midazolam has been researched along with Disease Models, Animal in 93 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to discover and develop drug-like anti-inflammatory agents against arthritis, based on "Hit" we found earlier and to overcome drawbacks of toxicity, twelve series of total 89 novel pyrimidine, pyrazolo[4,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives were designed, synthesized and screened for their anti-inflammatory activity against NO and toxicity for normal liver cells (LO2)." | 8.02 | Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. ( Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL, 2021) |
| "Rats pancreatitis model were randomly divided into 4 groups, model group, midazolam group, sufentanil group, and combined group, followed by an analysis of the general indicators, the onset time, duration, analgesic time, and adverse reactions, as well as pancreatic serological indicators." | 7.96 | Effects of midazolam combined with sufentanil on injury and expression of HMGB1 and NF-κB in rats with pancreatitis. ( Liu, Y; Liu, YY; Zhou, H; Zhu, ZH, 2020) |
| "This study aimed to investigate the effects of renal ischaemia/reperfusion (I/R)-induced acute kidney injury (AKI) on the distribution of midazolam (MDZ), a probe drug for cytochrome P450 3A (CYP3A) activity." | 7.91 | Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats. ( Fumoto, S; Miyamoto, H; Nishida, K; Tokunaga, A, 2019) |
| "Midazolam possesses antitumorigenic properties partly mediated by the peripheral benzodiazepine receptor, whereas dexmedetomidine promotes cancer cell survival through signaling via the α2-adrenoceptor in lung carcinoma and neuroglioma cells." | 7.88 | Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo. ( Bevan, C; Date, A; Datoo, T; Jiang, C; Ma, D; Sanders, RD; Wang, C; Wang, G; Wu, L; Zhao, H, 2018) |
| " Two common means of anesthesia before euthanasia and bronchoalveolar lavage in rats are intraperitoneal injection of pentobarbital and inhalation of isoflurane." | 7.83 | Effects of pentobarbital, isoflurane, or medetomidine-midazolam-butorphanol anesthesia on bronchoalveolar lavage fluid and blood chemistry in rats. ( Ajimi, S; Hashizume, N; Imatanaka, N; Kobayashi, T; Nakai, M; Oshima, Y; Tsubokura, Y, 2016) |
| "In dogs, intraoperative cardiac tamponade caused comparable changes in RBF under the different anesthetic techniques except that autoregulation was effective in maintaining RBF within the central nervous system only under isoflurane anesthesia." | 7.72 | Isoflurane preserves central nervous system blood flow during intraoperative cardiac tamponade in dogs. ( Crystal, GJ; Metwally, AA; Salem, MR, 2004) |
| "The contribution of GABAergic mechanisms to rat emotional behavior in two animal models of anxiety (open field test of neophobia and aversively conditioned freezing reaction), was confirmed by pharmacological analysis, using anxiolytic (midazolam) and anxiogenic (picrotoxin) compounds." | 7.72 | Rat behavior in two models of anxiety and brain [3H]muscimol binding: pharmacological, correlation, and multifactor analysis. ( Bidziński, A; Członkowska, AI; Lehner, M; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J; Turzyńska, D; Wisłowska, A; Zienowicz, M, 2003) |
| ") administration of a non-selective full benzodiazepine receptor agonist, midazolam, and a neuroactive steroid, allopregnanolone, on picrotoxin-induced seizures and striatal dopamine metabolism, were studied in mice." | 7.71 | Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures. ( Bidziński, A; Członkowska, AI; Krzaścik, P; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J, 2001) |
| "The pharmacodynamics of midazolam was studied in the kindling model of experimental epilepsy." | 7.70 | Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy. ( Cleton, A; Danhof, M; Ghijsen, W; Van der Graaf, PH; Voskuyl, R, 1999) |
| "Midazolam is an anesthetic widely used for anxiolysis and sedation; however, to date, a possible role for midazolam in diabetic kidney disease remains unknown." | 5.72 | Midazolam Ameliorates Hyperglycemia-Induced Glomerular Endothelial Dysfunction by Inhibiting Transglutaminase 2 in Diabetes. ( Cho, S; Ha, KS; Hong, SH; Jeon, HY; Kim, EB; Kim, M; Lee, YJ; Sayyed, ND; Seo, JA, 2022) |
| "All untreated rat pups had seizures within 10 minutes after termination of asphyxia." | 5.62 | Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. ( Ala-Kurikka, T; Gailus, B; Hampel, P; Johne, M; Kaila, K; Löscher, W; Römermann, K; Theilmann, W, 2021) |
| "Neuropathic pain is a complex, chronic pain condition and the treatment is a major clinical challenge." | 5.48 | Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats. ( Chen, J; Li, H; Li, N; Lim, G; Ma, W; McCabe, MF; Yang, Y; Zhao, W, 2018) |
| "Midazolam was administered to 6-week-old BALB/c male mice under hypoxic conditions and pregnant C57BL/6N mice under normoxic conditions." | 5.42 | Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system. ( Daijo, H; Fukuda, K; Harada, H; Kai, S; Matsuyama, T; Tanaka, T; Tatsumi, K, 2015) |
