Page last updated: 2024-10-31

midazolam and Coma

midazolam has been researched along with Coma in 35 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
" Thus, eight patients were treated with midazolam and 10 with barbiturate coma therapy using thiamylal."7.80Midazolam fails to prevent neurological damage in children with convulsive refractory febrile status epilepticus. ( Fujita, K; Maruyama, A; Nagase, H; Nakagawa, T; Nishiyama, M; Saji, Y, 2014)
"In 99 patients receiving IV fentanyl, midazolam, or both, we evaluated drug doses, covariates likely to influence drug effects (age, body mass index, and renal and hepatic dysfunction); delirium risk factors; concomitant administration of CYP3A and P-glycoprotein substrates/inhibitors; ABCB1, ABCG2, and CYP3A5 genetic polymorphisms; and fentanyl and midazolam plasma levels."7.79Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. ( Cossette, M; Leger, C; Michaud, V; Skrobik, Y; Turgeon, J, 2013)
"An outbreak of food poisoning that affected at least ten people in various regions of Japan was traced to exposure to Chinese dumplings contaminated with the organophosphate insecticide Methamidophos."7.74Chinese dumpling scare hits Japan--a case of methamidophos food poisoning. ( Oode, Y; Sumi, Y; Tanaka, H, 2008)
"We report a 14-year-old girl with carbamazepine intoxication who developed alpha coma and status epilepticus."7.71[A case of carbamazepine intoxication with alpha coma and status epilepticus]. ( Komatsu, K; Ono, A; Sawaishi, Y; Takada, G; Yano, T, 2001)
"Midazolam infusion, as per our described algorithm, is effective in terminating refractory status epilepticus."7.70Midazolam coma for refractory status epilepticus in children. ( Igartua, J; Maytal, J; Sagy, M; Silver, P, 1999)
"The purpose of this report is to describe the use of flumazenil as a diagnostic aid in the differential diagnosis of coma in a patient with an inadvertent overdose of benzodiazepines."7.69Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient. ( McLachlan, RS; Sharpe, MD; Sprenger, H, 1994)
" Therapeutic coma induction with midazolam, thiopentone, phenobarbitone or propofol is indicated when conventional antiepileptics fail to abort seizure."4.98High dose phenobarbitone coma in pediatric refractory status epilepticus; a retrospective case record analysis, a proposed protocol and review of literature. ( Chakrabarty, B; Gulati, S; Jauhari, P; Lodha, R; Sankar, J; Sondhi, V, 2018)
"While the treatment of refractory status epilepticus (SE) relies on the use of anesthetic agents, mostly barbiturates, propofol, or midazolam, the study of the available literature discloses that the evidence level is low."4.84Which anesthetic should be used in the treatment of refractory status epilepticus? ( Rossetti, AO, 2007)
" Late awakening was more frequent with midazolam (58% vs 45%) and was associated with higher rates of delirium (62% vs 39%) and unfavorable 3-months outcome (27% vs 12%; all p = 0."3.91Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery. ( Eckert, P; Miroz, JP; Oddo, M; Rey, A; Rossetti, AO, 2019)
"We compared two sedation regimens (propofol-remifentanil, period P2, vs midazolam-fentanyl, period P1) among comatose TTM-treated CA survivors."3.88Comparison of two sedation regimens during targeted temperature management after cardiac arrest. ( Ben Hadj Salem, O; Bougouin, W; Cariou, A; Champigneulle, B; Charpentier, J; Chiche, JD; Dumas, F; Geri, G; Guillemet, L; Legriel, S; Mira, JP; Paul, M; Sandroni, C, 2018)
" Thus, eight patients were treated with midazolam and 10 with barbiturate coma therapy using thiamylal."3.80Midazolam fails to prevent neurological damage in children with convulsive refractory febrile status epilepticus. ( Fujita, K; Maruyama, A; Nagase, H; Nakagawa, T; Nishiyama, M; Saji, Y, 2014)
"In 99 patients receiving IV fentanyl, midazolam, or both, we evaluated drug doses, covariates likely to influence drug effects (age, body mass index, and renal and hepatic dysfunction); delirium risk factors; concomitant administration of CYP3A and P-glycoprotein substrates/inhibitors; ABCB1, ABCG2, and CYP3A5 genetic polymorphisms; and fentanyl and midazolam plasma levels."3.79Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. ( Cossette, M; Leger, C; Michaud, V; Skrobik, Y; Turgeon, J, 2013)
