Page last updated: 2024-10-31

midazolam and Emesis

midazolam has been researched along with Emesis in 45 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Research Excerpts

ExcerptRelevanceReference
"The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain."9.69Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023)
"One hundred and twenty children, 1-9 years old, undergoing elective strabismus surgery, were randomly assigned to receive sevoflurane or remifentanil."9.13Effect of remifentanil on oculocardiac reflex in paediatric strabismus surgery. ( Choi, SR; Chung, CJ; Lee, JH; Lee, JM; Lee, SC, 2008)
"With the introduction of midazolam, 73% of patients had a reduction of at least one grade in nausea and vomiting intensity in comparison with the previous cycle of chemotherapy."9.11Midazolam for acute emesis refractory to dexamethasone and granisetron after highly emetogenic chemotherapy: a phase II study. ( Barni, S; Cabiddu, M; Cazzaniga, M; Cremonesi, M; Di Cosimo, S; Ferretti, G; Ghilardi, M; Mandalà, M; Rocca, A, 2005)
" The aim of this study was to investigate whether propofol influences vomiting induced by the dopamine agonist apomorphine."9.08The influence of propofol on vomiting induced by apomorphine. ( Hammas, B; Hvarfner, A; Thörn, SE; Wattwil, M, 1995)
"The purpose of this study was to assess the effect of midazolam on vomiting after tonsillectomy in children."9.08Midazolam reduces vomiting after tonsillectomy in children. ( Gould, MH; MacNeill, HB; Menard, EA; Rhine, EJ; Roberts, DJ; Splinter, WM, 1995)
"This is a prospective randomized double-blind trial conducted to determine whether preoperative orally administered clonidine causes or potentiates postoperative vomiting in 140 children (3-12 yr) undergoing strabismus surgery."9.08Oral clonidine premedication reduces vomiting in children after strabismus surgery. ( Asano, M; Maekawa, N; Mikawa, K; Nishina, K; Obara, H, 1995)
"This prospective study evaluated the effects of continuous sedation using midazolam, with or without remifentanil, on postoperative nausea and vomiting (PONV) in patients undergoing myringoplasty."7.78Postoperative nausea and vomiting after myringoplasty under continuous sedation using midazolam with or without remifentanil. ( Hwang, SM; Jang, JS; Lee, JH; Lee, JJ; Lee, SK; Lim, SY; Park, WJ, 2012)
"Forty-five breast cancer patients were randomized into three groups: Group I--chemotherapy, control, Group II--midazolam+chemotherapy, and Group III--propofol+chemotherapy."6.71Effect of sedation with midazolam or propofol on patient's comfort during cancer chemotherapy infusion: a prospective, randomized, double-blind study in breast cancer patients. ( Argun, G; Baran, O; Dikmen Mentes, S; Ertunc, FN; Unsal, D, 2005)
"The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain."5.69Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023)
"One hundred and twenty children, 1-9 years old, undergoing elective strabismus surgery, were randomly assigned to receive sevoflurane or remifentanil."5.13Effect of remifentanil on oculocardiac reflex in paediatric strabismus surgery. ( Choi, SR; Chung, CJ; Lee, JH; Lee, JM; Lee, SC, 2008)
"With the introduction of midazolam, 73% of patients had a reduction of at least one grade in nausea and vomiting intensity in comparison with the previous cycle of chemotherapy."5.11Midazolam for acute emesis refractory to dexamethasone and granisetron after highly emetogenic chemotherapy: a phase II study. ( Barni, S; Cabiddu, M; Cazzaniga, M; Cremonesi, M; Di Cosimo, S; Ferretti, G; Ghilardi, M; Mandalà, M; Rocca, A, 2005)
" The aim of this study was to investigate whether propofol influences vomiting induced by the dopamine agonist apomorphine."5.08The influence of propofol on vomiting induced by apomorphine. ( Hammas, B; Hvarfner, A; Thörn, SE; Wattwil, M, 1995)
"The purpose of this study was to assess the effect of midazolam on vomiting after tonsillectomy in children."5.08Midazolam reduces vomiting after tonsillectomy in children. ( Gould, MH; MacNeill, HB; Menard, EA; Rhine, EJ; Roberts, DJ; Splinter, WM, 1995)
"This is a prospective randomized double-blind trial conducted to determine whether preoperative orally administered clonidine causes or potentiates postoperative vomiting in 140 children (3-12 yr) undergoing strabismus surgery."5.08Oral clonidine premedication reduces vomiting in children after strabismus surgery. ( Asano, M; Maekawa, N; Mikawa, K; Nishina, K; Obara, H, 1995)
" The incidence of vomiting during the postoperative period was 31% in the codeine-group and 40% in the ketorolac-group."5.08Preoperative ketorolac increases bleeding after tonsillectomy in children. ( MacNeill, HB; Reid, CW; Rhine, EJ; Roberts, DW; Splinter, WM, 1996)
"Droperidol can reduce the high incidence of vomiting after pediatric strabismus surgery; however, its use may be associated with sedation, delayed hospital discharge, dysphoria and extrapyramidal signs."5.07Antiemetic prophylaxis for strabismus surgery. ( Bonn, G; Clarke, W; Noël, LP; Rhine, E; Roberts, D; Splinter, W, 1994)
" Our anesthetic protocol for strabismus surgery included postoperative nausea and vomiting prevention using dexamethasone and ondansetron."3.91Prospective evaluation of anesthetic protocols during pediatric ophthalmic surgery. ( Couret, C; Ducloyer, JB; Le Meur, G; Lebranchu, P; Lejus-Bourdeau, C; Magne, C; Weber, M, 2019)
