midazolam has been researched along with Hypertension, Portal in 3 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Hypertension, Portal: Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sedation with propofol has a shorter time recovery and a shorter time to discharge than midazolam and does not exacerbate sub-clinical hepatic encephalopathy in patients with compensated liver cirrhosis." | 9.15 | Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study. ( Alex, I; Kamal, D; Khamaysi, I; Nimer, A; Olga, A; Vladimir, M; William, N, 2011) |
| "Sedation with propofol has a shorter time recovery and a shorter time to discharge than midazolam and does not exacerbate sub-clinical hepatic encephalopathy in patients with compensated liver cirrhosis." | 5.15 | Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study. ( Alex, I; Kamal, D; Khamaysi, I; Nimer, A; Olga, A; Vladimir, M; William, N, 2011) |
| "The results of this study indicate that (1) the majority of patients with cirrhosis and suspected portal hypertension have evidence of subclinical hepatic encephalopathy, (2) the extent of encephalopathy correlates with the Child Pugh's score, (3) sedation with midazolam for upper GI endoscopy exacerbates the encephalopathy, and (4) this adverse effect is still evident 2 hours after the procedure." | 5.09 | Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis. ( Assy, N; Grahame, GR; Minuk, GY; Rosser, BG, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khamaysi, I | 1 |
| William, N | 1 |
| Olga, A | 1 |
| Alex, I | 1 |
| Vladimir, M | 1 |
| Kamal, D | 1 |
| Nimer, A | 1 |
| Steinlauf, AF | 1 |
| Garcia-Tsao, G | 1 |
| Zakko, MF | 1 |
| Dickey, K | 1 |
| Gupta, T | 1 |
| Groszmann, RJ | 1 |
| Assy, N | 1 |
| Rosser, BG | 1 |
| Grahame, GR | 1 |
| Minuk, GY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Fentanyl Analgesia on the Accuracy of Hepatic Venous Pressure Gradient Measurements in Patients With Portal Hypertension：a Prospective, Multicenter Study[NCT04724148] | 4 participants (Anticipated) | Interventional | 2022-01-01 | Recruiting | |||
| Evaluation of Gastroesophageal Varices in Cirrhotic and Non-cirrhotic Patients With Portal Hypertension by Transnasal Endoscopy.[NCT02767206] | 50 participants (Actual) | Observational | 2016-03-31 | Enrolling by invitation | |||
| A New Technique to Enhance Detection of Small Esophageal Varices by PillCam ESO Capsule Endoscopy[NCT00911131] | Phase 3 | 0 participants (Actual) | Interventional | Withdrawn (stopped due to Loss of funding) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for midazolam and Hypertension, Portal
| Article | Year |
|---|---|
Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study.
Topics: Adult; Aged; Anesthesia Recovery Period; Cognition; Conscious Sedation; Endoscopy, Gastrointestinal; | 2011 |
Low-dose midazolam sedation: an option for patients undergoing serial hepatic venous pressure measurements.
Topics: Anti-Anxiety Agents; Anxiety; Catheterization; Dose-Response Relationship, Drug; Double-Blind Method | 1999 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |