midazolam has been researched along with Crohn Disease in 5 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The systems information gathered on intestine, liver and blood proteins and other physiological parameters was incorporated into a physiologically based pharmacokinetic (PBPK) platform to create a virtual population of CD patients, with a view for guiding dose adjustment in the absence of clinical data in CD." | 2.82 | Altered Bioavailability and Pharmacokinetics in Crohn's Disease: Capturing Systems Parameters for PBPK to Assist with Predicting the Fate of Orally Administered Drugs. ( Alrubia, S; Barber, J; Chen, Y; Mao, J; Rostami-Hodjegan, A, 2022) |
| "Meperidine and midazolam were most commonly used." | 1.37 | Ileoscopy via stoma after diverting ileostomy: a safe and effective tool to evaluate for Crohn's recurrence of neoterminal ileum. ( Alkhouri, N; Lopez, R; Mahajan, L; Shen, B; Vadlamudi, N, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alrubia, S | 1 |
| Mao, J | 1 |
| Chen, Y | 1 |
| Barber, J | 1 |
| Rostami-Hodjegan, A | 1 |
| Ahmed, S | 1 |
| Naumann, DN | 1 |
| Karandikar, S | 1 |
| Wilson, A | 1 |
| Tirona, RG | 1 |
| Kim, RB | 1 |
| Richart Aznar, MT | 1 |
| Fernández Bañuls, E | 1 |
| Lagardera Miñana, A | 1 |
| Aragón Alvarez, S | 1 |
| Vadlamudi, N | 1 |
| Alkhouri, N | 1 |
| Mahajan, L | 1 |
| Lopez, R | 1 |
| Shen, B | 1 |
1 review available for midazolam and Crohn Disease
| Article | Year |
|---|---|
Altered Bioavailability and Pharmacokinetics in Crohn's Disease: Capturing Systems Parameters for PBPK to Assist with Predicting the Fate of Orally Administered Drugs.
Topics: Administration, Oral; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Crohn | 2022 |
4 other studies available for midazolam and Crohn Disease
| Article | Year |
|---|---|
Differences in screening vs non-screening colonoscopy: scope for improvement?
Topics: Adenoma; Adjuvants, Anesthesia; Aged; Anesthetics, Combined; Butylscopolammonium Bromide; Carcinoma; | 2016 |
CYP3A4 Activity is Markedly Lower in Patients with Crohn's Disease.
Topics: Adult; Aged; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control | 2017 |
[Intranasal midazolam for central venous catheterization of an anxious patient without a peripheral venous access].
Topics: Abscess; Administration, Intranasal; Amnesia, Anterograde; Anti-Anxiety Agents; Anxiety; Catheteriza | 2008 |
Ileoscopy via stoma after diverting ileostomy: a safe and effective tool to evaluate for Crohn's recurrence of neoterminal ileum.
Topics: Abdominal Pain; Adolescent; Adult; Anesthetics, Intravenous; Crohn Disease; Endoscopy, Gastrointesti | 2011 |