"Midazolam and ketamine were administered consecutively by intravenous route under cardiorespiratory monitoring for painful procedures of pediatric hematology."3.81The Efficacy and Safety of Procedural Sedoanalgesia with Midazolam and Ketamine in Pediatric Hematology. ( Çakmak, E; Demirsoy, U; Gelen, SA; Sarper, N; Zengin, E, 2015)
"This prospective study evaluated the effects of continuous sedation using midazolam, with or without remifentanil, on postoperative nausea and vomiting (PONV) in patients undergoing myringoplasty."3.78Postoperative nausea and vomiting after myringoplasty under continuous sedation using midazolam with or without remifentanil. ( Hwang, SM; Jang, JS; Lee, JH; Lee, JJ; Lee, SK; Lim, SY; Park, WJ, 2012)
"We conducted a prospective observational study of postdischarge behavioral changes and vomiting after sedation with ketamine, ketamine/midazolam, or fentanyl/midazolam."3.75Procedural sedation and analgesia outcomes in children after discharge from the emergency department: ketamine versus fentanyl/midazolam. ( Kaye, E; Kido, MM; Krauss, B; McQueen, A; Wright, RO, 2009)
" Patients receiving ketamine with or without midazolam experienced fewer respiratory adverse events but more vomiting than the commonly used combination of midazolam and fentanyl."3.73Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs. ( Bajaj, L; Bothner, JP; Roback, MG; Wathen, JE, 2005)
" For management of postoperative muscle spasm, an intravenous benzodiazepine was used (diazepam 0."3.69Pain management for children following selective dorsal rhizotomy. ( Geiduschek, JM; Haberkern, CM; Hays, RM; Jacobson, LE; McLaughlin, JF; Roberts, TS, 1994)
"We report difficulty with conscious sedation of a child taking methylphenidate for attention deficit disorder and possible delayed adverse interaction of ketamine and methylphenidate resulting in severe nausea, vomiting and dehydration."3.69Unexpected interaction of methylphenidate (Ritalin) with anaesthetic agents. ( Fox, L; Ririe, DG; Ririe, KL; Sethna, NF, 1997)
"Children with cancer often require sedation before undergoing invasive procedures."3.11The efficacy and safety of midazolam with fentanyl versus midazolam with ketamine for bedside invasive procedural sedation in pediatric oncology patients: A randomized, double-blinded, crossover trial. ( Lertvivatpong, N; Malaithong, W; Monsereenusorn, C; Photia, A; Rujkijyanont, P; Traivaree, C, 2022)
" Blood samples were collected predose and at selected time points up to 24 hours after dosing with midazolam for measurement of midazolam pharmacokinetic parameters."2.73Cinacalcet does not affect the activity of cytochrome P450 3A enzymes, a metabolic pathway for common immunosuppressive agents : a randomized, open-label, crossover, single-centre study in healthy volunteers. ( Emery, M; Padhi, D; Salfi, M, 2008)
"Forty-five breast cancer patients were randomized into three groups: Group I--chemotherapy, control, Group II--midazolam+chemotherapy, and Group III--propofol+chemotherapy."2.71Effect of sedation with midazolam or propofol on patient's comfort during cancer chemotherapy infusion: a prospective, randomized, double-blind study in breast cancer patients. ( Argun, G; Baran, O; Dikmen Mentes, S; Ertunc, FN; Unsal, D, 2005)
" Pharmacokinetic variables were determined by noncompartmental analysis."2.70The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam. ( Feldman, J; Ibrahim, A; Karim, A; Kharasch, E, 2002)
"There were less retching, gagging and salivation in the combination group compared to midazolam alone."2.67Sedation for gastroscopy: a comparison between midazolam and midazolam with nalbuphine. ( Chin, KW; Chin, MK; Tan, PK, 1994)
"Midazolam was found to be more effective than ketobemidone in reducing anxiety among more tense patients--those with a VAS grading before premedication of 2 or more (P less than 0."2.67Premedication before elective breast surgery, a comparison between ketobemidone and midazolam. ( Andersson, L; Askergren, J; Davidson, S; Jakobsson, J; Nilsson, A, 1991)
" The purpose of this study was to identify the factors and procedure time associated with the use of intravenous sedation with propofol alone or propofol combined with midazolam in dental patients with special needs."1.62A comparative study of propofol alone and propofol combined with midazolam for dental treatments in special needs patients. ( Chen, SL; Chong, SY; Huang, MS; Huang, TS; Lin, IH; Tsai, HH; Wang, PY, 2021)
"The study investigated patient discharge parameters and postdischarge adverse events after discharge among children who received oral conscious sedation for dental treatment."1.42Oral Sedation Postdischarge Adverse Events in Pediatric Dental Patients. ( Huang, A; Tanbonliong, T, 2015)
" We characterize the fasting status of patients receiving procedural sedation and analgesia in a pediatric ED and assess the relationship between fasting status and adverse events."1.32Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department. ( Agrawal, D; Gupta, R; Krauss, B; Manzi, SF, 2003)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.22)18.7374
1990's17 (37.78)18.2507
2000's15 (33.33)29.6817
2010's8 (17.78)24.3611
2020's4 (8.89)2.80

