | 1 |
| Nomura, Y | 1 |
| Hirakawa, K | 1 |
| Hotta, A | 1 |
| Nakamoto, A | 1 |
| Yoshikawa, N | 1 |
| Ohira, N | 1 |
| Tatekawa, S | 1 |
| Riphaus, A | 2 |
| Geist, C | 1 |
| Schrader, K | 1 |
| Martchenko, K | 1 |
| Wehrmann, T | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal[NCT06095570] | Phase 4 | 150 participants (Anticipated) | Interventional | 2022-07-23 | Recruiting | ||
| The Investigation of the Dose Range of Remimazolam Besylate in Different Age Groups of Adults and Its Effects on Hemodynamics[NCT06009991] | 1,876 participants (Anticipated) | Interventional | 2023-07-17 | Recruiting | |||
| Does Intravenous Lidocaine Reduce Propofol Consumption and the Side Effects of Sedation During Gastroscopy in ASA 1 and 2 Patients.[NCT05944887] | 46 participants (Actual) | Interventional | 2023-07-21 | Completed | |||
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05327296] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-06-30 | Recruiting | ||
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05312385] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-04-28 | Recruiting | ||
| Early Goal-Directed Sedation Compared With Standard Care in Mechanically Ventilated Critically Ill Patients: a Prospective Multicentre Randomised Controlled Trial[NCT01728558] | Phase 3 | 4,000 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Efficacy and Safety of Remimazolam for Sedation in ICU Patients Undergoing Mechanical Ventilation: a Single Center, Randomized, Controlled, Non-inferiority Trial[NCT04815265] | Phase 4 | 488 participants (Anticipated) | Interventional | 2021-04-01 | Not yet recruiting | ||
| Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Unit[NCT03194360] | 141 participants (Actual) | Observational | 2015-12-01 | Completed | |||
| Does the Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Randomized Controlled Trial in Ambulatory Surgery[NCT03534895] | Phase 4 | 168 participants (Anticipated) | Interventional | 2019-05-31 | Not yet recruiting | ||
| Does Preoperative Midazolam Dose Affect Postoperative Pain? - a Multicentric Observational Study in Open Inguinal Hernia Repair[NCT03499730] | 300 participants (Actual) | Observational | 2018-09-12 | Completed | |||
| Nasal Inhalation of Sevoflurane Versus Midazolm,Ketamine and Propofol For Pediatric Undergoing Upper Gastrointestinal Endoscopy[NCT05474937] | 74 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | |||
| High Flow Nasal Cannula (HFNC) Versus Standard Low Flow Nasal Cannula (LFNC) in Patients With Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation (RFCA) Under Deep Desaturation.[NCT04842253] | 210 participants (Anticipated) | Interventional | 2022-01-04 | Recruiting | |||
| A Pilot Study to Investigate the Efficacy and Safety of Dexmedetomidine and Fentanyl Versus Midazolam and Remifentanil for Sedation in Patients Undergoing Ablation Procedures for Treatment of a Tachyarrhythmia[NCT03451227] | 6 participants (Actual) | Interventional | 2017-12-01 | Terminated (stopped due to Unable to recruit eligible participants) | |||
| Cerebral Blood Flow During Propofol Anaesthesia[NCT02951273] | 30 participants (Actual) | Observational | 2016-12-08 | Completed | |||
| Bispectral Index Monitoring for Sedation in Elective Colonoscopies of Adult Patients: a Randomized Controlled Trial[NCT03453359] | 180 participants (Actual) | Interventional | 2018-01-28 | Completed | |||
| Do Patients Need Pre-Procedural Fasting for Coronary Artery Procedures?[NCT02562638] | 240 participants (Anticipated) | Interventional | 2015-10-31 | Not yet recruiting | |||
| [NCT02039453] | 160 participants (Anticipated) | Interventional | 2013-09-30 | Recruiting | |||
| Comparative Study Between Intravenous Nalbuphine Versus Intravenous Dexmedetomidine for Conscious Sedation in Patients Undergoing Colonoscopy[NCT05689242] | Phase 4 | 66 participants (Anticipated) | Interventional | 2023-03-31 | Not yet recruiting | ||