"An outbreak of food poisoning that affected at least ten people in various regions of Japan was traced to exposure to Chinese dumplings contaminated with the organophosphate insecticide Methamidophos."3.74Chinese dumpling scare hits Japan--a case of methamidophos food poisoning. ( Oode, Y; Sumi, Y; Tanaka, H, 2008)
"We report a 14-year-old girl with carbamazepine intoxication who developed alpha coma and status epilepticus."3.71[A case of carbamazepine intoxication with alpha coma and status epilepticus]. ( Komatsu, K; Ono, A; Sawaishi, Y; Takada, G; Yano, T, 2001)
"Midazolam infusion, as per our described algorithm, is effective in terminating refractory status epilepticus."3.70Midazolam coma for refractory status epilepticus in children. ( Igartua, J; Maytal, J; Sagy, M; Silver, P, 1999)
" In all five patients, the comatose state was immediately reversed by the benzodiazepine-receptor antagonist flumazenil."3.69Prolonged sedation due to accumulation of conjugated metabolites of midazolam. ( Bauer, TM; Ha, HR; Haberthür, C; Haefeli, WE; Hunkeler, W; Ritz, R; Scollo-Lavizzari, G; Sleight, AJ, 1995)
"The purpose of this report is to describe the use of flumazenil as a diagnostic aid in the differential diagnosis of coma in a patient with an inadvertent overdose of benzodiazepines."3.69Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient. ( McLachlan, RS; Sharpe, MD; Sprenger, H, 1994)
"Five cases of post narcotic delirium, somnolence or coma are interpreted as central anticholinergic syndromes as they were reversed by physostigmine."3.66[Physostigmine reversal of central anticholinergic syndrome induced by midazolam/fentanyl, benzoctamine/buprenorphine and etomidate/carticaine or by atropine/promethazine/pethidine for premedication? (author's transl)]. ( Jost, U; Ruppert, M; Schmid, A, 1982)
"Delirium was diagnosed in 226 of 420 assessed patients (53."2.80Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. ( Burns, K; Burry, L; Cook, D; Devlin, JW; Dodek, P; Ferguson, N; Fergusson, D; Fowler, R; Granton, J; Herridge, M; Jacka, M; Keenan, S; Mallick, R; Meade, M; Mehta, S; Olafson, K; Reynolds, S; Skrobik, Y; Steinberg, M; Tanios, M, 2015)
"Midazolam was given as continuous infusion."2.78Pharmacokinetics of midazolam in resuscitated patients treated with moderate hypothermia. ( Bastiaans, DE; Derijks, LJ; Swart, EL; van Akkeren, JP, 2013)
"General anesthetic-induced coma therapy has been recommended for the treatment of refractory status epilepticus (RSE)."1.42Induction of burst suppression or coma using intravenous anesthetics in refractory status epilepticus. ( Byun, JI; Chu, K; Jung, KH; Kang, BS; Kim, YS; Lee, SK; Lee, ST; Lim, JA; Moon, HJ; Moon, JS; Shin, JW, 2015)
"Treatment included induction of coma while a native immune response matured; rabies vaccine was not administered."1.33Survival after treatment of rabies with induction of coma. ( Amlie-Lefond, CM; Chusid, MJ; Ghanayem, NS; Hoffman, GM; Rupprecht, CE; Schwabe, MJ; Tieves, KS; Willoughby, RE, 2005)
"Ten ventilated comatose patients were receiving an intravenous MDZ bolus dose (0."1.30Dynamics of MLAEP changes in midazolam-induced sedation. ( Bertrand, O; Boulieu, R; Fischer, C; Morlet, D; Pernier, J; Salord, F, 1997)
"Only one anorectic patient became comatose after ingestion of 0."1.29[Acute overdose of Zolpidem (Stilnox)]. ( Meier-Abt, PJ; Radovanovic, D; Wyss, PA, 1996)
" The two patients with coma of unknown origin demonstrated no clinical response to flumazenil at a dosage of 2 mg."1.28[The efficacy of the benzodiazepine antagonist flumazenil (Ro 15-1788) based on the EEG of mechanically ventilated intensive care patients]. ( Kulka, PJ; Lauven, PM; Rommelsheim, K; Schwilden, H, 1989)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19903 (8.57)18.7374
1990's8 (22.86)18.2507
2000's8 (22.86)29.6817
2010's12 (34.29)24.3611
2020's4 (11.43)2.80

