midazolam has been researched along with Dyspnea in 27 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Dyspnea: Difficult or labored breathing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty-three ambulatory patients with advanced cancer and dyspnea were clinically characterized and then randomized to receive either oral morphine or oral midazolam." | 9.14 | Morphine versus midazolam as upfront therapy to control dyspnea perception in cancer patients while its underlying cause is sought or treated. ( Castro, MA; Cerchietti, LC; Navigante, AH, 2010) |
| "We herein report a case of dyspnea in an older patient with end-stage heart failure and renal insufficiency successfully controlled with high-dose oxycodone plus midazolam." | 8.31 | [The use of high-dose oxycodone with midazolam for dyspnea due to end-stage heart failure in an older patient with renal insufficiency]. ( Konishi, H; Mano, A; Matsui, H; Nagasawa, Y; Saito, E, 2023) |
| "Sixty-three ambulatory patients with advanced cancer and dyspnea were clinically characterized and then randomized to receive either oral morphine or oral midazolam." | 5.14 | Morphine versus midazolam as upfront therapy to control dyspnea perception in cancer patients while its underlying cause is sought or treated. ( Castro, MA; Cerchietti, LC; Navigante, AH, 2010) |
| "We herein report a case of dyspnea in an older patient with end-stage heart failure and renal insufficiency successfully controlled with high-dose oxycodone plus midazolam." | 4.31 | [The use of high-dose oxycodone with midazolam for dyspnea due to end-stage heart failure in an older patient with renal insufficiency]. ( Konishi, H; Mano, A; Matsui, H; Nagasawa, Y; Saito, E, 2023) |
| "A combination of opioid, midazolam, and scopolamine (that we call "distress protocol" [DP]) is used to induce transient sedation when emergencies occur in palliative care." | 3.83 | A Distress Protocol for Respiratory Emergencies in Terminally Ill Patients With Lung Cancer or Chronic Obstructive Pulmonary Disease. ( Godbout, K; Lacasse, Y; Tremblay, L, 2016) |
| " This case report presents a 70-year-old male who had angina and dyspnea after administration of midazolam at the beginning of a transurethral prostatectomy operation." | 3.81 | Acute coronary syndrome due to midazolam use: Kounis syndrome during a transurethral prostatectomy. ( Ateş, AH; Kul, S, 2015) |
| "Midazolam is a short-acting water-soluble benzodiazepine with a rapid onset of action and short half-life." | 2.82 | A randomised, double-blind controlled trial of intranasal midazolam for the palliation of dyspnoea in patients with life-limiting disease. ( Allan, S; Flatley, C; Gibbons, K; Hardy, J; Pinkerton, E; Randall, C, 2016) |
| "The most prevalent symptoms were: breathlessness, weakness/lack of energy, drowsiness, anxiety, agitation, confusion/delirium, and pain." | 1.72 | Symptom Control and Survival for People Severely ill With COVID: A Multicentre Cohort Study (CovPall-Symptom). ( Bajwah, S; Bradshaw, A; Chambers, RL; Dunleavy, L; Fraser, LK; Higginson, IJ; Hocaoglu, MB; Maddocks, M; Murtagh, FEM; Oluyase, AO; Preston, N; Sleeman, KE; Walshe, C, 2022) |
