midazolam has been researched along with Drug Withdrawal Symptoms in 86 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Benzodiazepine withdrawal-induced catatonia is a rare phenomenon in the adult population and has never been reported in a pediatric patient." | 5.46 | Case Report of Midazolam Withdrawal-Induced Catatonia in a 9-Year-Old Patient. ( Duncan-Azadi, CR; Gormley, A; Johnson, PN, 2017) |
| "Acute and chronic morphine dependence and naloxone-precipitated withdrawal models were employed in the present study." | 3.71 | Pretreatment with midazolam suppresses morphine withdrawal response in mice and rats. ( Cao, JL; Ding, HL; Duan, SM; Zeng, YM; Zhang, LC, 2002) |
| "Fentanyl and midazolam were adjusted to achieve a defined level of analgesia and sedation according to Hartwig score." | 2.79 | Continuous infusion of clonidine in ventilated newborns and infants: a randomized controlled trial. ( Balling, G; Behr, J; Blickheuser, R; Dohna-Schwake, C; Gebauer, C; Hahn, M; Harnischmacher, U; Hentschel, R; Hering, F; Hoehn, T; Hünseler, C; Huth, RG; Lieser, U; Möller, O; Müller, A; Müller, C; Röhlig, C; Roth, B; Schubert, S; Trieschmann, U; Wassmer, G, 2014) |
| "The methadone was then decreased to once daily and tapered off over the next 10 days." | 2.76 | A trial of methadone tapering schedules in pediatric intensive care unit patients exposed to prolonged sedative infusions. ( Bowens, CD; Breitzka, RL; Sheeran, PW; Thompson, DG; Thompson, JA; Thompson, MT, 2011) |
| "Naloxone has been hypothesized to limit opioid tolerance by decreasing adenylate cyclase/cyclic adenosine monophosphate activation." | 2.73 | Effect of low-dose naloxone infusion on fentanyl requirements in critically ill children. ( Darnell, CM; Roy, L; Sheeran, P; Stromberg, D; Thompson, J, 2008) |
| " There was no dose-response effect for effectiveness with either initial or continued drug administration." | 2.65 | Midazolam: dose-response studies of effectiveness and rebound insomnia. ( Bixler, EO; Goff, PJ; Kales, A; Soldatos, CR; Vela-Bueno, A, 1983) |
| "Midazolam was used in 95 patients (56%), with an average dose of 35 (±14) μg/kg/h." | 1.51 | Postsurgery analgesic and sedative drug use in a French neonatal intensive care unit: A single-center retrospective cohort study. ( Benahmed-Canat, A; Canat, G; Claris, O; Kassai, B; Nguyen, KA; Paret, N; Plaisant, F; Rabilloud, M; Riche, B, 2019) |
| "Treatment with carisoprodol and phenobarbital provided additional benefit and can be considered in cases of severe carisoprodol withdrawal." | 1.46 | Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. ( Benowitz, NL; Horng, H; Smollin, CG; Vo, KT, 2017) |
| "Benzodiazepine withdrawal-induced catatonia is a rare phenomenon in the adult population and has never been reported in a pediatric patient." | 1.46 | Case Report of Midazolam Withdrawal-Induced Catatonia in a 9-Year-Old Patient. ( Duncan-Azadi, CR; Gormley, A; Johnson, PN, 2017) |
| "Our aim was to describe the effect of dosing and genetic factors on sufentanil- and midazolam-induced analgosedation and withdrawal syndrome (WS) in pediatric population." | 1.43 | Sufentanil and midazolam dosing and pharmacogenetic factors in pediatric analgosedation and withdrawal syndrome. ( Hronová, K; Pokorná, P; Posch, L; Slanař, O, 2016) |
| "Because of acute renal failure resulting from rhabdomyolysis hemodialysis was necessary three times." | 1.35 | ["Liquid ecstasy": gamma-butyrolactone withdrawal delirium with rhabdomyolysis and dialysis dependent renal failure]. ( Busch, HJ; Schwab, T; Supady, A, 2009) |
| "Withdrawal symptoms were still present 24 h after detoxification and 80% of the patients relapsed during a 6-month follow-up." | 1.30 | Ultra-rapid opiate detoxification using deep sedation with oral midazolam: short and long-term results. ( Bertschy, G; Cucchia, AT; Ferrero, F; Monnat, M; Spagnoli, J, 1998) |
