midazolam has been researched along with Encephalopathy, Hepatic in 10 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol-based sedation exacerbated MHE after EIS similarly to midazolam-based sedation in patients with liver cirrhosis." | 9.27 | Propofol is a more effective and safer sedative agent than midazolam in endoscopic injection sclerotherapy for esophageal varices in patients with liver cirrhosis: a randomized controlled trial. ( Hashimoto, M; Hikichi, T; Irie, H; Kikuchi, H; Konno, N; Nakamura, J; Obara, K; Ohira, H; Sato, Y; Sugimoto, M; Suzuki, R; Takagi, T; Takasumi, M; Watanabe, K, 2018) |
| "Sedation with propofol has a shorter time recovery and a shorter time to discharge than midazolam and does not exacerbate sub-clinical hepatic encephalopathy in patients with compensated liver cirrhosis." | 9.15 | Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study. ( Alex, I; Kamal, D; Khamaysi, I; Nimer, A; Olga, A; Vladimir, M; William, N, 2011) |
| "Midazolam sedation for upper gastrointestinal (GI) endoscopy exacerbates minimal hepatic encephalopathy (HE) in patients with liver cirrhosis, therefore an alternative drug regimen for these patients is warranted." | 9.14 | Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study. ( Frenz, MB; Lechowicz, I; Riphaus, A; Wehrmann, T, 2009) |
| "The purpose of this report is to describe the use of flumazenil as a diagnostic aid in the differential diagnosis of coma in a patient with an inadvertent overdose of benzodiazepines." | 7.69 | Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient. ( McLachlan, RS; Sharpe, MD; Sprenger, H, 1994) |
| "Propofol-based sedation exacerbated MHE after EIS similarly to midazolam-based sedation in patients with liver cirrhosis." | 5.27 | Propofol is a more effective and safer sedative agent than midazolam in endoscopic injection sclerotherapy for esophageal varices in patients with liver cirrhosis: a randomized controlled trial. ( Hashimoto, M; Hikichi, T; Irie, H; Kikuchi, H; Konno, N; Nakamura, J; Obara, K; Ohira, H; Sato, Y; Sugimoto, M; Suzuki, R; Takagi, T; Takasumi, M; Watanabe, K, 2018) |
| "Sedation with propofol has a shorter time recovery and a shorter time to discharge than midazolam and does not exacerbate sub-clinical hepatic encephalopathy in patients with compensated liver cirrhosis." | 5.15 | Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study. ( Alex, I; Kamal, D; Khamaysi, I; Nimer, A; Olga, A; Vladimir, M; William, N, 2011) |
| "Midazolam sedation for upper gastrointestinal (GI) endoscopy exacerbates minimal hepatic encephalopathy (HE) in patients with liver cirrhosis, therefore an alternative drug regimen for these patients is warranted." | 5.14 | Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study. ( Frenz, MB; Lechowicz, I; Riphaus, A; Wehrmann, T, 2009) |
| "The results of this study indicate that (1) the majority of patients with cirrhosis and suspected portal hypertension have evidence of subclinical hepatic encephalopathy, (2) the extent of encephalopathy correlates with the Child Pugh's score, (3) sedation with midazolam for upper GI endoscopy exacerbates the encephalopathy, and (4) this adverse effect is still evident 2 hours after the procedure." | 5.09 | Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis. ( Assy, N; Grahame, GR; Minuk, GY; Rosser, BG, 1999) |
| "The objective of this study was to determine the frequency of clinically overt hepatic encephalopathy (HE) in cirrhotic patients undergoing diagnostic or therapeutic upper gastrointestinal endoscopy (UGE) who received midazolam for sedation." | 3.78 | Midazolam for sedation during diagnostic or therapeutic upper gastrointestinal endoscopy in cirrhotic patients. ( Arain, N; Faisal, N; Haq, MM; Haqqi, SA; Khalil, A; Shaikh, H, 2012) |
| "The purpose of this report is to describe the use of flumazenil as a diagnostic aid in the differential diagnosis of coma in a patient with an inadvertent overdose of benzodiazepines." | 3.69 | Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient. ( McLachlan, RS; Sharpe, MD; Sprenger, H, 1994) |
| "Midazolam was associated with the deterioration of psychometric scores for a longer period than propofol." | 2.52 | Propofol versus midazolam for upper gastrointestinal endoscopy in cirrhotic patients: a meta-analysis of randomized controlled trials. ( Chen, CY; Chen, TL; Ko, CL; Lin, YC; Lou, HY; Tam, KW; Tsai, HC, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jeong, J | 1 |