| "During the study period, 552 cancer patients died at the institution and 374 met the inclusion criteria for this study." | 1.48 | Continuous palliative sedation for patients with advanced cancer at a tertiary care cancer center. ( Del Giglio, A; Eiger, D; França, MS; Gomes, DBD; Hui, D; Mariano, RC; Prado, BL; Taranto, P; Usón Júnior, PLS, 2018) |
| "This syndrome is relatively uncommon and accompanies dyspnea and hypoxemia on changing to a sitting or standing from recumbent position." | 1.32 | [Anesthetic management for a patient with platypnea-orthodeoxia syndrome]. ( Kawamoto, K; Terasaki, H; Yoshitake, A, 2004) |
| " The mean dosage for midazolam was 18." | 1.32 | Use of sedation to relieve refractory symptoms in dying patients. ( Blitz-Lindeque, J; Bridge, D; Cameron, D, 2004) |
| "Midazolam was the most common medication prescribed to achieve sedation." | 1.31 | A multicentre international study of sedation for uncontrolled symptoms in terminally ill patients. ( Bengtson, K; Bercovici, M; deMoissac, D; Fainsinger, RL; Hosking, M; Landman, W; Nunez-Olarte, JM; Waller, A, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 11 (40.74) | 24.3611 |
| 2020's | 6 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Garcia, ACM | 1 |
| Isidoro, GM | 1 |
| Paiva, EMDC | 1 |
| Silva, AE | 1 |
| Costa, ICP | 1 |
| Bornemann-Cimenti, H | 1 |
| Higginson, IJ | 1 |
| Hocaoglu, MB | 1 |
| Fraser, LK | 1 |
| Maddocks, M | 1 |
| Sleeman, KE | 1 |
| Oluyase, AO | 1 |
| Chambers, RL | 1 |
| Preston, N | 1 |
| Dunleavy, L | 1 |
| Bradshaw, A | 1 |
| Bajwah, S | 1 |
| Murtagh, FEM | 1 |
| Walshe, C | 1 |
| Yasuda, S | 1 |
| Sugano, K | 1 |
| Matsuda, Y | 1 |
| Kako, J | 1 |
| Takagi, Y | 1 |
| Watanabe, H | 1 |
| Kasahara, Y | 1 |
| Goya, S | 1 |
| Kohara, H | 1 |
| Mori, M | 1 |
| Nakayama, T | 1 |
| Yamaguchi, T | 1 |
| Konishi, H | 1 |
| Nagasawa, Y | 1 |
| Matsui, H | 1 |
| Mano, A | 1 |
| Saito, E | 1 |
| Patel, C | 1 |
| Kleinig, P | 1 |
| Bakker, M | 1 |
| Tait, P | 1 |
| Cosentino, G | 1 |
| Romano, M | 1 |
| Algeri, M | 1 |
| Brighina, F | 1 |
| Alfonsi, E | 1 |
| Tassorelli, C | 1 |
| Crescimanno, G | 1 |
| Jackson, T | 1 |
| Hobson, K | 1 |
| Clare, H | 1 |
| Weegmann, D | 1 |
| Moloughney, C | 1 |
| McManus, S | 1 |
| Prado, BL | 1 |
| Gomes, DBD | 1 |
| Usón Júnior, PLS | 1 |
| Taranto, P | 1 |
| França, MS | 1 |
| Eiger, D | 1 |
| Mariano, RC | 1 |
| Hui, D | 1 |
| Del Giglio, A | 1 |
| Ingravallo, F | 1 |
| de Nooijer, K | 1 |
| Pucci, V | 1 |
| Casini, C | 1 |
| Miccinesi, G | 1 |
| Rietjens, JAC | 1 |
| Morino, P | 1 |
| Rady, MY | 1 |
| Verheijde, JL | 1 |
| Mercadante, S | 1 |
| Porzio, G | 1 |
| Valle, A | 1 |
| Aielli, F | 1 |
| Casuccio, A | 1 |
| Godbout, K | 1 |
| Tremblay, L | 1 |
| Lacasse, Y | 1 |
| Ateş, AH | 1 |
| Kul, S | 1 |
| Hardy, J | 1 |
| Randall, C | 1 |
| Pinkerton, E | 1 |
| Flatley, C | 1 |
| Gibbons, K | 1 |
| Allan, S | 1 |
| Varela, JA | 1 |
| Penide, L | 1 |
| Abad, A | 1 |
| Benito, J | 1 |
| Navia, J | 1 |
| Koh, YH | 1 |
| Lee, OK | 1 |
| Wu, HY | 1 |
| Navigante, AH | 2 |
| Castro, MA | 2 |
| Cerchietti, LC | 2 |
| Dang, D | 1 |
| Robinson, PC | 1 |
