midazolam has been researched along with Craniocerebral Injuries in 14 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe the case of a subject in a post-traumatic Minimally Conscious State (MCS) who retrieved full interaction with the environment after midazolam infusion." | 7.80 | A case of post-traumatic minimally conscious state reversed by midazolam: Clinical aspects and neurophysiological correlates. ( Andre, P; Arrighi, P; Bergamasco, M; Bonfiglio, L; Carboncini, MC; Frisoli, A; Piarulli, A; Rossi, B; Tomaiuolo, F; Virgillito, A, 2014) |
| "We describe the case of a subject in a post-traumatic Minimally Conscious State (MCS) who retrieved full interaction with the environment after midazolam infusion." | 3.80 | A case of post-traumatic minimally conscious state reversed by midazolam: Clinical aspects and neurophysiological correlates. ( Andre, P; Arrighi, P; Bergamasco, M; Bonfiglio, L; Carboncini, MC; Frisoli, A; Piarulli, A; Rossi, B; Tomaiuolo, F; Virgillito, A, 2014) |
| "Adult patients with head injuries were prospectively enrolled over a 1-year period by using the following inclusion criteria: Glasgow Coma Scale score of 3 to 8, transport time of greater than 10 minutes, and inability to intubate without RSI." | 2.70 | Paramedic-performed rapid sequence intubation of patients with severe head injuries. ( Bailey, D; Davis, D; Hoyt, D; Marshall, L; Ochs, M; Rosen, P, 2002) |
| " The incidence of adverse events during the sedation period was also similar." | 2.69 | Propofol versus midazolam: safety and efficacy for sedating the severe trauma patient. ( Alted-Lopez, E; Ambros-Checa, A; Caballero-Cubedo, RE; Cantalapiedra-Santiago, JA; Perez-Vela, JL; Sanchez-Izquierdo-Riera, JA, 1998) |
| " Median (range) values of pharmacokinetic parameters for sufentanil were: t1/2,z = 16 (7-49) h; CL = 1215 (519-2550) ml min-1; CLR = 7 (2-38) ml min-1; Vss = 10." | 2.67 | Pharmacokinetics and effects on intracranial pressure of sufentanil in head trauma patients. ( Bause, H; Klotz, U; Krishna, DR; Pohl, S; Scholz, J; Schulte am Esch, J; Schulz, M, 1994) |
| "Children with head injuries who require CTB are infrequently sedated." | 1.42 | Use of sedation in children receiving computed tomography after head injuries. ( Arpone, M; Babl, FE; Bressan, S; Goldwasser, T; Oakley, E, 2015) |
| "Adults with severe head trauma (Glasgow Coma Scale score 3 to 8) who were unable to be intubated without medications were enrolled." | 1.32 | The Combitube as a salvage airway device for paramedic rapid sequence intubation. ( Davis, DP; Hoyt, DB; Ochs, M; Valentine, C; Vilke, GM, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belze, O | 1 |
| Remérand, F | 1 |
| Pujol, A | 1 |
| Fusciardi, J | 1 |
| Goldwasser, T | 1 |
| Bressan, S | 1 |
| Oakley, E | 1 |
| Arpone, M | 1 |
| Babl, FE | 1 |
| Carboncini, MC | 1 |
| Piarulli, A | 1 |
| Virgillito, A | 1 |
| Arrighi, P | 1 |
| Andre, P | 1 |
| Tomaiuolo, F | 1 |
| Frisoli, A | 1 |
| Bergamasco, M | 1 |
| Rossi, B | 1 |
| Bonfiglio, L | 1 |
| Ochs, M | 3 |
| Davis, D | 1 |
| Hoyt, D | 1 |
| Bailey, D | 2 |
| Marshall, L | 1 |
| Rosen, P | 2 |
| Davis, DP | 2 |
| Hoyt, DB | 2 |
| Marshall, LK | 1 |
| Valentine, C | 1 |
| Vilke, GM | 1 |
| Ghori, KA | 1 |
| Harmon, DC | 1 |
| Elashaal, A | 1 |
| Butler, M | 1 |
| Walsh, F | 1 |
| O'Sullivan, MG | 1 |
| Shorten, GD | 1 |
| Scholz, J | 1 |
| Bause, H | 1 |
| Schulz, M | 1 |
| Klotz, U | 1 |
| Krishna, DR | 1 |
| Pohl, S | 1 |
| Schulte am Esch, J | 1 |
| Parent, JM | 1 |
| Lowenstein, DH | 1 |
| Bruder, N | 1 |
| Lassegue, D | 1 |
| Pelissier, D | 1 |
| Graziani, N | 1 |
| François, G | 1 |
| Papazian, L | 1 |
| Albanese, J | 1 |
| Thirion, X | 1 |
| Perrin, G | 1 |
| Durbec, O | 1 |
| Martin, C | 1 |
| Weinstabl, C | 1 |
| Spiss, CK | 1 |
| Sanchez-Izquierdo-Riera, JA | 1 |
| Caballero-Cubedo, RE | 1 |
| Perez-Vela, JL | 1 |
| Ambros-Checa, A | 1 |
| Cantalapiedra-Santiago, JA | 1 |
| Alted-Lopez, E | 1 |
| Chiolero, RL | 1 |
| Ravussin, P | 1 |
| Anderes, JP | 1 |
| Ledermann, P | 1 |
| de Tribolet, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Early Lactate-Directed Therapy on the ICU: A Randomized Controlled Trial[NCT00270673] | Phase 3 | 350 participants (Anticipated) | Interventional | 2006-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for midazolam and Craniocerebral Injuries
| Article | Year |
|---|---|
Paramedic-performed rapid sequence intubation of patients with severe head injuries.