| Prospective Study of Induction Medications Used in the Rapid Sequence Intubation of Trauma Patients and a Comparison of Effects on Outcomes[NCT04291521] | 7,000 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| [NCT00848861] | 92 participants (Actual) | Interventional | 2006-02-28 | Completed | |||
| Incidence of Sedation Related Complications With Propofol Alone Versus Propofol With Benzodiazepines and Opiates in a High Risk Group Undergoing Advanced Endoscopic Procedures: A Randomized Controlled Trial[NCT01315158] | 36 participants (Actual) | Interventional | 2011-01-31 | Terminated (stopped due to - The research team is not able to obtain the necessary support to continue the study.) | |||
| A Psychomotor Recuperation Study After Deep Sedation for Colonoscopy Between Target Controlled and Manual Titration of Propofol.[NCT02314559] | Phase 4 | 164 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Comparison of Dexmedetomidine and Midazolam as Intramuscular Premedication for Suspension Laryngoscopy[NCT01937611] | Phase 4 | 40 participants (Anticipated) | Interventional | 2013-03-31 | Recruiting | ||
| Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227] | Phase 4 | 748 participants | Interventional | 2001-09-30 | Completed | ||
| Double-blind, Randomized, Placebo-controlled Study on the Effect of Multimodal Analgesia on Pain With Insertion of Levonorgestrel-releasing Intrauterine System[NCT02799641] | 61 participants (Actual) | Interventional | 2016-07-31 | Completed | |||
| Effect of Clonidine vs. Dexmedetomidine in Addition to Standard Treatment in Agitated Delirium in Intensive Care Patients: Pilot Study.[NCT04758936] | Phase 4 | 50 participants (Anticipated) | Interventional | 2021-02-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Association by multiple regression between changes in unilateral internal carotid artery blood flow [ml/min] as outcome variable and changes in mean arterial pressure [mmHg] and cardiac output [l/min] as covariates.~Internal carotid artery blood flow [ml/min] was assessed by duplex ultrasound. Mean arterial pressure [mmHg] was recorded by a transducer connected to an arterial line. Cardiac output [l/min] was evaluated by pulse contour analysis (Modelflow) that estimates cardiac output by analysis of the arterial pressure curve taking age, gender, height and weigth into account." (NCT02951273)
Timeframe: Two measurements; one measurement during anaesthesia-induced hypotension (mean arterial pressure < 65 mmHg) before administration of phenylephrine and one measurement 3-5 min after administration of phenylephrine.
| Intervention | ml/min (Least Squares Mean) |
|---|---|
| Study of Cerebral Blood Flow | 376 |
Cardiac output [l/min] as evaluated continuously by pulse contour analysis of the arterial pressure curve (Modelflow). (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.
| Intervention | l/min (Mean) |
|---|---|
| Study of Cerebral Blood Flow | -2.7 |
Forehead skin blood flow [PU] assessed by laser Doppler flowmetry as compared between those patients who develop mesenteric traction syndrome (defined as flushing within 60 min after the start of surgery) and those who do not. Laser Doppler flowmetry applies a laser placed on the forehead that penetrates the skin and is scattered with a Doppler shift by the red blood cells and return to a detector that evaluates the amount of backscattered light and Doppler shift. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.
| Intervention | PU (Mean) |
|---|---|
| Study of Cerebral Blood Flow | 126 |
Forehead skin oxygenation [%] assessed by laser Doppler flowmetry as compared between those patients who develop a MTS (defined as flushing within 60 min after the start of surgery) and those who do not. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.
| Intervention | oxygenation [%] (Mean) |
|---|---|
| Study of Cerebral Blood Flow | -2 |
Near-infrared spectroscopy determined frontal lobe oxygenation [%] as compared between those patients who develop a MTS (defined as flushing within 60 min after the start of surgery) and those who do not. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.
