midazolam has been researched along with HIV Coinfection in 18 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used midazolam, dextromethorphan and digoxin as in vivo phenotyping probes for CYP3A (CYP3A4/5), CYP2D6 and P-glycoprotein activities, respectively, and compared these activities between 12 healthy Caucasian volunteers and 30 treatment-naive HIV-infected patients." | 3.76 | Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients? ( Doroshyenko, O; Fätkenheuer, G; Frank, D; Fuhr, U; Hein, W; Jetter, A; Kirchheiner, J; Klaassen, T; Schömig, E; Seeringer, A; Wyen, C, 2010) |
| " This work investigated if CAB was a substrate for efflux transporters, the potential for CAB to interact with drug-metabolizing enzymes and transporters to cause clinical drug interactions, and the effect of CAB on the pharmacokinetics of midazolam, a CYP3A4 probe substrate, in humans." | 2.82 | Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam. ( Bowers, GD; Ford, SL; Gould, EP; Humphreys, JE; Polli, JW; Reese, MJ; Webster, LO, 2016) |
| "Ritonavir is a powerful inhibitor of cytochrome P450 3A (CYP3A) that metabolizes many antiretrovirals." | 2.73 | Ritonavir greatly impairs CYP3A activity in HIV infection with chronic viral hepatitis. ( Greenblatt, DJ; Kaufman, RC; Knox, TA; Oleson, L; von Moltke, LL; Wanke, CA, 2008) |
| " The aim of present study was to test the hypothesis that the power balance between inhibition effects of RTV and induced activities of Pgp and CYP3A depends on the time after last RTV treatment (TimeR) in the chronic use of RTV; rhodamine 123 (Rho) and midazolam (MDZ) were administered at predetermined TimeR to rats pretreated with RTV for 7 days." | 1.39 | Time-dependent interaction of ritonavir in chronic use: the power balance between inhibition and induction of P-glycoprotein and cytochrome P450 3A. ( Aoyama, H; Fukushima, K; Kobuchi, S; Mizuhara, K; Sugioka, N; Takada, K, 2013) |
| " We calculated rates of adverse events according to benzodiazepine use and identified risk factors for complications using univariate and multivariate analyses." | 1.39 | Safety of midazolam for sedation of HIV-positive patients undergoing colonoscopy. ( Arpino, P; Backman, ES; Ehrenfeld, JM; Gandhi, RT; Losina, E; Lu, Z; Triant, VA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 7 (38.89) | 29.6817 |
| 2010's | 9 (50.00) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Bhatia, K | 1 |
| Moshkun, C | 1 |
| Fukushima, K | 1 |
| Kobuchi, S | 1 |
| Mizuhara, K | 1 |
| Aoyama, H | 1 |
| Takada, K | 1 |
| Sugioka, N | 1 |
| Reese, MJ | 1 |
| Bowers, GD | 1 |
| Humphreys, JE | 1 |
| Gould, EP | 1 |
| Ford, SL | 1 |
| Webster, LO | 1 |
| Polli, JW | 1 |
| Bruce, RD | 1 |
| Govindasamy, S | 1 |
| Sylla, L | 1 |
| Haddad, MS | 1 |
| Kamarulzaman, A | 1 |
| Altice, FL | 1 |
| Tomalik-Scharte, D | 1 |
| Doroshyenko, O | 2 |
| Kirchheiner, J | 2 |
| Jetter, A | 2 |
| Lazar, A | 1 |
| Klaassen, T | 2 |
| Frank, D | 2 |
| Wyen, C | 2 |
| Fätkenheuer, G | 2 |
| Fuhr, U | 2 |
| Knox, TA | 1 |
| Oleson, L | 1 |
| von Moltke, LL | 1 |
| Kaufman, RC | 1 |
| Wanke, CA | 1 |
| Greenblatt, DJ | 1 |
| Acosta, EP | 1 |
| Kubiak, DW | 1 |
| Fennerty, MB | 1 |
| Kerr, T | 1 |
| Hayashi, K | 1 |
| Fairbairn, N | 1 |
| Kaplan, K | 1 |
| Suwannawong, P | 1 |
| Zhang, R | 1 |
| Wood, E | 1 |
| Jones, AE | 1 |
| Brown, KC | 1 |
| Werner, RE | 1 |
| Gotzkowsky, K | 1 |
| Gaedigk, A | 1 |
| Blake, M | 1 |
| Hein, DW | 1 |
| van der Horst, C | 1 |
| Kashuba, AD | 1 |
| Seeringer, A | 1 |
| Hein, W | 1 |
| Schömig, E | 1 |
| Hsu, AJ | 2 |
| Carson, KA | 1 |
| Yung, R | 2 |
| Pham, PA | 2 |
| Brackett, CC | 1 |
| Backman, ES | 1 |
| Triant, VA | 1 |
| Ehrenfeld, JM | 1 |
| Lu, Z | 1 |
| Arpino, P | 1 |
| Losina, E | 1 |
| Gandhi, RT | 1 |
| Loughrey, JP | 1 |
| Tsen, LC | 1 |
| Fellay, J | 1 |
| Marzolini, C | 1 |
| Decosterd, L | 1 |
| Golay, KP | 1 |
| Baumann, P | 1 |
| Buclin, T | 1 |
| Telenti, A | 1 |
| Eap, CB | 1 |
| Abel, S | 1 |
| Russell, D | 1 |
| Whitlock, LA | 1 |
| Ridgway, CE | 1 |
| Muirhead, GJ | 1 |
| Merry, C | 1 |
| Mulcahy, F | 1 |
| Barry, M | 1 |
| Gibbons, S | 1 |
| Back, D | 1 |
4 trials available for midazolam and HIV Coinfection
| Article | Year |
|---|---|
Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam.