| "To record the number of children with withdrawal symptoms after the administration of sedatives for mechanical ventilation, and to discuss the possible connection with the administration of midazolam." | 1.30 | Occurrence of withdrawal in critically ill sedated children. ( Carl, P; Fonsmark, L; Rasmussen, YH, 1999) |
| "The fentanyl infusion was decreased by 1 microg/kg/hr every 12-24 hrs and the midazolam infusion was decreased by 0." | 1.30 | Subcutaneous administration of fentanyl and midazolam to prevent withdrawal after prolonged sedation in children. ( Tobias, JD, 1999) |
| "Alcohol use among head and neck cancer patients is common." | 1.29 | Trends in the management of alcohol withdrawal syndrome. ( Moore, M; Newman, JP; Terris, DJ, 1995) |
| " The overall incidence of adverse effects to midazolam in the patients studied was 17%." | 1.29 | A prospective study of the adverse effects of midazolam on withdrawal in critically ill children. ( Billingham, I; Choonara, I; Gill, A; Hughes, J; Leach, HJ; Nunn, AJ; Ratcliffe, J; Thornington, R, 1994) |
| " The switch to oral agents must take into consideration the differences in potency, half-life, and oral bioavailability between the agents." | 1.29 | Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit. ( Deshpande, JK; Gregory, DF; Tobias, JD, 1994) |
| "When midazolam was readministered, all symptoms disappeared." | 1.29 | Benzodiazepine withdrawal reaction in two children following discontinuation of sedation with midazolam. ( Booy, LH; Gimbrere, JS; van Engelen, BG, 1993) |
| " Using a cumulative dosing procedure, PTZ substituted for PTZ, and MDZ, chlordiazepoxide and diazepam (DZP) substituted for MDZ, in a dose-dependent manner." | 1.28 | Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam. ( Boone, MS; Emmett-Oglesby, MW; Pugh, SL, 1992) |
| " Our laboratory has demonstrated previously that physical dependence to the long-acting chlordiazepoxide in the rat is inducible by a single intoxicating dose, whereas maximal dependence required chronically equivalent maximally tolerable dosing b." | 1.28 | Tolerance and physical dependence to a short-acting benzodiazepine, midazolam. ( Boisse, NR; Guarino, JJ; Quaglietta, N; Samoriski, GM, 1990) |
| "This flumazenil treatment produced a slight attenuation in the degree of tolerance to midazolam on day 6, suggesting that receptor sensitivity to the benzodiazepine agonist may have partially reset." | 1.28 | Behavioral differentiation of benzodiazepine ligands after repeated administration in baboons. ( Cook, JM; Griffiths, RR; Sannerud, CA, 1989) |
| "Midazolam was initiated in an effort to resolve his agitation and the patient continued to receive frequent bolus injections, averaging 22 mg/d over 21 days." | 1.28 | Precipitation of benzodiazepine withdrawal following sudden discontinuation of midazolam. ( Finley, PR; Nolan, PE, 1989) |
| " In naive animals, after the chronic administration of midazolam at 0." | 1.27 | [Drug dependence tests on a new anesthesia inducer, midazolam]. ( Hakkei, M; Kubota, A; Kuwahara, A; Nakamura, K, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (10.47) | 18.7374 |
| 1990's | 32 (37.21) | 18.2507 |
| 2000's | 21 (24.42) | 29.6817 |
| 2010's | 20 (23.26) | 24.3611 |
| 2020's | 4 (4.65) | 2.80 |
| Authors | Studies |
|---|---|
| Duke, AN | 1 |
| Tiruveedhula, VVNPB | 1 |
| Sharmin, D | 1 |
| Knutson, DE | 1 |
| Cook, JM | 3 |
| Platt, DM | 1 |
| Rowlett, JK | 1 |
| Dokken, M | 1 |
| Rustøen, T | 1 |
| Diep, LM | 1 |
| Fagermoen, FE | 1 |
| Huse, RI | 1 |
| Egerod, I | 1 |
| Bentsen, GK | 1 |
| Asada, R | 1 |
| Hori, H | 1 |
| Iida, H | 1 |
| Kawasaki, H | 1 |
| Goulooze, SC | 1 |
| Ista, E | 4 |
| van Dijk, M | 3 |
| Hankemeier, T | 1 |
| Tibboel, D | 5 |
| Knibbe, CAJ | 1 |
| Krekels, EHJ | 1 |
| Teah, MK | 1 |
| Chan, GK | 1 |
| Wong, MTF | 1 |
| Yeap, TB | 1 |
| Neubert, A | 1 |
| Baarslag, MA | 1 |
| Dijk, MV | 1 |
| Rosmalen, JV | 1 |
| Standing, JF | 1 |
| Sheng, Y | 1 |
| Rascher, W | 1 |
| Roberts, D | 1 |
| Winslade, J | 1 |
