midazolam has been researched along with Drug Refractory Epilepsy in 9 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare efficacy and safety of Intranasal and Intramuscular routes of midazolam administration in terminating seizures." | 9.51 | The IN-MIDAZ study - Intranasal midazolam in aborting seizures - An epilepsy monitoring unit based randomized controlled trial for efficacy. ( Appukuttan, R; Mehta, S; Ramanujan, B; Shaikh, RG; Singh, RK; Tripathi, M; Vibha, D, 2022) |
| "To compare efficacy and safety of Intranasal and Intramuscular routes of midazolam administration in terminating seizures." | 5.51 | The IN-MIDAZ study - Intranasal midazolam in aborting seizures - An epilepsy monitoring unit based randomized controlled trial for efficacy. ( Appukuttan, R; Mehta, S; Ramanujan, B; Shaikh, RG; Singh, RK; Tripathi, M; Vibha, D, 2022) |
| " This study aimed to analyze the effects of midazolam-induced BS on the occurrence outcomes in refractory status epilepticus patients." | 3.88 | Does burst-suppression achieve seizure control in refractory status epilepticus? ( Chisurajinda, S; Geater, A; Phabphal, K; Somboon, T; Unwongse, K, 2018) |
| "In a rat model of status epilepticus (SE) induced by lithium and pilocarpine and refractory to midazolam, deep hypothermia (20 °C for 30 min) reduced EEG power over 50-fold, stopped SE within 12 min, and reduced EEG spikes by 87%." | 3.81 | Deep hypothermia for the treatment of refractory status epilepticus. ( Baldwin, R; Gezalian, M; Niquet, J; Wasterlain, CG, 2015) |
| " Five patients were sedated with initial lorazepam dose, but this side effect resolved on dosage reduction." | 1.72 | Enteral lorazepam is a promising weaning strategy for midazolam-responsive febrile infection-related epilepsy syndrome (FIRES): a case series ( Chaitra, R; Jain, V; Konanki, R; Sharma, R; Srivastava, K, 2022) |
| "At discharge, all survivors were seizure free." | 1.51 | Treatment options in pediatric super-refractory status epilepticus. ( Arayakarnkul, P; Chomtho, K, 2019) |
| "Ketamine was used in most severe cases." | 1.42 | Preliminary results of the global audit of treatment of refractory status epilepticus. ( Ferlisi, M; Grade, M; Hocker, S; Shorvon, S; Trinka, E, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Jain, V | 1 |
| Konanki, R | 1 |
| Chaitra, R | 1 |
| Srivastava, K | 1 |
| Sharma, R | 1 |
| Shaikh, RG | 1 |
| Ramanujan, B | 1 |
| Singh, RK | 1 |
| Vibha, D | 1 |
| Mehta, S | 1 |
| Appukuttan, R | 1 |
| Tripathi, M | 1 |
| Golub, V | 2 |
| Ramakrishnan, S | 2 |
| Reddy, DS | 2 |
| Niquet, J | 2 |
| Lumley, L | 1 |
| Baldwin, R | 2 |
| Rossetti, F | 1 |
| Schultz, M | 1 |
| de Araujo Furtado, M | 1 |
| Suchomelova, L | 1 |
| Naylor, D | 1 |
| Franco-Estrada, I | 1 |
| Wasterlain, CG | 2 |
| Phabphal, K | 1 |
| Chisurajinda, S | 1 |
| Somboon, T | 1 |
| Unwongse, K | 1 |
| Geater, A | 1 |
| Arayakarnkul, P | 1 |
| Chomtho, K | 1 |
| Ferlisi, M | 1 |
| Hocker, S | 1 |
| Grade, M | 1 |
| Trinka, E | 1 |
| Shorvon, S | 1 |
| Gezalian, M | 1 |
| Flügel, D | 1 |
2 reviews available for midazolam and Drug Refractory Epilepsy
| Article | Year |
|---|---|
Early polytherapy for benzodiazepine-refractory status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Administration Schedule; Drug Resistant Epilepsy; Dr | 2019 |
Topics: Adult; Anticonvulsants; Benzodiazepines; Drug Resistant Epilepsy; Electroencephalography; Humans; Mi | 2017 |
1 trial available for midazolam and Drug Refractory Epilepsy
| Article | Year |
|---|---|
The IN-MIDAZ study - Intranasal midazolam in aborting seizures - An epilepsy monitoring unit based randomized controlled trial for efficacy.
Topics: Administration, Intranasal; Adult; Anticonvulsants; Child; Drug Resistant Epilepsy; Humans; Midazola | 2022 |
6 other studies available for midazolam and Drug Refractory Epilepsy
| Article | Year |
|---|---|
Enteral lorazepam is a promising weaning strategy for midazolam-responsive febrile infection-related epilepsy syndrome (FIRES): a case series
Topics: Child; Drug Resistant Epilepsy; Encephalitis; Epileptic Syndromes; Humans; Lorazepam; Male; Midazola | 2022 |
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa | 2023 |
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa | 2023 |
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa | 2023 |
Isobolographic analysis of adjunct antiseizure activity of the FDA-approved cannabidiol with neurosteroids and benzodiazepines in adult refractory focal onset epilepsy.
Topics: Adult; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Drug Resistant Epilepsy; Epilepsies, Pa | 2023 |
Does burst-suppression achieve seizure control in refractory status epilepticus?
Topics: Adult; Anticonvulsants; Drug Resistant Epilepsy; Electroencephalography; Female; Humans; Male; Midaz | 2018 |
Treatment options in pediatric super-refractory status epilepticus.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diet, Ketogenic; Drug Resistant Epilepsy; Ence | 2019 |
Preliminary results of the global audit of treatment of refractory status epilepticus.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Dissociat | 2015 |
Deep hypothermia for the treatment of refractory status epilepticus.
Topics: Animals; Convulsants; Drug Resistant Epilepsy; Electroencephalography; Hypothermia, Induced; Lithium | 2015 |