midazolam has been researched along with Hemorrhagic Shock in 6 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Carbon monoxide (CO), when bound to red blood cells (CO-RBC) has the potential to protect the hepatic CYP protein to produce a resuscitative effect in a hemorrhagic shock rat model." | 7.81 | Kupffer cell inactivation by carbon monoxide bound to red blood cells preserves hepatic cytochrome P450 via anti-oxidant and anti-inflammatory effects exerted through the HMGB1/TLR-4 pathway during resuscitation from hemorrhagic shock. ( Ishima, Y; Maeda, H; Maruyama, T; Ogaki, S; Otagiri, M; Taguchi, K; Watanabe, H, 2015) |
| " Carbon monoxide (CO), when bound to red blood cells (CO-RBC) has the potential to protect the hepatic CYP protein to produce a resuscitative effect in a hemorrhagic shock rat model." | 3.81 | Kupffer cell inactivation by carbon monoxide bound to red blood cells preserves hepatic cytochrome P450 via anti-oxidant and anti-inflammatory effects exerted through the HMGB1/TLR-4 pathway during resuscitation from hemorrhagic shock. ( Ishima, Y; Maeda, H; Maruyama, T; Ogaki, S; Otagiri, M; Taguchi, K; Watanabe, H, 2015) |
| "In patients with hemorrhagic shock, the infusion of hypertonic saline (7." | 2.75 | [Assessment of efficacy of hypertonic saline - hydroxyethylstarch in haemorrhagic shock]. ( Auffray, JP; Bouzana, F; Couret, D; Delahaye, D; Dourlens, L; Michelet, P; Perrin, G, 2010) |
| " Blood samples were collected periodically in both phases and analyzed for parent drugs and metabolites (dextrorphan, 4'-hydroxy-flurbiprofen and 1'-hydroxy-midazolam) to calculate pharmacokinetic parameters." | 1.37 | Drug metabolism in hemorrhagic shock: pharmacokinetics of selective markers of cytochrome-P450 2C9, 2D6, and 3A4 enzyme activities in a porcine model. ( Beilman, GJ; Kumar, A; Mann, HJ; Remmel, RP, 2011) |
| "Ketamine/midazolam was used to minimize hemodynamic changes due to the anesthesia." | 1.37 | Hypothermia increases rebleeding during uncontrolled hemorrhage in the rat. ( Hahn, RG; Heinius, G; Sondén, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Tokuno, M | 1 |
| Taguchi, K | 3 |
| Sakai, H | 1 |
| Ohtsuki, S | 1 |
| Yamasaki, K | 1 |
| Otagiri, M | 3 |
| Ogaki, S | 2 |
| Maeda, H | 1 |
| Watanabe, H | 2 |
| Ishima, Y | 1 |
| Maruyama, T | 2 |
| Michelet, P | 1 |
| Bouzana, F | 1 |
| Couret, D | 1 |
| Delahaye, D | 1 |
| Perrin, G | 1 |
| Dourlens, L | 1 |
| Auffray, JP | 1 |
| Kumar, A | 1 |
| Remmel, RP | 1 |
| Mann, HJ | 1 |
| Beilman, GJ | 1 |
| Heinius, G | 1 |
| Hahn, RG | 1 |
| Sondén, A | 1 |
1 trial available for midazolam and Hemorrhagic Shock
| Article | Year |
|---|---|
[Assessment of efficacy of hypertonic saline - hydroxyethylstarch in haemorrhagic shock].
Topics: Adult; Aged; Aged, 80 and over; Chlorides; Female; Hemodynamics; Humans; Hydroxyethyl Starch Derivat | 2010 |
5 other studies available for midazolam and Hemorrhagic Shock
| Article | Year |
|---|---|
Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles.
Topics: Animals; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Interactions; Hemoglobins; Li | 2020 |
Kupffer cell inactivation by carbon monoxide bound to red blood cells preserves hepatic cytochrome P450 via anti-oxidant and anti-inflammatory effects exerted through the HMGB1/TLR-4 pathway during resuscitation from hemorrhagic shock.
Topics: Animals; Antioxidants; Carbon Monoxide; Chromans; Cytochrome P-450 Enzyme System; Cytokines; Erythro | 2015 |
Drug metabolism in hemorrhagic shock: pharmacokinetics of selective markers of cytochrome-P450 2C9, 2D6, and 3A4 enzyme activities in a porcine model.
Topics: Animals; Biomarkers; Cytochrome P-450 Enzyme System; Dextromethorphan; Dose-Response Relationship, D | 2011 |
Hypothermia increases rebleeding during uncontrolled hemorrhage in the rat.
Topics: Animals; Body Temperature; Hemodynamics; Hemorrhage; Hypothermia, Induced; Ketamine; Male; Midazolam | 2011 |
Carbon monoxide-bound red blood cells protect red blood cell transfusion-induced hepatic cytochrome P450 impairment in hemorrhagic-shock rats.
Topics: Animals; Blotting, Western; Carbon Monoxide; Cytochrome P-450 Enzyme System; Erythrocyte Transfusion | 2013 |