Page last updated: 2024-10-31

midazolam and Fatty Liver

midazolam has been researched along with Fatty Liver in 3 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.

Research Excerpts

ExcerptRelevanceReference
"Propofol is a widely used rapidly acting sedating or hypnotic agent in the intensive care setting."5.35Isolated fatty liver from prolonged propofol use in a pediatric patient with refractory status epilepticus. ( Ko, DY; Rison, RA, 2009)
"Caffeine elimination was accelerated by microvesicular steatosis, whereas midazolam elimination was delayed in macrovesicular steatosis."1.72Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism. ( Albadry, M; Böttcher, M; Christ, B; Christ, M; Dahmen, U; Dirsch, O; Ehteshamzad, N; Höpfl, S; Klopfleisch, R; König, M; Laue, H; Lupp, A; Neumann, J; Radde, N; Schwen, LO, 2022)
" An abnormal liver function test likely gives the clinician a hint about dosage adjustment."1.42Serum alanine transaminase total bilirubin concentrations predict CYP3A activity as measured by midazolam and 1'-hydroxylation. ( He, R; Li, Y; Ruan, J, 2015)
"Propofol is a widely used rapidly acting sedating or hypnotic agent in the intensive care setting."1.35Isolated fatty liver from prolonged propofol use in a pediatric patient with refractory status epilepticus. ( Ko, DY; Rison, RA, 2009)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Albadry, M2
Höpfl, S2
Ehteshamzad, N2
König, M2
Böttcher, M2
Neumann, J2
Lupp, A2
Dirsch, O2
Radde, N2
Christ, B2
Christ, M2
Schwen, LO2
Laue, H2
Klopfleisch, R2
Dahmen, U2
He, R1
Li, Y1
Ruan, J1
Rison, RA1
Ko, DY1

Other Studies

3 other studies available for midazolam and Fatty Liver

ArticleYear
Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism.
    Scientific reports, 2022, 12-17, Volume: 12, Issue:1

    Topics: Animals; Caffeine; Cytochrome P-450 Enzyme System; Fatty Liver; Metabolic Clearance Rate; Mice; Mida

2022
Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism.
    Scientific reports, 2022, 12-17, Volume: 12, Issue:1

    Topics: Animals; Caffeine; Cytochrome P-450 Enzyme System; Fatty Liver; Metabolic Clearance Rate; Mice; Mida

2022
Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism.
    Scientific reports, 2022, 12-17, Volume: 12, Issue:1

    Topics: Animals; Caffeine; Cytochrome P-450 Enzyme System; Fatty Liver; Metabolic Clearance Rate; Mice; Mida

2022
Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism.
    Scientific reports, 2022, 12-17, Volume: 12, Issue:1

    Topics: Animals; Caffeine; Cytochrome P-450 Enzyme System; Fatty Liver; Metabolic Clearance Rate; Mice; Mida

2022
Serum alanine transaminase total bilirubin concentrations predict CYP3A activity as measured by midazolam and 1'-hydroxylation.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, Feb-04, Volume: 21

    Topics: Alanine Transaminase; Analysis of Variance; Bilirubin; Biomarkers; Cytochrome P-450 CYP3A; End Stage

2015
Isolated fatty liver from prolonged propofol use in a pediatric patient with refractory status epilepticus.
    Clinical neurology and neurosurgery, 2009, Volume: 111, Issue:6

    Topics: Adolescent; Anticonvulsants; Fatty Liver; Female; Humans; Midazolam; Propofol; Status Epilepticus; T

2009