| Rawcliffe, L | 1 |
| Hanning, SM | 1 |
| Metsvaht, T | 1 |
| Giannuzzi, V | 1 |
| Larsson, P | 1 |
| Pokorná, P | 2 |
| Simonetti, A | 1 |
| Warrington, SE | 1 |
| Collier, HK | 1 |
| Himebauch, AS | 1 |
| Wolfe, HA | 1 |
| Kongkiattikul, L | 1 |
| Dagenais, M | 1 |
| Ruo, N | 1 |
| Fontela, P | 1 |
| Di Genova, T | 1 |
| Zavalkoff, S | 1 |
| Benahmed-Canat, A | 1 |
| Plaisant, F | 1 |
| Riche, B | 1 |
| Rabilloud, M | 1 |
| Canat, G | 1 |
| Paret, N | 1 |
| Claris, O | 1 |
| Kassai, B | 1 |
| Nguyen, KA | 1 |
| Larson, GE | 1 |
| Arnup, SJ | 1 |
| Clifford, M | 1 |
| Evans, J | 1 |
| Hünseler, C | 1 |
| Balling, G | 1 |
| Röhlig, C | 1 |
| Blickheuser, R | 1 |
| Trieschmann, U | 1 |
| Lieser, U | 1 |
| Dohna-Schwake, C | 1 |
| Gebauer, C | 1 |
| Möller, O | 1 |
| Hering, F | 1 |
| Hoehn, T | 1 |
| Schubert, S | 1 |
| Hentschel, R | 1 |
| Huth, RG | 1 |
| Müller, A | 1 |
| Müller, C | 1 |
| Wassmer, G | 1 |
| Hahn, M | 1 |
| Harnischmacher, U | 1 |
| Behr, J | 1 |
| Roth, B | 1 |
| Crispo, AL | 1 |
| Daley, MJ | 1 |
| Pepin, JL | 1 |
| Harford, PH | 1 |
| Brown, CV | 1 |
| Ortiz, V | 1 |
| Giachero, M | 1 |
| Espejo, PJ | 1 |
| Molina, VA | 1 |
| Martijena, ID | 1 |
| Stewart, R | 1 |
| Perez, R | 1 |
| Musial, B | 1 |
| Lukens, C | 1 |
| Adjepong, YA | 1 |
| Manthous, CA | 1 |
| Zhang, P | 1 |
| Austin, E | 1 |
| Thompson, M | 1 |
| Lin, S | 1 |
| Vo, KT | 1 |
| Horng, H | 1 |
| Smollin, CG | 1 |
| Benowitz, NL | 1 |
| Hronová, K | 1 |
| Posch, L | 1 |
| Slanař, O | 1 |
| Duncan-Azadi, CR | 1 |
| Johnson, PN | 1 |
| Gormley, A | 1 |
| Chandrasekaran, PK | 1 |
| Gamel, C | 1 |
| de Hoog, M | 2 |
| Easley, RB | 1 |
| Nichols, DG | 1 |
| Duivenvoorden, HJ | 1 |
| Supady, A | 1 |
| Schwab, T | 1 |
| Busch, HJ | 1 |
| Gupta, A | 1 |
| Lee, D | 1 |
| Su, M | 1 |
| Hafner, V | 1 |
| Jäger, M | 1 |
| Matthée, AK | 1 |
| Ding, R | 1 |
| Burhenne, J | 1 |
| Haefeli, WE | 1 |
| Mikus, G | 1 |
| Bowens, CD | 1 |
| Thompson, JA | 1 |
| Thompson, MT | 1 |
| Breitzka, RL | 1 |
| Thompson, DG | 1 |
| Sheeran, PW | 1 |
| Wildschut, E | 1 |
| da Silva, PS | 1 |
| Passos, RM | 1 |
| Waisberg, DR | 1 |
| Stein, M | 1 |
| Schomacher, J | 1 |
| Scharbrodt, W | 1 |
| Preuss, M | 1 |
| Oertel, MF | 1 |
| Fernández-Carrión, F | 1 |
| Gaboli, M | 1 |
| González-Celador, R | 1 |
| Gómez de Quero-Masía, P | 1 |
| Fernández-de Miguel, S | 1 |
| Murga-Herrera, V | 1 |
| Serrano-Ayestarán, O | 1 |
| Sánchez-Granados, JM | 1 |
| Payo-Pérez, R | 1 |
| Cao, JL | 1 |
| Ding, HL | 1 |
| Zhang, LC | 1 |
| Duan, SM | 1 |
| Zeng, YM | 1 |
| McMahon, LR | 3 |
| Jerussi, TP | 1 |
| France, CP | 3 |
| Cunliffe, M | 1 |
| McArthur, L | 1 |
| Dooley, F | 1 |
| Takara, I | 1 |
| Tomiyama, H | 1 |
| Tokumine, J | 1 |
| Sugahara, K | 1 |
| Korak-Leiter, M | 1 |
| Likar, R | 1 |
| Oher, M | 1 |
| Trampitsch, E | 1 |
| Ziervogel, G | 1 |
| Levy, JV | 1 |
| Freye, EC | 1 |
| Maruyama, S | 1 |
| Nomura, Y | 1 |
| Fukushige, T | 1 |
| Eguchi, T | 1 |
| Nishi, J | 1 |
| Yoshinaga, M | 1 |
| Kawano, Y | 1 |
| Javors, MA | 1 |
| Raffa, RB | 1 |
| Cavallo, F | 1 |
| Capasso, A | 1 |
| Epstein, D | 1 |
| Difazio, M | 1 |
| Hansen, CR | 1 |
| Gooch, JL | 1 |
| Such-Neibar, T | 1 |
| Weber, MD | 1 |
| Thammasitboon, S | 1 |
| Rosen, DA | 1 |
| Pohl-Schickinger, A | 1 |
| Lemmer, J | 1 |
| Hübler, M | 1 |
| Alexi-Meskishvili, V | 1 |
| Redlin, M | 1 |
| Berger, F | 1 |
| Stiller, B | 1 |
| Darnell, CM | 1 |
| Thompson, J | 1 |
| Stromberg, D | 1 |
| Roy, L | 1 |
| Sheeran, P | 1 |
| Li, JX | 1 |
| Gerak, LR | 1 |
| Becker, GL | 1 |
| Kales, A | 2 |
| Soldatos, CR | 2 |
| Bixler, EO | 2 |
| Goff, PJ | 1 |
| Vela-Bueno, A | 1 |
| Krajnik, M | 1 |
| Zylicz, Z | 1 |
| Strickland, RA | 1 |
| Berge, KH | 1 |
| Hantson, P | 1 |
| Clemessy, JL | 1 |
| Baud, FJ | 1 |
| Newman, JP | 1 |
| Terris, DJ | 1 |
| Moore, M | 1 |
| Hughes, J | 1 |
| Gill, A | 1 |
| Leach, HJ | 1 |
| Nunn, AJ | 1 |
| Billingham, I | 2 |
| Ratcliffe, J | 1 |
| Thornington, R | 2 |
