midazolam has been researched along with Epilepsy, Temporal Lobe in 6 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous human studies have demonstrated that midazolam-induced signal changes on scalp EEG recording include widespread augmentation of sigma-oscillations and that the amplitude of such oscillations is correlated to the severity of midazolam-induced amnesia." | 3.75 | In-vivo animation of midazolam-induced electrocorticographic changes in humans. ( Asano, E; Nishida, M; Sood, S, 2009) |
| "The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats." | 3.74 | Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy. ( Danhof, M; Gunput, RA; Liefaard, LC; Voskuyl, RA, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shima, A | 1 |
| Nitta, N | 2 |
| Suzuki, F | 3 |
| Laharie, AM | 1 |
| Nozaki, K | 1 |
| Depaulis, A | 2 |
| Mitsuya, K | 2 |
| Nishida, M | 1 |
| Sood, S | 1 |
| Asano, E | 1 |
| Heinrich, C | 1 |
| Boehrer, A | 1 |
| Kurokawa, K | 1 |
| Matsuda, M | 1 |
| Butler, T | 1 |
| Liefaard, LC | 1 |
| Gunput, RA | 1 |
| Danhof, M | 1 |
| Voskuyl, RA | 1 |
6 other studies available for midazolam and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Disease Model | 2015 |
Persistent zinc depletion in the mossy fiber terminals in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Carrier Proteins; Cation Transport Proteins; Disease Models, Animal; Electroencephalography | 2009 |
In-vivo animation of midazolam-induced electrocorticographic changes in humans.
Topics: Action Potentials; Adolescent; Amnesia; Anesthetics, Intravenous; Anticonvulsants; Biological Clocks | 2009 |
Glutamate receptor antagonists and benzodiazepine inhibit the progression of granule cell dispersion in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Benzodiazepines; Cell Count; Dentate Gyrus; Disease Models, Animal; Dizocilpine Maleate; Ep | 2005 |
Central and peripheral benzodiazepine receptors.
Topics: Animals; Benzodiazepines; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Epilepsy, Te | 2006 |
Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Beta Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Tem | 2007 |