midazolam has been researched along with Hypercapnia in 11 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients receiving midazolam had a more than doubled risk of respiratory depression as mirrored by hypercapnia and acidosis, but not hypoxemia." | 7.88 | Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis. ( Bürkle, G; Ehrlich, JR; Feurich, F; Kaess, BM, 2018) |
| "Patients receiving midazolam had a more than doubled risk of respiratory depression as mirrored by hypercapnia and acidosis, but not hypoxemia." | 3.88 | Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis. ( Bürkle, G; Ehrlich, JR; Feurich, F; Kaess, BM, 2018) |
| "The initial dosage introduced sedation before procedure was significantly higher in group 1." | 2.78 | Administration of additional analgesics can decrease the incidence of paradoxical reactions in patients under benzodiazepine-induced sedation during endoscopic transpapillary procedures: prospective randomized controlled trial. ( Inomata, M; Terui, T, 2013) |
| "Targeted temperature management after cardiac arrest requires deep sedation to prevent shivering and discomfort." | 1.46 | Isoflurane Sedation on the ICU in Cardiac Arrest Patients Treated With Targeted Temperature Management: An Observational Propensity-Matched Study. ( Engels, M; Jörres, A; Krannich, A; Kruse, J; Leithner, C; Nee, J; Petzinka, V; Schröder, T; Storm, C, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Strohleit, D | 1 |
| Galetin, T | 1 |
| Kosse, N | 1 |
| Lopez-Pastorini, A | 1 |
| Stoelben, E | 1 |
| Mercado-Longoría, R | 1 |
| Armeaga-Azoños, C | 1 |
| Tapia-Orozco, J | 1 |
| González-Aguirre, JE | 1 |
| Kaess, BM | 1 |
| Feurich, F | 1 |
| Bürkle, G | 1 |
| Ehrlich, JR | 1 |
| Miyoshi, H | 1 |
| Shimatani, M | 1 |
| Kato, K | 1 |
| Sumimoto, K | 1 |
| Kurishima, A | 1 |
| Kusuda, T | 1 |
| Fukata, N | 1 |
| Ikeura, T | 1 |
| Takaoka, M | 1 |
| Okazaki, K | 1 |
| Krannich, A | 1 |
| Leithner, C | 1 |
| Engels, M | 1 |
| Nee, J | 1 |
| Petzinka, V | 1 |
| Schröder, T | 1 |
| Jörres, A | 1 |
| Kruse, J | 1 |
| Storm, C | 1 |
| Terui, T | 1 |
| Inomata, M | 1 |
| De Jonghe, B | 1 |
| Mora, CT | 1 |
| Torjman, M | 1 |
| White, PF | 1 |
| Mak, KH | 1 |
| Wang, YT | 1 |
| Cheong, TH | 1 |
| Poh, SC | 1 |
| Blouin, RT | 1 |
| Conard, PF | 1 |
| Perreault, S | 1 |
| Gross, JB | 1 |
| Takahashi, K | 1 |
| Nosaka, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Non-anesthesiologist-administered Propofol is Not Related to a Higher Increase in Transcutaneous CO2 Pressure During the Flexible Bronchoscopy Compared to Guideline-based Sedation: A Randomized Controlled Trial[NCT02820051] | 91 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05327296] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-06-30 | Recruiting | ||
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05312385] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-04-28 | Recruiting | ||
| Etomidate With Meperidine vs Midazolam With Meperidine for Sedation During Endodscopic Retrograde Cholangiopancreatogram (ERCP)[NCT02027311] | Phase 4 | 63 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Hypoxia defined as peripheral blood oxygen saturation measured by pulse oxymeter < 90% (NCT02027311)
Timeframe: Every 5min in Preoperative, intraoperative phase and 15 min in Recovery phase
| Intervention | Hypoxia events (Number) |
|---|---|
| Midazolam | 19 |
| Etomidate | 27 |
The frequency of intervention which was defined as any restraint of the patient's head, arms, or legs if they became agitated, or if patient movement was not controlled with verbal instruction from the endoscopist during the whole intraoperative phases. (NCT02027311)
Timeframe: Throughout the whole ERCP procedure
| Intervention | Number of intervention (Mean) |
|---|---|
| Etomidate | 1.9 |
| Midazolam | 7.5 |
1 review available for midazolam and Hypercapnia
| Article | Year |
|---|---|
Guidelines on analgosedation, monitoring, and recovery time for flexible bronchoscopy: a systematic review.
