midazolam has been researched along with Hypertension in 29 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the safety and efficacy of midazolam and estazolam in hypertensive patients with chronic insomnia." | 9.12 | [Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial]. ( Ke, YN; Wang, XL, 2006) |
| "To compare the incidence of rebound hypertension associated with cessation of dexmedetomidine infusion with other sedative medications." | 7.91 | Incidence of Rebound Hypertension after Discontinuation of Dexmedetomidine. ( Alaniz, C; Flieller, LA; Miller, JT; Pleva, MR, 2019) |
| " To investigate the mechanisms by which bupivacaine may act within the CNS to produce cardiovascular toxicity, we studied four groups of halothane-anesthetized rabbits in which infusion of intracerebroventricular (icv) bupivacaine or intravenous (iv) phenylephrine resulted in dysrhythmias and hypertension." | 7.68 | Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits. ( Artu, AA; Bernards, CM, 1991) |
| "This study was undertaken to determine whether midazolam alleviates sympathoadrenal response evoked by tracheal intubation in elderly patients with hypertension." | 7.68 | [Plasma catecholamine response to tracheal intubation after midazolam and vecuronium in elderly patients with hypertension]. ( Kaneda, T; Morisaki, H; Takino, Y, 1990) |
| "The effectiveness and side effects of dexmedetomidine (DEX) in combination with midazolam and propofol have not been comparatively studied in a single clinical trial as sedative agents to general anesthesia before." | 5.51 | Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery. ( Gao, Y; Yan, F, 2022) |
| "To compare the safety and efficacy of midazolam and estazolam in hypertensive patients with chronic insomnia." | 5.12 | [Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial]. ( Ke, YN; Wang, XL, 2006) |
| " Two patients in group 2 required treatment with nitroglycerin for myocardial ischemia." | 5.08 | The effect of midazolam at two plasma concentrations of hemodynamics and sufentanil requirement in coronary artery surgery. ( Epema, AH; Hennis, PJ; Huet, RC; van der Maaten, JM, 1996) |
| "To compare the incidence of rebound hypertension associated with cessation of dexmedetomidine infusion with other sedative medications." | 3.91 | Incidence of Rebound Hypertension after Discontinuation of Dexmedetomidine. ( Alaniz, C; Flieller, LA; Miller, JT; Pleva, MR, 2019) |
| "An increase in blood pressure, accompanied by atrial fibrillation, agitation, incomprehensible shouts and loss of consciousness, was observed in an elderly, ASA classification group II, cardiovascularly medicated male, 12 min after performance of axillary block with mepivacaine 850 mg containing adrenaline 0." | 3.70 | An unusual toxic reaction to axillary block by mepivacaine with adrenaline. ( Koscielniak-Nielsen, ZJ, 1998) |
| "Although desflurane is commonly used to control surgically induced hypertension, its effects on left ventricular (LV) function have not been investigated in this clinical situation." | 3.70 | Does desflurane alter left ventricular function when used to control surgical stimulation during aortic surgery? ( Benmalek, F; Bertrand, M; Coriat, P; Eyraud, D; Mouren, S; Teugels, K, 1999) |
| " To investigate the mechanisms by which bupivacaine may act within the CNS to produce cardiovascular toxicity, we studied four groups of halothane-anesthetized rabbits in which infusion of intracerebroventricular (icv) bupivacaine or intravenous (iv) phenylephrine resulted in dysrhythmias and hypertension." | 3.68 | Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits. ( Artu, AA; Bernards, CM, 1991) |
