Page last updated: 2024-10-31

midazolam and ENT Diseases

midazolam has been researched along with ENT Diseases in 9 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Research Excerpts

ExcerptRelevanceReference
"The symptoms of disorientation, restlessness, inconsolable crying and thrashing resemble an acute psychosis similar to an agitated central anticholinergic syndrome."6.73Physostigmine and anaesthesia emergence delirium in preschool children: a randomized blinded trial. ( Funk, W; Geroldinger, J; Hollnberger, H, 2008)
"The symptoms of disorientation, restlessness, inconsolable crying and thrashing resemble an acute psychosis similar to an agitated central anticholinergic syndrome."2.73Physostigmine and anaesthesia emergence delirium in preschool children: a randomized blinded trial. ( Funk, W; Geroldinger, J; Hollnberger, H, 2008)
"Midazolam 15 mg orally, was compared with the combination of pentobarbital, promethazine, opial and scopolamine as premedication for ear surgery under local anaesthesia in the first of a series of three double blind clinical trials."2.66[Premedication in ENT operations under local anesthesia]. ( Booij, LH; Feenstra, L; Nauta, JJ; van der Baan, S; van Drie, JC, 1989)
"Chloral hydrate was significantly less palatable than midazolam."2.66Comparison of chloral hydrate and midazolam by mouth as premedicants in children undergoing otolaryngological surgery. ( Klemola, UM; Lindgren, L; Saarnivaara, L, 1988)
" This finding is in keeping with pharmacokinetics showing a tmax of intranasal midazolam of 11 minutes and a bioavailability of 51% in children (10)."1.28[Intranasal premedication of young children using midazolam (Dormicum). Clinical experience]. ( Bünz, R; Gossler, M, 1991)
"Perioperative antiarrhythmic therapy with lidocaine (bolus dosage 100 mg followed by infusion of 200 mg/h) was performed in 24 patients; 12 of them simultaneously received an intravenous injection of 10 mg midazolam with the bolus of lidocaine (group I: with midazolam; group II: without midazolam)."1.28[Is the plasma protein binding of lidocaine modified by the simultaneous administration of midazolam?]. ( Bachmann-M, B; Biscoping, J; Hempelmann, G; Schürg, R, 1991)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19904 (44.44)18.7374
1990's3 (33.33)18.2507
2000's1 (11.11)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
De Vito, A1
Carrasco Llatas, M1
Vanni, A1
Bosi, M1
Braghiroli, A1
Campanini, A1
de Vries, N1
Hamans, E1
Hohenhorst, W1
Kotecha, BT1
Maurer, J1
Montevecchi, F1
Piccin, O1
Sorrenti, G1
Vanderveken, OM1
Vicini, C1
Funk, W1
Hollnberger, H1
Geroldinger, J1
Chollet-Rivier, M1
Ravussin, P1
Bünz, R1
Gossler, M1
Schürg, R1
Biscoping, J1
Bachmann-M, B1
Hempelmann, G1
van Drie, JC1
van der Baan, S1
Nauta, JJ1
Booij, LH1
Feenstra, L1
Mechelany-Leroy, L1
Fourniaud, R1
Galinski, R1
Trotoux, J1
Castor, G1
Steigerwald, F1
Altmayer, P1
Molter, G1
Saarnivaara, L1
Lindgren, L1
Klemola, UM1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Role of Drug-Induced Sleep Endoscopy for the Optimisation of Treatment of Patients With Obstruction Sleep Apnoea[NCT02855515]120 participants (Actual)Interventional2016-05-31Completed
Propofolsleep - A Observational Study on Cardiopulmonary and Pharyngeal Reactions While Drug Induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea Syndrome Under PSI Monitoring[NCT03224936]20 participants (Anticipated)Observational2017-08-22Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for midazolam and ENT Diseases

ArticleYear
[Midazolam in ORL endoscopy in adults].
    Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris, 1989, Volume: 106, Issue:8

    Topics: Adult; Aged; Anesthesia, Local; Endoscopy; Humans; Midazolam; Middle Aged; Otorhinolaryngologic Dise

1989

Trials

4 trials available for midazolam and ENT Diseases

ArticleYear
Physostigmine and anaesthesia emergence delirium in preschool children: a randomized blinded trial.
    European journal of anaesthesiology, 2008, Volume: 25, Issue:1

    Topics: Analgesics; Anesthesia; Anesthetics, Inhalation; Child, Preschool; Delirium; Female; Humans; Intraop

2008
Midazolam-flumazenil vs. propofol in ambulatory ENT endoscopic procedures.
    European journal of anaesthesiology, 1992, Volume: 9, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Anesthesia Recovery Period; Anesthesia,

1992
[Premedication in ENT operations under local anesthesia].
    Nederlands tijdschrift voor geneeskunde, 1989, Oct-07, Volume: 133, Issue:40

    Topics: Adolescent; Adult; Aged; Drug Combinations; Female; Humans; Male; Midazolam; Middle Aged; Narcotics;

1989
Comparison of chloral hydrate and midazolam by mouth as premedicants in children undergoing otolaryngological surgery.
    British journal of anaesthesia, 1988, Volume: 61, Issue:4

    Topics: Administration, Oral; Anesthesia Recovery Period; Anxiety; Child; Child, Preschool; Chloral Hydrate;

1988

Other Studies

4 other studies available for midazolam and ENT Diseases

ArticleYear
European position paper on drug-induced sedation endoscopy (DISE).
    Sleep & breathing = Schlaf & Atmung, 2014, Volume: 18, Issue:3

    Topics: Airway Obstruction; Conscious Sedation; Drug Therapy, Combination; Endoscopy; Europe; Evidence-Based

2014
European position paper on drug-induced sedation endoscopy (DISE).
    Sleep & breathing = Schlaf & Atmung, 2014, Volume: 18, Issue:3

    Topics: Airway Obstruction; Conscious Sedation; Drug Therapy, Combination; Endoscopy; Europe; Evidence-Based

2014
European position paper on drug-induced sedation endoscopy (DISE).
    Sleep & breathing = Schlaf & Atmung, 2014, Volume: 18, Issue:3

    Topics: Airway Obstruction; Conscious Sedation; Drug Therapy, Combination; Endoscopy; Europe; Evidence-Based

2014
European position paper on drug-induced sedation endoscopy (DISE).
    Sleep & breathing = Schlaf & Atmung, 2014, Volume: 18, Issue:3

    Topics: Airway Obstruction; Conscious Sedation; Drug Therapy, Combination; Endoscopy; Europe; Evidence-Based

2014
[Intranasal premedication of young children using midazolam (Dormicum). Clinical experience].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1991, Volume: 26, Issue:2

    Topics: Administration, Intranasal; Ambulatory Surgical Procedures; Anesthesia, General; Child; Child, Presc

1991
[Is the plasma protein binding of lidocaine modified by the simultaneous administration of midazolam?].
    Regional-Anaesthesie, 1991, Volume: 14, Issue:4

    Topics: Adult; Anesthesia, Conduction; Anesthesia, Inhalation; Arrhythmias, Cardiac; Blood Proteins; Humans;

1991
[Postoperative monitoring following short duration surgery of the ear, nose and throat. Experiences with midazolam as an anesthesia induction agent].
    HNO, 1989, Volume: 37, Issue:9

    Topics: Adolescent; Adult; Aged; Anesthesia, General; Arousal; Blood Pressure; Female; Humans; Male; Midazol

1989