| Intervention | oxygenation [%] (Mean) |
|---|---|
| Study of Cerebral Blood Flow | 2 |
Heart rate [bpm] as recorded continuously by a transducer connected to an arterial line. (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.
| Intervention | beats/min (Mean) |
|---|---|
| Study of Cerebral Blood Flow | -13 |
Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound as compared between those patients who develop a MTS (defined as flushing within 60 min after the start of surgery) and those who do not. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.
| Intervention | ml/min (Mean) |
|---|---|
| Study of Cerebral Blood Flow | -3 |
Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound. (NCT02951273)
Timeframe: Two measurements; one measurement 5-10 min before induction of anaesthesia and one measurement 5-20 min after induction of anaesthesia.
| Intervention | ml/min (Mean) |
|---|---|
| Study of Cerebral Blood Flow | -144 |
Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound. (NCT02951273)
Timeframe: Two measurements; one measurement during anaesthesia-induced hypotension (mean arterial pressure < 65 mmHg) before administration of phenylephrine and one measurement 3-5 min after administration of phenylephrine.
| Intervention | ml/min (Mean) |
|---|---|
| Study of Cerebral Blood Flow | 27 |
Mean arterial pressure [mmHg] as recorded continuously by a transducer connected to an arterial line. (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.
| Intervention | mmHg (Mean) |
|---|---|
| Study of Cerebral Blood Flow | -41 |
Stroke volume [ml] as evaluated continuously by pulse contour analysis of the arterial pressure curve (Modelflow). (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.
| Intervention | ml (Mean) |
|---|---|
| Study of Cerebral Blood Flow | -24 |
"Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound and arterial CO2 tension (PaCO2) [kPa] was evaluated by gas analysis. Changes in PaCO2 are guided by evaluation of end-tidal CO2 tension.~The CO2 reactivity to hypocapnia when awake and during anaesthesia is calculated as the percentage change in internal carotid artery blood flow per kPa change in PaCO2. The CO2 reactivity when awake and when anaesthetized is compared." (NCT02951273)
Timeframe: Four measurements; before induction of anaesthesia during normoventilation and during hyperventilation to reduce PaCO2 by 1.5 kPa and during anaesthesia at a PaCO2 at the value before induction of anaesthesia and 1.5 kPa below that value.
| Intervention | %/kPa (Mean) |
|---|---|
| Study of Cerebral Blood Flow | 7.4 |
In high risk patients (meeting at least of 1 of 3 criteria: ASA ≥ 3, BMI ≥ 30, those at risk for OSA) undergoing advanced endoscopy procedures, compare the number of participants who experience airway maneuvers (AMs) when sedated with propofol alone versus propofol in combination with benzodiazepines and opioids. (NCT01315158)
Timeframe: One day (during procedure)
| Intervention | participants (Number) |
|---|---|
| Propofol+Benzo/Opioids | 4 |
| Propofol Alone | 4 |
Compare the number of participants who experience other sedation related complications such as hypotension, hypoxemia and need for termination of the procedure between the two groups (NCT01315158)
Timeframe: One day (during procedure)
| Intervention | participants (Number) |
|---|---|
| Propofol+Benzo/Opioids | 0 |
| Propofol Alone | 0 |
The number of participants who experience symptoms of nausea and vomiting in the two groups of patients will be recorded. This will be recorded during the follow-up phone call made 24-48 hours after the procedure. (NCT01315158)
Timeframe: 24-48 hours
| Intervention | participants (Number) |
|---|---|
| Propofol+Benzo/Opioids | 2 |
| Propofol Alone | 1 |
(NCT01315158)
Timeframe: One year
| Intervention | incidences (Number) |
|---|---|
| Propofol+Benzo/Opioids | 0 |
| Propofol Alone | 0 |
(NCT01315158)
Timeframe: One year
| Intervention | incidences (Number) |
|---|---|
| Propofol+Benzo/Opioids | 0 |
| Propofol Alone | 0 |
(NCT01315158)
Timeframe: One year
| Intervention | incidences (Number) |
|---|---|
| Propofol+Benzo/Opioids | 0 |
| Propofol Alone | 0 |
(NCT01315158)
Timeframe: One year
| Intervention | participants (Number) |
|---|---|
| Propofol+Benzo/Opioids | 0 |
| Propofol Alone | 0 |
5 reviews available for midazolam and Hypotension
| Article | Year |
|---|---|
Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis.
