midazolam and Coma
midazolam has been researched along with Coma in 35 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus, eight patients were treated with midazolam and 10 with barbiturate coma therapy using thiamylal." | 7.80 | Midazolam fails to prevent neurological damage in children with convulsive refractory febrile status epilepticus. ( Fujita, K; Maruyama, A; Nagase, H; Nakagawa, T; Nishiyama, M; Saji, Y, 2014) |
| "In 99 patients receiving IV fentanyl, midazolam, or both, we evaluated drug doses, covariates likely to influence drug effects (age, body mass index, and renal and hepatic dysfunction); delirium risk factors; concomitant administration of CYP3A and P-glycoprotein substrates/inhibitors; ABCB1, ABCG2, and CYP3A5 genetic polymorphisms; and fentanyl and midazolam plasma levels." | 7.79 | Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. ( Cossette, M; Leger, C; Michaud, V; Skrobik, Y; Turgeon, J, 2013) |
| "An outbreak of food poisoning that affected at least ten people in various regions of Japan was traced to exposure to Chinese dumplings contaminated with the organophosphate insecticide Methamidophos." | 7.74 | Chinese dumpling scare hits Japan--a case of methamidophos food poisoning. ( Oode, Y; Sumi, Y; Tanaka, H, 2008) |
| "We report a 14-year-old girl with carbamazepine intoxication who developed alpha coma and status epilepticus." | 7.71 | [A case of carbamazepine intoxication with alpha coma and status epilepticus]. ( Komatsu, K; Ono, A; Sawaishi, Y; Takada, G; Yano, T, 2001) |
| "Midazolam infusion, as per our described algorithm, is effective in terminating refractory status epilepticus." | 7.70 | Midazolam coma for refractory status epilepticus in children. ( Igartua, J; Maytal, J; Sagy, M; Silver, P, 1999) |
| "The purpose of this report is to describe the use of flumazenil as a diagnostic aid in the differential diagnosis of coma in a patient with an inadvertent overdose of benzodiazepines." | 7.69 | Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient. ( McLachlan, RS; Sharpe, MD; Sprenger, H, 1994) |
| " Therapeutic coma induction with midazolam, thiopentone, phenobarbitone or propofol is indicated when conventional antiepileptics fail to abort seizure." | 4.98 | High dose phenobarbitone coma in pediatric refractory status epilepticus; a retrospective case record analysis, a proposed protocol and review of literature. ( Chakrabarty, B; Gulati, S; Jauhari, P; Lodha, R; Sankar, J; Sondhi, V, 2018) |
| "While the treatment of refractory status epilepticus (SE) relies on the use of anesthetic agents, mostly barbiturates, propofol, or midazolam, the study of the available literature discloses that the evidence level is low." | 4.84 | Which anesthetic should be used in the treatment of refractory status epilepticus? ( Rossetti, AO, 2007) |
| " Late awakening was more frequent with midazolam (58% vs 45%) and was associated with higher rates of delirium (62% vs 39%) and unfavorable 3-months outcome (27% vs 12%; all p = 0." | 3.91 | Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery. ( Eckert, P; Miroz, JP; Oddo, M; Rey, A; Rossetti, AO, 2019) |