| "Status epilepticus was induced by intra-amygdala microinjection of kainic acid in 8week old C57Bl/6 mice." | 5.42 | Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice. ( Diviney, M; Henshall, DC; Reynolds, JP, 2015) |
| " Anticonvulsant effective doses (ED(50)) were determined using an up-down dosing procedure over successive animals." | 5.36 | Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801. ( McDonough, JH; Shih, TM; Skovira, JW, 2010) |
| "Midazolam is a water-soluble benzodiazepine proven to be efficacious in sedation, hypnosis, and induction and maintenance of anesthesia." | 5.29 | Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine. ( Bradford, SM; Orebaugh, SL, 1994) |
| "In order to discover and develop drug-like anti-inflammatory agents against arthritis, based on "Hit" we found earlier and to overcome drawbacks of toxicity, twelve series of total 89 novel pyrimidine, pyrazolo[4,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives were designed, synthesized and screened for their anti-inflammatory activity against NO and toxicity for normal liver cells (LO2)." | 4.02 | Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis. ( Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL, 2021) |
| "The development of refractory status epilepticus (SE) induced by sarin intoxication presents a therapeutic challenge." | 4.02 | Neuroprotection by delayed triple therapy following sarin nerve agent insult in the rat. ( Baranes, S; Chapman, S; David, T; Dekel Jaoui, H; Efrati, R; Egoz, I; Gez, R; Gore, A; Grauer, E; Lazar, S; Neufeld-Cohen, A; Yampolsky, M, 2021) |
| "Rats pancreatitis model were randomly divided into 4 groups, model group, midazolam group, sufentanil group, and combined group, followed by an analysis of the general indicators, the onset time, duration, analgesic time, and adverse reactions, as well as pancreatic serological indicators." | 3.96 | Effects of midazolam combined with sufentanil on injury and expression of HMGB1 and NF-κB in rats with pancreatitis. ( Liu, Y; Liu, YY; Zhou, H; Zhu, ZH, 2020) |
| "None of the five drugs was able to suppress potentiation appearing immediately after cortical epileptic afterdischarges, but all of them exhibited delayed anticonvulsant action 10 (in the case of midazolam and muscimol) or 20 min (all three steroids) after cortical seizures." | 3.96 | Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats. ( Kubová, H; Kudová, E; Mareš, P; Valeš, K, 2020) |
| "This study aimed to investigate the effects of renal ischaemia/reperfusion (I/R)-induced acute kidney injury (AKI) on the distribution of midazolam (MDZ), a probe drug for cytochrome P450 3A (CYP3A) activity." | 3.91 | Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats. ( Fumoto, S; Miyamoto, H; Nishida, K; Tokunaga, A, 2019) |
| "These experiments identify a novel role for PER2 during a midazolam- or constant light-induced delirium-like state, highlight the importance of hippocampal PER2 expression for cognitive function, and suggest the PER2 enhancer nobiletin as potential therapy in delirium-like conditions associated with circadian disruption." | 3.88 | The Period 2 Enhancer Nobiletin as Novel Therapy in Murine Models of Circadian Disruption Resembling Delirium. ( Eckle, T; Gile, J; Scott, B, 2018) |
| "Midazolam possesses antitumorigenic properties partly mediated by the peripheral benzodiazepine receptor, whereas dexmedetomidine promotes cancer cell survival through signaling via the α2-adrenoceptor in lung carcinoma and neuroglioma cells." | 3.88 | Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo. ( Bevan, C; Date, A; Datoo, T; Jiang, C; Ma, D; Sanders, RD; Wang, C; Wang, G; Wu, L; Zhao, H, 2018) |
| " Two common means of anesthesia before euthanasia and bronchoalveolar lavage in rats are intraperitoneal injection of pentobarbital and inhalation of isoflurane." | 3.83 | Effects of pentobarbital, isoflurane, or medetomidine-midazolam-butorphanol anesthesia on bronchoalveolar lavage fluid and blood chemistry in rats. ( Ajimi, S; Hashizume, N; Imatanaka, N; Kobayashi, T; Nakai, M; Oshima, Y; Tsubokura, Y, 2016) |
| "To evaluate the effects of pretreatment, midazolam (M), propofol (P), ziprasidone (Z), and two combinations of [(midazolam plus propofol (MP); midazolam plus ziprasidone (MZ)] in mice models in the prevention of seizures, and death due to acute cocaine toxicity." | 3.79 | Assessment of propofol, midazolam and ziprasidone, or the combinations for the prevention of acute cocaine toxicity in a mouse model. ( Erdur, B; Ergin, A; Kortunay, S; Yuksel, A, 2013) |
| "The number of animals with seizures was lower in the etomidate (60%), phenytoin (40%), and phenytoin/midazolam (40%) groups (P<0." | 3.78 | Effects of pretreatment with etomidate, ketamine, phenytoin, and phenytoin/midazolam on acute, lethal cocaine toxicity. ( Degirmenci, E; Erdur, B; Ergin, A; Kortunay, S; Seyit, M; Yuksel, A, 2012) |