Authors

AuthorsStudies
Cortellazzo Wiel, L1
Monasta, L1
Pascolo, P1
Servidio, AG1
Levantino, L1
Fasoli, S1
Saccari, A1
Cozzi, G1
Barbi, E1
Monsereenusorn, C1
Malaithong, W1
Lertvivatpong, N1
Photia, A1
Rujkijyanont, P1
Traivaree, C1
Brant, AR1
Reeves, MF1
Ye, PP1
Scott, RK1
Floyd, S1
Tefera, E1
Lotke, PS1
Lin, IH1
Huang, MS1
Wang, PY1
Huang, TS1
Chong, SY1
Chen, SL1
Tsai, HH1
Ducloyer, JB1
Couret, C1
Magne, C1
Lejus-Bourdeau, C1
Weber, M1
Le Meur, G1
Lebranchu, P1
Chan, S1
Weinstein, AR1
Ritwik, P1
Cao, LT1
Curran, R1
Musselman, RJ1
Weichselbaumer, E1
Weixler, D1
Gelen, SA1
Sarper, N1
Demirsoy, U1
Zengin, E1
Çakmak, E1
Huang, A1
Tanbonliong, T1
Breuer, L1
Kasper, BS1
Schwarze, B1
Gschossmann, JM1
Kornhuber, J1
Müller, HH1
Padhi, D1
Salfi, M1
Emery, M1
Chung, CJ1
Lee, JM1
Choi, SR1
Lee, SC1
Lee, JH2
Dilli, D1
Dallar, Y1
Sorgui, NH1
McQueen, A1
Wright, RO1
Kido, MM1
Kaye, E1
Krauss, B2
Jang, JS1
Lee, JJ1
Park, WJ1
Hwang, SM1
Lee, SK1
Lim, SY1
Ibrahim, A1
Karim, A1
Feldman, J1
Kharasch, E1
Tamura, M1
Nakamura, K1
Kitamura, R1
Kitagawa, S1
Mori, N1
Ueda, Y1
Agrawal, D1
Manzi, SF1
Gupta, R1
Mandalà, M1
Cremonesi, M1
Rocca, A1
Cazzaniga, M1
Ferretti, G1
Di Cosimo, S1
Ghilardi, M1
Cabiddu, M1
Barni, S1
Roback, MG1
Wathen, JE1
Bajaj, L1
Bothner, JP1
Tobias, JD1
Dikmen Mentes, S1
Unsal, D1
Baran, O1
Argun, G1
Ertunc, FN1
Jacoby, J1
Heller, M1
Nicholas, J1
Patel, N1
Cesta, M1
Smith, G1
Jacob, S1
Reed, J1
Lu, DP1
Lu, WI1
Bleiberg, AH1
Salvaggio, CA1
Roy, LC1
Kassutto, Z1
Munro, A1
Machonochie, I1
Hvarfner, A1
Hammas, B1
Thörn, SE1
Wattwil, M1
Splinter, WM2
MacNeill, HB2
Menard, EA1
Rhine, EJ2
Roberts, DJ1
Gould, MH1
Splinter, W1
Noël, LP1
Roberts, D1
Rhine, E1
Bonn, G1
Clarke, W1
Chin, KW1
Tan, PK1
Chin, MK1
Geiduschek, JM1
Haberkern, CM1
McLaughlin, JF1
Jacobson, LE1
Hays, RM1
Roberts, TS1
Di Florio, T2
Goucke, R1
Bryant, DG1
Williams, MD1
Mikawa, K1
Nishina, K1
Maekawa, N1
Asano, M1
Obara, H1
Rose, JB1
Brenn, BR1
Corddry, DH1
Thomas, PC1
Roberts, DW1
Reid, CW1
Ririe, DG1
Ririe, KL1
Sethna, NF1
Fox, L1
Sanderson, PM1
Loeb, P1
Adnet, P1
Boittiaux, P1
Forget, AP1
Mille, FX1
Parnis, SJ1
Foate, JA1
van der Walt, JH1
Short, T1
Crowe, CE1
Jakobsson, J1
Andersson, L1
Nilsson, A1
Davidson, S1
Askergren, J1
Jakobbson, J1
Andreen, M1
Westgren, M1
Thomasson, K1
Olynyk, JK1
Cullen, SR1
Leahy, MF1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Gabapentin as an Adjunct for Pain Management During Dilation and Evacuation: A Double-blind Randomized Controlled Trial[NCT03635905]Phase 4130 participants (Actual)Interventional2017-05-26Completed
