midazolam and Glioma
midazolam has been researched along with Glioma in 9 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study aimed to determine whether the exacerbated upper limb motor-sensory deficits are mediated through benzodiazepine sites by demonstrating reversibility by flumazenil in patients with gliomas in eloquent areas." | 7.91 | Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas. ( Gelb, AW; Han, R; Hui, X; Lin, N; Zhang, K, 2019) |
| "Midazolam possesses antitumorigenic properties partly mediated by the peripheral benzodiazepine receptor, whereas dexmedetomidine promotes cancer cell survival through signaling via the α2-adrenoceptor in lung carcinoma and neuroglioma cells." | 7.88 | Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo. ( Bevan, C; Date, A; Datoo, T; Jiang, C; Ma, D; Sanders, RD; Wang, C; Wang, G; Wu, L; Zhao, H, 2018) |
| " This study aimed to determine whether the exacerbated upper limb motor-sensory deficits are mediated through benzodiazepine sites by demonstrating reversibility by flumazenil in patients with gliomas in eloquent areas." | 3.91 | Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas. ( Gelb, AW; Han, R; Hui, X; Lin, N; Zhang, K, 2019) |
| "Midazolam possesses antitumorigenic properties partly mediated by the peripheral benzodiazepine receptor, whereas dexmedetomidine promotes cancer cell survival through signaling via the α2-adrenoceptor in lung carcinoma and neuroglioma cells." | 3.88 | Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo. ( Bevan, C; Date, A; Datoo, T; Jiang, C; Ma, D; Sanders, RD; Wang, C; Wang, G; Wu, L; Zhao, H, 2018) |
| " Acute seizures were treated with intranasal midazolam." | 3.83 | Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study. ( Heimans, JJ; Koekkoek, JA; Postma, TJ; Reijneveld, JC; Taphoorn, MJ, 2016) |
| "In patients with high-grade glioma seizures occur relatively frequently during the end-of-life phase." | 1.40 | [Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase]. ( Boddaert, MS; Koekkoek, JA; Taphoorn, M, 2014) |
| "In animals without tumors, the temperature subcutaneously on the foot was 0." | 1.29 | Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model. ( Dahl, O; Krossnes, BK; Mella, O, 1996) |
Research
Studies (9)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Wang, C | 1 |
| Datoo, T | 1 |
| Zhao, H | 1 |
| Wu, L | 1 |
| Date, A | 1 |
| Jiang, C | 1 |
| Sanders, RD | 1 |
| Wang, G | 1 |
| Bevan, C | 1 |
| Ma, D | 1 |
| Lin, N | 1 |
| Han, R | 1 |
| Hui, X | 1 |
| Zhang, K | 1 |
| Gelb, AW | 1 |
| Vlisides, PE | 1 |
| Mashour, GA | 1 |
| Koekkoek, JA | 2 |
| Boddaert, MS | 1 |
| Taphoorn, M | 1 |
| Postma, TJ | 1 |
| Heimans, JJ | 1 |
| Reijneveld, JC | 1 |
| Taphoorn, MJ | 1 |
| Postovsky, S | 1 |
| Moaed, B | 1 |
| Krivoy, E | 1 |
| Ofir, R | 1 |
| Ben Arush, MW | 1 |
| Krossnes, BK | 1 |
| Mella, O | 1 |
| Dahl, O | 1 |
| Ishizawa, Y | 1 |
| Furuya, K | 1 |
| Yamagishi, S | 1 |
| Dohi, S | 1 |
| Massei, R | 1 |
| Baratta, P | 1 |
| Beretta, L | 1 |
| de Silva, E | 1 |
| Tomei, G | 1 |
| Gaini, SM | 1 |
| Rampini, P | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Remimazolam Tosilate for General Anesthesia on Prognosis After Bladder Cancer Surgery: a Randomized Controlled Trial[NCT04532606] | Phase 4 | 1,128 participants (Anticipated) | Interventional | 2021-02-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Other Studies
9 other studies available for midazolam and Glioma
| Article | Year |
|---|---|
Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dexmedetom | 2018 |
Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas.
Topics: Adult; Brain Neoplasms; Female; Flumazenil; GABA Modulators; Glioma; Humans; Hypnotics and Sedatives | 2019 |
Pharmacologic Unmasking of Neurologic Deficits: A Stress Test for the Brain.
Topics: Brain; Exercise Test; Flumazenil; Glioma; Humans; Midazolam; Upper Extremity | 2019 |
[Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase].
Topics: Anticonvulsants; Clonazepam; Epilepsy; Glioma; Humans; Midazolam; Seizures; Terminal Care | 2014 |
Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study.
Topics: Administration, Buccal; Administration, Intranasal; Aged; Brain Neoplasms; Clonazepam; Feasibility S | 2016 |
Practice of palliative sedation in children with brain tumors and sarcomas at the end of life.
Topics: Adolescent; Bone Neoplasms; Brain Neoplasms; Child; Combined Modality Therapy; Consciousness; Glioma | 2007 |
Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model.
Topics: Animals; Blood Pressure; Body Temperature; Butyrophenones; Fentanyl; Glioma; Hyperthermia, Induced; | 1996 |
Non-GABAergic effects of midazolam, diazepam and flumazenil on voltage-dependent ion currents in NG108-15 cells.
Topics: Animals; Calcium Channels; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyri | 1997 |
[Variations of intracranial pressure during induction with midazolam].
Topics: Adenoma; Adult; Anesthetics; Benzodiazepines; Brain Neoplasms; Cranial Nerve Neoplasms; Craniopharyn | 1985 |