| "The aim of the present study was to investigate the preemptive analgesic effects of intraperitoneally administrated midazolam and diclofenac, before acute and inflammatory induced pain in rat model." | 3.77 | Preemptive analgesic effects of midazolam and diclofenac in rat model. ( Hasani, A; Jakupi, M; Soljakova, M; Ustalar-Ozgen, S, 2011) |
| " Here, we show that inhibition of spinal CA activity with acetazolamide (ACT) reduces neuropathic allodynia." | 3.76 | Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. ( Asiedu, M; Kaila, K; Ossipov, MH; Price, TJ, 2010) |
| "Cocaine toxicity results in cardiovascular complications, seizures, and death and accounts for approximately 20% of drug-related emergency department visits every year." | 3.75 | A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality. ( Baladi, MG; Cooper, ZD; Jutkiewicz, EM; Narasimhan, D; Sunahara, RK; Woods, JH, 2009) |
| "The objective of this investigation was to characterize quantitatively the time-dependent changes in midazolam (MDL) efficacy in the silent period after induction of status epilepticus (SE) in rats." | 3.74 | Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy. ( Danhof, M; Gunput, RA; Liefaard, LC; Voskuyl, RA, 2007) |
| " We hypothesized that chrysin decreases anxiety via interaction with the GABA(A) receptor in laboratory rats as measured by elevated plus-maze (EPM), corticosterone, and catecholamine assays." | 3.74 | Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. ( Brown, E'; Ceremuga, TE; Hurd, NS; McCall, S, 2007) |
| "The contribution of GABAergic mechanisms to rat emotional behavior in two animal models of anxiety (open field test of neophobia and aversively conditioned freezing reaction), was confirmed by pharmacological analysis, using anxiolytic (midazolam) and anxiogenic (picrotoxin) compounds." | 3.72 | Rat behavior in two models of anxiety and brain [3H]muscimol binding: pharmacological, correlation, and multifactor analysis. ( Bidziński, A; Członkowska, AI; Lehner, M; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J; Turzyńska, D; Wisłowska, A; Zienowicz, M, 2003) |
| "In dogs, intraoperative cardiac tamponade caused comparable changes in RBF under the different anesthetic techniques except that autoregulation was effective in maintaining RBF within the central nervous system only under isoflurane anesthesia." | 3.72 | Isoflurane preserves central nervous system blood flow during intraoperative cardiac tamponade in dogs. ( Crystal, GJ; Metwally, AA; Salem, MR, 2004) |
| ") administration of a non-selective full benzodiazepine receptor agonist, midazolam, and a neuroactive steroid, allopregnanolone, on picrotoxin-induced seizures and striatal dopamine metabolism, were studied in mice." | 3.71 | Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures. ( Bidziński, A; Członkowska, AI; Krzaścik, P; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J, 2001) |
| "The effects of intra-amygdala injection of midazolam (20 nmol) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 8 and 16 nmol) were investigated in rats submitted to the elevated T-maze, a new animal model of anxiety." | 3.70 | Anxiolytic effect of intra-amygdala injection of midazolam and 8-hydroxy-2-(di-n-propylamino)tetralin in the elevated T-maze. ( Graeff, FG; Viana, MB; Zangrossi, H, 1999) |
| "The pharmacodynamics of midazolam was studied in the kindling model of experimental epilepsy." | 3.70 | Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy. ( Cleton, A; Danhof, M; Ghijsen, W; Van der Graaf, PH; Voskuyl, R, 1999) |
| "Midazolam is a benzodiazepine commonly utilized in anesthesia and intensive care." | 1.72 | Midazolam suppresses ischemia/reperfusion-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway. ( Cai, D; Zhou, W, 2022) |
| "Midazolam is an anesthetic widely used for anxiolysis and sedation; however, to date, a possible role for midazolam in diabetic kidney disease remains unknown." | 1.72 | Midazolam Ameliorates Hyperglycemia-Induced Glomerular Endothelial Dysfunction by Inhibiting Transglutaminase 2 in Diabetes. ( Cho, S; Ha, KS; Hong, SH; Jeon, HY; Kim, EB; Kim, M; Lee, YJ; Sayyed, ND; Seo, JA, 2022) |
| "All untreated rat pups had seizures within 10 minutes after termination of asphyxia." | 1.62 | Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. ( Ala-Kurikka, T; Gailus, B; Hampel, P; Johne, M; Kaila, K; Löscher, W; Römermann, K; Theilmann, W, 2021) |
| "Acetaminophen (APAP) was used as a model drug to induce DILI in C57BL/6J mice at different ages of days 10 (infant), 22 (child), and 60 (adult)." | 1.56 | Acetaminophen-Induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-Dependent Manner in Mouse Liver. ( Bao, Y; Ma, X; Manautou, JE; Shao, X; Shi, J; Wang, P; Xiao, J; Zhang, L; Zhong, XB; Zhu, HJ; Zhu, J, 2020) |
| "MDZ-induced seizure suppression was equivalent in magnitude regardless of treatment delay (ie, seizure duration)." | 1.51 | Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure. ( Bealer, SL; Dudek, FE; Pouliot, W; Roach, B; Spampanato, J, 2019) |
| "Neuropathic pain is a complex, chronic pain condition and the treatment is a major clinical challenge." | 1.48 | Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats. ( Chen, J; Li, H; Li, N; Lim, G; Ma, W; McCabe, MF; Yang, Y; Zhao, W, 2018) |