| "Forty patients who had undergone coronary artery graft surgery and who required vasodilator therapy for postoperative hypertension were given infusions of either propofol (2,6,di-isopropylphenol) or midazolam, together with an infusion of morphine for analgesia while ventilation was controlled artificially." | 3.68 | Sedation after cardiac bypass surgery: comparison of propofol and midazolam in the presence of a computerized closed loop arterial pressure controller. ( Chaudhri, S; Kenny, GN, 1992) |
| "This study was undertaken to determine whether midazolam alleviates sympathoadrenal response evoked by tracheal intubation in elderly patients with hypertension." | 3.68 | [Plasma catecholamine response to tracheal intubation after midazolam and vecuronium in elderly patients with hypertension]. ( Kaneda, T; Morisaki, H; Takino, Y, 1990) |
| "Midazolam is an anxiolytic, and thought to be effective for the management of this sort of transient hypertension." | 2.82 | Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study. ( Higuchi, H; Honda, Y; Ishii-Maruhama, M; Maeda, S; Miyawaki, T; Tomoyasu, Y; Watanabe, Y; Yabuki-Kawase, A; Yamane-Hirano, A, 2016) |
| "Hypertension and tachycardia are common during fiber-optic bronchoscopy (FOB), and this may lead to cardiac ischemia." | 2.73 | Benzodiazepine and opioid sedation attenuate the sympathetic response to fiberoptic bronchoscopy. Prophylactic labetalol gave no additional benefit. Results of a randomized double-blind placebo-controlled study. ( Ben-Zvi, I; Fox, BD; Kramer, MR; Krylov, Y; Leon, P; Peled, N; Shitrit, D, 2008) |
| "Phenobarbital was trialed for possible propofol withdrawal syndrome, allowing for a dose reduction of 10 μg/kg/min within 2 hours of the first dose without any corresponding symptoms." | 1.91 | Successful management of suspected propofol dependence with phenobarbital in an adult patient with COVID-19. ( Feeney, ME; Steiling, K, 2023) |
| " When only inhibition or induction was incorporated into a model, the AUCR of midazolam changed depending on the dosing period and dose level of esaxerenone and the timing of midazolam administration." | 1.56 | Drug-Drug Interaction Risk Assessment of Esaxerenone as a Perpetrator by In Vitro Studies and Static and Physiologically Based Pharmacokinetic Models. ( Fischer, T; Inoue, SI; Ishizuka, T; Rozehnal, V; Sugiyama, D; Yamada, M, 2020) |
| "Shock was more common in patients with variceal bleeding compared to those with non-variceal bleeding (12." | 1.43 | Outcomes of Propofol Sedation During Emergency Endoscopy Performed for Upper Gastrointestinal Bleeding. ( Eun, CS; Han, DS; Jeon, YC; Jeong, JY; Park, CH; Sohn, JH; Yoo, KS, 2016) |
| "Prolonged dexmedetomidine administration in children with heart disease appears to be safe and is associated with decreased opioid and benzodiazepine requirement and decreased inotropic support." | 1.38 | Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease*. ( Gossett, JM; Gupta, P; Roth, SJ; Sabati, A; Tesoro, TM; Tobias, JD; Whiteside, W, 2012) |
| "Hypertension was present in all groups during anaesthesia with mean (+/- SD) systolic pressure of 30." | 1.33 | Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus). ( Jago, M; Stegmann, GF, 2006) |
| "001) and the total dosage of both intraoperative sedative agents (p < 0." | 1.30 | Optimization of conscious sedation in plastic surgery. ( Few, JW; Fine, NA; Marcus, JR; Mustoe, TA; Tyrone, JW, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (37.93) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, Y | 1 |
| Yan, F | 1 |
