midazolam has been researched along with Consciousness, Loss of in 23 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An increase in blood pressure, accompanied by atrial fibrillation, agitation, incomprehensible shouts and loss of consciousness, was observed in an elderly, ASA classification group II, cardiovascularly medicated male, 12 min after performance of axillary block with mepivacaine 850 mg containing adrenaline 0." | 3.70 | An unusual toxic reaction to axillary block by mepivacaine with adrenaline. ( Koscielniak-Nielsen, ZJ, 1998) |
| "Propofol is a rapid, efficient hypnotic agent with antiemetic effects." | 2.84 | Effects of remifentanil with or without midazolam pretreatment on the 95% effective dose of propofol for loss of consciousness during induction: A randomized, clinical trial. ( Han, DW; Kim, NY; Ko, SH; Koh, JC; Park, J; You, AH, 2017) |
| "Alfentanil was found to reduce the midazolam ED50 value for the induction of anesthesia in a dose-dependent fashion." | 2.67 | Alfentanil potentiates midazolam-induced unconsciousness in subanalgesic doses. ( Bradley, EL; Castillo, R; Kissin, I; Vinik, HR, 1990) |
| "Midazolam treatment resulted on average in a statistically significant reduction of the BIS values (-4." | 1.43 | Bispectral Index Monitoring in Terminally Ill Patients: A Validation Study. ( Baar, FP; Blussé van Oud-Alblas, HJ; Ista, E; Masman, AD; Tibboel, D; van Dijk, M; van Rosmalen, J, 2016) |
| "Midazolam is a benzodiazepine commonly used for conscious sedation in dentistry." | 1.40 | An unusual response to intravenous sedation: a case report. ( Lourenço-Matharu, L; Raval, P, 2014) |
| "The case is reported of a female patient with attack-like neuropathic pain following lower arm injury with repeated respiratory depression and unconsciousness even after several administrations of sufficiently dosed analgetics for suppression of the attacks." | 1.35 | [Life-threatening respiratory depression after pain therapy]. ( Gläser, M; Kohlhaas, K; Maier, C; Tegenthoff, M, 2008) |
| " Reduction of the barbiturate dosage resulted in clinical and subclinical partial seizures appearing repetitively in clusters." | 1.34 | Acute encephalitis with refractory, repetitive partial seizures: case reports of this unusual post-encephalitic epilepsy. ( Inoue, T; Maegaki, Y; Nanba, Y; Ogura, K; Ohno, K; Okamoto, R; Saito, Y; Takahashi, Y; Togawa, M, 2007) |
| "A fatal case of gas embolism during diagnostic hysteroscopy using carbon dioxide (CO2) is presented." | 1.30 | Gas embolism during hysteroscopy. ( Hanaoka, K; Nishiyama, T, 1999) |
| "Sex differences, and the influence of drug dosage and additional upper airway obstruction were studied in midazolam-induced breathing patterns and sedation in 30 healthy volunteers (8 males and 22 females)." | 1.29 | Differences in midazolam-induced breathing patterns in healthy volunteers. ( Haji, A; Ito, Y; Masuda, A; Shakunaga, K; Shibuya, N; Wakasugi, M, 1995) |
| "The effect of midazolam on the induction dose-response curve for alfentanil was studied in nonpremedicated ASA physical status I or II patients." | 1.28 | Midazolam-alfentanil synergism for anesthetic induction in patients. ( Bradley, EL; Kissin, I; Vinik, HR, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 9 (39.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barbato, M | 1 |
| Barclay, G | 1 |
| Potter, J | 1 |
| Yeo, W | 1 |
| Sanders, RD | 1 |
| Tononi, G | 2 |
| Koh, JC | 1 |
| Park, J | 1 |
| Kim, NY | 1 |
| You, AH | 1 |
| Ko, SH | 1 |
| Han, DW | 1 |
| Finley, J | 1 |
| Lourenço-Matharu, L | 1 |
| Raval, P | 1 |
| Li, YH | 1 |
| He, R | 1 |
| Ruan, JG | 1 |
| Masman, AD | 1 |
| van Dijk, M | 1 |
| van Rosmalen, J | 1 |