Do Patients Need Pre-Procedural Fasting for Coronary Artery Procedures?[NCT02562638]240 participants (Anticipated)Interventional2015-10-31Not yet recruiting
A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation[NCT03255824]Phase 4144 participants (Actual)Interventional2018-03-20Completed
Comparison of Ketamine Versus Co-Administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department[NCT01387139]Phase 3183 participants (Actual)Interventional2011-01-31Completed
US Guided Interscalene Block Compared With Sedation for Shoulder Dislocation Reduction in the ER[NCT03041506]90 participants (Anticipated)Interventional2017-02-15Not yet recruiting
Positive Imagery Therapy and the Incidence of Emergence Reactions With the Use of Ketamine[NCT04746079]180 participants (Anticipated)Interventional2021-02-05Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cooperation Scale

Surgeon satisfaction is measured by the Cooperation Scale. Minimum score of 0 and maximum of 9. Higher indicates a worse outcome (i.e., discomfort and movement) (NCT03255824)
Timeframe: 15 minutes following surgery

Interventionscore on a scale (Mean)
Propofol Group2.07
Dexmedetomidine Group1.47

Hemodynamic Stability - Blood Pressure

"To compare the differences in hemodynamic stability using a D/M combination compared to the MFP combination. (In this study, a deviation from baseline by 20% or greater will be considered clinically significant)~a. Change in blood pressure (NIBP) (change ≥ 20%) Blood pressure is presented as mean arterial pressure" (NCT03255824)
Timeframe: During the procedure, up to 40 minutes

Interventionmm Hg (Mean)
Propofol Group78
Dexmedetomidine Group88

Hemodynamic Stability - Heart Rate

"To compare the differences in hemodynamic stability using a D/M combination compared to the MFP combination. (In this study, a deviation from baseline of both the blood pressure and heart rate by 20% or greater will be considered clinically significant)~a. Change in heart rate (change ≥ 20 BPM)" (NCT03255824)
Timeframe: During the procedure, up to 40 minutes

Interventionbeats per minute (Mean)
Propofol Group77
Dexmedetomidine Group62

Patient Satisfaction

"Visual Analog Scale was used to measure overall satisfaction with the IV sedation and memory of the procedure.~The minimum score is 0 (not satisfied at all) to a maximum score of 100 (completely satisfied).~A higher score is a better outcome." (NCT03255824)
Timeframe: 30 minutes following surgery

