midazolam has been researched along with Down Syndrome in 7 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the pharmacokinetics and pharmacodynamics of IV midazolam after cardiac surgery between children with and without Down syndrome." | 8.02 | Sedation With Midazolam After Cardiac Surgery in Children With and Without Down Syndrome: A Pharmacokinetic-Pharmacodynamic Study. ( Breatnach, CV; Goulooze, SC; Knibbe, CAJ; Mathôt, RAA; Peeters, MYM; Tibboel, D; Valkenburg, AJ; van Dijk, M, 2021) |
| "Midazolam sedation was estimated by Bayesian inference for generalized linear mixed models." | 5.56 | Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients. ( Enomoto, Y; Hiramatsu, Y; Hoshino, H; Inoue, Y; Mathis, BJ; Matsuishi, Y; Sakuramoto, H; Shimojo, N, 2020) |
| "To compare the pharmacokinetics and pharmacodynamics of IV midazolam after cardiac surgery between children with and without Down syndrome." | 4.02 | Sedation With Midazolam After Cardiac Surgery in Children With and Without Down Syndrome: A Pharmacokinetic-Pharmacodynamic Study. ( Breatnach, CV; Goulooze, SC; Knibbe, CAJ; Mathôt, RAA; Peeters, MYM; Tibboel, D; Valkenburg, AJ; van Dijk, M, 2021) |
| " A significant odds ratio related to decreased SpO2 was observed for age, sex, midazolam and propofol levels, concurrent use of nitrous oxide, cerebral palsy, Down syndrome, and mental retardation." | 3.79 | Risk factors with intravenous sedation for patients with disabilities. ( Fukayama, H; Ishikawa, M; Jinno, S; Kohase, H; Kunimori, H; Miwa, Z; Nakamura, Z; Okumura, H; Shimoyama, K; Tamaki, Y; Yoshikawa, F, 2013) |
| "Midazolam sedation was estimated by Bayesian inference for generalized linear mixed models." | 1.56 | Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients. ( Enomoto, Y; Hiramatsu, Y; Hoshino, H; Inoue, Y; Mathis, BJ; Matsuishi, Y; Sakuramoto, H; Shimojo, N, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuishi, Y | 1 |
| Sakuramoto, H | 1 |
| Hoshino, H | 1 |
| Shimojo, N | 1 |
| Enomoto, Y | 1 |
| Mathis, BJ | 1 |
| Hiramatsu, Y | 1 |
| Inoue, Y | 1 |
| Valkenburg, AJ | 1 |
| Goulooze, SC | 1 |
| Breatnach, CV | 1 |
| Mathôt, RAA | 1 |
| Tibboel, D | 1 |
| van Dijk, M | 1 |
| Knibbe, CAJ | 1 |
| Peeters, MYM | 1 |
| Yoshikawa, F | 1 |
| Tamaki, Y | 1 |
| Okumura, H | 1 |
| Miwa, Z | 1 |
| Ishikawa, M | 1 |
| Shimoyama, K | 1 |
| Nakamura, Z | 1 |
| Kunimori, H | 1 |
| Jinno, S | 1 |
| Kohase, H | 1 |
| Fukayama, H | 1 |
| Revesz, T | 1 |
| Orban, T | 1 |
| DeBuse, P | 1 |
| Ariño, P | 1 |
| Aguado, L | 1 |
| Cortada, V | 1 |
| Baltasar, M | 1 |
| Puig, MM | 1 |
| Tobias, JD | 1 |
| Berkenbosch, JW | 1 |
| Riley, DP | 1 |
| McBride, LJ | 1 |
7 other studies available for midazolam and Down Syndrome
| Article | Year |
|---|---|
Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients.
Topics: Bayes Theorem; Benzodiazepines; Cardiovascular System; Deep Sedation; Down Syndrome; Female; Heart D | 2020 |
Sedation With Midazolam After Cardiac Surgery in Children With and Without Down Syndrome: A Pharmacokinetic-Pharmacodynamic Study.
Topics: Cardiac Surgical Procedures; Child; Down Syndrome; Humans; Hypnotics and Sedatives; Midazolam; Prosp | 2021 |
Risk factors with intravenous sedation for patients with disabilities.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia Recovery Period; Anesthesia, Dental; Anesthes | 2013 |
Transient respiratory depression in two patients with Down's syndrome following Midazolam premedication.
Topics: Down Syndrome; Humans; Male; Midazolam; Premedication; Respiration Disorders | 1993 |
Cold urticaria associated with intraoperative hypotension and facial edema.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anesthetics, General; Angioedema; Anti-Inflamm | 1999 |
Tolerance during sedation in a pediatric ICU patient: effects on the BIS monitor.
Topics: Adjuvants, Anesthesia; Anesthesia; Anesthetics; Anesthetics, Intravenous; Child; Down Syndrome; Drug | 2001 |
Ketamine, midazolam and vecuronium infusion. Anaesthesia for Down's syndrome and congenital heart disease.
Topics: Adult; Anesthesia, Intravenous; Cataract Extraction; Down Syndrome; Female; Heart Septal Defects, Ve | 1991 |