Page last updated: 2024-10-31

midazolam and Hemorrhage, Subarachnoid

midazolam has been researched along with Hemorrhage, Subarachnoid in 11 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Research Excerpts

ExcerptRelevanceReference
"Agitation is common in subarachnoid hemorrhage (SAH), and sedation with midazolam, propofol and dexmedetomidine is essential in agitation management."8.12Cerebrospinal fluid metabolic profiling reveals divergent modulation of pentose phosphate pathway by midazolam, propofol and dexmedetomidine in patients with subarachnoid hemorrhage: a cohort study. ( A, JY; Ding, XS; Ge, WH; Li, YC; Liu, T; Na, SJ; Sun, RB; Wang, R, 2022)
"We present a case of diltiazem intoxication resulting in repeated asystole after the induction of anesthesia."7.78[Suspected diltiazem intoxication resulting in repeated asystole after the induction of anesthesia]. ( Hara, T; Harioka, T; Ishiyama, T; Kimura, Y; Matsukawa, T; Nakasato, A; Okamura, M, 2012)
" Intra-arterial verapamil was started; during this treatment, the patient developed right-sided focal motor seizures."7.74Intra-arterial verapamil-induced seizures: case report and review of the literature. ( Nwagwu, CI; Westhout, FD, 2007)
"Agitation is common in subarachnoid hemorrhage (SAH), and sedation with midazolam, propofol and dexmedetomidine is essential in agitation management."4.12Cerebrospinal fluid metabolic profiling reveals divergent modulation of pentose phosphate pathway by midazolam, propofol and dexmedetomidine in patients with subarachnoid hemorrhage: a cohort study. ( A, JY; Ding, XS; Ge, WH; Li, YC; Liu, T; Na, SJ; Sun, RB; Wang, R, 2022)
" Patients with aneurysmal subarachnoid hemorrhage are often sedated, and GABAergic sedation, such as midazolam and propofol, is commonly used."3.83Use of GABAergic sedatives after subarachnoid hemorrhage is associated with worse outcome-preliminary findings. ( Beynon, C; Hertle, DN; Neumann, JO; Sakowitz, OW; Sánchez-Porras, R; Santos, E; Unterberg, AW, 2016)
"We present a case of diltiazem intoxication resulting in repeated asystole after the induction of anesthesia."3.78[Suspected diltiazem intoxication resulting in repeated asystole after the induction of anesthesia]. ( Hara, T; Harioka, T; Ishiyama, T; Kimura, Y; Matsukawa, T; Nakasato, A; Okamura, M, 2012)
" Intra-arterial verapamil was started; during this treatment, the patient developed right-sided focal motor seizures."3.74Intra-arterial verapamil-induced seizures: case report and review of the literature. ( Nwagwu, CI; Westhout, FD, 2007)
"Patients with aneurysmal subarachnoid hemorrhage (aSAH) are common in intensive care units (ICU)."1.42The effect of tracheotomy on drug consumption in patients with acute aneurysmal subarachnoid hemorrhage: an observational study. ( Kongsgaard, U; Narum, J; Rosseland, LA; Sorteberg, A; Sorteberg, W; Stubhaug, A, 2015)
"Thiopental was added for treatment of intracranial hypertension."1.38Frequency of non-convulsive seizures and non-convulsive status epilepticus in subarachnoid hemorrhage patients in need of controlled ventilation and sedation. ( Lindgren, C; Naredi, S; Nordh, E; Olivecrona, M, 2012)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's7 (63.64)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
Li, YC1
Wang, R1
A, JY1
Sun, RB1
Na, SJ1
Liu, T1
Ding, XS1
Ge, WH1
Santos, E2
Olivares-Rivera, A1
Major, S1
Sánchez-Porras, R2
Uhlmann, L1
Kunzmann, K1
Zerelles, R1
Kentar, M1
Kola, V1
Aguilera, AH1
Herrera, MG1
Lemale, CL1
Woitzik, J1
Hartings, JA1
Sakowitz, OW2
Unterberg, AW2
Dreier, JP1
Kallioinen, M1
Posti, JP1
Rahi, M1
Sharma, D1
Katila, A1
Grönlund, J1
Vahlberg, T1
Frantzén, J1
Olkkola, KT1
Saari, TI1
Takala, R1
Rosseland, LA1
Narum, J1
Stubhaug, A1
Kongsgaard, U1
Sorteberg, W1
Sorteberg, A1
Hertle, DN1
Beynon, C1
Neumann, JO1
Fernández-Torre, JL1
Hernández-Hernández, MA1
Stein, M1
Schomacher, J1
Scharbrodt, W1
Preuss, M1
Oertel, MF1
Kimura, Y1
Okamura, M1
Harioka, T1
Hara, T1
Nakasato, A1
Ishiyama, T1
Matsukawa, T1
Lindgren, C1
Nordh, E1
Naredi, S1
Olivecrona, M1
Dennis, LJ1
Claassen, J1
Hirsch, LJ1
Emerson, RG1
Connolly, ES1
Mayer, SA1
Westhout, FD1
Nwagwu, CI1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study of Ketamine Sedation Initiated Early After Aneurysmal Subarachnoid Hemorrhage: Effect on Vasospasm, Delayed Cerebral Ischemia, and Functional Outcomes[NCT05032118]Phase 2/Phase 30 participants (Actual)Interventional2023-04-27Withdrawn (stopped due to Institution change, no IRB approval)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