Topics: Administration, Oral; Adolescent; Adult; Aged; Animals; Anti-HIV Agents; Area Under Curve; ATP-Bindi | 2016 |
Ritonavir greatly impairs CYP3A activity in HIV infection with chronic viral hepatitis.
Topics: Administration, Oral; Adult; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome | 2008 |
Variations of CYP3A activity induced by antiretroviral treatment in HIV-1 infected patients.
Topics: Adult; Aged; Anti-HIV Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Drug Interactio | 2005 |
Effect of maraviroc on the pharmacokinetics of midazolam, lamivudine/zidovudine, and ethinyloestradiol/levonorgestrel in healthy volunteers.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anti-HIV Agents; CCR5 Receptor Antagonists; Contraceptives, | 2008 |
14 other studies available for midazolam and HIV Coinfection
| Article | Year |
|---|---|
Sedation and HIV medication.
Topics: Conscious Sedation; HIV Infections; Humans; Hypnotics and Sedatives; Midazolam | 2022 |
Time-dependent interaction of ritonavir in chronic use: the power balance between inhibition and induction of P-glycoprotein and cytochrome P450 3A.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome | 2013 |
Case series of buprenorphine injectors in Kuala Lumpur, Malaysia.
Topics: Adult; Buprenorphine; Catchment Area, Health; Female; HIV Infections; Humans; Hypnotics and Sedative | 2008 |
No role for the CYP3A5*3 polymorphism in intestinal and hepatic metabolism of midazolam.
Topics: Administration, Oral; Adult; Biological Availability; Case-Control Studies; Cytochrome P-450 CYP3A; | 2008 |
Antiretroviral rounds. Happy 50th? Sedation for colonoscopy in HIV-infected patients.
Topics: Anti-HIV Agents; Colonoscopy; Conscious Sedation; Contraindications; HIV Infections; Humans; Hypnoti | 2009 |
Expanding the reach of harm reduction in Thailand: experiences with a drug user-run drop-in centre.
Topics: Adult; Drug Users; Female; Harm Reduction; Health Services Accessibility; Heroin; HIV Infections; Hu | 2010 |
Variability in drug metabolizing enzyme activity in HIV-infected patients.
Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Fe | 2010 |
Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?
Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Cy | 2010 |
Severe prolonged sedation associated with coadministration of protease inhibitors and intravenous midazolam during bronchoscopy.
Topics: Adult; Bronchoscopy; Cohort Studies; Databases, Factual; Deep Sedation; Drug Interactions; Electroni | 2012 |
Severe prolonged sedation associated with coadministration of protease inhibitors and intravenous midazolam during bronchoscopy: a commentary.
Topics: Bronchoscopy; Deep Sedation; HIV Infections; HIV Protease Inhibitors; Humans; Hypnotics and Sedative | 2013 |
Authors' reply.
Topics: Bronchoscopy; Deep Sedation; HIV Infections; HIV Protease Inhibitors; Humans; Hypnotics and Sedative | 2013 |
Safety of midazolam for sedation of HIV-positive patients undergoing colonoscopy.
Topics: Adult; Anesthetics, Intravenous; Colonoscopy; Diazepam; Drug-Related Side Effects and Adverse Reacti | 2013 |
Human immunodeficiency virus in pregnancy.
Topics: Contraindications; Drug Interactions; Female; GABA Modulators; HIV Infections; HIV Protease Inhibito | 2002 |
Saquinavir interaction with midazolam: pharmacokinetic considerations when prescribing protease inhibitors for patients with HIV disease.
Topics: Adult; Anti-HIV Agents; Cytochrome P-450 Enzyme System; Drug Interactions; HIV Infections; HIV Prote | 1997 |