| Choonara, I | 1 |
| Tobias, JD | 2 |
| Deshpande, JK | 1 |
| Gregory, DF | 1 |
| Bruder, N | 1 |
| Lassegue, D | 1 |
| Pelissier, D | 1 |
| Graziani, N | 1 |
| François, G | 1 |
| Legarda, JJ | 1 |
| Gossop, M | 1 |
| van Engelen, BG | 1 |
| Gimbrere, JS | 1 |
| Booy, LH | 1 |
| Lawrence, K | 1 |
| Evans, EB | 1 |
| Balster, RL | 1 |
| Loimer, N | 3 |
| Hofmann, P | 1 |
| Chaudhry, H | 1 |
| Gil-Martín, E | 1 |
| Colado, I | 1 |
| Fernández-López, A | 1 |
| Fernández-Briera, A | 1 |
| Calvo, P | 1 |
| Weerts, EM | 1 |
| Kaminski, BJ | 1 |
| Griffiths, RR | 3 |
| Loeb, P | 1 |
| Adnet, P | 1 |
| Boittiaux, P | 1 |
| Forget, AP | 1 |
| Mille, FX | 1 |
| Cucchia, AT | 1 |
| Monnat, M | 1 |
| Spagnoli, J | 1 |
| Ferrero, F | 1 |
| Bertschy, G | 1 |
| Kesavulu, V | 1 |
| Costarino, AT | 1 |
| Fonsmark, L | 1 |
| Rasmussen, YH | 1 |
| Carl, P | 1 |
| Hickey, R | 1 |
| Wells, L | 1 |
| Wilson, LB | 1 |
| DeMaria, PA | 1 |
| Kane, HL | 1 |
| Reining, KM | 1 |
| Streel, E | 1 |
| Dan, B | 1 |
| Bredas, P | 1 |
| Clement, B | 1 |
| Pelc, I | 1 |
| Verbanck, P | 1 |
| Pugh, SL | 1 |
| Boone, MS | 1 |
| Emmett-Oglesby, MW | 1 |
| Vigorito, M | 1 |
| Lau, CE | 2 |
| Tang, M | 2 |
| Falk, JL | 2 |
| Sannerud, CA | 2 |
| Allen, M | 1 |
| Kauffman, RE | 1 |
| Lenz, K | 2 |
| Presslich, O | 2 |
| Schmid, R | 2 |
| Mets, B | 1 |
| Horsell, A | 1 |
| Linton, DM | 1 |
| McLellan, I | 1 |
| Douglas, E | 1 |
| Conway, EE | 1 |
| Singer, LP | 1 |
| Boisse, NR | 1 |
| Quaglietta, N | 1 |
| Samoriski, GM | 1 |
| Guarino, JJ | 1 |
| Böhrer, H | 1 |
| Bach, A | 1 |
| Layer, M | 1 |
| Werning, P | 1 |
| Yutrzenka, GJ | 1 |
| Patrick, GA | 1 |
| Rosenberger, W | 1 |
| Finley, PR | 1 |
| Nolan, PE | 1 |
| Kales, JD | 1 |
| Jacoby, JA | 1 |
| Sury, MR | 1 |
| Russell, GN | 1 |
| Hopkins, CS | 1 |
| Vivori, E | 1 |
| Newman, LM | 1 |
| Hoffman, WE | 1 |
| Miletich, DJ | 1 |
| Albrecht, RF | 1 |
| Kubota, A | 1 |
| Kuwahara, A | 1 |
| Hakkei, M | 1 |
| Nakamura, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double Blind, Randomised, Multicentre, Active Controlled, Parallel-group, Phase III Trial to Evaluate the Efficacy, Safety and Pharmacokinetics of Intravenous Clonidine (Hydrochloride) Compared to Midazolam for Sedation in Children From Birth to Less Th[NCT02509273] | Phase 3 | 28 participants (Actual) | Interventional | 2016-05-31 | Terminated (stopped due to lack of recruitment) | ||
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| Intranasal Sufentanil for Analgesia of Severe Sickle Cell Vaso-occlusive Pain Crisis in the Pediatric Emergency Department: a Double Blind Randomized Versus Placebo Controlled Trial[NCT06181695] | Phase 3 | 182 participants (Anticipated) | Interventional | 2024-05-02 | Not yet recruiting | ||
| Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit[NCT02025855] | Phase 4 | 46 participants (Anticipated) | Interventional | 2014-01-31 | Enrolling by invitation | ||
| Opioid Withdrawal Symptoms in Critically Ill Patients[NCT03374722] | 55 participants (Actual) | Observational | 2018-01-01 | Completed | |||
| Protocolized Initiation of Clonidine to Prevent Dexmedetomidine Withdrawal: A Prospective Cohort Study[NCT05575219] | Phase 4 | 300 participants (Anticipated) | Interventional | 2022-10-08 | Recruiting | ||
| Efficacy of Clonidine in Reducing Iatrogenic-induced Opioid Dependence in Infants:[NCT01360450] | Phase 2/Phase 3 | 12 participants (Actual) | Interventional | 2011-07-31 | Terminated (stopped due to The study was treminated because of low accural) | ||
| The Impact of Concomitant Ultra Low Dose Infusion Naloxone and Therapeutic Infusion Opioid on Opioid Requirements in Pediatric ICU Patients[NCT00286052] | Phase 3 | 128 participants | Interventional | 2002-12-31 | Completed | ||
| Early Lactate-Directed Therapy on the ICU: A Randomized Controlled Trial[NCT00270673] | Phase 3 | 350 participants (Anticipated) | Interventional | 2006-02-28 | Completed | ||