Topics: Adult; Analgesics, Opioid; Blood Gas Monitoring, Transcutaneous; Bronchoscopy; Carbon Dioxide; Consc | 2021 |
4 trials available for midazolam and Hypercapnia
| Article | Year |
|---|---|
Non-anesthesiologist-administered Propofol is not Related to an Increase in Transcutaneous CO
Topics: Adult; Aged; Ambulatory Care; Blood Gas Monitoring, Transcutaneous; Bronchoscopy; Carbon Dioxide; De | 2017 |
Administration of additional analgesics can decrease the incidence of paradoxical reactions in patients under benzodiazepine-induced sedation during endoscopic transpapillary procedures: prospective randomized controlled trial.
Topics: Adjuvants, Anesthesia; Aged; Analysis of Variance; Cholangiopancreatography, Endoscopic Retrograde; | 2013 |
Sedative and ventilatory effects of midazolam infusion: effect of flumazenil reversal.
Topics: Adult; Ambulatory Care; Anesthetics, Intravenous; Double-Blind Method; Female; Fentanyl; Flumazenil; | 1995 |
The effect of flumazenil on midazolam-induced depression of the ventilatory response to hypoxia during isohypercarbia.
Topics: Adult; Depression, Chemical; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interaction | 1993 |
6 other studies available for midazolam and Hypercapnia
| Article | Year |
|---|---|
Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis.
Topics: Acidosis; Aged; Anesthetics, Intravenous; Drug Therapy, Combination; Female; Fentanyl; Follow-Up Stu | 2018 |
Transcutaneous monitoring of partial pressure of carbon dioxide during endoscopic retrograde cholangiopancreatography using a double-balloon endoscope with carbon dioxide insufflation under conscious sedation.
Topics: Aged; Aged, 80 and over; Carbon Dioxide; Cholangiopancreatography, Endoscopic Retrograde; Cohort Stu | 2014 |
Isoflurane Sedation on the ICU in Cardiac Arrest Patients Treated With Targeted Temperature Management: An Observational Propensity-Matched Study.
Topics: Administration, Inhalation; Administration, Intravenous; Aged; Anesthetics, Inhalation; Anesthetics, | 2017 |
Isoflurane Sedation on the ICU in Cardiac Arrest Patients Treated With Targeted Temperature Management: An Observational Propensity-Matched Study.
Topics: Administration, Inhalation; Administration, Intravenous; Aged; Anesthetics, Inhalation; Anesthetics, | 2017 |
Isoflurane Sedation on the ICU in Cardiac Arrest Patients Treated With Targeted Temperature Management: An Observational Propensity-Matched Study.
Topics: Administration, Inhalation; Administration, Intravenous; Aged; Anesthetics, Inhalation; Anesthetics, | 2017 |
Isoflurane Sedation on the ICU in Cardiac Arrest Patients Treated With Targeted Temperature Management: An Observational Propensity-Matched Study.
Topics: Administration, Inhalation; Administration, Intravenous; Aged; Anesthetics, Inhalation; Anesthetics, | 2017 |
Permissive hypercapnia: does a high PaCO2 level require high sedative doses?
Topics: Carbon Dioxide; Dose-Response Relationship, Drug; Humans; Hypercapnia; Hypnotics and Sedatives; Mida | 2006 |
The effect of oral midazolam and diazepam on respiration in normal subjects.
Topics: Administration, Oral; Analysis of Variance; Diazepam; Humans; Hypercapnia; Hypoxia; Male; Midazolam; | 1993 |
Carbon dioxide narcosis caused by midazolam in a patient with myotonic dystrophy.
Topics: Adult; Anesthesia, Epidural; Female; Humans; Hypercapnia; Hypnotics and Sedatives; Midazolam; Myoton | 2000 |