Page last updated: 2024-10-31

midazolam and Dizzyness

midazolam has been researched along with Dizzyness in 12 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Research Excerpts

ExcerptRelevanceReference
"Modafinil 200 mg was administered to the treatment group patients 1 h before sedation/analgesia."2.75Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. ( Boesjes, H; Galvin, E; Hol, J; Klein, J; Ubben, JF; Verbrugge, SJ, 2010)
"In this randomized, double-blinded study, we compared the onset and recovery characteristics of an investigational benzodiazepine, Ro 48-6791 (when administered alone or combined with meperidine), a midazolam-meperidine combination for sedation during gastrointestinal (GI) endoscopic procedures."2.69Comparison of the sedation and recovery profiles of Ro 48-6791, a new benzodiazepine, and midazolam in combination with meperidine for outpatient endoscopic procedures. ( Gold, J; Gold, M; Tang, J; Wang, B; White, PF, 1999)
" We recorded adverse events during the endoscopic procedure and additionally retrieved questionnaires investigating subjective parameters 24 h after the endoscopic procedure."1.40Safety analysis of endoscopist-directed propofol sedation: a prospective, national multicenter study of 24 441 patients in German outpatient practices. ( Beck, S; Friedrich, K; Gotthardt, DN; Heil, FJ; Rex, DK; Scholl, SG; Sieg, A; Stremmel, W, 2014)
"The objectives of this study were to describe the type and frequency of postdischarge adverse events related to sedation for elective diagnostic imaging in children and to determine if any patient or drug characteristics were associated with such adverse events."1.38Postdischarge adverse events related to sedation for diagnostic imaging in children. ( Chen, X; Kaila, R; Kannikeswaran, N, 2012)
" The aim of this prospective observational audit was to evaluate our practice and report the occurrence of adverse events and behavioral reactions related to the use of ketamine, propofol, and midazolam combinations."1.35Adverse events and behavioral reactions related to ketamine based anesthesia for anorectal manometry in children. ( Dalal, PG; Seth, N; Somerville, N; Taylor, D, 2008)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19902 (16.67)18.7374
1990's2 (16.67)18.2507
2000's2 (16.67)29.6817
2010's6 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xia, L1
Wu, XW1
Li, JY1
Yan, ZW1
Ze, HC1
Liu, SY1
Sieg, A1
Beck, S1
Scholl, SG1
Heil, FJ1
Gotthardt, DN1
Stremmel, W1
Rex, DK1
Friedrich, K1
Dilli, D1
Dallar, Y1
Sorgui, NH1
Galvin, E1
Boesjes, H1
Hol, J1
Ubben, JF1
Klein, J1
Verbrugge, SJ1
Lee, JJ1
Lee, JH1
Hand, D1
Averley, P1
Lyne, J1
Girdler, N1
Kaila, R1
Chen, X1
Kannikeswaran, N1
Dalal, PG1
Taylor, D1
Somerville, N1
Seth, N1
Donnelly, MB1
Scott, WA1
Daly, DS1
Tang, J1
Wang, B1
White, PF1
Gold, M1
Gold, J1
Short, TG1
Galletly, DC1
Rodrigo, MR1
Cheung, LK1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102]Phase 4105 participants (Actual)Interventional2016-02-29Terminated
Use of Sevoflurane, Midazolam and Ketamine in Children for Dental Sedation Treatment: Occurrence of Adverse Events[NCT02284204]Phase 227 participants (Actual)Interventional2012-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit

Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours

Interventionminutes (Mean)
Placebo53.5
Modafinil61.0

Postanesthesia Quality Recovery Scale Score

Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery

Interventionunits on a scale (Mean)
Placebo-5.67
Modafinil-8.91

Trials

7 trials available for midazolam and Dizzyness

ArticleYear
Intravenous ketamine plus midazolam vs. intravenous ketamine for sedation in lumbar puncture: a randomized controlled trial.
    Indian pediatrics, 2008, Volume: 45, Issue:11

    Topics: Adolescent; Anesthetics, Dissociative; Anesthetics, Intravenous; Child; Confidence Intervals; Dizzin

2008
Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia Recovery Period; Anesthetics, Inha

2010
Middle-ear surgery under sedation: comparison of midazolam alone or midazolam with remifentanil.
    The Journal of laryngology and otology, 2011, Volume: 125, Issue:6

    Topics: Adult; Anesthetics, Local; Anxiety; Conscious Sedation; Dizziness; Drug Therapy, Combination; Ear, M

2011
Sedation for upper gastrointestinal endoscopy: a comparison of alfentanil-midazolam and meperidine-diazepam.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:12

    Topics: Age Factors; Alfentanil; Anesthesia Recovery Period; Apnea; Conscious Sedation; Diazepam; Dizziness;

1994
Comparison of the sedation and recovery profiles of Ro 48-6791, a new benzodiazepine, and midazolam in combination with meperidine for outpatient endoscopic procedures.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:4

    Topics: Adjuvants, Anesthesia; Ambulatory Care; Analgesics, Opioid; Anesthesia Recovery Period; Anti-Anxiety

1999
Residual psychomotor effects following reversal of midazolam sedation with flumazenil.
    Anaesthesia and intensive care, 1989, Volume: 17, Issue:3

    Topics: Adult; Affect; Dizziness; Flumazenil; Heart Rate; Humans; Hypnotics and Sedatives; Locomotion; Male;

1989
Oral midazolam sedation in third molar surgery.
    International journal of oral and maxillofacial surgery, 1987, Volume: 16, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Anesthesia, Dental; Dizziness; Double-Blind Method; Female;

1987

Other Studies

5 other studies available for midazolam and Dizzyness

ArticleYear
[Effect of simulated navigation stimulation on the sedative action of midazolam in patients].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2013, Volume: 29, Issue:2

    Topics: Adult; Dizziness; Humans; Hypnotics and Sedatives; Male; Midazolam; Naval Medicine; Young Adult

2013
Safety analysis of endoscopist-directed propofol sedation: a prospective, national multicenter study of 24 441 patients in German outpatient practices.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:3

    Topics: Colonoscopy; Conscious Sedation; Dizziness; Dose-Response Relationship, Drug; Drug Therapy, Combinat

2014
Advanced paediatric conscious sedation: an alternative to dental general anaesthetic in the U.K.
    SAAD digest, 2011, Volume: 27

    Topics: Adolescent; Anesthesia, Dental; Anesthetics, General; Anesthetics, Inhalation; Anesthetics, Intraven

2011
Postdischarge adverse events related to sedation for diagnostic imaging in children.
    Pediatric emergency care, 2012, Volume: 28, Issue:8

    Topics: Child; Child, Preschool; Dizziness; Female; Fentanyl; Follow-Up Studies; Humans; Hypnotics and Sedat

2012
Adverse events and behavioral reactions related to ketamine based anesthesia for anorectal manometry in children.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:3

    Topics: Anal Canal; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics,

2008