Page last updated: 2024-10-31

midazolam and Epilepsy, Complex Partial

midazolam has been researched along with Epilepsy, Complex Partial in 2 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Epilepsy, Complex Partial: A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)

Research Excerpts

Excerpt	Relevance	Reference
" We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal administration of liquid diazepam in the acute treatment of seizures."	9.09	Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. ( Besag, FM; Neville, BG; Scott, RC, 1999)
" We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal administration of liquid diazepam in the acute treatment of seizures."	5.09	Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. ( Besag, FM; Neville, BG; Scott, RC, 1999)

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Cortina, J	1
Ancillo, P	1
Duarte, J	1
Sempere, AP	1
Coria, F	1
Clavería, LE	1
Scott, RC	1
Besag, FM	1
Neville, BG	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612]			Phase 2	358 participants (Actual)	Interventional	2006-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Seizure After Study Medication Administration

Length of seizure. (NCT00326612)
Timeframe: 24 hours

Intervention	Minutes (Median)
Intranasal Midazolam	3.0
Rectal Diazepam	4.3

Number of Patients Needed to be Seen or Treated in the Emergency Department for Their Seizure and Use of Study Medication.

(NCT00326612)
Timeframe: 24 hours

Intervention	participants (Number)
Intranasal Midazolam	21
Rectal Diazepam	17

Number of Patients That Were Admitted to the Hospital After Their Seizure and Use of Study Medication.

(NCT00326612)
Timeframe: 24 hours

Intervention	participants (Number)
Intranasal Midazolam	4
Rectal Diazepam	3

Number of Patients Who Had a Repeat Seizure Within 12 Hours After Their Seizure Who Used Study Medication

(NCT00326612)
Timeframe: 12 hours

Intervention	participants (Number)
Intranasal Midazolam	1
Rectal Diazepam	1

Number of Patients Who Needed Additional Medication to Treat the Seizure in the Emergency Department Within 24 Hours

(NCT00326612)
Timeframe: 24 hours

Intervention	participants (Number)
Intranasal Midazolam	5
Rectal Diazepam	5

Respiratory Depression Requiring Intubation

Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours

Intervention	participants (Number)
Intranasal Midazolam	1
Rectal Diazepam	0

Respiratory Depression Requiring Oxygen at Discharge From the Emergency Department.

Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours

Intervention	participants (Number)
Intranasal Midazolam	3
Rectal Diazepam	1

Trials

1 trial available for midazolam and Epilepsy, Complex Partial

Article	Year
Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. Lancet (London, England), 1999, Feb-20, Volume: 353, Issue:9153 Topics: Administration, Buccal; Administration, Rectal; Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsa	1999

Other Studies

1 other study available for midazolam and Epilepsy, Complex Partial

Article	Year
Intravenous midazolam suppression of complex partial status refractory to intravenous phenytoin and diazepam. Clinical neuropharmacology, 1993, Volume: 16, Issue:5 Topics: Diazepam; Epilepsy, Complex Partial; Female; Humans; Injections, Intravenous; Midazolam; Middle Aged	1993