Interventionscore on a scale (Mean)
Propofol Group93.5
Dexmedetomidine Group86.6

Postoperative Recovery Time - Ambulation

"To assess whether a D/M combination increases postoperative recovery time when compared the MFP combination.~a. Time to ambulation (to recovery room) will be recorded" (NCT03255824)
Timeframe: After the procedure until ambulation, up to 20 minutes

Interventionminutes (Mean)
Propofol Group10.8
Dexmedetomidine Group11.6

Postoperative Recovery Time - Duration of Procedure

"To assess whether a D/M combination increases postoperative recovery time when compared the MFP combination.~a. Duration of procedure will be recorded" (NCT03255824)
Timeframe: During the procedure, up to 40 minutes

InterventionMINUTES (Mean)
Propofol Group24.2
Dexmedetomidine Group22.1

Postoperative Recovery Time - Time to Discharge

"To assess whether a D/M combination increases postoperative recovery time when compared the MFP combination.~a. Time to discharge or virtual discharge (comparative statistic) - Aldrete score of ≥ 9 or pre-procedure score is met The minimum score is 0 and the maximum score is 10. A higher score indicates wakefulness, hemodynamically stable, and able to ambulate.~ii. All subjects are required to stay a minimum of 30 minutes after the end of the procedure. Therefore, at least two postoperative vital sign readings will be obtained. If the subject meets discharge criteria prior to 30 minutes, this time will be the virtual discharge time" (NCT03255824)
Timeframe: After the procedure until discharge, up to 45 minutes

Interventionminutes (Mean)
Propofol Group26.5
Dexmedetomidine Group29.9

Reaction to Administration of Local Anesthesia

"To compare the groups regarding movement of the patient during the first injection of local anesthesia during the IVS at time of injection measured using the Behavioral Pain Scale - Non-Intubated patients.~The minimum value is 3 and the maximum value is 12. Higher scores mean a worse outcome (i.e., more pain and movement on injection)" (NCT03255824)
Timeframe: During the first injection of local anesthesia during surgery

Interventionscore on a scale (Mean)
Propofol Group3.9
Dexmedetomidine Group4.2

Respiratory Depression - Oxygen Saturation

"To assess whether a D/M combination leads to a significant change in respiratory depression compared to the MFP combination.~a. Change in arterial oxygen saturation (as measured by pulse oximeter) i. number of events of ≤92%" (NCT03255824)
Timeframe: During the procedure, up to 40 minutes

InterventionSaturation percent (Mean)
Propofol Group98.7
Dexmedetomidine Group98.9

Respiratory Depression - Respiratory Rate

"To assess whether a D/M combination leads to a significant change in respiratory depression compared to the MFP combination.~a. Change in respiratory rate (change ≥ 20%)" (NCT03255824)
Timeframe: During the procedure, up to 40 minutes

Interventionbreaths per minute (Mean)
Propofol Group18
Dexmedetomidine Group18

Respiratory Events Requiring Intervention

To compare the groups regarding the number of respiratory events requiring intervention, described as: Chin lift/jaw thrust, Tongue thrust, Yankauer suctioning, Positive pressure oxygen administration, Placement of an oral or nasal airway. (NCT03255824)
Timeframe: During surgery

InterventionParticipants (Count of Participants)
Propofol Group17
Dexmedetomidine Group2

Surgeon Satisfaction - Survey

"Surgeon satisfaction was measured by the surgeon grading the Operating Conditions scale.~The minimum value was 0 and the maximum was 3. 0=very poor, 1=poor, 2=fair, 3=good" (NCT03255824)
Timeframe: 15 minutes following surgery

Interventionscore on a scale (Mean)
Propofol Group2.8
Dexmedetomidine Group2.9

Efficacy of Sedation

"Efficacy is defined as:~The patient does not have unpleasant recall of the procedure.~The patient did not experience sedation-related adverse events resulting in abandonment of the procedure or a permanent complication or an unplanned admission to the hospital or prolonged emergency department (ED) observation~The patient did not actively resist or require physical restraint for completion of the procedure. The need for minimal redirection of movements should not be considered as active resistance or physical restraint.~The procedure was successful" (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionparticipants (Number)
Ketamine Alone97
Ketamine Co-Administered With Propofol81