Topics: Colonoscopy; Humans; Hypnotics and Sedatives; Hypotension; Midazolam; Propofol; Retrospective Studie | 2022 |
Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis.
Topics: Colonoscopy; Humans; Hypnotics and Sedatives; Hypotension; Midazolam; Propofol; Retrospective Studie | 2022 |
Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis.
Topics: Colonoscopy; Humans; Hypnotics and Sedatives; Hypotension; Midazolam; Propofol; Retrospective Studie | 2022 |
Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis.
Topics: Colonoscopy; Humans; Hypnotics and Sedatives; Hypotension; Midazolam; Propofol; Retrospective Studie | 2022 |
Pediatric intensive care treatment of uncontrolled status epilepticus.
Topics: Adjuvants, Anesthesia; Anticonvulsants; Barbiturates; Child; Critical Care; Humans; Hypotension; Int | 2013 |
Propofol versus midazolam for upper gastrointestinal endoscopy in cirrhotic patients: a meta-analysis of randomized controlled trials.
Topics: Anesthesia Recovery Period; Bradycardia; Deep Sedation; Endoscopy, Gastrointestinal; Fibrosis; Hepat | 2015 |
Anaesthetic and sedative agents used for electrical cardioversion.
Topics: Anesthetics; Apnea; Diazepam; Electric Countershock; Etomidate; Fentanyl; Humans; Hypnotics and Seda | 2015 |
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy | 2005 |
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy | 2005 |
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy | 2005 |
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy | 2005 |
29 trials available for midazolam and Hypotension
| Article | Year |
|---|---|
Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery.
Topics: Anesthesia; Apnea; Dexmedetomidine; Humans; Hypertension; Hypnotics and Sedatives; Hypotension; Hypo | 2022 |
Discharge readiness after remimazolam versus propofol for colonoscopy: A randomised, double-blind trial.
Topics: Adult; Benzodiazepines; Bradycardia; Colonoscopy; Humans; Hypnotics and Sedatives; Hypotension; Mida | 2022 |
Effects of intravenous lidocaine on hypoxemia induced by propofol-based sedation for gastrointestinal endoscopy procedures: study protocol for a prospective, randomized, controlled trial.
Topics: Conscious Sedation; Endoscopy, Gastrointestinal; Humans; Hypotension; Hypoxia; Lidocaine; Midazolam; | 2022 |
Comparison between Dexmedetomidine and Midazolam for Sedation in Patients with Intubation after Oral and Maxillofacial Surgery.
Topics: Aged; Bradycardia; Conscious Sedation; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Seda | 2020 |
Efficacy and safety of etomidate-based sedation compared with propofol-based sedation during ERCP in low-risk patients: a double-blind, randomized, noninferiority trial.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Cholangiopancreatography, Endoscopic Retro | 2018 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Early Sedation with Dexmedetomidine in Critically Ill Patients.
Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi | 2019 |
Stepwise sedation for elderly patients with mild/moderate COPD during upper gastrointestinal endoscopy.
Topics: Age Factors; Aged; Aged, 80 and over; Biomarkers; Blood Pressure; Chi-Square Distribution; China; Dr | 2013 |
Midazolam and propofol used alone or sequentially for long-term sedation in critically ill, mechanically ventilated patients: a prospective, randomized study.
Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthetics, Intravenous; Critical Illness; Dru | 2014 |
Comparison of Intravenous Dexmedetomidine and Midazolam for Bispectral Index-Guided Sedation During Spinal Anesthesia.