| Jung, K | 1 |
| Seo, KI | 1 |
| Yun, BC | 1 |
| Han, BH | 1 |
| Lee, SU | 1 |
| Moon, W | 1 |
| Watanabe, K | 1 |
| Hikichi, T | 1 |
| Takagi, T | 1 |
| Suzuki, R | 1 |
| Nakamura, J | 1 |
| Sugimoto, M | 1 |
| Kikuchi, H | 1 |
| Konno, N | 1 |
| Takasumi, M | 1 |
| Sato, Y | 1 |
| Hashimoto, M | 1 |
| Irie, H | 1 |
| Obara, K | 1 |
| Ohira, H | 1 |
| Tsai, HC | 1 |
| Lin, YC | 1 |
| Ko, CL | 1 |
| Lou, HY | 1 |
| Chen, TL | 1 |
| Tam, KW | 1 |
| Chen, CY | 1 |
| Riphaus, A | 1 |
| Lechowicz, I | 1 |
| Frenz, MB | 1 |
| Wehrmann, T | 1 |
| Khamaysi, I | 1 |
| William, N | 1 |
| Olga, A | 1 |
| Alex, I | 1 |
| Vladimir, M | 1 |
| Kamal, D | 1 |
| Nimer, A | 1 |
| Sharma, P | 1 |
| Singh, S | 1 |
| Sharma, BC | 1 |
| Haq, MM | 1 |
| Faisal, N | 1 |
| Khalil, A | 1 |
| Haqqi, SA | 1 |
| Shaikh, H | 1 |
| Arain, N | 1 |
| Velioğlu, SK | 1 |
| Gazioğlu, S | 1 |
| Sprenger, H | 1 |
| Sharpe, MD | 1 |
| McLachlan, RS | 1 |
| Assy, N | 1 |
| Rosser, BG | 1 |
| Grahame, GR | 1 |
| Minuk, GY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Gastroesophageal Varices in Cirrhotic and Non-cirrhotic Patients With Portal Hypertension by Transnasal Endoscopy.[NCT02767206] | 50 participants (Actual) | Observational | 2016-03-31 | Enrolling by invitation | |||
| A New Technique to Enhance Detection of Small Esophageal Varices by PillCam ESO Capsule Endoscopy[NCT00911131] | Phase 3 | 0 participants (Actual) | Interventional | Withdrawn (stopped due to Loss of funding) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for midazolam and Encephalopathy, Hepatic
| Article | Year |
|---|---|
Propofol versus midazolam for upper gastrointestinal endoscopy in cirrhotic patients: a meta-analysis of randomized controlled trials.
Topics: Anesthesia Recovery Period; Bradycardia; Deep Sedation; Endoscopy, Gastrointestinal; Fibrosis; Hepat | 2015 |
5 trials available for midazolam and Encephalopathy, Hepatic
| Article | Year |
|---|---|
Propofol is a more effective and safer sedative agent than midazolam in endoscopic injection sclerotherapy for esophageal varices in patients with liver cirrhosis: a randomized controlled trial.
Topics: Aged; Esophageal and Gastric Varices; Female; Hepatic Encephalopathy; Humans; Hypnotics and Sedative | 2018 |
Propofol sedation for upper gastrointestinal endoscopy in patients with liver cirrhosis as an alternative to midazolam to avoid acute deterioration of minimal encephalopathy: a randomized, controlled study.
Topics: Aged; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Female; Hepatic Encephalopathy; H | 2009 |
Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: a randomized controlled study.
Topics: Adult; Aged; Anesthesia Recovery Period; Cognition; Conscious Sedation; Endoscopy, Gastrointestinal; | 2011 |
Propofol in patients with cirrhosis and minimal hepatic encephalopathy.
Topics: Anesthetics, Intravenous; Endoscopy, Gastrointestinal; Hepatic Encephalopathy; Humans; Liver Cirrhos | 2011 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |
Risk of sedation for upper GI endoscopy exacerbating subclinical hepatic encephalopathy in patients with cirrhosis.
Topics: Adult; Analysis of Variance; Anesthetics, Intravenous; Chi-Square Distribution; Conscious Sedation; | 1999 |
4 other studies available for midazolam and Encephalopathy, Hepatic
| Article | Year |
|---|---|
Propofol alone prevents worsening hepatic encephalopathy rather than midazolam alone or combined sedation after esophagogastroduodenoscopy in compensated or decompensated cirrhotic patients.
Topics: Conscious Sedation; Endoscopy, Digestive System; Hepatic Encephalopathy; Humans; Hypnotics and Sedat | 2020 |
Midazolam for sedation during diagnostic or therapeutic upper gastrointestinal endoscopy in cirrhotic patients.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Conscious Sedation; Endoscopy, Gastrointestinal | 2012 |
Non-convulsive status epilepticus secondary to valproic acid-induced hyperammonemic encephalopathy.
Topics: Adult; Ammonia; Anticonvulsants; Brain; Electroencephalography; Hepatic Encephalopathy; Humans; Hype | 2007 |
Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient.
Topics: Aged; Bacterial Infections; Coma; Critical Illness; Diagnosis, Differential; Diazepam; Flumazenil; H | 1994 |