| Assessing Current Analgesia and Sedation Weaning Practices in Adult Critically Ill Patients[NCT04422808] | 2,437 participants (Actual) | Observational | 2021-06-01 | Completed | |||
| Effect of Clonidine vs. Dexmedetomidine in Addition to Standard Treatment in Agitated Delirium in Intensive Care Patients: Pilot Study.[NCT04758936] | Phase 4 | 50 participants (Anticipated) | Interventional | 2021-02-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Time to complete detoxification is defined as 48 hrs off all opioids/benzodiazepines and study drug with acceptable withdrawal scores of <9 (on average we expect the infant to be enrolled in the study for 2-4 weeks). The scale used to assess withdrawal was the Modified Finnegan Neonatal Withdrawal Scale, which ranges from 0-41, 0 represents no withdrawal and 41 represent maximum withdrawal. (NCT01360450)
Timeframe: up to 4 weeks
| Intervention | days (Mean) | |
|---|---|---|
| total days on narcotics | duration on study drug in days | |
| Control | 37.2 | 14.2 |
| Treatment | 89.5 | 21 |
4 reviews available for midazolam and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Managing sedation withdrawal in children who undergo prolonged PICU admission after discharge to the ward.
Topics: Analgesics; Child; Chloral Hydrate; Clinical Protocols; Critical Care; Follow-Up Studies; Hospital U | 2004 |
Subcutaneous fentanyl and midazolam: an alternative method of weaning after intravenous sedation in pediatric patients.
Topics: Analgesics, Opioid; Child; Fentanyl; Humans; Hypnotics and Sedatives; Injections, Intravenous; Injec | 1999 |
Anesthesia-assisted rapid opiate detoxification: a new procedure in the postanesthesia care unit.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Heroin Dependence; Humans; Male; Midazolam; Na | 1999 |
Rebound insomnia and elimination half-life: assessment of individual subject response.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D | 1985 |
8 trials available for midazolam and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial.
Topics: Adolescent; Analgesics, Opioid; Child; Child Development; Child, Preschool; Clonidine; Delirium; Hum | 2017 |
Continuous infusion of clonidine in ventilated newborns and infants: a randomized controlled trial.
Topics: Age Factors; Analgesics; Analgesics, Opioid; Clonidine; Double-Blind Method; Female; Fentanyl; Human | 2014 |
Effect of simultaneous induction and inhibition of CYP3A by St John's Wort and ritonavir on CYP3A activity.
Topics: Administration, Oral; Adult; Area Under Curve; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Ind | 2010 |
A trial of methadone tapering schedules in pediatric intensive care unit patients exposed to prolonged sedative infusions.
Topics: Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedul | 2011 |
Withdrawal following sufentanil/propofol and sufentanil/midazolam. Sedation in surgical ICU patients: correlation with central nervous parameters and endogenous opioids.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; beta-Endorphin; Blood Pressure; Conscious Sedation; Cri | 2005 |
Effect of low-dose naloxone infusion on fentanyl requirements in critically ill children.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Conscious Sedation; Critical Illness; Doubl | 2008 |
Midazolam: dose-response studies of effectiveness and rebound insomnia.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Electroe | 1983 |
Rebound insomnia and elimination half-life: assessment of individual subject response.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, D | 1985 |
75 other studies available for midazolam and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Tolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABA
Topics: Alprazolam; Animals; Benzodiazepines; Drug Tolerance; Female; Macaca mulatta; Midazolam; Receptors, | 2021 |
Implementation of an algorithm for tapering analgosedation reduces iatrogenic withdrawal syndrome in pediatric intensive care.