| Blussé van Oud-Alblas, HJ | 1 |
| Ista, E | 1 |
| Baar, FP | 1 |
| Tibboel, D | 1 |
| Gläser, M | 1 |
| Kohlhaas, K | 1 |
| Tegenthoff, M | 1 |
| Maier, C | 1 |
| Ferrarelli, F | 1 |
| Massimini, M | 1 |
| Sarasso, S | 1 |
| Casali, A | 1 |
| Riedner, BA | 1 |
| Angelini, G | 1 |
| Pearce, RA | 1 |
| Oppitz, F | 1 |
| Gil-Gouveia, R | 1 |
| Wilkinson, PA | 1 |
| Kaube, H | 1 |
| Saito, Y | 1 |
| Maegaki, Y | 1 |
| Okamoto, R | 1 |
| Ogura, K | 1 |
| Togawa, M | 1 |
| Nanba, Y | 1 |
| Inoue, T | 1 |
| Takahashi, Y | 1 |
| Ohno, K | 1 |
| Collier, CB | 1 |
| Masuda, A | 1 |
| Haji, A | 1 |
| Wakasugi, M | 1 |
| Shibuya, N | 1 |
| Shakunaga, K | 1 |
| Ito, Y | 1 |
| Koscielniak-Nielsen, ZJ | 1 |
| Nishiyama, T | 2 |
| Hanaoka, K | 2 |
| Pypendop, B | 1 |
| Poncelet, L | 1 |
| Verstegen, J | 1 |
| Haberham, ZL | 1 |
| van den Brom, WE | 1 |
| Venker-van Haagen, AJ | 1 |
| Baumans, V | 1 |
| de Groot, HN | 1 |
| Hellebrekers, LJ | 1 |
| Matsukawa, T | 1 |
| Yokoyama, T | 1 |
| Hiller, A | 1 |
| Olkkola, KT | 1 |
| Isohanni, P | 1 |
| Saarnivaara, L | 1 |
| Davis, TR | 1 |
| Holloway, I | 1 |
| Pooley, J | 1 |
| Kissin, I | 2 |
| Vinik, HR | 2 |
| Castillo, R | 1 |
| Bradley, EL | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Haemodynamic Stability During Induction of General Anesthesia With Propofol and Remifentanil: A Randomized, Controlled, Double-blind Study Comparing Low vs High Propofol Doses.[NCT03861364] | Phase 4 | 68 participants (Actual) | Interventional | 2019-09-03 | Completed | ||
| The Effect of Remifentanil and Midazolam on Propofol for Loss of Consciousness During Induction of Anesthesia[NCT02536690] | 120 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| Low Dose Fentanyl/Midazolam Improves Sevoflurane Induction in Adults[NCT00723164] | 80 participants (Actual) | Interventional | 2005-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for midazolam and Consciousness, Loss of
| Article | Year |
|---|---|
Severe hemiplegic migraine attack precipitated by fentanyl sedation for esophagogastroscopy.
Topics: Analgesics, Opioid; Esophagoscopy; Female; Fentanyl; Gastroscopy; Hemiplegia; Humans; Hypnotics and | 2004 |
4 trials available for midazolam and Consciousness, Loss of
| Article | Year |
|---|---|
Effects of remifentanil with or without midazolam pretreatment on the 95% effective dose of propofol for loss of consciousness during induction: A randomized, clinical trial.
Topics: Adult; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female | 2017 |
Effects of remifentanil with or without midazolam pretreatment on the 95% effective dose of propofol for loss of consciousness during induction: A randomized, clinical trial.
Topics: Adult; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female | 2017 |
Effects of remifentanil with or without midazolam pretreatment on the 95% effective dose of propofol for loss of consciousness during induction: A randomized, clinical trial.
Topics: Adult; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female | 2017 |
Effects of remifentanil with or without midazolam pretreatment on the 95% effective dose of propofol for loss of consciousness during induction: A randomized, clinical trial.
Topics: Adult; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female | 2017 |
Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness.
Topics: Adult; Anesthetics, Intravenous; Brain Mapping; Cerebral Cortex; Electroencephalography; Evoked Pote | 2010 |
Rapid inhalation induction with 7% sevoflurane combined with intravenous midazolam.
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, In | 2002 |
Alfentanil potentiates midazolam-induced unconsciousness in subanalgesic doses.