| "Midazolam was administered to 6-week-old BALB/c male mice under hypoxic conditions and pregnant C57BL/6N mice under normoxic conditions." | 1.42 | Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system. ( Daijo, H; Fukuda, K; Harada, H; Kai, S; Matsuyama, T; Tanaka, T; Tatsumi, K, 2015) |
| "Brain edema was maximal on MR imaging 3 h after poisoning." | 1.42 | Early brain magnetic resonance imaging can predict short and long-term outcomes after organophosphate poisoning in a rat model. ( Cohen, Y; Eisenkraft, A; Kadar, T; Kassirer, M; Milk, N; Rosman, Y; Shiyovich, A; Shrot, S; Tauber, M, 2015) |
| "Status epilepticus was induced by intra-amygdala microinjection of kainic acid in 8week old C57Bl/6 mice." | 1.42 | Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice. ( Diviney, M; Henshall, DC; Reynolds, JP, 2015) |
| "Post-traumatic stress disorder (PTSD) is a debilitating anxiety disorder that may develop after an individual has experienced or witnessed a severe traumatic event." | 1.40 | Midazolam ameliorates the behavior deficits of a rat posttraumatic stress disorder model through dual 18 kDa translocator protein and central benzodiazepine receptor and neurosteroidogenesis. ( Fang, WW; Guo, WZ; Li, BW; Li, YF; Liu, J; Liu, Y; Miao, YL; Shi, WZ; Wu, W, 2014) |
| "In animal convulsion models, some anticonvulsants have been found to suppress oxidative reactions associated with convulsions." | 1.38 | Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model. ( Arai, Y; Higuchi, H; Maeda, S; Miyawaki, T; Shimada, M; Tomoyasu, Y, 2012) |
| "Midazolam is a short-acting benzodiazepine that is widely used as an i." | 1.38 | Role of neurosteroids in the anticonvulsant activity of midazolam. ( Dhir, A; Rogawski, MA, 2012) |
| "An asphyxial cardiac arrest rat model was used and mild hypothermia (33°C) was induced 1 hr post injury by surface cooling and continued for 10 hrs to mimic the prolonged clinical application of hypothermia accompanied by intensive care interventions." | 1.38 | Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest. ( Empey, PE; Kochanek, PM; Melick, JA; Miller, TM; Philbrick, AH; Poloyac, SM, 2012) |
| "Rett syndrome is a severe neurodevelopmental disease caused by mutations of the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2) that induce complex, disabling symptoms, including breathing symptoms." | 1.37 | The benzodiazepine Midazolam mitigates the breathing defects of Mecp2-deficient mice. ( Hilaire, G; Voituron, N, 2011) |
| " Anticonvulsant effective doses (ED(50)) were determined using an up-down dosing procedure over successive animals." | 1.36 | Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801. ( McDonough, JH; Shih, TM; Skovira, JW, 2010) |
| "Unlike LRT, renal failure derived from long ischemia time was observed in CRT recipients, and it is speculated that renal failure affects the PK of CyA." | 1.35 | Comparison of pharmacokinetics of cyclosporine A in cadaveric and living-related renal transplant recipients and in an experimental rat model of renal failure. ( Fujimoto, K; Fukushima, K; Ito, Y; Kokuhu, T; Okamoto, M; Sugioka, N; Takada, K; Tanaka, Y; Yoshimura, N, 2009) |
| "Midazolam clearance was significantly increased and decreased, compared with baseline in groups P and I respectively (p < 0." | 1.35 | Increased hepatic cytochrome P4503A activity decreases the risk of developing steroid-induced osteonecrosis in a rabbit model. ( Iwaki, H; Iwakiri, K; Kaneshiro, Y; Masada, T; Oda, Y; Ohashi, H; Takaoka, K, 2008) |
| "Linalool is a major component of the essential oil of lavender." | 1.35 | Investigation of the anxiolytic effects of linalool, a lavender extract, in the male Sprague-Dawley rat. ( Bracken, S; Ceremuga, TE; Cline, M; Flores, J; McCall, S; Taylor, JE, 2008) |
| "Saline-treated CCI rats developed thermal hyperalgesia on Day 3 with a more pronounced effect on Day 7." | 1.35 | Midazolam administration reverses thermal hyperalgesia and prevents gamma-aminobutyric acid transporter loss in a rodent model of neuropathic pain. ( Miletic, G; Miletic, V; Shih, A; Smith, LJ, 2008) |
| "We hypothesized that seizures, during limited substrate availability, aggravate hypoglycemia-induced brain damage." | 1.34 | Hypoglycemic seizures during transient hypoglycemia exacerbate hippocampal dysfunction. ( Abdelmalik, PA; Adamchik, Y; Burnham, WM; Carlen, PL; Liang, P; Samoilova, M; Shannon, P; Weisspapir, M; Yiu, A, 2007) |
| "Ramelteon did not produce benzodiazepine-like discriminative stimulus effects at doses up to 10 mg/kg." | 1.33 | Acute and chronic effects of ramelteon in rhesus monkeys (Macaca mulatta): dependence liability studies. ( Cruź, CM; France, CP; Koek, W; McMahon, LR; Weltman, RH, 2006) |
| "With midazolam, however, the increase was comparable to that of the control group." | 1.33 | Flumazenil mimics whereas midazolam abolishes ischemic preconditioning in a rabbit heart model of ischemia-reperfusion. ( Berenshtein, E; Chevion, M; Drenger, B; Gozal, Y; Raphael, J; Rivo, J, 2006) |