Topics: Adult; Allied Health Personnel; Craniocerebral Trauma; Emergency Medical Services; Humans; Hypnotics | 2002 |
Effect of midazolam versus propofol sedation on markers of neurological injury and outcome after isolated severe head injury: a pilot study.
Topics: Adolescent; Adult; Aged; Biomarkers; Craniocerebral Trauma; Double-Blind Method; Female; Glasgow Out | 2007 |
Pharmacokinetics and effects on intracranial pressure of sufentanil in head trauma patients.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Blood Pressure; Child; Craniocerebral Trauma; Female; | 1994 |
Propofol versus midazolam: safety and efficacy for sedating the severe trauma patient.
Topics: Adult; Analgesics, Opioid; Anesthesia Recovery Period; Blood Pressure; Brain; Craniocerebral Trauma; | 1998 |
10 other studies available for midazolam and Craniocerebral Injuries
| Article | Year |
|---|---|
Hyperammonaemic encephalopathy and a flat electroencephalogram caused by valproic acid.
Topics: Adult; Anesthesia, General; Anticonvulsants; Brain Diseases; Craniocerebral Trauma; Electroencephalo | 2013 |
Use of sedation in children receiving computed tomography after head injuries.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Cohort Studies; Confidence Intervals; Conscious Se | 2015 |
A case of post-traumatic minimally conscious state reversed by midazolam: Clinical aspects and neurophysiological correlates.
Topics: Adult; Brain; Central Nervous System Agents; Craniocerebral Trauma; Electroencephalography; Humans; | 2014 |
Paramedic-administered neuromuscular blockade improves prehospital intubation success in severely head-injured patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allied Health Personnel; Androstanols; Case-Control Stud | 2003 |
The Combitube as a salvage airway device for paramedic rapid sequence intubation.
Topics: Abbreviated Injury Scale; Adult; Androstanols; Anesthetics, Intravenous; Blood Gas Analysis; Califor | 2003 |
Treatment of refractory generalized status epilepticus with continuous infusion of midazolam.
Topics: Adult; Carcinoma, Renal Cell; Child, Preschool; Craniocerebral Trauma; Drug Administration Schedule; | 1994 |
Energy expenditure and withdrawal of sedation in severe head-injured patients.
Topics: Acute Disease; Adult; Blood Pressure; Craniocerebral Trauma; Energy Metabolism; Fentanyl; Glasgow Co | 1994 |
Effect of bolus doses of midazolam on intracranial pressure and cerebral perfusion pressure in patients with severe head injury.
Topics: Adolescent; Adult; Cerebrovascular Circulation; Craniocerebral Trauma; Female; Humans; Infusions, In | 1993 |
Fentanyl and sufentanil increase intracranial pressure in head trauma patients.
Topics: Craniocerebral Trauma; Fentanyl; Humans; Intracranial Pressure; Midazolam; Morphine; Pseudotumor Cer | 1993 |
The effects of midazolam reversal by RO 15-1788 on cerebral perfusion pressure in patients with severe head injury.
Topics: Adult; Cerebrovascular Circulation; Coma; Craniocerebral Trauma; Female; Flumazenil; Humans; Intracr | 1988 |