| "We compared two sedation regimens (propofol-remifentanil, period P2, vs midazolam-fentanyl, period P1) among comatose TTM-treated CA survivors." | 3.88 | Comparison of two sedation regimens during targeted temperature management after cardiac arrest. ( Ben Hadj Salem, O; Bougouin, W; Cariou, A; Champigneulle, B; Charpentier, J; Chiche, JD; Dumas, F; Geri, G; Guillemet, L; Legriel, S; Mira, JP; Paul, M; Sandroni, C, 2018) |
| " Thus, eight patients were treated with midazolam and 10 with barbiturate coma therapy using thiamylal." | 3.80 | Midazolam fails to prevent neurological damage in children with convulsive refractory febrile status epilepticus. ( Fujita, K; Maruyama, A; Nagase, H; Nakagawa, T; Nishiyama, M; Saji, Y, 2014) |
| "In 99 patients receiving IV fentanyl, midazolam, or both, we evaluated drug doses, covariates likely to influence drug effects (age, body mass index, and renal and hepatic dysfunction); delirium risk factors; concomitant administration of CYP3A and P-glycoprotein substrates/inhibitors; ABCB1, ABCG2, and CYP3A5 genetic polymorphisms; and fentanyl and midazolam plasma levels." | 3.79 | Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. ( Cossette, M; Leger, C; Michaud, V; Skrobik, Y; Turgeon, J, 2013) |
| "An outbreak of food poisoning that affected at least ten people in various regions of Japan was traced to exposure to Chinese dumplings contaminated with the organophosphate insecticide Methamidophos." | 3.74 | Chinese dumpling scare hits Japan--a case of methamidophos food poisoning. ( Oode, Y; Sumi, Y; Tanaka, H, 2008) |
| "We report a 14-year-old girl with carbamazepine intoxication who developed alpha coma and status epilepticus." | 3.71 | [A case of carbamazepine intoxication with alpha coma and status epilepticus]. ( Komatsu, K; Ono, A; Sawaishi, Y; Takada, G; Yano, T, 2001) |
| "Midazolam infusion, as per our described algorithm, is effective in terminating refractory status epilepticus." | 3.70 | Midazolam coma for refractory status epilepticus in children. ( Igartua, J; Maytal, J; Sagy, M; Silver, P, 1999) |
| " In all five patients, the comatose state was immediately reversed by the benzodiazepine-receptor antagonist flumazenil." | 3.69 | Prolonged sedation due to accumulation of conjugated metabolites of midazolam. ( Bauer, TM; Ha, HR; Haberthür, C; Haefeli, WE; Hunkeler, W; Ritz, R; Scollo-Lavizzari, G; Sleight, AJ, 1995) |
| "The purpose of this report is to describe the use of flumazenil as a diagnostic aid in the differential diagnosis of coma in a patient with an inadvertent overdose of benzodiazepines." | 3.69 | Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient. ( McLachlan, RS; Sharpe, MD; Sprenger, H, 1994) |
| "Five cases of post narcotic delirium, somnolence or coma are interpreted as central anticholinergic syndromes as they were reversed by physostigmine." | 3.66 | [Physostigmine reversal of central anticholinergic syndrome induced by midazolam/fentanyl, benzoctamine/buprenorphine and etomidate/carticaine or by atropine/promethazine/pethidine for premedication? (author's transl)]. ( Jost, U; Ruppert, M; Schmid, A, 1982) |
| "Delirium was diagnosed in 226 of 420 assessed patients (53." | 2.80 | Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. ( Burns, K; Burry, L; Cook, D; Devlin, JW; Dodek, P; Ferguson, N; Fergusson, D; Fowler, R; Granton, J; Herridge, M; Jacka, M; Keenan, S; Mallick, R; Meade, M; Mehta, S; Olafson, K; Reynolds, S; Skrobik, Y; Steinberg, M; Tanios, M, 2015) |
