midazolam has been researched along with Drug Overdose in 35 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report a case of serotonin syndrome (SS) after sibutramine overdose in a child." | 7.75 | Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma. ( Barros, RF; Bucaretchi, F; da Costa, JL; de Capitani, EM; Fernandes, LC; Hyslop, S; Lanaro, R; Mello, SM, 2009) |
| "We report two patients who experienced status epilepticus after carbamazepine overdose." | 7.71 | Status epilepticus after massive carbamazepine overdose. ( Carlisle, RD; Spiller, HA, 2002) |
| " The investigators studied a patient with a nortriptyline HCI level of 1,205 ng/mL who had four generalized grand mal seizures, each lasting between 60 and 90 seconds that were immediately followed by hypotension requiring norepinephrine support." | 7.69 | Recurrent hypotension immediately after seizures in nortriptyline overdose. ( Bell, A; Gaynor, B; Lipper, B, 1994) |
| "A 6-year-old girl displayed symptoms of serotonin syndrome after accidental ingestion of Vyvanse (lisdexamfetamine dimesylate)." | 3.78 | Dexmedetomidine to treat lisdexamfetamine overdose and serotonin toxidrome in a 6-year-old girl. ( Akingbola, OA; Singh, D, 2012) |
| " Initial electrocardiograms revealed sinus tachycardia at a rate of 180 beats per minute, a prolonged QRS of 130 milliseconds (from a baseline of 65 milliseconds), and a positive terminal R wave in aVR, which later resolved after sodium bicarbonate treatment." | 3.77 | Wide complex tachycardia in a pediatric diphenhydramine overdose treated with sodium bicarbonate. ( Cole, JB; Gross, EA; Smith, SW; Stellpflug, SJ, 2011) |
| "To report a case of serotonin syndrome (SS) after sibutramine overdose in a child." | 3.75 | Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma. ( Barros, RF; Bucaretchi, F; da Costa, JL; de Capitani, EM; Fernandes, LC; Hyslop, S; Lanaro, R; Mello, SM, 2009) |
| "We report a case of citalopram poisoning in a 10-month-old infant with refractory seizures, and an absence of cardiovascular events with subsequent excellent outcome." | 3.73 | Clinical course and toxicokinetic data following isolated citalopram overdose in an infant. ( Baker, SD; Bose, S; Levsky, M; Masullo, LN; Miller, MA, 2006) |
| "We report two patients who experienced status epilepticus after carbamazepine overdose." | 3.71 | Status epilepticus after massive carbamazepine overdose. ( Carlisle, RD; Spiller, HA, 2002) |
| " The investigators studied a patient with a nortriptyline HCI level of 1,205 ng/mL who had four generalized grand mal seizures, each lasting between 60 and 90 seconds that were immediately followed by hypotension requiring norepinephrine support." | 3.69 | Recurrent hypotension immediately after seizures in nortriptyline overdose. ( Bell, A; Gaynor, B; Lipper, B, 1994) |
| " When sedation with benzodiazepines is carried out, the specific antagonist, flumazenil should always be available for use in emergencies such as accidental oversedation, iatrogenic overdose or paradoxical reactions." | 3.69 | Use of inhalational and intravenous sedation in dentistry. ( Rodrigo, MR, 1997) |
| " Dosage adjustments must be considered in the elderly, individuals with medical disorders, and patients taking multiple medications." | 2.38 | Antianxiety/sedative drugs. The benzodiazepines. ( Giacalone, VF, 1992) |
| " Each dosing error was reviewed by two investigators." | 1.91 | Medication Errors in Pediatric Patients after Implementation of a Field Guide with Volume-Based Dosing. ( Hulac, S; Markowitz, G; Rappaport, LD; Roosevelt, G, 2023) |
| "Treatment with carisoprodol and phenobarbital provided additional benefit and can be considered in cases of severe carisoprodol withdrawal." | 1.46 | Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. ( Benowitz, NL; Horng, H; Smollin, CG; Vo, KT, 2017) |