| Feeney, ME | 1 |
| Steiling, K | 1 |
| Flieller, LA | 1 |
| Alaniz, C | 1 |
| Pleva, MR | 1 |
| Miller, JT | 1 |
| Yamada, M | 1 |
| Ishizuka, T | 1 |
| Inoue, SI | 1 |
| Rozehnal, V | 1 |
| Fischer, T | 1 |
| Sugiyama, D | 1 |
| Sezen, G | 1 |
| Demiraran, Y | 1 |
| Seker, IS | 1 |
| Karagoz, I | 1 |
| Iskender, A | 1 |
| Ankarali, H | 1 |
| Ersoy, O | 1 |
| Ozlu, O | 1 |
| Park, CH | 1 |
| Han, DS | 1 |
| Jeong, JY | 1 |
| Eun, CS | 1 |
| Yoo, KS | 1 |
| Jeon, YC | 1 |
| Sohn, JH | 1 |
| Watanabe, Y | 1 |
| Higuchi, H | 1 |
| Ishii-Maruhama, M | 1 |
| Honda, Y | 1 |
| Yabuki-Kawase, A | 1 |
| Yamane-Hirano, A | 1 |
| Tomoyasu, Y | 1 |
| Maeda, S | 1 |
| Miyawaki, T | 1 |
| Miller, M | 1 |
| Groombridge, CJ | 1 |
| Lyon, R | 1 |
| Gupta, P | 1 |
| Whiteside, W | 1 |
| Sabati, A | 1 |
| Tesoro, TM | 1 |
| Gossett, JM | 1 |
| Tobias, JD | 1 |
| Roth, SJ | 1 |
| Shafiq, B | 1 |
| Zuckerman, RL | 1 |
| Queale, WS | 1 |
| Cosgarea, AJ | 1 |
| Stephens, LC | 1 |
| Katz, SG | 1 |
| Cillo, JE | 1 |
| Finn, R | 1 |
| Wang, XL | 1 |
| Ke, YN | 1 |
| Stegmann, GF | 1 |
| Jago, M | 1 |
| Zhao, JZ | 1 |
| Wan, K | 1 |
| Jing, Q | 1 |
| Chen, X | 1 |
| Alfa, JA | 1 |
| Bamgbade, OA | 1 |
| Fox, BD | 1 |
| Krylov, Y | 1 |
| Leon, P | 1 |
| Ben-Zvi, I | 1 |
| Peled, N | 1 |
| Shitrit, D | 1 |
| Kramer, MR | 1 |
| van der Maaten, JM | 1 |
| Epema, AH | 1 |
| Huet, RC | 1 |
| Hennis, PJ | 1 |
| Mainwaring, CJ | 1 |
| Wong, C | 1 |
| Lush, RJ | 1 |
| Smith, JG | 1 |
| Singer, CR | 1 |
| Koscielniak-Nielsen, ZJ | 1 |
| Lluch Fernández, M | 1 |
| Vallejo Uclés, A | 1 |
| Vallejo Cantarero, F | 1 |
| Zurita Castro, F | 1 |
| Huelva Ramírez, E | 1 |
| Moreno Carmona, C | 1 |
| Eyraud, D | 1 |
| Benmalek, F | 1 |
| Teugels, K | 1 |
| Bertrand, M | 1 |
| Mouren, S | 1 |
| Coriat, P | 1 |
| Marcus, JR | 1 |
| Tyrone, JW | 1 |
| Few, JW | 1 |
| Fine, NA | 1 |
| Mustoe, TA | 1 |
| Gardiner, SM | 1 |
| March, JE | 1 |
| Kemp, PA | 1 |
| Bennett, T | 1 |
| Bernards, CM | 1 |
| Artu, AA | 1 |
| Chaudhri, S | 1 |
| Kenny, GN | 1 |
| Chraemmer-Jørgensen, B | 1 |
| Høilund-Carlsen, PF | 1 |
| Marving, J | 1 |
| Strøm, J | 1 |
| Nielsen, MD | 1 |
| Jensen, BH | 1 |
| Lønborg-Jensen, H | 1 |
| Schmidt, K | 1 |
| Takino, Y | 1 |
| Kaneda, T | 1 |
| Morisaki, H | 1 |
| Tuman, KJ | 1 |
| McCarthy, RJ | 1 |
| el-Ganzouri, AR | 1 |
| Spiess, BD | 1 |
| Ivankovich, AD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Does the Use of Dexmedetomidine for Premedication Provide Hemodynamic Stability in Hypertensive Patients?[NCT02058485] | Phase 3 | 162 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| Opioid-Free Versus Transitional Anesthetic With Opioids From Tonsillectomy[NCT04528173] | Phase 4 | 550 participants (Anticipated) | Interventional | 2020-07-22 | Recruiting | ||
| Auricular Acupressure as an Adjunct Treatment for Opioid Tapering in a Pediatric Cardiac Intensive Care Unit: A Pilot Feasibility Study[NCT05025384] | 40 participants (Actual) | Interventional | 2021-10-25 | Completed | |||
| Safety and Efficacy of Sedation for Flexible Fiberoptic Bronchoscopy: Comparison of Propofol/Alfentanil With Propofol/Ketamine[NCT02000206] | 80 participants (Anticipated) | Interventional | 2014-02-28 | Not yet recruiting | |||
| [NCT00394537] | Phase 4 | 72 participants (Anticipated) | Interventional | Completed | |||
| Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227] | Phase 4 | 748 participants | Interventional | 2001-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 trials available for midazolam and Hypertension
| Article | Year |
|---|---|
Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery.