| Winnicki, S | 1 |
| Jersmann, HP | 1 |
| Currow, DC | 1 |
| Abernethy, AP | 1 |
| Kawamoto, K | 1 |
| Yoshitake, A | 1 |
| Terasaki, H | 1 |
| Cameron, D | 1 |
| Bridge, D | 1 |
| Blitz-Lindeque, J | 1 |
| Lutteral, MA | 1 |
| Cabalar, ME | 1 |
| Edwards, MJ | 1 |
| Taguchi, S | 1 |
| Shimizu, K | 1 |
| Yokote, R | 1 |
| Uchiyama, M | 1 |
| Sekii, H | 1 |
| Kiyota, K | 1 |
| Sironi, O | 1 |
| Sbanotto, A | 1 |
| Banfi, MG | 1 |
| Beltrami, C | 1 |
| Fainsinger, RL | 1 |
| Waller, A | 1 |
| Bercovici, M | 1 |
| Bengtson, K | 1 |
| Landman, W | 1 |
| Hosking, M | 1 |
| Nunez-Olarte, JM | 1 |
| deMoissac, D | 1 |
| Mendes de Leon, C | 1 |
| Bezel, R | 1 |
| Karrer, W | 1 |
| Brändli, O | 1 |
4 reviews available for midazolam and Dyspnea
| Article | Year |
|---|---|
Palliative Sedation at Home: A Scoping Review.
Topics: Adult; Child; Death; Dyspnea; Humans; Hypnotics and Sedatives; Midazolam; Neoplasms; Pain; Palliativ | 2023 |
Systematic review and meta-analysis of the efficacy of benzodiazepines for dyspnea in patients with cancer.
Topics: Analgesics, Opioid; Benzodiazepines; Dyspnea; Humans; Midazolam; Morphine; Neoplasms; Sleepiness | 2023 |
Palliative sedation: A safety net for the relief of refractory and intolerable symptoms at the end of life.
Topics: Aged; Analgesics; Conscious Sedation; Dehydration; Dyspnea; Humans; Hydromorphone; Hypnotics and Sed | 2019 |
Opioids and benzodiazepines appear paradoxically to delay inevitable death after ventilator withdrawal.
Topics: Adult; Aged; Analgesics, Opioid; Analysis of Variance; Anti-Anxiety Agents; Conscious Sedation; Cons | 2005 |
4 trials available for midazolam and Dyspnea
| Article | Year |
|---|---|
A randomised, double-blind controlled trial of intranasal midazolam for the palliation of dyspnoea in patients with life-limiting disease.
Topics: Administration, Intranasal; Aged; Anxiety; Double-Blind Method; Drug Delivery Systems; Dyspnea; Fema | 2016 |
Morphine versus midazolam as upfront therapy to control dyspnea perception in cancer patients while its underlying cause is sought or treated.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Anxiety Agents; Drug Administration Schedul | 2010 |
Midazolam as adjunct therapy to morphine in the alleviation of severe dyspnea perception in patients with advanced cancer.
Topics: Adult; Aged; Analgesics, Opioid; Drug Therapy, Combination; Dyspnea; Female; Humans; Hypnotics and S | 2006 |
[Premedication in fiber optic bronchoscopy from the patient's and the physician's viewpoint--a randomized study for the comparison of midazolam and hydrocodone].
Topics: Adult; Aged; Bronchoscopy; Codeine; Consumer Behavior; Cough; Dyspnea; Female; Fiber Optic Technolog | 1986 |
19 other studies available for midazolam and Dyspnea
| Article | Year |
|---|---|
Symptom Control and Survival for People Severely ill With COVID: A Multicentre Cohort Study (CovPall-Symptom).
Topics: Aged; Cohort Studies; COVID-19; Delirium; Dyspnea; Humans; Midazolam; Morphine; Pain; Palliative Car | 2022 |
[The use of high-dose oxycodone with midazolam for dyspnea due to end-stage heart failure in an older patient with renal insufficiency].