| " Ongoing monitoring of this particular adverse event will be required with a sustained patient safety message to health services to maintain awareness of the issue and reduction in the number of midazolam-related errors." | 1.42 | Reducing risk of overdose with midazolam injection in adults: an evaluation of change in clinical practice to improve patient safety in England. ( Flood, C; Lamont, T; Mansaray, M; Marsh, R; Matthew, L; Patel, B, 2015) |
| "Tiagabine (Gabitril) is a unique anticonvulsant that is prescribed for a variety of psychiatric disorders." | 1.32 | Intentional overdose with tiagabine: an unusual clinical presentation. ( Cantrell, FL; Himes, E; Ritter, M, 2004) |
| " However, the situations suggest that we should carefully check the dosage and review the correct procedures, even when using a drug that is considered to be familiar with most practitioners." | 1.31 | Accidental overdose of midazolam as intramuscular premedication. ( Hanaoka, K; Nishiyama, T, 2002) |
| "Flumazenil (Anexate) was an effective antidote in mono- and combined intoxications involving zolpidem." | 1.29 | [Acute overdose of Zolpidem (Stilnox)]. ( Meier-Abt, PJ; Radovanovic, D; Wyss, PA, 1996) |
| "Midazolam was replaced by saline in the other 12." | 1.28 | Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog. ( Askenasi, R; Leduc, D; Lheureux, P; Vranckx, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (28.57) | 18.2507 |
| 2000's | 13 (37.14) | 29.6817 |
| 2010's | 11 (31.43) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Rappaport, LD | 1 |
| Markowitz, G | 1 |
| Hulac, S | 1 |
| Roosevelt, G | 1 |
| Rech, MA | 1 |
| Barbas, B | 1 |
| Chaney, W | 1 |
| Greenhalgh, E | 1 |
| Turck, C | 1 |
| Židková, M | 1 |
| Horsley, R | 1 |
| Hloch, O | 1 |
| Hložek, T | 1 |
| Ameline, A | 1 |
| Raul, JS | 1 |
| Kintz, P | 1 |
| Selbst, SM | 1 |
| Flood, C | 1 |
| Matthew, L | 2 |
| Marsh, R | 1 |
| Patel, B | 1 |
| Mansaray, M | 1 |
| Lamont, T | 3 |
| Zhang, P | 1 |
| Austin, E | 1 |
| Thompson, M | 1 |
| Lin, S | 1 |
| Vo, KT | 1 |
| Horng, H | 1 |
| Smollin, CG | 1 |
| Benowitz, NL | 1 |
| Morris, E | 1 |
| Green, D | 1 |
| Graudins, A | 1 |
| Bucaretchi, F | 1 |
| de Capitani, EM | 1 |
| Mello, SM | 1 |
| Lanaro, R | 1 |
| Barros, RF | 1 |
| Fernandes, LC | 1 |
| da Costa, JL | 1 |
| Hyslop, S | 1 |
| Cousins, D | 1 |
| Green, J | 1 |
| Scarpello, J | 1 |
| Weaver, JM | 1 |
| Wilson, KE | 1 |
| Thorpe, RJ | 1 |
| McCabe, JF | 1 |
| Girdler, NM | 1 |
| Cole, JB | 1 |
| Stellpflug, SJ | 1 |
| Gross, EA | 1 |
| Smith, SW | 1 |
| Akingbola, OA | 1 |
| Singh, D | 1 |
| Ranson, D | 1 |
| Nishiyama, T | 1 |
| Hanaoka, K | 1 |
| Caldicott, DG | 1 |
| Edwards, NA | 1 |
| Kruys, A | 1 |
| Kirkbride, KP | 1 |
| Sims, DN | 1 |
| Byard, RW | 1 |
| Prior, M | 1 |
| Irvine, RJ | 1 |
| Cantrell, FL | 1 |
| Ritter, M | 1 |
| Himes, E | 1 |
| Masullo, LN | 1 |
| Miller, MA | 1 |
| Baker, SD | 1 |
| Bose, S | 1 |
| Levsky, M | 1 |
| Jette, N | 1 |
| Cappell, J | 1 |
| VanPassel, L | 1 |
| Akman, CI | 1 |
| Kohjitani, A | 1 |
| Higuchi, H | 1 |
| Shimada, M | 1 |
| Miyawaki, T | 1 |
| Shenkman, Z | 1 |
| Ornstein, E | 1 |
| Adler, D | 1 |
| Hantson, P | 1 |
| Clemessy, JL | 1 |
| Baud, FJ | 1 |
| Lipper, B | 1 |
| Bell, A | 1 |
| Gaynor, B | 1 |
| Wyss, PA | 1 |
| Radovanovic, D | 1 |
| Meier-Abt, PJ | 1 |
| Hoes, MJ | 1 |
| Zeijpveld, JH | 1 |
| Rodrigo, MR | 1 |
| Briassoulis, G | 1 |
| Kalabalikis, P | 1 |
| Tamiolaki, M | 1 |
| Hatzis, T | 1 |
| Michalodimitrakis, M | 1 |
| Christodoulou, P | 1 |
| Tsatsakis, AM | 1 |
| Askoxilakis, I | 1 |
| Stiakakis, I | 1 |
| Mouzas, I | 1 |
| Sandler, NA | 1 |
| Sparks, BS | 1 |
| Spiller, HA | 1 |
| Carlisle, RD | 1 |
| Lheureux, P | 1 |
| Vranckx, M | 1 |
| Leduc, D | 1 |
| Askenasi, R | 1 |
| Giacalone, VF | 1 |
2 reviews available for midazolam and Drug Overdose
| Article | Year |
|---|---|
When to Pick the Nose: Out-of-Hospital and Emergency Department Intranasal Administration of Medications.
