Page last updated: 2024-10-31

midazolam and Glioma

midazolam has been researched along with Glioma in 9 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
" This study aimed to determine whether the exacerbated upper limb motor-sensory deficits are mediated through benzodiazepine sites by demonstrating reversibility by flumazenil in patients with gliomas in eloquent areas."7.91Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas. ( Gelb, AW; Han, R; Hui, X; Lin, N; Zhang, K, 2019)
"Midazolam possesses antitumorigenic properties partly mediated by the peripheral benzodiazepine receptor, whereas dexmedetomidine promotes cancer cell survival through signaling via the α2-adrenoceptor in lung carcinoma and neuroglioma cells."7.88Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo. ( Bevan, C; Date, A; Datoo, T; Jiang, C; Ma, D; Sanders, RD; Wang, C; Wang, G; Wu, L; Zhao, H, 2018)
" This study aimed to determine whether the exacerbated upper limb motor-sensory deficits are mediated through benzodiazepine sites by demonstrating reversibility by flumazenil in patients with gliomas in eloquent areas."3.91Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas. ( Gelb, AW; Han, R; Hui, X; Lin, N; Zhang, K, 2019)
"Midazolam possesses antitumorigenic properties partly mediated by the peripheral benzodiazepine receptor, whereas dexmedetomidine promotes cancer cell survival through signaling via the α2-adrenoceptor in lung carcinoma and neuroglioma cells."3.88Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo. ( Bevan, C; Date, A; Datoo, T; Jiang, C; Ma, D; Sanders, RD; Wang, C; Wang, G; Wu, L; Zhao, H, 2018)
" Acute seizures were treated with intranasal midazolam."3.83Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study. ( Heimans, JJ; Koekkoek, JA; Postma, TJ; Reijneveld, JC; Taphoorn, MJ, 2016)
"In patients with high-grade glioma seizures occur relatively frequently during the end-of-life phase."1.40[Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase]. ( Boddaert, MS; Koekkoek, JA; Taphoorn, M, 2014)
"In animals without tumors, the temperature subcutaneously on the foot was 0."1.29Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model. ( Dahl, O; Krossnes, BK; Mella, O, 1996)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's2 (22.22)18.2507
2000's1 (11.11)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, C1
Datoo, T1
Zhao, H1
Wu, L1
Date, A1
Jiang, C1
Sanders, RD1
Wang, G1
Bevan, C1
Ma, D1
Lin, N1
Han, R1
Hui, X1
Zhang, K1
Gelb, AW1
Vlisides, PE1
Mashour, GA1
Koekkoek, JA2
Boddaert, MS1
Taphoorn, M1
Postma, TJ1
Heimans, JJ1
Reijneveld, JC1
Taphoorn, MJ1
Postovsky, S1
Moaed, B1
Krivoy, E1
Ofir, R1
Ben Arush, MW1
Krossnes, BK1
Mella, O1
Dahl, O1
Ishizawa, Y1
Furuya, K1
Yamagishi, S1
Dohi, S1
Massei, R1
Baratta, P1
Beretta, L1
de Silva, E1
Tomei, G1
Gaini, SM1
Rampini, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Remimazolam Tosilate for General Anesthesia on Prognosis After Bladder Cancer Surgery: a Randomized Controlled Trial[NCT04532606]Phase 41,128 participants (Anticipated)Interventional2021-02-05Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

9 other studies available for midazolam and Glioma

ArticleYear
Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo.
    Anesthesiology, 2018, Volume: 129, Issue:5

    Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dexmedetom

2018
Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas.
    Anesthesiology, 2019, Volume: 131, Issue:1

    Topics: Adult; Brain Neoplasms; Female; Flumazenil; GABA Modulators; Glioma; Humans; Hypnotics and Sedatives

2019
Pharmacologic Unmasking of Neurologic Deficits: A Stress Test for the Brain.
    Anesthesiology, 2019, Volume: 131, Issue:1

    Topics: Brain; Exercise Test; Flumazenil; Glioma; Humans; Midazolam; Upper Extremity

2019
[Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase].
    Nederlands tijdschrift voor geneeskunde, 2014, Volume: 158, Issue:1

    Topics: Anticonvulsants; Clonazepam; Epilepsy; Glioma; Humans; Midazolam; Seizures; Terminal Care

2014
Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016, Volume: 24, Issue:4

    Topics: Administration, Buccal; Administration, Intranasal; Aged; Brain Neoplasms; Clonazepam; Feasibility S

2016
Practice of palliative sedation in children with brain tumors and sarcomas at the end of life.
    Pediatric hematology and oncology, 2007, Volume: 24, Issue:6

    Topics: Adolescent; Bone Neoplasms; Brain Neoplasms; Child; Combined Modality Therapy; Consciousness; Glioma

2007
Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model.
    International journal of radiation oncology, biology, physics, 1996, Sep-01, Volume: 36, Issue:2

    Topics: Animals; Blood Pressure; Body Temperature; Butyrophenones; Fentanyl; Glioma; Hyperthermia, Induced;

1996
Non-GABAergic effects of midazolam, diazepam and flumazenil on voltage-dependent ion currents in NG108-15 cells.
    Neuroreport, 1997, Jul-28, Volume: 8, Issue:11

    Topics: Animals; Calcium Channels; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyri

1997
[Variations of intracranial pressure during induction with midazolam].
    Minerva anestesiologica, 1985, Volume: 51, Issue:10

    Topics: Adenoma; Adult; Anesthetics; Benzodiazepines; Brain Neoplasms; Cranial Nerve Neoplasms; Craniopharyn

1985