Topics: Adult; Anesthesia, Spinal; Conscious Sedation; Dexmedetomidine; Female; Heart Rate; Hemodynamics; Hu | 2016 |
Sedation during upper GI endoscopy in cirrhotic outpatients: a randomized, controlled trial comparing propofol and fentanyl with midazolam and fentanyl.
Topics: Analgesics, Opioid; Anesthesia Recovery Period; Bradycardia; Conscious Sedation; Deep Sedation; Endo | 2011 |
Preemptive analgesia with midazolam and diclofenac for hernia repair pain.
Topics: Adult; Aged; Anesthesia Recovery Period; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; | 2011 |
Preemptive analgesia with midazolam and diclofenac for hernia repair pain.
Topics: Adult; Aged; Anesthesia Recovery Period; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; | 2011 |
Preemptive analgesia with midazolam and diclofenac for hernia repair pain.
Topics: Adult; Aged; Anesthesia Recovery Period; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; | 2011 |
Preemptive analgesia with midazolam and diclofenac for hernia repair pain.
Topics: Adult; Aged; Anesthesia Recovery Period; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; | 2011 |
Moderate sedation for elective upper endoscopy with balanced propofol versus fentanyl and midazolam alone: a randomized clinical trial.
Topics: Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Deep Sedation; Endoscopy, Digesti | 2012 |
Bispectral index monitoring of midazolam and propofol sedation during endoscopic retrograde cholangiopancreatography: a randomized clinical trial (the EndoBIS study).
Topics: Aged; Aged, 80 and over; Anesthesia Recovery Period; Bradycardia; Cholangiopancreatography, Endoscop | 2012 |
Flurbiprofen axetil provides a prophylactic benefit against mesenteric traction syndrome associated with remifentanil infusion during laparotomy.
Topics: 6-Ketoprostaglandin F1 alpha; Abdomen; Aged; Anesthesia, General; Anesthetics, Intravenous; Anti-Inf | 2012 |
Intermittent manually controlled versus continuous infusion of propofol for deep sedation during interventional endoscopy: a prospective randomized trial.
Topics: Anesthesia Recovery Period; Cholangiopancreatography, Endoscopic Retrograde; Deep Sedation; Endosono | 2012 |
Propofol sedation with bispectral index monitoring is useful for endoscopic submucosal dissection: a randomized prospective phase II clinical trial.
Topics: Adenoma; Aged; Aged, 80 and over; Anesthetics, Intravenous; Bradycardia; Chi-Square Distribution; Co | 2012 |
A comparison of 3 anesthetic protocols for 24 hours of mechanical ventilation in cats.
Topics: Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Cats; Cross- | 2012 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti | 2003 |
Efficacy of continuous midazolam infusion and mortality in childhood refractory generalized convulsive status epilepticus.
Topics: Adolescent; Bradycardia; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Hypn | 2005 |
Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study.
Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Comorbidity; Conscious Sedation; Feasibility | 2005 |
Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study.
Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Comorbidity; Conscious Sedation; Feasibility | 2005 |
Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study.
Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Comorbidity; Conscious Sedation; Feasibility | 2005 |
Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study.
Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Comorbidity; Conscious Sedation; Feasibility | 2005 |
Etomidate versus midazolam for out-of-hospital intubation: a prospective, randomized trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allied Health Personnel; Attitude of Health Personnel; B | 2006 |
Effect of local anesthesia and intravenous sedation on pain perception and vasovagal reactions during femoral arterial sheath removal after percutaneous coronary intervention.
Topics: Aged; Anesthetics, Local; Angioplasty, Balloon, Coronary; Bradycardia; Cardiovascular Diseases; Cons | 2007 |
Sedation analgesia during office-based plastic surgery procedures: comparison of two opioid regimens.
Topics: Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics, Opioid; Conscious Sedati | 2007 |
Combination of low doses of intrathecal ketamine and midazolam with bupivacaine improves postoperative analgesia in orthopaedic surgery.
Topics: Adjuvants, Anesthesia; Adult; Analgesics; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Doubl | 2008 |
Use of dexmedetomidine in the pediatric intensive care unit.