| "Midazolam was given as continuous infusion." | 2.78 | Pharmacokinetics of midazolam in resuscitated patients treated with moderate hypothermia. ( Bastiaans, DE; Derijks, LJ; Swart, EL; van Akkeren, JP, 2013) |
| "General anesthetic-induced coma therapy has been recommended for the treatment of refractory status epilepticus (RSE)." | 1.42 | Induction of burst suppression or coma using intravenous anesthetics in refractory status epilepticus. ( Byun, JI; Chu, K; Jung, KH; Kang, BS; Kim, YS; Lee, SK; Lee, ST; Lim, JA; Moon, HJ; Moon, JS; Shin, JW, 2015) |
| "Treatment included induction of coma while a native immune response matured; rabies vaccine was not administered." | 1.33 | Survival after treatment of rabies with induction of coma. ( Amlie-Lefond, CM; Chusid, MJ; Ghanayem, NS; Hoffman, GM; Rupprecht, CE; Schwabe, MJ; Tieves, KS; Willoughby, RE, 2005) |
| "Ten ventilated comatose patients were receiving an intravenous MDZ bolus dose (0." | 1.30 | Dynamics of MLAEP changes in midazolam-induced sedation. ( Bertrand, O; Boulieu, R; Fischer, C; Morlet, D; Pernier, J; Salord, F, 1997) |
| "Only one anorectic patient became comatose after ingestion of 0." | 1.29 | [Acute overdose of Zolpidem (Stilnox)]. ( Meier-Abt, PJ; Radovanovic, D; Wyss, PA, 1996) |
| " The two patients with coma of unknown origin demonstrated no clinical response to flumazenil at a dosage of 2 mg." | 1.28 | [The efficacy of the benzodiazepine antagonist flumazenil (Ro 15-1788) based on the EEG of mechanically ventilated intensive care patients]. ( Kulka, PJ; Lauven, PM; Rommelsheim, K; Schwilden, H, 1989) |
Research
Studies (35)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.57) | 18.7374 |
| 1990's | 8 (22.86) | 18.2507 |
| 2000's | 8 (22.86) | 29.6817 |
| 2010's | 12 (34.29) | 24.3611 |
| 2020's | 4 (11.43) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Matsuishi, Y | 1 |
| Hoshino, H | 1 |
| Enomoto, Y | 1 |
| Shimojo, N | 1 |
| Matsubara, M | 1 |
| Kato, H | 1 |
| Mathis, BJ | 1 |
| Morita, K | 1 |
| Hiramatsu, Y | 1 |
| Inoue, Y | 1 |
| Olsen, HT | 1 |
| Nedergaard, HK | 1 |
| Strøm, T | 1 |
| Oxlund, J | 1 |
| Wian, KA | 1 |
| Ytrebø, LM | 1 |
| Kroken, BA | 1 |
| Chew, M | 1 |
| Korkmaz, S | 1 |
| Lauridsen, JT | 1 |
| Toft, P | 1 |
| Caronna, E | 1 |
| Vilaseca, A | 1 |
| Maria Gràcia Gozalo, R | 1 |
| Sanchez Corral, A | 1 |
| Santafé, M | 1 |
| Sueiras, M | 1 |
| Guzmán, L | 1 |
| Quintana, M | 1 |
| Toledo-Argany, M | 1 |
| Santamarina, E | 1 |
| Tanios, M | 2 |
| Nguyen, HM | 1 |
| Le, QA | 1 |
| Park, H | 1 |
| Devlin, JW | 2 |
| Gulati, S | 1 |
| Sondhi, V | 1 |
| Chakrabarty, B | 1 |
| Jauhari, P | 1 |
| Lodha, R | 1 |
| Sankar, J | 1 |
| Paul, M | 1 |
| Bougouin, W | 1 |
| Dumas, F | 1 |
| Geri, G | 1 |
| Champigneulle, B | 1 |
| Guillemet, L | 1 |
| Ben Hadj Salem, O | 1 |
| Legriel, S | 1 |
| Chiche, JD | 1 |
| Charpentier, J | 1 |
| Mira, JP | 1 |
| Sandroni, C | 1 |
| Cariou, A | 1 |
| Rey, A | 1 |
| Rossetti, AO | 2 |
| Miroz, JP | 1 |
| Eckert, P | 1 |
| Oddo, M | 1 |
| Fraser, GL | 1 |
| Worby, CP | 1 |
| Riker, RR | 1 |
| Gusmao-Flores, D | 1 |
| Carvalho, JP | 1 |
| Quarantini, LC | 1 |
| Nagase, H | 1 |