11 other studies available for midazolam and Hemorrhage, Subarachnoid

ArticleYear
Cerebrospinal fluid metabolic profiling reveals divergent modulation of pentose phosphate pathway by midazolam, propofol and dexmedetomidine in patients with subarachnoid hemorrhage: a cohort study.
    BMC anesthesiology, 2022, 01-27, Volume: 22, Issue:1

    Topics: Aged; Cohort Studies; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Mid

2022
Lasting s-ketamine block of spreading depolarizations in subarachnoid hemorrhage: a retrospective cohort study.
    Critical care (London, England), 2019, 12-30, Volume: 23, Issue:1

    Topics: Adult; Aged; Cohort Studies; Female; Humans; Hypnotics and Sedatives; Ketamine; Length of Stay; Male

2019
Cerebral autoregulation after aneurysmal subarachnoid haemorrhage. A preliminary study comparing dexmedetomidine to propofol and/or midazolam.
    Acta anaesthesiologica Scandinavica, 2020, Volume: 64, Issue:9

    Topics: Cerebrovascular Circulation; Dexmedetomidine; Homeostasis; Humans; Midazolam; Propofol; Subarachnoid

2020
The effect of tracheotomy on drug consumption in patients with acute aneurysmal subarachnoid hemorrhage: an observational study.
    BMC anesthesiology, 2015, Volume: 15

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Cerebrovascular Circulation;

2015
Use of GABAergic sedatives after subarachnoid hemorrhage is associated with worse outcome-preliminary findings.
    Journal of clinical anesthesia, 2016, Volume: 35

    Topics: Adult; Aged; Brain; Conscious Sedation; Female; Flunitrazepam; GABA Modulators; Glasgow Coma Scale;

2016
Utility of bilateral Bispectral index (BIS) monitoring in a comatose patient with focal nonconvulsive status epilepticus.
    Seizure, 2012, Volume: 21, Issue:1

    Topics: Aged; Aneurysm, Ruptured; Coma; Consciousness Monitors; Deep Sedation; Electroencephalography; Femal

2012
Cerebrospinal fluid lactate concentration after withdrawal of metabolic suppressive therapy in subarachnoid hemorrhage.
    Acta neurochirurgica. Supplement, 2012, Volume: 114

    Topics: Adult; Aged; Female; Fentanyl; Glasgow Outcome Scale; Humans; Hypnotics and Sedatives; Intensive Car

2012
[Suspected diltiazem intoxication resulting in repeated asystole after the induction of anesthesia].
    Masui. The Japanese journal of anesthesiology, 2012, Volume: 61, Issue:1

    Topics: Adult; Anesthesia; Diltiazem; Drug Interactions; Embolization, Therapeutic; Heart Arrest; Humans; In

2012
Frequency of non-convulsive seizures and non-convulsive status epilepticus in subarachnoid hemorrhage patients in need of controlled ventilation and sedation.
    Neurocritical care, 2012, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Aged; Conscious Sedation; Critical Care; Electroencephalography; Female; Humans;

2012
Nonconvulsive status epilepticus after subarachnoid hemorrhage.
    Neurosurgery, 2002, Volume: 51, Issue:5

    Topics: Aged; Anticonvulsants; Electroencephalography; Female; Humans; Incidence; Infusion Pumps; Infusions,

2002
Intra-arterial verapamil-induced seizures: case report and review of the literature.
    Surgical neurology, 2007, Volume: 67, Issue:5

    Topics: Adult; Anticonvulsants; Aphasia, Broca; Carotid Artery, Internal; Female; Functional Laterality; Hum

2007