Authors

AuthorsStudies
Matsuishi, Y1
Hoshino, H1
Enomoto, Y1
Shimojo, N1
Matsubara, M1
Kato, H1
Mathis, BJ1
Morita, K1
Hiramatsu, Y1
Inoue, Y1
Olsen, HT1
Nedergaard, HK1
Strøm, T1
Oxlund, J1
Wian, KA1
Ytrebø, LM1
Kroken, BA1
Chew, M1
Korkmaz, S1
Lauridsen, JT1
Toft, P1
Caronna, E1
Vilaseca, A1
Maria Gràcia Gozalo, R1
Sanchez Corral, A1
Santafé, M1
Sueiras, M1
Guzmán, L1
Quintana, M1
Toledo-Argany, M1
Santamarina, E1
Tanios, M2
Nguyen, HM1
Le, QA1
Park, H1
Devlin, JW2
Gulati, S1
Sondhi, V1
Chakrabarty, B1
Jauhari, P1
Lodha, R1
Sankar, J1
Paul, M1
Bougouin, W1
Dumas, F1
Geri, G1
Champigneulle, B1
Guillemet, L1
Ben Hadj Salem, O1
Legriel, S1
Chiche, JD1
Charpentier, J1
Mira, JP1
Sandroni, C1
Cariou, A1
Rey, A1
Rossetti, AO2
Miroz, JP1
Eckert, P1
Oddo, M1
Fraser, GL1
Worby, CP1
Riker, RR1
Gusmao-Flores, D1
Carvalho, JP1
Quarantini, LC1
Nagase, H1
Nishiyama, M1
Nakagawa, T1
Fujita, K1
Saji, Y1
Maruyama, A1
Mehta, S1
Cook, D1
Skrobik, Y2
Meade, M1
Fergusson, D1
Herridge, M1
Steinberg, M1
Granton, J1
Ferguson, N1
Dodek, P1
Fowler, R1
Burns, K1
Jacka, M1
Olafson, K1
Mallick, R1
Reynolds, S1
Keenan, S1
Burry, L1
Kang, BS1
Jung, KH1
Shin, JW1
Moon, JS1
Byun, JI1
Lim, JA1
Moon, HJ1
Kim, YS1
Lee, ST1
Chu, K1
Lee, SK1
Prüss, H1
Holtkamp, M1
Sumi, Y1
Oode, Y1
Tanaka, H1
Meierhans, R1
Stover, JF1
Béchir, M1
Keel, M1
Stocker, R1
Chamorro, C1
Borrallo, JM1
Romera, MA1
Fernández-Torre, JL1
Hernández-Hernández, MA1
Bastiaans, DE1
Swart, EL1
van Akkeren, JP1
Derijks, LJ1
Leger, C1
Cossette, M1
Michaud, V1
Turgeon, J1
Willoughby, RE1
Tieves, KS1
Hoffman, GM1
Ghanayem, NS1
Amlie-Lefond, CM1
Schwabe, MJ1
Chusid, MJ1
Rupprecht, CE1
Jackson, AC1
Kim, F1
Olsufka, M1
Carlbom, D1
Deem, S1
Longstreth, WT1
Hanrahan, M1
Maynard, C1
Copass, MK1
Cobb, LA1
Jost, U1
Schmid, A1
Ruppert, M1
Bauer, TM1
Ritz, R1
Haberthür, C1
Ha, HR1
Hunkeler, W1
Sleight, AJ1
Scollo-Lavizzari, G1
Haefeli, WE1
Sprenger, H1
Sharpe, MD1
McLachlan, RS1
Abad-Alegría, F1
Adelantado, S1
González, P1
Wyss, PA1
Radovanovic, D1
Meier-Abt, PJ1
Hoes, MJ1
Zeijpveld, JH1
Morlet, D1
Bertrand, O1
Salord, F1
Boulieu, R1
Pernier, J1
Fischer, C1
Igartua, J1
Silver, P1
Maytal, J1
Sagy, M1
Ono, A1
Yano, T1
Sawaishi, Y1
Komatsu, K1
Takada, G1
Salmore, R1
Kulka, PJ1
Lauven, PM1
Schwilden, H1
Rommelsheim, K1
Chiolero, RL1
Ravussin, P1
Anderes, JP1
Ledermann, P1
de Tribolet, N1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation. The NONSEDA-trial. An Investigator-initiated, Randomised, Clinical, Parallel-group, Multinational, Superiority Trial[NCT01967680]700 participants (Actual)Interventional2014-01-31Completed
Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Unit[NCT03194360]141 participants (Actual)Observational2015-12-01Completed
A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885]Phase 26 participants (Anticipated)Interventional2022-08-26Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for midazolam and Coma