| "Thermal hyperalgesia and mechanical allodynia induced by chronic constriction nerve injury (CCI) in rats were attenuated by the short-acting benzodiazepine midazolam (20=10>5 mug>vehicle) administered intrathecally once daily for 7 postoperative days." | 1.33 | Intrathecal midazolam regulates spinal AMPA receptor expression and function after nerve injury in rats. ( Lim, G; Lim, J; Mao, J; Sung, B; Wang, S, 2006) |
| "Ketamine has not elicited the HSR in this model of experimental burns and, therefore, its protective effects were not shown to be mediated through this mechanism." | 1.32 | Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl. ( Lázaro Da Silva, A; Neder Meyer, T, 2004) |
| "Flumazenil was administered by a randomly selected route [0." | 1.30 | Comparison of routes of flumazenil administration to reverse midazolam-induced respiratory depression in a canine model. ( Cordell, WH; Heniff, MS; Moore, GP; Nelson, DR; Trout, A, 1997) |
| "Midazolam is a water-soluble benzodiazepine proven to be efficacious in sedation, hypnosis, and induction and maintenance of anesthesia." | 1.29 | Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine. ( Bradford, SM; Orebaugh, SL, 1994) |
| "The effect of renal failure upon the "in vitro" binding of midazolam, a new water-soluble short-acting benzodiazepine, has been studied in man." | 1.28 | The influence of renal failure on the kinetics of intravenous midazolam: an "in vitro" and "in vivo" study. ( Calvo, R; Martínez, I; Rodríguez-Sasiain, JM; Suárez, E, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.08) | 18.7374 |
| 1990's | 8 (8.60) | 18.2507 |
| 2000's | 28 (30.11) | 29.6817 |
| 2010's | 43 (46.24) | 24.3611 |
| 2020's | 13 (13.98) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, LZ | 1 |
| Shu, HY | 1 |
| Wu, J | 2 |
| Yu, YL | 1 |
| Ma, D | 2 |
| Huang, X | 1 |
| Liu, MM | 1 |
| Liu, XH | 1 |
| Shi, JB | 1 |
| Zhou, W | 1 |
| Cai, D | 1 |
| Seo, JA | 1 |
| Sayyed, ND | 1 |
| Lee, YJ | 1 |
| Jeon, HY | 1 |
| Kim, EB | 1 |
| Hong, SH | 1 |
| Cho, S | 1 |
| Kim, M | 1 |
| Ha, KS | 1 |
| Oshima, Y | 2 |
| Sano, M | 1 |
| Kajiwara, I | 1 |
| Ichimaru, Y | 1 |
| Itaya, T | 1 |
| Kuramochi, T | 1 |
| Hayashi, E | 1 |
| Kim, J | 1 |
| Kitajima, O | 1 |
| Masugi, Y | 1 |
| Masamune, A | 1 |
| Ijichi, H | 1 |
| Ishii, Y | 1 |
| Suzuki, T | 2 |
| Tokunaga, A | 2 |
| Miyamoto, H | 2 |
| Fumoto, S | 2 |
| Nishida, K | 2 |
| Yuan, J | 1 |
| Yang, MC | 1 |
| Wu, MJ | 1 |
| Gou, YS | 1 |
| Chuang, SH | 1 |
| Reddy, DS | 1 |
| Swissa, E | 1 |
| Bar-Klein, G | 1 |
| Serlin, Y | 1 |
| Weissberg, I | 1 |
| Kamintsky, L | 1 |
| Eisenkraft, A | 2 |
| Statlender, L | 1 |
| Shrot, S | 2 |
| Rosman, Y | 2 |
| Prager, O | 1 |
| Friedman, A | 1 |
| Bao, Y | 1 |
| Wang, P | 1 |
| Shao, X | 1 |
| Zhu, J | 1 |
| Xiao, J | 1 |
| Shi, J | 1 |
| Zhang, L | 2 |
| Zhu, HJ | 1 |
| Ma, X | 1 |
| Manautou, JE | 1 |
| Zhong, XB | 1 |
| Zhou, H | 1 |
| Zhu, ZH | 1 |
| Liu, Y | 2 |
| Liu, YY | 1 |
| Mareš, P | 1 |
| Kudová, E | 1 |
| Valeš, K | 1 |
| Kubová, H | 1 |
| Johne, M | 1 |
| Römermann, K | 1 |
| Hampel, P | 1 |
| Gailus, B | 1 |
| Theilmann, W | 1 |
| Ala-Kurikka, T | 1 |
| Kaila, K | 2 |
| Löscher, W | 1 |
| Marrero-Rosado, BM | 1 |
| Stone, MF | 1 |
| de Araujo Furtado, M | 1 |
| Schultz, CR | 1 |
| Cadieux, CL | 1 |
| Lumley, LA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Remimazolam Tosilate for General Anesthesia on Prognosis After Bladder Cancer Surgery: a Randomized Controlled Trial[NCT04532606] | Phase 4 | 1,128 participants (Anticipated) | Interventional | 2021-02-05 | Recruiting | ||
| Bright Light Exposure in Critical Ill Patients and Patients Undergoing Cardiac Surgery[NCT03822949] | 70 participants (Anticipated) | Interventional | 2019-07-12 | Recruiting | |||
| Efficacy of Combined Ketamine and Midazolam for Treatment of Generalized Convulsive Status Epilepticus in Children .[NCT05779657] | Phase 2/Phase 3 | 144 participants (Anticipated) | Interventional | 2023-03-21 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for midazolam and Disease Models, Animal
| Article | Year |
|---|---|
[Treatment of status epilepticus].
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electric Stimulation Therapy; Humans; Ma | 2001 |
92 other studies available for midazolam and Disease Models, Animal
| Article | Year |
|---|---|
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.
Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dos | 2021 |
Midazolam suppresses ischemia/reperfusion-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway.
Topics: Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; JNK Mitogen-Activated Protein Kinases; | 2022 |
Midazolam Ameliorates Hyperglycemia-Induced Glomerular Endothelial Dysfunction by Inhibiting Transglutaminase 2 in Diabetes.
Topics: Animals; Biomarkers; Calcium; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Neph | 2022 |
Midazolam exhibits antitumour and anti-inflammatory effects in a mouse model of pancreatic ductal adenocarcinoma.