Topics: Anesthesia; Apnea; Dexmedetomidine; Humans; Hypertension; Hypnotics and Sedatives; Hypotension; Hypo | 2022 |
Does premedication with dexmedetomidine provide perioperative hemodynamic stability in hypertensive patients?
Topics: Adult; Dexmedetomidine; Female; Hemodynamics; Humans; Hypertension; Hypnotics and Sedatives; Hystere | 2014 |
Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study.
Topics: Anti-Anxiety Agents; Blood Pressure; Conscious Sedation; Dental Anxiety; Double-Blind Method; Humans | 2016 |
[Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial].
Topics: Aged; Estazolam; Female; Humans; Hypertension; Hypnotics and Sedatives; Male; Midazolam; Middle Aged | 2006 |
Blood pressure changes of elderly hypertensive patients during dental extraction under sedation with continuous intravenous infusion of midazolam.
Topics: Aged; Blood Pressure; Diastole; Humans; Hypertension; Hypnotics and Sedatives; Infusions, Intravenou | 2007 |
Benzodiazepine and opioid sedation attenuate the sympathetic response to fiberoptic bronchoscopy. Prophylactic labetalol gave no additional benefit. Results of a randomized double-blind placebo-controlled study.
Topics: Adrenergic beta-Antagonists; Alfentanil; Analgesics, Opioid; Antihypertensive Agents; Benzodiazepine | 2008 |
Benzodiazepine and opioid sedation attenuate the sympathetic response to fiberoptic bronchoscopy. Prophylactic labetalol gave no additional benefit. Results of a randomized double-blind placebo-controlled study.
Topics: Adrenergic beta-Antagonists; Alfentanil; Analgesics, Opioid; Antihypertensive Agents; Benzodiazepine | 2008 |
Benzodiazepine and opioid sedation attenuate the sympathetic response to fiberoptic bronchoscopy. Prophylactic labetalol gave no additional benefit. Results of a randomized double-blind placebo-controlled study.
Topics: Adrenergic beta-Antagonists; Alfentanil; Analgesics, Opioid; Antihypertensive Agents; Benzodiazepine | 2008 |
Benzodiazepine and opioid sedation attenuate the sympathetic response to fiberoptic bronchoscopy. Prophylactic labetalol gave no additional benefit. Results of a randomized double-blind placebo-controlled study.
Topics: Adrenergic beta-Antagonists; Alfentanil; Analgesics, Opioid; Antihypertensive Agents; Benzodiazepine | 2008 |
The effect of midazolam at two plasma concentrations of hemodynamics and sufentanil requirement in coronary artery surgery.
Topics: Adjuvants, Anesthesia; Adrenergic beta-Antagonists; Analgesics, Opioid; Anesthesia Recovery Period; | 1996 |
22 other studies available for midazolam and Hypertension
| Article | Year |
|---|---|
Successful management of suspected propofol dependence with phenobarbital in an adult patient with COVID-19.
Topics: Adult; COVID-19; Dexmedetomidine; Fentanyl; Humans; Hypertension; Hypnotics and Sedatives; Male; Mid | 2023 |
Incidence of Rebound Hypertension after Discontinuation of Dexmedetomidine.
Topics: Critical Care; Dexmedetomidine; Drug Administration Schedule; Female; Humans; Hypertension; Hypnotic | 2019 |
Drug-Drug Interaction Risk Assessment of Esaxerenone as a Perpetrator by In Vitro Studies and Static and Physiologically Based Pharmacokinetic Models.
Topics: Administration, Oral; Area Under Curve; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-45 | 2020 |
Outcomes of Propofol Sedation During Emergency Endoscopy Performed for Upper Gastrointestinal Bleeding.
Topics: Adult; Age Factors; Aged; Anticoagulants; Cerebrovascular Disorders; Cohort Studies; Comorbidity; Di | 2016 |
Haemodynamic changes to a midazolam-fentanyl-rocuronium protocol for pre-hospital anaesthesia following return of spontaneous circulation after cardiac arrest.