ArticleYear
High dose phenobarbitone coma in pediatric refractory status epilepticus; a retrospective case record analysis, a proposed protocol and review of literature.
    Brain & development, 2018, Volume: 40, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Protocols; Coma; Drug Resistance; Fem

2018
Which anesthetic should be used in the treatment of refractory status epilepticus?
    Epilepsia, 2007, Volume: 48 Suppl 8

    Topics: Anesthetics; Anesthetics, Intravenous; Anticonvulsants; Barbiturates; Coma; Electroencephalography;

2007

Trials

3 trials available for midazolam and Coma

ArticleYear
Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients.
    The New England journal of medicine, 2020, 03-19, Volume: 382, Issue:12

    Topics: Aged; Aged, 80 and over; Coma; Conscious Sedation; Critical Illness; Delirium; Female; Humans; Hypno

2020
Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults.
    Critical care medicine, 2015, Volume: 43, Issue:3

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Opioid; Antipsychotic Agents; APACHE; Benzo

2015
Pharmacokinetics of midazolam in resuscitated patients treated with moderate hypothermia.
    International journal of clinical pharmacy, 2013, Volume: 35, Issue:2

    Topics: Aged; Coma; Female; Humans; Hypnotics and Sedatives; Hypothermia, Induced; Intensive Care Units; Mal

2013

Other Studies

30 other studies available for midazolam and Coma

ArticleYear
Pediatric delirium is associated with increased brain injury marker levels in cardiac surgery patients.
    Scientific reports, 2022, 11-04, Volume: 12, Issue:1

    Topics: Adult; Bayes Theorem; Biomarkers; Brain Injuries; Cardiac Surgical Procedures; Child; Coma; Delirium

2022
Long-term prognosis related to deep sedation in refractory status Epilepticus.
    Acta neurologica Scandinavica, 2020, Volume: 142, Issue:6

    Topics: Adolescent; Adult; Aged; Barbiturates; Coma; Deep Sedation; Female; Humans; Hypnotics and Sedatives;

2020
Fentanyl- and midazolam-induced coma each influence days of mechanical ventilation and 28-day mortality.
    Intensive care medicine, 2021, Volume: 47, Issue:7

    Topics: Coma; Fentanyl; Humans; Hypnotics and Sedatives; Midazolam; Respiration, Artificial

2021
Comparison of two sedation regimens during targeted temperature management after cardiac arrest.
    Resuscitation, 2018, Volume: 128

    Topics: Adult; Aged; Anesthetics, Intravenous; Coma; Deep Sedation; Drug Therapy, Combination; Female; Fenta

2018
Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery.
    Critical care medicine, 2019, Volume: 47, Issue:1

    Topics: Aged; Cohort Studies; Coma; Delirium; Electroencephalography; Evoked Potentials, Motor; Female; Hear

2019
Dissecting sedation-induced delirium.
    Critical care medicine, 2013, Volume: 41, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member

2013
Benzodiazepines and delirium: the best option for the right patient.
    Critical care medicine, 2013, Volume: 41, Issue:10

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Coma; Cy

2013
Midazolam fails to prevent neurological damage in children with convulsive refractory febrile status epilepticus.
    Pediatric neurology, 2014, Volume: 51, Issue:1

    Topics: Aged, 80 and over; Brain; Child; Child, Preschool; Coma; Female; Follow-Up Studies; Humans; Hypnotic

2014
Induction of burst suppression or coma using intravenous anesthetics in refractory status epilepticus.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015, Volume: 22, Issue:5

    Topics: Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; A

2015
Ketamine successfully terminates malignant status epilepticus.
    Epilepsy research, 2008, Volume: 82, Issue:2-3

    Topics: Anesthesia, General; Anesthetics, Dissociative; Anticonvulsants; Coma; DNA Polymerase gamma; DNA-Dir

2008
Chinese dumpling scare hits Japan--a case of methamidophos food poisoning.
    The Journal of toxicological sciences, 2008, Volume: 33, Issue:4

    Topics: Atropine; Child, Preschool; China; Coma; Female; Foodborne Diseases; Humans; Insecticides; Japan; Mi

2008
Reduced midazolam clearance must be considered in prolonged coma.
    Anaesthesia and intensive care, 2008, Volume: 36, Issue:6

    Topics: Adult; Anesthetics, Intravenous; Antidotes; Cholinesterase Inhibitors; Coma; Flumazenil; Humans; Mal

2008
Therapeutic hypothermia after cardiac arrest.
    The New England journal of medicine, 2011, 01-13, Volume: 364, Issue:2

    Topics: Analgesics; Coma; Fentanyl; Heart Arrest; Humans; Hypnotics and Sedatives; Hypothermia, Induced; Mid