Topics: Animals; Carcinoma, Pancreatic Ductal; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Midaz | 2022 |
Effect of renal ischaemia/reperfusion-induced acute kidney injury on pharmacokinetics of midazolam in rats.
Topics: Acute Kidney Injury; Animals; Cytochrome P-450 CYP3A; Disease Models, Animal; Male; Midazolam; Prote | 2019 |
Sedative depth on neurological outcomes in a juvenile rat model of cardiopulmonary resuscitation.
Topics: Animals; Apoptosis; Brain; Cardiopulmonary Resuscitation; Child; Disease Models, Animal; Electroence | 2019 |
Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam.
Topics: Animals; Anticonvulsants; beta-Cyclodextrins; Disease Models, Animal; Dose-Response Relationship, Dr | 2020 |
Midazolam and isoflurane combination reduces late brain damage in the paraoxon-induced status epilepticus rat model.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Isoflurane; Male; Midazolam; Paraoxon; Rats | 2020 |
Acetaminophen-Induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-Dependent Manner in Mouse Liver.
Topics: Acetaminophen; Adult; Age Factors; Animals; Chemical and Drug Induced Liver Injury; Child; Cytochrom | 2020 |
Effects of midazolam combined with sufentanil on injury and expression of HMGB1 and NF-κB in rats with pancreatitis.
Topics: Acute Disease; Administration, Oral; Animals; Disease Models, Animal; Drug Combinations; HMGB1 Prote | 2020 |
Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electrodes, Implanted; Male; Midazolam; Muscimol; | 2020 |
Effect of Chronic Kidney Disease on Hepatic Clearance of Drugs in Rats.
Topics: Acetaminophen; Adenine; Administration, Intravenous; Animals; Cytochrome P-450 CYP3A; Disease Models | 2020 |
Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Bumetanide; Disease Models, Animal; | 2021 |
Novel Genetically Modified Mouse Model to Assess Soman-Induced Toxicity and Medical Countermeasure Efficacy: Human Acetylcholinesterase Knock-in Serum Carboxylesterase Knockout Mice.
Topics: Acetylcholinesterase; Anesthetics; Animals; Brain; Carboxylesterase; Chemical Warfare Agents; Diseas | 2021 |
Neuroprotection by delayed triple therapy following sarin nerve agent insult in the rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Carrier Proteins; Dinoprostone; Disease Models, A | 2021 |
Simultaneous triple therapy for the treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Brain Waves; Combined Modality Therapy; Disease Models, Animal; Dose-Respo | 2017 |
Altered hepatic drug-metabolizing activity in rats suffering from hypoxemia with experimentally induced acute lung impairment.
Topics: Acute Lung Injury; Animals; Cytochrome P-450 CYP3A; Disease Models, Animal; Hypoxia; Male; Microsome | 2018 |
Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats.
Topics: Animals; Dexmedetomidine; Disease Models, Animal; Hedgehog Proteins; Hyperalgesia; Male; Midazolam; | 2018 |
The Period 2 Enhancer Nobiletin as Novel Therapy in Murine Models of Circadian Disruption Resembling Delirium.
Topics: Animals; Chronobiology Disorders; Delirium; Disease Models, Animal; Hippocampus; Memory Disorders; M | 2018 |
Midazolam and Dexmedetomidine Affect Neuroglioma and Lung Carcinoma Cell Biology In Vitro and In Vivo.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dexmedetom | 2018 |
The Circadian PER2 Enhancer Nobiletin Reverses the Deleterious Effects of Midazolam in Myocardial Ischemia and Reperfusion Injury.
Topics: Animals; Disease Models, Animal; Flavones; Mice; Mice, Knockout; Midazolam; Myocardial Ischemia; Per | 2018 |
Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Isoflurophate; Male; Midazolam; Neuroprotective Ag | 2019 |
Activation of 5-HT1A receptors in the rat basolateral amygdala induces both anxiolytic and antipanic-like effects.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Dark Adapta | 2013 |
Depression of neuronal activity by sedatives is associated with adverse effects after brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries; Disease Models, Animal; Electroencephalography; Hypno | 2013 |
Novel anticonvulsive effects of progesterone in a mouse model of hippocampal electrical kindling.
Topics: Action Potentials; Animals; Anticonvulsants; Berberine Alkaloids; Carbamazepine; Convulsants; Diseas | 2014 |
Effects of tetrahydropalmatine on post-traumatic stress disorder-induced changes in rat brain gene expression.
Topics: Adjuvants, Anesthesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Berberine Alkaloids; | 2013 |
Midazolam ameliorates the behavior deficits of a rat posttraumatic stress disorder model through dual 18 kDa translocator protein and central benzodiazepine receptor and neurosteroidogenesis.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Carrier Proteins; Disease Models, Anim | 2014 |
The benzodiazepine midazolam acts on the expression of the defensive behavior, but not on the processing of aversive information, produced by exposure to the elevated plus maze and electrical stimulations applied to the inferior colliculus of rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 2015 |
Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Disease Model | 2015 |
The effect of Midazolam and Propranolol on fear memory reconsolidation in ethanol-withdrawn rats: influence of d-cycloserine.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Conditioning, Psychologi | 2015 |
Early brain magnetic resonance imaging can predict short and long-term outcomes after organophosphate poisoning in a rat model.
Topics: Animals; Aspartic Acid; Atropine; Behavior, Animal; Brain; Brain Edema; Choline; Cholinesterase Reac | 2015 |
Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system.