Topics: Adult; Aged; Anesthesia; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Emergency Medic | 2017 |
Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease*.
Topics: Blood Pressure; Child, Preschool; Critical Care; Critical Illness; Dexmedetomidine; Female; Heart Di | 2012 |
Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease*.
Topics: Blood Pressure; Child, Preschool; Critical Care; Critical Illness; Dexmedetomidine; Female; Heart Di | 2012 |
Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease*.
Topics: Blood Pressure; Child, Preschool; Critical Care; Critical Illness; Dexmedetomidine; Female; Heart Di | 2012 |
Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease*.
Topics: Blood Pressure; Child, Preschool; Critical Care; Critical Illness; Dexmedetomidine; Female; Heart Di | 2012 |
Hypertensive crisis secondary to pheochromocytoma during routine knee surgery.
Topics: Adrenal Gland Neoplasms; Adult; Anesthetics, Intravenous; Arthroscopy; Fentanyl; Humans; Hypertensio | 2004 |
Phentermine and anaesthesia.
Topics: Alfentanil; Androstanols; Anesthesia; Anesthetics, Intravenous; Appetite Depressants; Blood Pressure | 2005 |
Correlation and comparison of body mass index on hemodynamics in hypertensive and normotensive patients undergoing intravenous sedation.
Topics: Adult; Anesthesia, Dental; Anesthetics, Intravenous; Blood Pressure; Body Mass Index; Conscious Seda | 2006 |
Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus).
Topics: Acinonyx; Anesthetics, Combined; Animals; Blood Gas Analysis; Heart Rate; Hypertension; Immobilizati | 2006 |
Acute myoclonus following spinal anaesthesia.
Topics: Acute Disease; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, Intr | 2008 |
The role of midazolam-induced sedation in bone marrow aspiration/trephine biopsies.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Antidotes; Awareness; Bone Marrow; Conscious Sedation; | 1996 |
An unusual toxic reaction to axillary block by mepivacaine with adrenaline.
Topics: Absorption; Aged; Akathisia, Drug-Induced; Anesthetics, Local; Anti-Arrhythmia Agents; Antihypertens | 1998 |
[Anesthesia and intraoperative treatment in 2 cases of simultaneous liver, pancreas, and kidney transplantation].
Topics: Adult; Anesthesia, General; Cardiomyopathy, Hypertrophic; Diabetes Mellitus, Type 1; Diabetic Nephro | 1999 |
Does desflurane alter left ventricular function when used to control surgical stimulation during aortic surgery?
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Aorta; Atracurium; Blood Pressure; Cardiac Output | 1999 |
Optimization of conscious sedation in plastic surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics, Opioid; Cons | 1999 |
Cardiovascular effects of endothelin-1 and endothelin antagonists in conscious, hypertensive ((mRen-2)27) rats.
Topics: Anesthetics; Animals; Animals, Genetically Modified; Baroreflex; Blood Pressure; Butyrophenones; Car | 2000 |
Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Brain; Bupivacaine; Halotha | 1991 |
Sedation after cardiac bypass surgery: comparison of propofol and midazolam in the presence of a computerized closed loop arterial pressure controller.
Topics: Adult; Aged; Coronary Artery Bypass; Humans; Hypertension; Hypnotics and Sedatives; Midazolam; Middl | 1992 |
Left-ventricular performance, volumes, and catecholamine responses during anaesthesia induction--monitoring by combined radionuclide cardiography and right heart catheterization.
Topics: Adult; Anesthesia, Intravenous; Blood Pressure; Cardiac Catheterization; Cardiac Volume; Epinephrine | 1991 |
[Plasma catecholamine response to tracheal intubation after midazolam and vecuronium in elderly patients with hypertension].
Topics: Aged; Aged, 80 and over; Catecholamines; Female; Humans; Hypertension; Intubation, Intratracheal; Ma | 1990 |
Sufentanil-midazolam anesthesia for coronary artery surgery.
Topics: Adrenergic beta-Antagonists; Anesthesia, Intravenous; Anesthetics; Blood Pressure; Cardiac Output; C | 1990 |