Topics: Adrenergic alpha-2 Receptor Agonists; Child; Critical Care; Dexmedetomidine; Dose-Response Relations | 2008 |
Comparison of intramuscular dexmedetomidine and midazolam premedication for elective abdominal hysterectomy.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Bradycardia; Double-Blind Method; Femal | 1994 |
The effects of midazolam and ephedrine on post-exercise autonomic chronotropic control of the heart in normal subjects.
Topics: Adrenergic Agonists; Adult; Analysis of Variance; Anesthetics, Intravenous; Anti-Anxiety Agents; Aut | 1996 |
[Midazolam for anesthetic induction in neonates].
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Anesthetics, Local; Apnea; Bilirubin; Blood Press | 1998 |
A double-blind placebo controlled trial of oral midazolam as premedication before flexible sigmoidoscopy.
Topics: Administration, Oral; Anxiety; Blood Pressure; Double-Blind Method; Female; Humans; Hypnotics and Se | 1999 |
50 other studies available for midazolam and Hypotension
| Article | Year |
|---|---|
Cardiovascular complications of prehospital emergency anaesthesia in patients with return of spontaneous circulation following medical cardiac arrest: a retrospective comparison of ketamine-based and midazolam-based induction protocols.
Topics: Aged; Anesthesia; Emergency Medical Services; Heart Arrest; Humans; Hypotension; Ketamine; Midazolam | 2022 |
Reducing Benzodiazepine Exposure by Instituting a Guideline for Dexmedetomidine Usage in the NICU.
Topics: Airway Extubation; Analgesics, Opioid; Bradycardia; Dexmedetomidine; Drug Administration Schedule; D | 2021 |
Comparison of drugs used for intubation of pediatric trauma patients.
Topics: Adolescent; Brain Injuries, Traumatic; Child; Child, Preschool; Etomidate; Female; Hospitals, Pediat | 2020 |
A descriptive monitoring study of a non-anesthetist sedation quality program.
Topics: Adjuvants, Anesthesia; Bradycardia; Clinical Protocols; Deep Sedation; Endoscopy, Digestive System; | 2019 |
Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit.
Topics: Administration, Intranasal; Analgesics, Opioid; Arterial Pressure; Bradycardia; Catheterization, Per | 2019 |
Sevoflurane sedation for weaning from mechanical ventilation in pediatric intensive care unit.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Conscious Sedation; Consciousness Disorders | 2019 |
Deep sedation for transvenous lead extraction: a large single-centre experience.
Topics: Cardiac Catheters; Cardiac Imaging Techniques; Deep Sedation; Defibrillators, Implantable; Device Re | 2019 |
Computer-Assisted Propofol Sedation for Esophagogastroduodenoscopy Is Effective, Efficient, and Safe.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Anesthetists; Blood Gas Monitorin | 2019 |
Risk of sedation for diagnostic esophagogastroduodenoscopy in obstructive sleep apnea patients.
Topics: Adult; Case-Control Studies; Chi-Square Distribution; Deep Sedation; Endoscopy, Digestive System; Fe | 2013 |
Conscious sedation for upper endoscopy in the gastric bypass patient: prevalence of cardiopulmonary adverse events and predictors of sedation requirement.
Topics: Adult; Anesthetics, Intravenous; Arrhythmias, Cardiac; Body Mass Index; Conscious Sedation; Endoscop | 2014 |
Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Service, Hospital; Female; | 2015 |
Anticonvulsant effectiveness and hemodynamic safety of midazolam in full-term infants treated with hypothermia.
Topics: Anticonvulsants; Arterial Pressure; Asphyxia Neonatorum; Electroencephalography; Female; Hemodynamic | 2015 |
Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study.
Topics: Adolescent; Child; Child, Preschool; Critical Illness; Female; Fentanyl; Hemodynamics; Humans; Hypno | 2015 |
Risk Factors and Outcomes of Reversal Agent Use in Moderate Sedation During Endoscopy and Colonoscopy.