Topics: Animals; Astrocytes; Basic Helix-Loop-Helix Transcription Factors; Brain; Cells, Cultured; Disease M | 2015 |
Evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from Gotu kola or Centella asiatica, in the male Sprague Dawley rat.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Centella; Depression; Disease Models, | 2015 |
Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Hippocampus; Kainic Aci | 2015 |
GABAergic control of the activity of the central nucleus of the amygdala in low- and high-anxiety rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Basolateral Nuclear Complex; Central Amygdaloid Nuc | 2015 |
The usage of a three-compartment model to investigate the metabolic differences between hepatic reductase null and wild-type mice.
Topics: Angiogenesis Inhibitors; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; GABA Modul | 2017 |
Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Basolateral Nuclear Complex; Disease Models, Animal | 2016 |
Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits.
Topics: Animals; Anticonvulsants; Brain; Cholinergic Agents; Disease Models, Animal; Drug Synergism; Drug Th | 2016 |
Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.
Topics: Animals; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucuron | 2016 |
Effects of pentobarbital, isoflurane, or medetomidine-midazolam-butorphanol anesthesia on bronchoalveolar lavage fluid and blood chemistry in rats.
Topics: Administration, Inhalation; Analgesics, Opioid; Anesthesia; Anesthetics, Inhalation; Animals; Biomar | 2016 |
Intra-periaqueductal gray matter injections of midazolam fail to alter anxiety in plus-maze experienced mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Avoidance Learning; Disease Models, Animal | 2008 |
Changes of midazolam pharmacokinetics in Wistar rats treated with lipopolysaccharide: relationship between total CYP and CYP3A2.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cyto | 2008 |
A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality.
Topics: Animals; Anticonvulsants; Bacteria; Carboxylic Ester Hydrolases; Cocaine; Cocaine-Related Disorders; | 2009 |
The role of GABA and anxiety in the reconsolidation of conditioned fear.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Bicuculline; Conditioning, Psychological; | 2008 |
A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam.
Topics: Animals; Appetite Depressants; Behavior, Animal; Bulimia; Cyclobutanes; Disease Models, Animal; Eati | 2009 |
Persistent zinc depletion in the mossy fiber terminals in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Carrier Proteins; Cation Transport Proteins; Disease Models, Animal; Electroencephalography | 2009 |
Effects of deep sedation or general anesthesia on cardiac function in mice undergoing cardiovascular magnetic resonance.
Topics: Anesthesia, General; Anesthetics, Inhalation; Animals; Body Temperature; Conscious Sedation; Deep Se | 2009 |
Low-dose ketamine combined with pentobarbital in a miniature porcine model for a cardiopulmonary bypass procedure: a randomized controlled study.
Topics: Adjuvants, Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Animals; Cardiopulmonary By | 2009 |
Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801.
Topics: Amygdala; Animals; Anticonvulsants; Brain; Cholinergic Antagonists; Cholinesterase Inhibitors; Disea | 2010 |
Comparison of pharmacokinetics of cyclosporine A in cadaveric and living-related renal transplant recipients and in an experimental rat model of renal failure.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Animals; Area Under Curve; Child; Cycl | 2009 |
The alarm pheromone in male rats as a unique anxiety model: psychopharmacological evidence using anxiolytics.
Topics: Administration, Inhalation; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Clonidine; Disease Mod | 2010 |
Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.
Topics: Acetazolamide; Anesthetics, Intravenous; Animals; Carbonic Anhydrase Inhibitors; Disease Models, Ani | 2010 |
Prenatal ethanol exposure attenuates GABAergic inhibition in basolateral amygdala leading to neuronal hyperexcitability and anxiety-like behavior of adult rat offspring.
Topics: Amygdala; Animals; Anxiety; Cornified Envelope Proline-Rich Proteins; Disease Models, Animal; Ethano | 2010 |
The effects of midazolam and D-cycloserine on the release of glutamate and GABA in the basolateral amygdala of low and high anxiety rats during extinction trial of a conditioned fear test.
Topics: Amygdala; Analysis of Variance; Animals; Anxiety; Anxiety Disorders; Conditioning, Classical; Cyclos | 2010 |
The benzodiazepine Midazolam mitigates the breathing defects of Mecp2-deficient mice.
Topics: Animals; Benzodiazepines; Disease Models, Animal; GABA Agonists; gamma-Aminobutyric Acid; Methyl-CpG | 2011 |
Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex.
Topics: Analysis of Variance; Animals; Anisoles; Disease Models, Animal; Electroencephalography; Electromyog | 2011 |
Preemptive analgesic effects of midazolam and diclofenac in rat model.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Fo | 2011 |
Facilitating influence of stress on the consolidation of fear memory induced by a weak training: reversal by midazolam pretreatment.
Topics: Amygdala; Anesthetics, Intravenous; Animals; Conditioning, Psychological; Disease Models, Animal; Do | 2011 |
Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Gene Expression; Heme Oxygenase-1; Hippocam | 2012 |
Role of neurosteroids in the anticonvulsant activity of midazolam.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Ani | 2012 |
Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.
Topics: Animals; Cytochrome P-450 CYP3A; Disease Models, Animal; Fentanyl; Heart Arrest; Hypnotics and Sedat | 2012 |
Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzophenones; Catechol O-Meth | 2012 |
Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model.
Topics: Animals; Disease Models, Animal; Embryo, Mammalian; Etomidate; Female; Lipid Peroxidation; Male; Mic | 2012 |
Effects of pretreatment with etomidate, ketamine, phenytoin, and phenytoin/midazolam on acute, lethal cocaine toxicity.