Topics: Adolescent; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Critical Care; Humans; Hypnotic | 2023 |
Benzodiazepine withdrawal catatonia after discontinuing midazolam in young patient with intellectual developmental disorder: A case report.
Topics: Adult; Benzodiazepines; Catatonia; Developmental Disabilities; Humans; Intellectual Disability; Male | 2023 |
Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms.
Topics: Child; Child, Preschool; Drug Therapy, Combination; Female; Fentanyl; Humans; Iatrogenic Disease; In | 2019 |
Treatment of benzodiazepine withdrawal syndrome in a severe traumatic brain injury patient.
Topics: Adolescent; Brain Injuries, Traumatic; Humans; Hypnotics and Sedatives; Male; Midazolam; Substance W | 2021 |
Evaluation of IV to Enteral Benzodiazepine Conversion Calculations in a Pediatric Intensive Care Setting.
Topics: Airway Extubation; Child, Preschool; Diazepam; Drug Dosage Calculations; Drug Substitution; Female; | 2018 |
The impact of a quality improvement project to standardize pain, agitation, and withdrawal assessments on the use of morphine and midazolam in the Pediatric Intensive Care Unit.
Topics: Analgesics, Opioid; Compliance; Conscious Sedation; Critical Care; Dexmedetomidine; Humans; Hypnotic | 2019 |
Postsurgery analgesic and sedative drug use in a French neonatal intensive care unit: A single-center retrospective cohort study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Cohort Studies; Drug Utilization; Femal | 2019 |
How does the introduction of a pain and sedation management guideline in the paediatric intensive care impact on clinical practice? A comparison of audits pre and post guideline introduction.
Topics: Analgesics; Clonidine; Documentation; Guideline Adherence; Humans; Intensive Care Units, Pediatric; | 2013 |
Comparison of clinical outcomes in nonintubated patients with severe alcohol withdrawal syndrome treated with continuous-infusion sedatives: dexmedetomidine versus benzodiazepines.
Topics: Adult; Aged; Benzodiazepines; Cohort Studies; Dexmedetomidine; Ethanol; Female; Humans; Hypnotics an | 2014 |
The effect of Midazolam and Propranolol on fear memory reconsolidation in ethanol-withdrawn rats: influence of d-cycloserine.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Conditioning, Psychologi | 2015 |
Outcomes of Patients with Alcohol Withdrawal Syndrome Treated with High-Dose Sedatives and Deferred Intubation.
Topics: Adult; Alcohol Withdrawal Seizures; APACHE; Central Nervous System Depressants; Cohort Studies; Crit | 2016 |
Challenges in a large mixed drug overdose patient.
Topics: Adult; Anticonvulsants; Body Temperature Regulation; Critical Care; Delirium; Diazepam; Drug Overdos | 2016 |
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose.
Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Se | 2017 |
Sufentanil and midazolam dosing and pharmacogenetic factors in pediatric analgosedation and withdrawal syndrome.
Topics: Adjuvants, Anesthesia; Child; Dose-Response Relationship, Drug; Female; Genetic Variation; Humans; I | 2016 |
Case Report of Midazolam Withdrawal-Induced Catatonia in a 9-Year-Old Patient.
Topics: Catatonia; Child; Drug Administration Schedule; Humans; Hypnotics and Sedatives; Infusions, Intraven | 2017 |
Employing mirtazapine to aid benzodiazepine withdrawal.
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Humans; Male; Mianserin; Midazolam; Mi | 2008 |
Withdrawal symptoms in critically ill children after long-term administration of sedatives and/or analgesics: a first evaluation.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Hospitalized; Child, Preschool; Female; Humans; Hypnot | 2008 |
Withdrawal assessment in the pediatric intensive care unit: quantifying a morbidity of pain and sedation management in the critically ill child.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Humans; Infant; Intensive Care Units, Pediatric; Midaz | 2008 |
Construction of the Sophia Observation withdrawal Symptoms-scale (SOS) for critically ill children.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Hospitalized; Critical Illness; Female; Humans; Hypnot | 2009 |
["Liquid ecstasy": gamma-butyrolactone withdrawal delirium with rhabdomyolysis and dialysis dependent renal failure].
Topics: 4-Butyrolactone; Acute Kidney Injury; Adrenergic alpha-Agonists; Benzodiazepines; Clonidine; GABA Mo | 2009 |
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU.
Topics: Adrenergic alpha-Agonists; Conscious Sedation; Critical Care; Dexmedetomidine; GABA Modulators; Huma | 2009 |
Creating or preventing opioid addiction, finding the right dose.
Topics: Female; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Units, Pediatric; Male; Methadone; | 2011 |
Withdrawal treatment with clonidine after prolonged use of chloral hydrate in a pediatric intensive care patient.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Chloral Hydrate; Clonidine; Fentanyl; Humans; Hypnoti | 2011 |
Cerebrospinal fluid lactate concentration after withdrawal of metabolic suppressive therapy in subarachnoid hemorrhage.
Topics: Adult; Aged; Female; Fentanyl; Glasgow Outcome Scale; Humans; Hypnotics and Sedatives; Intensive Car | 2012 |
Withdrawal syndrome in the pediatric intensive care unit. Incidence and risk factors.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Cohort Studies; Female; Fentanyl; Humans; H | 2013 |
Pretreatment with midazolam suppresses morphine withdrawal response in mice and rats.