Topics: Adult; Alfentanil; Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Female; Hu | 1990 |
18 other studies available for midazolam and Consciousness, Loss of
| Article | Year |
|---|---|
The Moment of Death.
Topics: Algorithms; Analgesics, Opioid; Consciousness Monitors; Death; Electroencephalography; Electromyogra | 2017 |
Change in functional networks for transitions between states of consciousness during midazolam-induced sedation.
Topics: Consciousness; Electroencephalography; Midazolam; Parietal Lobe; Unconsciousness | 2017 |
Cellular stress and AMPK links metformin and diverse compounds with accelerated emergence from anesthesia and potential recovery from disorders of consciousness.
Topics: AMP-Activated Protein Kinases; Anesthesia; Anesthesia Recovery Period; Anesthetics; Animals; Brain M | 2019 |
An unusual response to intravenous sedation: a case report.
Topics: Adolescent; Conscious Sedation; Delayed Emergence from Anesthesia; Female; Humans; Hypnotics and Sed | 2014 |
Effect of hepatic function on the EC50 of midazolam and the BIS50 at the time of loss of consciousness.
Topics: Adult; Anesthetics, Intravenous; Cholecystectomy, Laparoscopic; Cholelithiasis; Electroencephalograp | 2014 |
Bispectral Index Monitoring in Terminally Ill Patients: A Validation Study.
Topics: Aged; Aged, 80 and over; Brain; Delirium; Electroencephalography; Feasibility Studies; Female; Human | 2016 |
[Life-threatening respiratory depression after pain therapy].
Topics: Adult; Analgesics; Anesthetics, Local; Arm Injuries; Female; Humans; Hypnotics and Sedatives; Mepiva | 2008 |
[Case report: a 65-year-old man loses consciousness after colonoscopy].
Topics: Aged; Ambulatory Care; Anesthetics, Intravenous; Atropine; Bradycardia; Cholinergic Antagonists; Col | 2010 |
Acute encephalitis with refractory, repetitive partial seizures: case reports of this unusual post-encephalitic epilepsy.
Topics: Acute Disease; Anti-Inflammatory Agents; Anticonvulsants; Brain; Cell Count; Cerebrospinal Fluid; Ch | 2007 |
Unplanned 'unconsciousness' at Caesarean section: hysteria or drug reaction?
Topics: Adult; Amides; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthetics, Intravenous; Anesthetics, L | 2007 |
Differences in midazolam-induced breathing patterns in healthy volunteers.
Topics: Abdominal Muscles; Adult; Body Height; Body Weight; Conscious Sedation; Female; Flumazenil; Humans; | 1995 |
An unusual toxic reaction to axillary block by mepivacaine with adrenaline.
Topics: Absorption; Aged; Akathisia, Drug-Induced; Anesthetics, Local; Anti-Arrhythmia Agents; Antihypertens | 1998 |
Gas embolism during hysteroscopy.
Topics: Aged; Anticoagulants; Carbon Dioxide; Cardiopulmonary Resuscitation; Catheterization, Central Venous | 1999 |
Use of midlatency auditory-evoked potentials as indicator of unconsciousness in the dog: characterisation of the effects of acepromazine-thiopentone, medetomidine-thiopentone and medetomidine-butorphanol-midazolam combinations.
Topics: Acepromazine; Anesthesia; Animals; Butorphanol; Dogs; Drug Combinations; Evoked Potentials, Auditory | 1999 |
EEG evaluation of reflex testing as assessment of depth of pentobarbital anaesthesia in the rat.
Topics: Analgesics, Opioid; Anesthesia; Anesthetics, Intravenous; Animals; Buprenorphine; Butyrophenones; El | 1999 |
Unconsciousness associated with midazolam and erythromycin.
Topics: Adenoidectomy; Child; Drug Interactions; Erythromycin; Female; Humans; Male; Midazolam; Premedicatio | 1990 |
The effect of anaesthesia on the bone blood flow of the rabbit.
Topics: Anesthesia; Animals; Blood Flow Velocity; Bone and Bones; Consciousness; Injections; Microspheres; M | 1990 |
Midazolam-alfentanil synergism for anesthetic induction in patients.
Topics: Adolescent; Adult; Alfentanil; Anesthesia, Intravenous; Anesthetics; Dose-Response Relationship, Dru | 1989 |