Topics: Animals; Cocaine; Disease Models, Animal; Etomidate; Ketamine; Mice; Midazolam; Phenytoin; Random Al | 2012 |
Assessment of propofol, midazolam and ziprasidone, or the combinations for the prevention of acute cocaine toxicity in a mouse model.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Cocaine-Related Disorders; Disease Models, Animal; D | 2013 |
Rat behavior in two models of anxiety and brain [3H]muscimol binding: pharmacological, correlation, and multifactor analysis.
Topics: Analysis of Variance; Animals; Anxiety; Autoradiography; Behavior, Animal; Binding Sites; Brain; Dis | 2003 |
Infusions of midazolam into the medial prefrontal cortex produce anxiolytic effects in the elevated plus-maze and shock-probe burying tests.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Anima | 2004 |
Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl.
Topics: Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Burns; Disease | 2004 |
Isoflurane preserves central nervous system blood flow during intraoperative cardiac tamponade in dogs.
Topics: Analgesics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cardiac Tamponade; Central N | 2004 |
Glutamate receptor antagonists and benzodiazepine inhibit the progression of granule cell dispersion in a mouse model of mesial temporal lobe epilepsy.
Topics: Animals; Benzodiazepines; Cell Count; Dentate Gyrus; Disease Models, Animal; Dizocilpine Maleate; Ep | 2005 |
Concurrent nociceptive stimulation impairs the anxiolytic effect of midazolam injected into the periaqueductal gray in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Disease Models, Animal; | 2005 |
Central and peripheral benzodiazepine receptors.
Topics: Animals; Benzodiazepines; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Epilepsy, Te | 2006 |
Acute and chronic effects of ramelteon in rhesus monkeys (Macaca mulatta): dependence liability studies.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzodiazepines; Conditioning, Classical; Condition | 2006 |
Flumazenil mimics whereas midazolam abolishes ischemic preconditioning in a rabbit heart model of ischemia-reperfusion.
Topics: Animals; Disease Models, Animal; Flumazenil; Heart Rate; Ischemic Preconditioning, Myocardial; Midaz | 2006 |
Intrathecal midazolam regulates spinal AMPA receptor expression and function after nerve injury in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Modulators; Hyperalgesia; In | 2006 |
Ethanol blocks nicotine-induced seizures in mice: comparison with midazolam and baclofen.
Topics: Animals; Anticonvulsants; Baclofen; Central Nervous System Depressants; Disease Models, Animal; Dose | 2006 |
Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy.
Topics: Animals; Autoradiography; Beta Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Tem | 2007 |
Hypoglycemic seizures during transient hypoglycemia exacerbate hippocampal dysfunction.
Topics: Action Potentials; Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Cortical Spreading D | 2007 |
Increased hepatic cytochrome P4503A activity decreases the risk of developing steroid-induced osteonecrosis in a rabbit model.
Topics: Anesthetics, Intravenous; Animals; Antifungal Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A | 2008 |
Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Catecholamines; Corti | 2007 |
Investigation of the anxiolytic effects of linalool, a lavender extract, in the male Sprague-Dawley rat.
Topics: Acyclic Monoterpenes; Animals; Anti-Anxiety Agents; Antidotes; Anxiety; Behavior, Animal; Disease Mo | 2008 |
Midazolam administration reverses thermal hyperalgesia and prevents gamma-aminobutyric acid transporter loss in a rodent model of neuropathic pain.
Topics: Animals; Disease Models, Animal; GABA Plasma Membrane Transport Proteins; Hot Temperature; Hyperalge | 2008 |
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Injections, Intraventricul | 1995 |
Intravenous versus intramuscular midazolam in treatment of chemically induced generalized seizures in swine.
Topics: Animals; Disease Models, Animal; Injections, Intramuscular; Injections, Intravenous; Midazolam; Pent | 1994 |
High-performance liquid chromatographic determination of midazolam in rat brain.
Topics: Animals; Anti-Anxiety Agents; Brain Chemistry; Chromatography, High Pressure Liquid; Diazepam; Disea | 1996 |
Comparison of routes of flumazenil administration to reverse midazolam-induced respiratory depression in a canine model.
Topics: Administration, Rectal; Administration, Sublingual; Animals; Antidotes; Cross-Over Studies; Disease | 1997 |
Anxiolytic effect of intra-amygdala injection of midazolam and 8-hydroxy-2-(di-n-propylamino)tetralin in the elevated T-maze.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Analysis of Variance; Animals; Anti-Anxiety Agents | 1999 |
Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy.
Topics: Adaptation, Physiological; Animals; Anticonvulsants; Brain; Chlorine; Disease Models, Animal; Dose-R | 1999 |
Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Drug Combinations; Drug Tolerance; Male; | 2001 |
The influence of renal failure on the kinetics of intravenous midazolam: an "in vitro" and "in vivo" study.
Topics: Adolescent; Adult; Animals; Blood Proteins; Brain; Disease Models, Animal; Female; Humans; Injection | 1992 |
Intrathecal antiepileptic drugs in experimental epilepsy.
Topics: Animals; Anticonvulsants; Catheters, Indwelling; Disease Models, Animal; Dose-Response Relationship, | 1991 |
The skin-dwelling microfilariae of Monanema martini in Lemniscomys striatus as potential drug screening model for onchocerciasis: midazolam effect in vitro.
Topics: Animals; Cell Movement; Disease Models, Animal; Drug Evaluation, Preclinical; Ear, External; Filario | 1988 |