midazolam has been researched along with Heart Disease, Ischemic in 19 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Two patients in group 2 required treatment with nitroglycerin for myocardial ischemia." | 5.08 | The effect of midazolam at two plasma concentrations of hemodynamics and sufentanil requirement in coronary artery surgery. ( Epema, AH; Hennis, PJ; Huet, RC; van der Maaten, JM, 1996) |
| " Cardiac morbidity (postoperative myocardial ischemia, postoperative myocardial infarction, and perioperative sympathoadrenal stress response), respiratory morbidity (postextubation apnea, alveolar-arterial oxygen gradient, pulmonary shunting, oxygen consumption, atelectasis, and reintubation), hemodynamic values and vasoactive medication requirements, intraoperative awareness, postoperative cognitive function, 30 day mortality, and intensive care unit and hospital lengths of stay were compared between the two groups." | 5.08 | Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial. ( Asokumar, B; Carroll, J; Cheng, DC; David, T; Karski, J; Mickle, D; Nierenberg, H; Peniston, C; Raveendran, G; Roger, S; Sandler, A; Tong, J; Zelovitsky, J, 1996) |
| "It is hypothesized that because of its potential to increase coronary flow and simultaneously decrease myocardial performance and O2 consumption, midazolam would minimize regional metabolic impairment during myocardial ischemia." | 3.69 | Midazolam's effects on myocardial load and coronary perfusion: reduced regional O2 consumption and lactate production during ischemia in dogs. ( Rush, W; Sidi, A, 1994) |
| "Myocardial ischemia was assessed perioperatively by monitoring ST segment deviation via continuous three-lead Holter electrocardiography, and it was evaluated during operation by monitoring left ventricular wall motion abnormality via transesophageal echocardiography." | 2.68 | Multicenter study of target-controlled infusion of propofol-sufentanil or sufentanil-midazolam for coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group. ( Bellows, W; Body, SC; Jain, U; Mangano, CM; Mangano, DT; Mathew, J; Wilson, R; Wolman, R; Youngs, E; Zhang, A, 1996) |
| "Patients with unstable angina pectoris or who have just had a myocardial infarction underwent full treatment for pain-induced dental problems, with the use of an incremental three-level antiangina and antianxiety medication: before dental treatment; in the waiting room, and c) during dental treatment." | 1.29 | Dental treatment in very high risk patients with active ischemic heart disease. ( Findler, M; Galili, D; Garfunkel, AA; Meidan, Z; Yakirevitch, V, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (78.95) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oyama, Y | 1 |
| Bartman, CM | 1 |
| Gile, J | 1 |
| Sehrt, D | 1 |
| Eckle, T | 1 |
| Biswas, AK | 1 |
| Feldman, BL | 1 |
| Davis, DH | 1 |
| Zintz, EA | 1 |
| Neuhäuser, C | 1 |
| Müller, M | 1 |
| Welters, I | 1 |
| Scholz, S | 1 |
| Kwapisz, MM | 1 |
| Shorten, GD | 1 |
| Sieber, T | 1 |
| Maslow, AD | 1 |
| Haering, JM | 1 |
| Robertson, LK | 1 |
| Comunale, ME | 1 |
| Quíntin, L | 1 |
| Cicala, R | 1 |
| Kent, M | 1 |
| Thomsen, B | 1 |
| Sidi, A | 1 |
| Rush, W | 1 |
| Spahn, DR | 1 |
| Hu, WC | 1 |
| Smith, LR | 1 |
| Leone, BJ | 1 |
| Lischke, V | 1 |
| Probst, S | 1 |
| Behne, M | 1 |
| Kessler, P | 1 |
| Findler, M | 1 |
| Galili, D | 1 |
| Meidan, Z | 1 |
| Yakirevitch, V | 1 |
| Garfunkel, AA | 1 |
| Wahr, JA | 1 |
| Plunkett, JJ | 1 |
| Ramsay, JG | 1 |
| Reeves, J | 1 |
| Jain, U | 2 |
| Ley, C | 1 |
| Wilson, R | 2 |
| Mangano, DT | 2 |
| van der Maaten, JM | 1 |
| Epema, AH | 1 |
| Huet, RC | 1 |
| Hennis, PJ | 1 |
| Cheng, DC | 1 |
| Karski, J | 1 |
| Peniston, C | 1 |
| Asokumar, B | 1 |
| Raveendran, G | 1 |
| Carroll, J | 1 |
| Nierenberg, H | 1 |
| Roger, S | 1 |
| Mickle, D | 1 |
| Tong, J | 1 |
| Zelovitsky, J | 1 |
| David, T | 1 |
| Sandler, A | 1 |
| Body, SC | 1 |
| Bellows, W | 1 |
| Wolman, R | 1 |
| Mangano, CM | 1 |
| Mathew, J | 1 |
| Youngs, E | 1 |
| Zhang, A | 1 |
| Watanabe, S | 1 |
| Kono, Y | 1 |
| Kaneko, S | 1 |
| Kano, T | 1 |
| Middlehurst, R | 1 |
| Coulthard, P | 1 |
| Rieke, H | 1 |
| Kazmaier, S | 1 |
| Lange, H | 1 |
| Weyland, A | 1 |
| Sonntag, H | 1 |
| Middlehurst, RJ | 1 |
| Gibbs, A | 1 |
| Walton, G | 1 |
| Zhang, HY | 1 |
| McPherson, BC | 1 |
| Liu, H | 1 |
| Baman, TS | 1 |
| Rock, P | 1 |
| Yao, Z | 1 |
| Vrána, M | 1 |
| Fejfar, Z | 1 |
| Hess, L | 1 |
| Blazek, Z | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Bright Light Exposure in Critical Ill Patients and Patients Undergoing Cardiac Surgery[NCT03822949] | 70 participants (Anticipated) | Interventional | 2019-07-12 | Recruiting | |||
| Safety of Local Dental Anesthesia in Patients With Cardiac Channelopathies[NCT03182777] | 31 participants (Actual) | Interventional | 2015-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 trials available for midazolam and Heart Disease, Ischemic
| Article | Year |
|---|---|
Effect of isoflurane on echocardiographic left-ventricular relaxation indices in patients with diastolic dysfunction due to concentric hypertrophy and ischemic heart disease.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Antihypertensive Agents; Cardiovascular Phy | 2006 |
Left ventricular regional wall motion and haemodynamic changes following bolus administration of pipecuronium or pancuronium to adult patients undergoing coronary artery bypass grafting.