Topics: Age Factors; Anti-Arrhythmia Agents; Antidotes; Atropine; Body Mass Index; Bradycardia; Case-Control | 2016 |
Anaphylactoid-like Reaction to Midazolam During Oral and Maxillofacial Surgery.
Topics: Anaphylaxis; Anesthetics, Inhalation; Bronchial Diseases; Constriction, Pathologic; Drug Hypersensit | 2015 |
Propofol sedation administered by cardiologists for patients undergoing catheter ablation for ventricular tachycardia.
Topics: Aged; Blood Pressure; Cardiologists; Catheter Ablation; Defibrillators, Implantable; Female; Germany | 2016 |
Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice.
Topics: Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous | 2016 |
A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients?
Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; | 2016 |
Haemodynamic changes to a midazolam-fentanyl-rocuronium protocol for pre-hospital anaesthesia following return of spontaneous circulation after cardiac arrest.
Topics: Adult; Aged; Anesthesia; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Emergency Medic | 2017 |
Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience.
Topics: Adolescent; Age Factors; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Body Mass Index; Bradyca | 2011 |
Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation.
Topics: Aged; Anesthetics, Intravenous; Atrial Fibrillation; Cardiac Tamponade; Catheter Ablation; Cohort St | 2012 |
Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation.
Topics: Aged; Anesthetics, Intravenous; Atrial Fibrillation; Cardiac Tamponade; Catheter Ablation; Cohort St | 2012 |
Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation.
Topics: Aged; Anesthetics, Intravenous; Atrial Fibrillation; Cardiac Tamponade; Catheter Ablation; Cohort St | 2012 |
Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation.
Topics: Aged; Anesthetics, Intravenous; Atrial Fibrillation; Cardiac Tamponade; Catheter Ablation; Cohort St | 2012 |
Significant hypotension following buccal midazolam administration.
Topics: Administration, Buccal; Epilepsy; GABA Modulators; Humans; Hypotension; Male; Midazolam; Severity of | 2010 |
Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department.
Topics: Adjuvants, Anesthesia; Analgesia; Anesthetics, Combined; Child; Child, Preschool; Chloral Hydrate; C | 2003 |
When is a patient safe for discharge after procedural sedation? The timing of adverse effect events in 1367 pediatric procedural sedations.
Topics: Adjuvants, Anesthesia; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Dissociative; | 2003 |
Trauma in pregnancy: anesthetic management of a parturient with hypotensive shock and trauma to the gravid uterus.
Topics: Abdominal Injuries; Accidents, Traffic; Adult; Anesthesia, General; Anesthetics, Intravenous; Female | 2004 |
Midazolam/ketamine induction and isoflurane maintenance of anaesthesia in a 2-month-old, hand-raised African buffalo (Syncerus caffer).
Topics: Anesthetics, Combined; Anesthetics, Inhalation; Animals; Buffaloes; Hypnotics and Sedatives; Hypoten | 2004 |
Midazolam is more likely to cause hypotension than etomidate in emergency department rapid sequence intubation.
Topics: Age Factors; Aged; Anesthetics, Intravenous; Blood Pressure; Emergency Treatment; Etomidate; Female; | 2004 |
[Etiology and management of neonatal seizures--successful treatment by midazolam].
Topics: Humans; Hypnotics and Sedatives; Hypotension; Infant, Newborn; Infusions, Intravenous; Injections, I | 2006 |
Procedural sedation and analgesia in a Canadian adult tertiary care emergency department: a case series.
Topics: Age Distribution; Aged; Canada; Conscious Sedation; Drug Therapy, Combination; Drug Utilization; Eme | 2006 |
Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS).
Topics: Adolescent; Adult; Age Factors; Aged; Apnea; Blood Gas Monitoring, Transcutaneous; Bradycardia; Cana | 2006 |
[Burst suppression entropy response to moderate hypothermia in a patient receiving a massive transfusion].
Topics: Abdominal Injuries; Adjustment Disorders; Adult; Anesthesia, Inhalation; Blood Component Transfusion | 2006 |
Spinal anesthesia in neonates and infants - a single-center experience of 505 cases.