Nurse Satisfaction

Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionunits on a scale (Median)
Ketamine Alone10
Ketamine Co-Administered With Propofol8

Parent Satisfaction

Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionunits on a scale (1-10) (Median)
Ketamine Alone10
Ketamine Co-Administered With Propofol10

Physician Performing Procedure Satisfaction

Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionunits on a scale (Median)
Ketamine Alone9
Ketamine Co-Administered With Propofol8

Recovery Time

Time until the patient has a Vancouver Sedation Recovery Scale Score of 18 or greater. (NCT01387139)
Timeframe: Once Vancouver Sedation Recovery Scale Score reaches 18 or greater, on average less than 1 hour

Interventionminutes (Median)
Ketamine Alone44
Ketamine Co-Administered With Propofol43.5

Frequency of Adverse Events

We will record all adverse events during the sedation, and then perform a follow-up call to determine if any additional adverse events occured after discharge. (NCT01387139)
Timeframe: From enrollment through completion of follow-up, up to 7 days

,
Interventionparticipants (Number)
Respiratory depressionCardiovascular eventvomiting/retchingUnpleasant recovery reaction
Ketamine Alone121214
Ketamine Co-Administered With Propofol150182

Reviews

1 review available for midazolam and Emesis

ArticleYear
Midazolam or ketamine for procedural sedation of children in the emergency department.
    Emergency medicine journal : EMJ, 2007, Volume: 24, Issue:8

    Topics: Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Emergency Medicine; Humans;

2007

Trials

20 trials available for midazolam and Emesis

ArticleYear
The efficacy and safety of midazolam with fentanyl versus midazolam with ketamine for bedside invasive procedural sedation in pediatric oncology patients: A randomized, double-blinded, crossover trial.
    Pediatric hematology and oncology, 2022, Volume: 39, Issue:8

    Topics: Child; Cross-Over Studies; Fentanyl; Humans; Hypnotics and Sedatives; Ketamine; Midazolam; Neoplasms

2022
Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial.
    Contraception, 2023, Volume: 118

    Topics: Dilatation; Double-Blind Method; Female; Fentanyl; Gabapentin; Humans; Midazolam; Nausea; Pain; Pain

2023
Cinacalcet does not affect the activity of cytochrome P450 3A enzymes, a metabolic pathway for common immunosuppressive agents : a randomized, open-label, crossover, single-centre study in healthy volunteers.
    Drugs in R&D, 2008, Volume: 9, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Calcium; Calcium Channel Agonists; Cinaca

2008
Effect of remifentanil on oculocardiac reflex in paediatric strabismus surgery.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:9

    Topics: Anesthesia; Blood Pressure; Child; Child, Preschool; Female; Heart Rate; Humans; Infant; Male; Midaz

2008
Intravenous ketamine plus midazolam vs. intravenous ketamine for sedation in lumbar puncture: a randomized controlled trial.
    Indian pediatrics, 2008, Volume: 45, Issue:11

    Topics: Adolescent; Anesthetics, Dissociative; Anesthetics, Intravenous; Child; Confidence Intervals; Dizzin

2008
The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam.
    Anesthesia and analgesia, 2002, Volume: 95, Issue:3

    Topics: Adult; Area Under Curve; Biotransformation; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP3A; Cytoc

2002
Oral premedication with fentanyl may be a safe and effective alternative to oral midazolam.
    European journal of anaesthesiology, 2003, Volume: 20, Issue:6

    Topics: Adjuvants, Anesthesia; Administration, Oral; Age Distribution; Body Weight; Child, Preschool; Consci

2003
Midazolam for acute emesis refractory to dexamethasone and granisetron after highly emetogenic chemotherapy: a phase II study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2005, Volume: 13, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents; Cisplatin; Dexamethasone; Female; Graniset

2005
Effect of sedation with midazolam or propofol on patient's comfort during cancer chemotherapy infusion: a prospective, randomized, double-blind study in breast cancer patients.
    Journal of chemotherapy (Florence, Italy), 2005, Volume: 17, Issue:3

    Topics: Adult; Anesthetics, Intravenous; Antineoplastic Agents; Anxiety; Breast Neoplasms; Double-Blind Meth

2005
Etomidate versus midazolam for out-of-hospital intubation: a prospective, randomized trial.
    Annals of emergency medicine, 2006, Volume: 47, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allied Health Personnel; Attitude of Health Personnel; B