Topics: Adult; Aged; Anesthetics, Intravenous; Blood Pressure; Cardiac Output; Central Venous Pressure; Coro | 1995 |
Effect of clonidine on myocardial ischaemia: a double-blind pilot trial.
Topics: Anesthesia, Intravenous; Cardiopulmonary Bypass; Clonidine; Double-Blind Method; Electrocardiography | 1993 |
[ST segment changes in the ECG. Anesthesia induction with propofol, etomidate or midazolam in patients with coronary heart disease].
Topics: Aged; Anesthesia; Blood Pressure; Coronary Artery Bypass; Electrocardiography; Etomidate; Female; Fe | 1993 |
Cardiovascular responses during sedation after coronary revascularization. Incidence of myocardial ischemia and hemodynamic episodes with propofol versus midazolam. Institutions of the McSPI Research Group.
Topics: Adult; Aged; Double-Blind Method; Female; Hemodynamics; Humans; Hypnotics and Sedatives; Incidence; | 1996 |
The effect of midazolam at two plasma concentrations of hemodynamics and sufentanil requirement in coronary artery surgery.
Topics: Adjuvants, Anesthesia; Adrenergic beta-Antagonists; Analgesics, Opioid; Anesthesia Recovery Period; | 1996 |
Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial.
Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Apnea; Catecholamines; | 1996 |
Multicenter study of target-controlled infusion of propofol-sufentanil or sufentanil-midazolam for coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.
Topics: Aged; Anesthetics, Intravenous; Coronary Artery Bypass; Electrocardiography; Female; Hemodynamics; H | 1996 |
The effect of midazolam sedation on indicators for myocardial ischemia.
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Intravenous; Conscious Sedation; Dental Care for | 1999 |
[Does method of anesthesia modify postoperative ischemia incidence? A study of patients after aortocoronary bypass operations].
Topics: Adult; Aged; Anesthesia, General; Coronary Artery Bypass; Electrocardiography; Enflurane; Fentanyl; | 1999 |
Cardiovascular risk: the safety of local anesthesia, vasoconstrictors, and sedation in heart disease.
Topics: Anesthesia, Dental; Anesthetics, Local; Arrhythmias, Cardiac; Blood Pressure; Conscious Sedation; El | 1999 |
8 other studies available for midazolam and Heart Disease, Ischemic
| Article | Year |
|---|---|
The Circadian PER2 Enhancer Nobiletin Reverses the Deleterious Effects of Midazolam in Myocardial Ischemia and Reperfusion Injury.
Topics: Animals; Disease Models, Animal; Flavones; Mice; Mice, Knockout; Midazolam; Myocardial Ischemia; Per | 2018 |
Myocardial ischemia as a result of severe benzodiazepine and opioid withdrawal.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Benzodiazepines; Diazepam; Electrocardiography; Female; F | 2005 |
Midazolam's effects on myocardial load and coronary perfusion: reduced regional O2 consumption and lactate production during ischemia in dogs.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Female; Hea | 1994 |
Pacing-induced left ventricular asynchronies in dogs with critical coronary stenosis: mechanisms and effect of anesthetics.
Topics: Anesthetics; Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiac Output; Cardiac Pacing, Artifici | 1993 |
Dental treatment in very high risk patients with active ischemic heart disease.
Topics: Aged; Anesthesia, Dental; Anesthesia, Local; Angina, Unstable; Conscious Sedation; Dental Care for D | 1993 |
Effects of a bolus injection of adenosine triphosphate on atrioventricular conduction and hemodynamics in patients undergoing coronary artery bypass grafting.
Topics: Adenosine Triphosphate; Anesthetics, Intravenous; Atrioventricular Node; Blood Pressure; Bradycardia | 1999 |
H(2)O(2) opens mitochondrial K(ATP) channels and inhibits GABA receptors via protein kinase C-epsilon in cardiomyocytes.
Topics: Animals; Calcium Channel Blockers; Chick Embryo; Decanoic Acids; Enzyme Inhibitors; Fluoresceins; Fl | 2002 |
Analgosedation raises baroreflex sensitivity in acute myocardial ischaemia.
Topics: Animals; Baroreflex; Conscious Sedation; Dogs; Electrocardiography; Fentanyl; Heart Ventricles; Hemo | 1992 |