Topics: Administration, Intranasal; Analgesics, Opioid; Conscious Sedation; Dexmedetomidine; Drug Overdose; | 2017 |
Antianxiety/sedative drugs. The benzodiazepines.
Topics: Age Factors; Anxiety Disorders; Benzodiazepines; Conscious Sedation; Drug Interactions; Drug Overdos | 1992 |
1 trial available for midazolam and Drug Overdose
| Article | Year |
|---|---|
The use of bispectral analysis in patients undergoing intravenous sedation for third molar extractions.
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthetics, Intravenous; Anesthetics, Local; Conscious Sedat | 2000 |
32 other studies available for midazolam and Drug Overdose
| Article | Year |
|---|---|
Medication Errors in Pediatric Patients after Implementation of a Field Guide with Volume-Based Dosing.
Topics: Child; Drug Overdose; Emergency Medical Services; Epinephrine; Humans; Infant; Infant, Newborn; Medi | 2023 |
Near-fatal Intoxication with the "New" Synthetic Opioid U-47700: The First Reported Case in the Czech Republic.
Topics: Adult; Benzamides; Benzodiazepines; Chromatography, Liquid; Citalopram; Czech Republic; Drug Overdos | 2019 |
Testing for midazolam and oxycodone in blood after formalin-embalmment: About a complex medico-legal case.
Topics: Adult; Autopsy; Chromatography, High Pressure Liquid; Diagnosis; Drug Monitoring; Drug Overdose; For | 2019 |
Pediatric emergency medicine: legal briefs.
Topics: Accidents, Traffic; Amputation, Surgical; Baseball; Brain Damage, Chronic; Child; Colon; Commitment | 2013 |
Reducing risk of overdose with midazolam injection in adults: an evaluation of change in clinical practice to improve patient safety in England.
Topics: Antidotes; Dose-Response Relationship, Drug; Drug Overdose; England; Flumazenil; Health Knowledge, A | 2015 |
Challenges in a large mixed drug overdose patient.
Topics: Adult; Anticonvulsants; Body Temperature Regulation; Critical Care; Delirium; Diazepam; Drug Overdos | 2016 |
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose.
Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Se | 2017 |
Neuroleptic malignant syndrome developing after acute overdose with olanzapine and chlorpromazine.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bromocriptine; Chlorpromazine; Citalopram; Combined Mo | 2009 |
Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma.
Topics: Antidotes; Appetite Depressants; Child, Preschool; Chloral Hydrate; Chromatography, High Pressure Li | 2009 |
Avoiding midazolam overdose: summary of a safety report from the National Patient Safety Agency.
Topics: Drug Overdose; Humans; Hypnotics and Sedatives; Medication Errors; Midazolam; Practice Guidelines as | 2009 |
National Patient Safety Agency: combining stories with statistics to minimise harm.
Topics: Drug Information Services; Drug Overdose; Humans; Hypnotics and Sedatives; Medication Errors; Midazo | 2009 |
The fallacy of a lifesaving sublingual injection of flumazenil.