Topics: Aged, 80 and over; Dyspnea; Female; Heart Failure; Humans; Midazolam; Oxycodone; Renal Insufficiency | 2023 |
Intranasal midazolam for treating acute respiratory crises in a woman with stiff person syndrome.
Topics: Administration, Intranasal; Benzodiazepines; Dyspnea; Female; Humans; Midazolam; Middle Aged; Respir | 2020 |
End-of-life care in COVID-19: An audit of pharmacological management in hospital inpatients.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Betacoronavirus; Biopharmaceutics; Coronavirus I | 2020 |
Continuous palliative sedation for patients with advanced cancer at a tertiary care cancer center.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Deep Sedation; Delirium; Dyspnea; Female; Humans; Hyp | 2018 |
Discussions about palliative sedation in hospice: Frequency, timing and factors associated with patient involvement.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Antipsychotic Agents; Decision Making, Shared; Delirium | 2019 |
The science and ethics of withdrawing mechanical positive pressure ventilatory support in the terminally ill.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Conscious Sedation; Dyspnea; Female; Humans; Male; Midazola | 2013 |
Palliative sedation in patients with advanced cancer followed at home: a prospective study.
Topics: Adult; Aged; Aged, 80 and over; Delirium; Dyspnea; Family; Feasibility Studies; Female; Home Care Se | 2014 |
A Distress Protocol for Respiratory Emergencies in Terminally Ill Patients With Lung Cancer or Chronic Obstructive Pulmonary Disease.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Clinical Protocols; Dyspnea; Emergencies; Female; Human | 2016 |
Acute coronary syndrome due to midazolam use: Kounis syndrome during a transurethral prostatectomy.
Topics: Adjuvants, Anesthesia; Aged; Angina Pectoris; Coronary Angiography; Coronary Vasospasm; Diagnosis, D | 2015 |
[Pneumomediastinum and extensive subcutaneous emphysema after normal labor].
Topics: Adult; Chest Pain; Dyspnea; Female; Humans; Hypnotics and Sedatives; Mediastinal Emphysema; Midazola | 2008 |
"Palliative" and not "terminal" sedation.
Topics: Analgesics, Opioid; Conscious Sedation; Dyspnea; Esophageal Neoplasms; Fatal Outcome; Humans; Hypnot | 2009 |
The safety of flexible fibre-optic bronchoscopy and proceduralist-administered sedation: a tertiary referral centre experience.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; Bronchoscopy; Conscious Sedation; Dyspnea; Femal | 2012 |
Potential opioid-sparing effect of regular benzodiazepines in dyspnea: longer duration of studies needed.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Clinical Trials as Topic; Drug Administration Schedule; Dys | 2010 |
[Anesthetic management for a patient with platypnea-orthodeoxia syndrome].
Topics: Aged; Anesthesia, General; Dyspnea; Fentanyl; Heart Septal Defects, Atrial; Humans; Hypoxia; Male; M | 2004 |
Use of sedation to relieve refractory symptoms in dying patients.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Aged, 80 and over; Communication; Conscious Sedatio | 2004 |
[Three cases of inhalation of household pyrethroid and metoxadiazone insecticides with remarkable dyspnea].
Topics: Adult; Dyspnea; Female; Humans; Hydrocortisone; Hypersensitivity; Inhalation Exposure; Insecticides; | 2006 |
Midazolam as adjunct therapy to morphine to relieve dyspnea?
Topics: Analgesics, Opioid; Drug Therapy, Combination; Dyspnea; Humans; Hypnotics and Sedatives; Midazolam; | 2007 |
A multicentre international study of sedation for uncontrolled symptoms in terminally ill patients.
Topics: Aged; Analgesics, Opioid; Anti-Anxiety Agents; Consciousness; Delirium; Drug Therapy, Combination; D | 2000 |