2006
The influence of propofol on vomiting induced by apomorphine.
    Anesthesia and analgesia, 1995, Volume: 80, Issue:5

    Topics: Adult; Apomorphine; Conscious Sedation; Humans; Male; Midazolam; Propofol; Vomiting

1995
Midazolam reduces vomiting after tonsillectomy in children.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:3

    Topics: Adenoidectomy; Adolescent; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, I

1995
Antiemetic prophylaxis for strabismus surgery.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1994, Volume: 29, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Droperidol; Humans; Incidence; Infant; Midazolam; Oculomotor Mu

1994
Sedation for gastroscopy: a comparison between midazolam and midazolam with nalbuphine.
    Annals of the Academy of Medicine, Singapore, 1994, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Aged; Conscious Sedation; Double-Blind Method; Female; Gagging; Gastroscopy; Huma

1994
Oral clonidine premedication reduces vomiting in children after strabismus surgery.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:11

    Topics: Administration, Oral; Adrenergic alpha-Agonists; Anesthesia, Inhalation; Anti-Inflammatory Agents, N

1995
Preoperative oral ondansetron for pediatric tonsillectomy.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:3

    Topics: Administration, Oral; Anesthesia, Inhalation; Anesthetics, Inhalation; Antiemetics; Child; Child, Pr

1996
Preoperative ketorolac increases bleeding after tonsillectomy in children.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:6

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anesthesia, Inhalation; Anesthet

1996
Oral midazolam is an effective premedication for children having day-stay anaesthesia.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Administration, Oral; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Inhala

1992
Premedication before elective breast surgery, a comparison between ketobemidone and midazolam.
    Acta anaesthesiologica Scandinavica, 1991, Volume: 35, Issue:6

    Topics: Aged; Analgesics, Opioid; Anxiety; Breast; Female; Humans; Injections, Intramuscular; Meperidine; Mi

1991
Discomfort after outpatient abortion using paracervical block: a comparison between two opioids and one non-opioid drug for premedication.
    Gynecologic and obstetric investigation, 1990, Volume: 30, Issue:2

    Topics: Abortion, Induced; Adult; Ambulatory Care; Anesthesia, Local; Anxiety; Female; Humans; Meperidine; M

1990

Other Studies

24 other studies available for midazolam and Emesis

ArticleYear
Recovery characteristics and parental satisfaction in pediatric procedural sedation.
    Paediatric anaesthesia, 2022, Volume: 32, Issue:3

    Topics: Child; Conscious Sedation; Dexmedetomidine; Hallucinations; Humans; Hypnotics and Sedatives; Ketamin

2022
A comparative study of propofol alone and propofol combined with midazolam for dental treatments in special needs patients.
    Medicine, 2021, Jun-04, Volume: 100, Issue:22

    Topics: Adjuvants, Anesthesia; Administration, Intravenous; Adolescent; Adult; Affective Symptoms; Child; Co

2021
Prospective evaluation of anesthetic protocols during pediatric ophthalmic surgery.
    European journal of ophthalmology, 2019, Volume: 29, Issue:6

    Topics: Acetaminophen; Anesthesia, Local; Anesthetics, Combined; Anesthetics, Intravenous; Anti-Anxiety Agen

2019
Seizure as the Presenting Symptom for Atypical Hemolytic Uremic Syndrome.
    The Journal of emergency medicine, 2019, Volume: 56, Issue:4

    Topics: Atypical Hemolytic Uremic Syndrome; Buffers; Calcium Gluconate; Electroencephalography; Female; Huma

2019
Post-sedation events in children sedated for dental care.
    Anesthesia progress, 2013,Summer, Volume: 60, Issue:2

    Topics: Adjuvants, Anesthesia; Anesthesia, Dental; Child; Child Behavior; Child, Preschool; Conscious Sedati

2013
[Palliative sedation for psycho-existential suffering].
    Wiener medizinische Wochenschrift (1946), 2014, Volume: 164, Issue:9-10

    Topics: Attitude to Death; Austria; Caregivers; Conscious Sedation; Ethics, Medical; Existentialism; Female;

2014
The Efficacy and Safety of Procedural Sedoanalgesia with Midazolam and Ketamine in Pediatric Hematology.
    Turkish journal of haematology : official journal of Turkish Society of Haematology, 2015, Volume: 32, Issue:4