2011
Utility of bilateral Bispectral index (BIS) monitoring in a comatose patient with focal nonconvulsive status epilepticus.
    Seizure, 2012, Volume: 21, Issue:1

    Topics: Aged; Aneurysm, Ruptured; Coma; Consciousness Monitors; Deep Sedation; Electroencephalography; Femal

2012
Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors.
    Critical care medicine, 2013, Volume: 41, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member

2013
Survival after treatment of rabies with induction of coma.
    The New England journal of medicine, 2005, Jun-16, Volume: 352, Issue:24

    Topics: Adolescent; Amantadine; Anesthetics; Animals; Antiviral Agents; Athetosis; Benzodiazepines; Bites an

2005
Recovery from rabies.
    The New England journal of medicine, 2005, Jun-16, Volume: 352, Issue:24

    Topics: Amantadine; Anesthetics; Animals; Antiviral Agents; Bites and Stings; Chiroptera; Coma; Excitatory A

2005
Pilot study of rapid infusion of 2 L of 4 degrees C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrest.
    Circulation, 2005, Aug-02, Volume: 112, Issue:5

    Topics: Adult; Cold Temperature; Coma; Heart Arrest; Humans; Hypnotics and Sedatives; Hypothermia, Induced;

2005
[Physostigmine reversal of central anticholinergic syndrome induced by midazolam/fentanyl, benzoctamine/buprenorphine and etomidate/carticaine or by atropine/promethazine/pethidine for premedication? (author's transl)].
    Der Anaesthesist, 1982, Volume: 31, Issue:1

    Topics: Adult; Aged; Anthracenes; Atropine; Benzodiazepines; Buprenorphine; Carticaine; Coma; Delirium; Etom

1982
Prolonged sedation due to accumulation of conjugated metabolites of midazolam.
    Lancet (London, England), 1995, Jul-15, Volume: 346, Issue:8968

    Topics: Aged; Aged, 80 and over; Animals; Coma; Electroencephalography; Female; Flumazenil; Glucuronates; Hu

1995
Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:1

    Topics: Aged; Bacterial Infections; Coma; Critical Illness; Diagnosis, Differential; Diazepam; Flumazenil; H

1994
[Episodic depression in electroencephalography and midazolam].
    Revista de neurologia, 1996, Volume: 24, Issue:129

    Topics: Adult; Aged; Anti-Anxiety Agents; Brain; Coma; Female; Humans; Male; Midazolam; Middle Aged

1996
[Acute overdose of Zolpidem (Stilnox)].
    Schweizerische medizinische Wochenschrift, 1996, May-04, Volume: 126, Issue:18

    Topics: Adolescent; Adult; Aged; Antidotes; Coma; Drug Overdose; Female; Flumazenil; Humans; Hypnotics and S

1996
First report of mirtazapine overdose.
    International clinical psychopharmacology, 1996, Volume: 11, Issue:2

    Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Coma; Depressive Dis

1996
Dynamics of MLAEP changes in midazolam-induced sedation.
    Electroencephalography and clinical neurophysiology, 1997, Volume: 104, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Coma; Electroencephalography; Evoked Potentials, Auditory; Humans; H

1997
Midazolam coma for refractory status epilepticus in children.
    Critical care medicine, 1999, Volume: 27, Issue:9

    Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Child; Child, Preschool; Coma; Electroencephalogra

1999
[A case of carbamazepine intoxication with alpha coma and status epilepticus].
    No to hattatsu = Brain and development, 2001, Volume: 33, Issue:6

    Topics: Adolescent; Carbamazepine; Charcoal; Coma; Electroencephalography; Female; Gastric Lavage; Humans; M

2001
Aminophylline reversal of midazolam sedation.
    Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates, 1990,Fall, Volume: 13, Issue:2

    Topics: Aminophylline; Coma; Humans; Midazolam

1990
[The efficacy of the benzodiazepine antagonist flumazenil (Ro 15-1788) based on the EEG of mechanically ventilated intensive care patients].
    Der Anaesthesist, 1989, Volume: 38, Issue:8

    Topics: Adult; Aged; Arousal; Benzodiazepines; Coma; Critical Care; Electroencephalography; Flumazenil; Huma

1989
The effects of midazolam reversal by RO 15-1788 on cerebral perfusion pressure in patients with severe head injury.
    Intensive care medicine, 1988, Volume: 14, Issue:3

    Topics: Adult; Cerebrovascular Circulation; Coma; Craniocerebral Trauma; Female; Flumazenil; Humans; Intracr

1988