Topics: Adenosine Monophosphate; Animals; Anti-Anxiety Agents; Mice; Midazolam; Morphine Dependence; Naloxon | 2002 |
Stereoselective discriminative stimulus effects of zopiclone in rhesus monkeys.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Diazepam; Discrimination L | 2003 |
[Withdrawal syndrome in a critically ill child after sedation with midazolam and fentanyl].
Topics: Child; Critical Illness; Esophageal Stenosis; Esophagoplasty; Female; Fentanyl; Humans; Hypnotics an | 2004 |
Suspected takotsubo cardiomyopathy caused by withdrawal of bupirenorphine in a child.
Topics: Age Factors; Analgesics, Opioid; Buprenorphine; Cardiomyopathies; Child, Preschool; Echocardiography | 2006 |
Changes in relative potency among positive GABA(A) receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzodiazepines; Diazepam; Discrimination Learning; Dose-Response Relatio | 2007 |
Flumazenil-sensitive dose-related physical dependence in planarians produced by two benzodiazepine and one non-benzodiazepine benzodiazepine-receptor agonists.
Topics: Analysis of Variance; Animals; Benzodiazepines; Clorazepate Dipotassium; Dose-Response Relationship, | 2007 |
Orofacial automatisms induced by acute withdrawal from high-dose midazolam mimicking nonconvulsive status epilepticus in a child.
Topics: Analgesics, Opioid; Child, Preschool; Critical Care; Dose-Response Relationship, Drug; Drug Administ | 2007 |
Prolonged, severe intrathecal baclofen withdrawal syndrome: a case report.
Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Critical Care; Cross Infection; Device Removal; Dose-Re | 2007 |
Acute discontinuation syndrome from dexmedetomidine after protracted use in a pediatric patient.
Topics: Analgesia, Epidural; Blood Pressure; Cardiac Catheterization; Cardiovascular Diseases; Child, Presch | 2008 |
Intravenous clonidine infusion in infants after cardiovascular surgery.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Blood Pressure; Body Temperature; Clonidine; Female; Fent | 2008 |
Interactions between Delta(9)-tetrahydrocannabinol and mu opioid receptor agonists in rhesus monkeys: discrimination and antinociception.
Topics: Analgesics; Analgesics, Opioid; Animals; Data Interpretation, Statistical; Discrimination, Psycholog | 2008 |
Terminal restlessness and nicotine withdrawal.
Topics: Aged; Akathisia, Drug-Induced; Humans; Hypnotics and Sedatives; Male; Midazolam; Nicotine; Substance | 1995 |
Management of alcohol withdrawal.
Topics: Adrenergic alpha-Agonists; Alcoholism; Anti-Anxiety Agents; Clonidine; Diazepam; Humans; Midazolam; | 1995 |
Withdrawal syndrome following midazolam infusion.
Topics: Adult; Amitriptyline; Drug Overdose; Female; Humans; Midazolam; Seizures; Substance Withdrawal Syndr | 1995 |
Trends in the management of alcohol withdrawal syndrome.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Chlordiazepoxide; | 1995 |
A prospective study of the adverse effects of midazolam on withdrawal in critically ill children.
Topics: Child; Child Behavior; Child, Preschool; Critical Illness; Hallucinations; Humans; Incidence; Infant | 1994 |
Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit.
Topics: Child; Female; Fentanyl; Humans; Iatrogenic Disease; Infant; Lorazepam; Male; Methadone; Midazolam; | 1994 |
Energy expenditure and withdrawal of sedation in severe head-injured patients.
Topics: Acute Disease; Adult; Blood Pressure; Craniocerebral Trauma; Energy Metabolism; Fentanyl; Glasgow Co | 1994 |
A 24-h inpatient detoxification treatment for heroin addicts: a preliminary investigation.
Topics: Administration, Oral; Adult; Conscious Sedation; Drug Administration Schedule; Follow-Up Studies; Gu | 1994 |
Benzodiazepine withdrawal reaction in two children following discontinuation of sedation with midazolam.
Topics: Aerophagy; Conscious Sedation; Fever; Humans; Infant; Infant, Newborn; Male; Midazolam; Substance Wi | 1993 |
Reversal of midazolam sedation.
Topics: Akathisia, Drug-Induced; Conscious Sedation; Critical Care; Flumazenil; Humans; Midazolam; Substance | 1993 |
Inhaled 1,1,1-trichloroethane-produced physical dependence in mice: effects of drugs and vapors on withdrawal.
Topics: Administration, Inhalation; Animals; Chlorpromazine; Ethanol; Male; Mice; Midazolam; Pentobarbital; | 1993 |
Ultrashort noninvasive opiate detoxification.
Topics: Adult; Heroin Dependence; Humans; Male; Midazolam; Naloxone; Naltrexone; Ondansetron; Substance With | 1993 |
Effects of chronic treatment with ethanol and withdrawal on levels of monoamines in rat cerebral cortex and striatum. Influence of midazolam, thiopenthal and somatostatin.