| Nishiyama, M | 1 |
| Nakagawa, T | 1 |
| Fujita, K | 1 |
| Saji, Y | 1 |
| Maruyama, A | 1 |
| Mehta, S | 1 |
| Cook, D | 1 |
| Skrobik, Y | 2 |
| Meade, M | 1 |
| Fergusson, D | 1 |
| Herridge, M | 1 |
| Steinberg, M | 1 |
| Granton, J | 1 |
| Ferguson, N | 1 |
| Dodek, P | 1 |
| Fowler, R | 1 |
| Burns, K | 1 |
| Jacka, M | 1 |
| Olafson, K | 1 |
| Mallick, R | 1 |
| Reynolds, S | 1 |
| Keenan, S | 1 |
| Burry, L | 1 |
| Kang, BS | 1 |
| Jung, KH | 1 |
| Shin, JW | 1 |
| Moon, JS | 1 |
| Byun, JI | 1 |
| Lim, JA | 1 |
| Moon, HJ | 1 |
| Kim, YS | 1 |
| Lee, ST | 1 |
| Chu, K | 1 |
| Lee, SK | 1 |
| Prüss, H | 1 |
| Holtkamp, M | 1 |
| Sumi, Y | 1 |
| Oode, Y | 1 |
| Tanaka, H | 1 |
| Meierhans, R | 1 |
| Stover, JF | 1 |
| Béchir, M | 1 |
| Keel, M | 1 |
| Stocker, R | 1 |
| Chamorro, C | 1 |
| Borrallo, JM | 1 |
| Romera, MA | 1 |
| Fernández-Torre, JL | 1 |
| Hernández-Hernández, MA | 1 |
| Bastiaans, DE | 1 |
| Swart, EL | 1 |
| van Akkeren, JP | 1 |
| Derijks, LJ | 1 |
| Leger, C | 1 |
| Cossette, M | 1 |
| Michaud, V | 1 |
| Turgeon, J | 1 |
| Willoughby, RE | 1 |
| Tieves, KS | 1 |
| Hoffman, GM | 1 |
| Ghanayem, NS | 1 |
| Amlie-Lefond, CM | 1 |
| Schwabe, MJ | 1 |
| Chusid, MJ | 1 |
| Rupprecht, CE | 1 |
| Jackson, AC | 1 |
| Kim, F | 1 |
| Olsufka, M | 1 |
| Carlbom, D | 1 |
| Deem, S | 1 |
| Longstreth, WT | 1 |
| Hanrahan, M | 1 |
| Maynard, C | 1 |
| Copass, MK | 1 |
| Cobb, LA | 1 |
| Jost, U | 1 |
| Schmid, A | 1 |
| Ruppert, M | 1 |
| Bauer, TM | 1 |
| Ritz, R | 1 |
| Haberthür, C | 1 |
| Ha, HR | 1 |
| Hunkeler, W | 1 |
| Sleight, AJ | 1 |
| Scollo-Lavizzari, G | 1 |
| Haefeli, WE | 1 |
| Sprenger, H | 1 |
| Sharpe, MD | 1 |
| McLachlan, RS | 1 |
| Abad-Alegría, F | 1 |
| Adelantado, S | 1 |
| González, P | 1 |
| Wyss, PA | 1 |
| Radovanovic, D | 1 |
| Meier-Abt, PJ | 1 |
| Hoes, MJ | 1 |
| Zeijpveld, JH | 1 |
| Morlet, D | 1 |
| Bertrand, O | 1 |
| Salord, F | 1 |
| Boulieu, R | 1 |
| Pernier, J | 1 |
| Fischer, C | 1 |
| Igartua, J | 1 |
| Silver, P | 1 |
| Maytal, J | 1 |
| Sagy, M | 1 |
| Ono, A | 1 |
| Yano, T | 1 |
| Sawaishi, Y | 1 |
| Komatsu, K | 1 |
| Takada, G | 1 |
| Salmore, R | 1 |
| Kulka, PJ | 1 |
| Lauven, PM | 1 |
| Schwilden, H | 1 |
| Rommelsheim, K | 1 |
| Chiolero, RL | 1 |
| Ravussin, P | 1 |
| Anderes, JP | 1 |
| Ledermann, P | 1 |
| de Tribolet, N | 1 |
Clinical Trials (3)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation. The NONSEDA-trial. An Investigator-initiated, Randomised, Clinical, Parallel-group, Multinational, Superiority Trial[NCT01967680] | 700 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Unit[NCT03194360] | 141 participants (Actual) | Observational | 2015-12-01 | Completed | |||
| A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy[NCT05019885] | Phase 2 | 6 participants (Anticipated) | Interventional | 2022-08-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for midazolam and Coma
| Article | Year |
|---|---|
High dose phenobarbitone coma in pediatric refractory status epilepticus; a retrospective case record analysis, a proposed protocol and review of literature.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Protocols; Coma; Drug Resistance; Fem | 2018 |
Which anesthetic should be used in the treatment of refractory status epilepticus?