Topics: Anesthesia Recovery Period; Antidotes; Benzodiazepines; Conscious Sedation; Drug Overdose; Flumazeni | 2011 |
Complications associated with intravenous midazolam sedation in anxious dental patients.
Topics: Adolescent; Adult; Aged; Anesthesia, Dental; Anesthetics, Intravenous; Child; Clinical Audit; Consci | 2011 |
Wide complex tachycardia in a pediatric diphenhydramine overdose treated with sodium bicarbonate.
Topics: Anticonvulsants; Cholinergic Antagonists; Diphenhydramine; Drug Overdose; Electrocardiography; Emerg | 2011 |
Dexmedetomidine to treat lisdexamfetamine overdose and serotonin toxidrome in a 6-year-old girl.
Topics: Adrenergic alpha-2 Receptor Agonists; Anti-Anxiety Agents; Central Nervous System Stimulants; Child; | 2012 |
Therapeutic drugs and death.
Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Anti-Anxiety Agents; Cocaine; Drug Overdose; Fatal Out | 2001 |
Accidental overdose of midazolam as intramuscular premedication.
Topics: Adjuvants, Anesthesia; Aged; Drug Overdose; Humans; Injections, Intramuscular; Male; Medication Erro | 2002 |
Dancing with "death": p-methoxyamphetamine overdose and its acute management.
Topics: Acute Disease; Adult; Amphetamines; Chromatography, Gas; Drug Overdose; Female; Glasgow Coma Scale; | 2003 |
Intentional overdose with tiagabine: an unusual clinical presentation.
Topics: Anticonvulsants; Drug Overdose; Female; Humans; Hypnotics and Sedatives; Midazolam; Middle Aged; Ner | 2004 |
Clinical course and toxicokinetic data following isolated citalopram overdose in an infant.
Topics: Charcoal; Citalopram; Drug Overdose; Female; Humans; Hypnotics and Sedatives; Infant; Intensive Care | 2006 |
Tiagabine-induced nonconvulsive status epilepticus in an adolescent without epilepsy.
Topics: Adolescent; Drug Overdose; Electroencephalography; Female; GABA Modulators; Humans; Infusions, Intra | 2006 |
Oral midazolam for sedation in minor oral operations in children: a retrospective study.
Topics: Administration, Oral; Age Factors; Anesthesia, Dental; Body Weight; Child; Conscious Sedation; Denta | 2008 |
Drug overdose as a consequence of misuse of a syringe pump.
Topics: Adult; Drug Overdose; Humans; Infusion Pumps; Injections, Intravenous; Male; Mathematical Computing; | 1995 |
Withdrawal syndrome following midazolam infusion.
Topics: Adult; Amitriptyline; Drug Overdose; Female; Humans; Midazolam; Seizures; Substance Withdrawal Syndr | 1995 |
Recurrent hypotension immediately after seizures in nortriptyline overdose.
Topics: Biological Availability; Blood Pressure; Drug Overdose; Female; Heart; Humans; Hypotension; Midazola | 1994 |
[Acute overdose of Zolpidem (Stilnox)].
Topics: Adolescent; Adult; Aged; Antidotes; Coma; Drug Overdose; Female; Flumazenil; Humans; Hypnotics and S | 1996 |
First report of mirtazapine overdose.
Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Coma; Depressive Dis | 1996 |
Use of inhalational and intravenous sedation in dentistry.
Topics: Accidents; Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Local; A | 1997 |
Lamotrigine childhood overdose.
Topics: Anticonvulsants; Child, Preschool; Drug Overdose; Epilepsy, Tonic-Clonic; Gastric Lavage; Humans; La | 1998 |
Death related to midazolam overdose during endoscopic retrograde cholangiopancreatography.
Topics: Anti-Anxiety Agents; Cholangiopancreatography, Endoscopic Retrograde; Chromatography, High Pressure | 1999 |
Status epilepticus after massive carbamazepine overdose.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Drug Overdose; Fatal Outcome; Female; Humans; Hypnotics | 2002 |
Flumazenil in mixed benzodiazepine/tricyclic antidepressant overdose: a placebo-controlled study in the dog.
Topics: Amitriptyline; Animals; Arrhythmias, Cardiac; Dogs; Drug Interactions; Drug Overdose; Electrocardiog | 1992 |