midazolam has been researched along with Endotoxemia in 3 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, midazolam given in the designated dosage did not offer any modulatory effects on hemodynamic responses, multiple organic dysfunction and survival rate in rats with endotoxemia." | 7.75 | Effects of midazolam on organ dysfunction in rats with endotoxemia induced by lipopolysaccharide. ( Ho, ST; Liaw, WJ; Tsao, CM; Wu, CC, 2009) |
| " However, midazolam given in the designated dosage did not offer any modulatory effects on hemodynamic responses, multiple organic dysfunction and survival rate in rats with endotoxemia." | 3.75 | Effects of midazolam on organ dysfunction in rats with endotoxemia induced by lipopolysaccharide. ( Ho, ST; Liaw, WJ; Tsao, CM; Wu, CC, 2009) |
| "Midazolam sleep time was prolonged by lipopolysaccharide." | 1.30 | Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia. ( Funae, Y; Hirohashi, K; Imaoka, S; Inoue, M; Kinoshita, H; Minamiyama, Y; Takemura, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kato, R | 1 |
| Yamashita, S | 1 |
| Moriguchi, J | 1 |
| Nakagawa, M | 1 |
| Tsukura, Y | 1 |
| Uchida, K | 1 |
| Amano, F | 1 |
| Hirotani, Y | 1 |
| Ijiri, Y | 1 |
| Tanaka, K | 1 |
| Tsao, CM | 1 |
| Wu, CC | 1 |
| Liaw, WJ | 1 |
| Ho, ST | 1 |
| Takemura, S | 1 |
| Minamiyama, Y | 1 |
| Imaoka, S | 1 |
| Funae, Y | 1 |
| Hirohashi, K | 1 |
| Inoue, M | 1 |
| Kinoshita, H | 1 |
3 other studies available for midazolam and Endotoxemia
| Article | Year |
|---|---|
Changes of midazolam pharmacokinetics in Wistar rats treated with lipopolysaccharide: relationship between total CYP and CYP3A2.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cyto | 2008 |
Effects of midazolam on organ dysfunction in rats with endotoxemia induced by lipopolysaccharide.
Topics: Adjuvants, Anesthesia; Animals; Endotoxemia; Hemodynamics; Lipopolysaccharides; Male; Midazolam; Mul | 2009 |
Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endotoxemia; Hydroxylat | 1999 |