    Topics: Adolescent; Analgesia; Analgesics; Bone Marrow Examination; Child; Child, Preschool; Deep Sedation;

2015
Oral Sedation Postdischarge Adverse Events in Pediatric Dental Patients.
    Anesthesia progress, 2015,Fall, Volume: 62, Issue:3

    Topics: Administration, Oral; Analgesics, Opioid; Anesthesia, Dental; Anesthetics, Inhalation; Child; Child

2015
"Herbal seizures"--atypical symptoms after ibogaine intoxication: a case report.
    Journal of medical case reports, 2015, Oct-31, Volume: 9

    Topics: Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Hallucinogens; Humans; Hypnotics and Sedatives; Ibog

2015
Procedural sedation and analgesia outcomes in children after discharge from the emergency department: ketamine versus fentanyl/midazolam.
    Annals of emergency medicine, 2009, Volume: 54, Issue:2

    Topics: Adjuvants, Anesthesia; Anesthetics, Dissociative; Child; Child Behavior Disorders; Emergency Service

2009
Postoperative nausea and vomiting after myringoplasty under continuous sedation using midazolam with or without remifentanil.
    Yonsei medical journal, 2012, Volume: 53, Issue:5

    Topics: Adult; Age Factors; Female; Humans; Male; Midazolam; Middle Aged; Myringoplasty; Piperidines; Postop

2012
Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department.
    Annals of emergency medicine, 2003, Volume: 42, Issue:5

    Topics: Adjuvants, Anesthesia; Analgesia; Anesthetics, Combined; Child; Child, Preschool; Chloral Hydrate; C

2003
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2005, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesics; Cardiovascular Diseases; Child; Child, Preschool; Cohort S

2005
Dexmedetomidine in the treatment of cyclic vomiting syndrome.
    Paediatric anaesthesia, 2005, Volume: 15, Issue:8

    Topics: Adrenergic alpha-Agonists; Bradycardia; Child; Clonidine; Dexmedetomidine; Humans; Hypnotics and Sed

2005
Practical oral sedation in dentistry. Part II--Clinical application of various oral sedatives and discussion.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2006, Volume: 27, Issue:9

    Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, Dental; Child; Child,

2006
Low-dose ketamine: efficacy in pediatric sedation.
    Pediatric emergency care, 2007, Volume: 23, Issue:3

    Topics: Adolescent; Atropine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Evaluation; Dr

2007
Pain management for children following selective dorsal rhizotomy.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:6

    Topics: Adolescent; Adult; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Bupiva

1994
Reduction of dopamine release and postoperative emesis by benzodiazepines.
    British journal of anaesthesia, 1993, Volume: 71, Issue:2

    Topics: Animals; Dopamine; Flunitrazepam; Midazolam; Postoperative Complications; Rats; Vomiting

1993
"Poswillo'.
    British dental journal, 1993, May-08, Volume: 174, Issue:9

    Topics: Anesthesia, Dental; Conscious Sedation; Dental Care for Disabled; Diabetes Mellitus; Fasting; Humans

1993
Unexpected interaction of methylphenidate (Ritalin) with anaesthetic agents.
    Paediatric anaesthesia, 1997, Volume: 7, Issue:1

    Topics: Anesthetics, Dissociative; Attention Deficit Disorder with Hyperactivity; Central Nervous System Sti

1997
A survey of pentobarbital sedation for children undergoing abdominal CT scans after oral contrast medium.
    Paediatric anaesthesia, 1997, Volume: 7, Issue:4

    Topics: Adjuvants, Anesthesia; Administration, Oral; Airway Obstruction; Anesthesiology; Bronchial Spasm; Ch

1997
[Benzodiazepine withdrawal presenting as pseudo-surgical abdominal pain].
    Annales francaises d'anesthesie et de reanimation, 1997, Volume: 16, Issue:5

    Topics: Abdomen, Acute; Adult; Alprazolam; Anti-Anxiety Agents; Bromazepam; Diagnosis, Differential; Headach

1997
The use of midazolam for persistent postoperative nausea and vomiting.
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:3

    Topics: Adult; Aged; Female; Humans; Male; Midazolam; Nausea; Postoperative Complications; Vomiting

1992
Midazolam: an effective antiemetic agent for cytotoxic chemotherapy.
    The Medical journal of Australia, 1989, Apr-17, Volume: 150, Issue:8

    Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Humans; Midazolam; Nausea; Vomiting

1989