midazolam has been researched along with Disorders of Excessive Somnolence in 3 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Disorders of Excessive Somnolence: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Serial plasma samples were collected for pharmacokinetic analyses." | 2.73 | The effect of multiple-dose, oral rifaximin on the pharmacokinetics of intravenous and oral midazolam in healthy volunteers. ( Bettenhausen, DK; Connolly, M; Forbes, WP; Pentikis, HS; Trapnell, CB, 2007) |
| "To compare the occurrence of post-discharge adverse events in children having received a high dose of either chloral hydrate (CH) or midazolam (MZ) during outpatient dental treatment." | 1.38 | Post-discharge adverse events following pediatric sedation with high doses of oral medication. ( Bendo, CB; Brasileiro, SV; Costa, LR; Costa, PS; Paiva, SM; Viegas, CM, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, LR | 1 |
| Costa, PS | 1 |
| Brasileiro, SV | 1 |
| Bendo, CB | 1 |
| Viegas, CM | 1 |
| Paiva, SM | 1 |
| Pentikis, HS | 1 |
| Connolly, M | 1 |
| Trapnell, CB | 1 |
| Forbes, WP | 1 |
| Bettenhausen, DK | 1 |
| Ozone, M | 1 |
| Itoh, H | 1 |
| Ohbuchi, K | 1 |
| Ohyama, E | 1 |
| Hayashida, K | 1 |
| Sato, M | 1 |
| Sasaki, M | 1 |
| Ushijima, S | 1 |
| Tanifuji, Y | 1 |
2 trials available for midazolam and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
The effect of multiple-dose, oral rifaximin on the pharmacokinetics of intravenous and oral midazolam in healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Anti-Anxiety Agents; Anti-Infective Agents; Area Under Curv | 2007 |
The effects of flumazenil on sleepiness, task performance and nocturnal sleep after anesthesia with midazolam.
Topics: Adult; Anesthetics, Intravenous; Disorders of Excessive Somnolence; Flumazenil; GABA Modulators; Hum | 2001 |
1 other study available for midazolam and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
Post-discharge adverse events following pediatric sedation with high doses of oral medication.
Topics: Administration, Oral; Ambulatory Care; Anesthesia, Dental; Child; Child, Preschool; Chloral Hydrate; | 2012 |