Topics: Anesthesia, Spinal; Anesthetics, Local; Apnea; Body Weight; Bradycardia; Bupivacaine; Female; Gestat | 2007 |
[Use of midazolam in the patient with atherosclerosis].
Topics: Anesthetics; Arteriosclerosis; Hemodynamics; Humans; Hypotension; Midazolam | 1995 |
Recurrent hypotension immediately after seizures in nortriptyline overdose.
Topics: Biological Availability; Blood Pressure; Drug Overdose; Female; Heart; Humans; Hypotension; Midazola | 1994 |
The role of midazolam-induced sedation in bone marrow aspiration/trephine biopsies.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Antidotes; Awareness; Bone Marrow; Conscious Sedation; | 1996 |
Evaluation of the safety and efficacy of deep sedation for electrophysiology procedures administered in the absence of an anesthetist.
Topics: Adjuvants, Anesthesia; Airway Obstruction; Anesthesia, Intravenous; Anesthesiology; Anesthetics, Int | 1997 |
Cold urticaria associated with intraoperative hypotension and facial edema.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anesthetics, General; Angioedema; Anti-Inflamm | 1999 |
Effects of a bolus injection of adenosine triphosphate on atrioventricular conduction and hemodynamics in patients undergoing coronary artery bypass grafting.
Topics: Adenosine Triphosphate; Anesthetics, Intravenous; Atrioventricular Node; Blood Pressure; Bradycardia | 1999 |
Changes in cerebral venous prostanoids during midazolam-induced cerebrovascular hypotension in newborn piglets.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anti-Anxiety Agents; Brain; Female; Hemodynamics; H | 2000 |
[Premedication and sedation complications during ophthalmic anesthesia].
Topics: Adjuvants, Anesthesia; Alfentanil; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anesthesi | 2000 |
Sedation for endoscopy: the safe use of propofol by general practitioner sedationists.
Topics: Anesthetics, Combined; Anesthetics, Intravenous; Australia; Colonoscopy; Family Practice; Fentanyl; | 2002 |
Pharmacokinetics of midazolam during continuous infusion in critically ill neonates.
Topics: Blood Pressure; Critical Illness; Heart Rate; Humans; Hypotension; Infant, Newborn; Infusions, Intra | 1992 |
Hypotension with midazolam and fentanyl in the newborn.
Topics: Drug Synergism; Drug Therapy, Combination; Fentanyl; Humans; Hypotension; Infant, Newborn; Midazolam | 1991 |
Amiodarone and anaesthesia: concurrent therapy with ACE inhibitors--an additional cause for concern?
Topics: Adult; Amiodarone; Anesthesia, Intravenous; Enalapril; Fentanyl; Humans; Hypotension; Male; Midazola | 1991 |
Clonidine as a sedative adjunct in intensive care.
Topics: Clonidine; Critical Care; Drug Synergism; Drug Therapy, Combination; Fentanyl; Gastrectomy; Humans; | 1990 |
Investigation of midazolam's influence on physiological and hormonal responses to hypotension.
Topics: Animals; Diazepam; Dogs; Epinephrine; Half-Life; Hemodynamics; Hormones; Hydrocortisone; Hypotension | 1987 |
Midazolam, hypotension and neurological sequelae.
Topics: Aged; Humans; Hypotension; Midazolam | 1989 |
[Midazolam causing respiratory arrest and hypotension].
Topics: Humans; Hypotension; Male; Midazolam; Middle Aged; Respiratory Insufficiency | 1989 |
Sudden hypotension associated with midazolam and sufentanil.
Topics: Fentanyl; Humans; Hypotension; Male; Midazolam; Middle Aged; Sufentanil | 1987 |
Hypotension and neurological sequelae following intramuscular midazolam.
Topics: Aged; Dysarthria; Humans; Hypotension; Male; Midazolam; Preanesthetic Medication; Sleep Stages; Spee | 1988 |