Topics: Animals; Anti-Anxiety Agents; Biogenic Monoamines; Cerebral Cortex; Corpus Striatum; Ethanol; Hydrox | 1995 |
Stable low-rate midazolam self-injection with concurrent physical dependence under conditions of long-term continuous availability in baboons.
Topics: Animals; Anti-Anxiety Agents; Feeding Behavior; Flumazenil; Male; Midazolam; Papio; Self Administrat | 1998 |
[Benzodiazepine withdrawal presenting as pseudo-surgical abdominal pain].
Topics: Abdomen, Acute; Adult; Alprazolam; Anti-Anxiety Agents; Bromazepam; Diagnosis, Differential; Headach | 1997 |
Ultra-rapid opiate detoxification using deep sedation with oral midazolam: short and long-term results.
Topics: Administration, Oral; Adolescent; Adult; Anesthesia, General; Clonidine; Drug Therapy, Combination; | 1998 |
Pediatric sedation withdrawal: recognizing the need for refinement in a necessary therapy.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Critical Care; Dose-Response Relationship, | 1999 |
Occurrence of withdrawal in critically ill sedated children.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Critical Care; Dose-Response Relationship, | 1999 |
Subcutaneous administration of fentanyl and midazolam to prevent withdrawal after prolonged sedation in children.
Topics: Analgesics, Opioid; Body Weight; Child; Child, Preschool; Conscious Sedation; Fentanyl; Humans; Hypn | 1999 |
Interference with withdrawal signs of naloxone-induced opiate withdrawal under anesthesia is anesthetic-specific in opiate-dependent rats.
Topics: Anesthesia, General; Anesthetics, Dissociative; Animals; Defecation; Dose-Response Relationship, Dru | 2001 |
Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam.
Topics: Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug | 1992 |
Midazolam withdrawal and discriminative motor control: effects of FG 7142 and Ro 15-1788.
Topics: Animals; Brain Chemistry; Carbolines; Discrimination, Psychological; Dose-Response Relationship, Dru | 1991 |
Behavioral effects of benzodiazepine ligands in non-dependent, diazepam-dependent and diazepam-withdrawn baboons.
Topics: Animals; Behavior, Animal; Benzodiazepines; Carbolines; Diazepam; Dose-Response Relationship, Drug; | 1991 |
Fentanyl, fads, and folly: who will adopt the therapeutic orphans?
Topics: Drug Tolerance; Fentanyl; Humans; Infant; Infant, Newborn; Midazolam; Substance Withdrawal Syndrome | 1991 |
Rapid transition from methadone maintenance to naltrexone.
Topics: Flumazenil; Humans; Methadone; Midazolam; Naltrexone; Substance Withdrawal Syndrome | 1990 |
Midazolam-induced benzodiazepine withdrawal syndrome.
Topics: Akathisia, Drug-Induced; Humans; Intermittent Positive-Pressure Ventilation; Male; Midazolam; Middle | 1991 |
Midazolam withdrawal syndrome.
Topics: Conscious Sedation; Humans; Isoflurane; Midazolam; Substance Withdrawal Syndrome | 1991 |
Technique for greatly shortening the transition from methadone to naltrexone maintenance of patients addicted to opiates.
Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methadone; Mid | 1991 |
Acute benzodiazepine withdrawal after midazolam in children.
Topics: Acute Disease; Child; Humans; Infant; Midazolam; Substance Withdrawal Syndrome | 1990 |
Tolerance and physical dependence to a short-acting benzodiazepine, midazolam.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tole | 1990 |
Clonidine as a sedative adjunct in intensive care.
Topics: Clonidine; Critical Care; Drug Synergism; Drug Therapy, Combination; Fentanyl; Gastrectomy; Humans; | 1990 |
Behavioral differentiation of benzodiazepine ligands after repeated administration in baboons.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Carbolines; Drug Tolerance; Flumazenil; Injections, | 1989 |
Substitution of temazepam and midazolam in pentobarbital-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Arousal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred St | 1989 |
Precipitation of benzodiazepine withdrawal following sudden discontinuation of midazolam.
Topics: Anxiety; Humans; Jejunostomy; Male; Midazolam; Middle Aged; Morphine; Pneumonia; Postoperative Compl | 1989 |
Acute benzodiazepine withdrawal syndrome after midazolam infusions in children.
Topics: Acute Disease; Akathisia, Drug-Induced; Child; Child, Preschool; Cognition Disorders; Confusion; Fem | 1989 |
Regional blood flow and cerebral metabolic changes during alcohol withdrawal and following midazolam therapy.
Topics: Anesthesia, Inhalation; Animals; Benzodiazepines; Blood Gas Analysis; Blood Pressure; Brain; Ethanol | 1985 |
Midazolam and discriminative motor control: chronic administration, withdrawal and modulation by the antagonist Ro 15-1788.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Mal | 1988 |
[Drug dependence tests on a new anesthesia inducer, midazolam].
Topics: Animals; Injections, Intravenous; Macaca fascicularis; Male; Midazolam; Pentobarbital; Self Administ | 1986 |