Topics: Anesthetics; Anesthetics, Intravenous; Anticonvulsants; Barbiturates; Coma; Electroencephalography; | 2007 |
Trials
3 trials available for midazolam and Coma
| Article | Year |
|---|---|
Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients.
Topics: Aged; Aged, 80 and over; Coma; Conscious Sedation; Critical Illness; Delirium; Female; Humans; Hypno | 2020 |
Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Opioid; Antipsychotic Agents; APACHE; Benzo | 2015 |
Pharmacokinetics of midazolam in resuscitated patients treated with moderate hypothermia.
Topics: Aged; Coma; Female; Humans; Hypnotics and Sedatives; Hypothermia, Induced; Intensive Care Units; Mal | 2013 |
Other Studies
30 other studies available for midazolam and Coma
| Article | Year |
|---|---|
Pediatric delirium is associated with increased brain injury marker levels in cardiac surgery patients.
Topics: Adult; Bayes Theorem; Biomarkers; Brain Injuries; Cardiac Surgical Procedures; Child; Coma; Delirium | 2022 |
Long-term prognosis related to deep sedation in refractory status Epilepticus.
Topics: Adolescent; Adult; Aged; Barbiturates; Coma; Deep Sedation; Female; Humans; Hypnotics and Sedatives; | 2020 |
Fentanyl- and midazolam-induced coma each influence days of mechanical ventilation and 28-day mortality.
Topics: Coma; Fentanyl; Humans; Hypnotics and Sedatives; Midazolam; Respiration, Artificial | 2021 |
Comparison of two sedation regimens during targeted temperature management after cardiac arrest.
Topics: Adult; Aged; Anesthetics, Intravenous; Coma; Deep Sedation; Drug Therapy, Combination; Female; Fenta | 2018 |
Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery.
Topics: Aged; Cohort Studies; Coma; Delirium; Electroencephalography; Evoked Potentials, Motor; Female; Hear | 2019 |
Dissecting sedation-induced delirium.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2013 |
Benzodiazepines and delirium: the best option for the right patient.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Coma; Cy | 2013 |
Midazolam fails to prevent neurological damage in children with convulsive refractory febrile status epilepticus.
Topics: Aged, 80 and over; Brain; Child; Child, Preschool; Coma; Female; Follow-Up Studies; Humans; Hypnotic | 2014 |
Induction of burst suppression or coma using intravenous anesthetics in refractory status epilepticus.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; A | 2015 |
Ketamine successfully terminates malignant status epilepticus.
Topics: Anesthesia, General; Anesthetics, Dissociative; Anticonvulsants; Coma; DNA Polymerase gamma; DNA-Dir | 2008 |
Chinese dumpling scare hits Japan--a case of methamidophos food poisoning.
Topics: Atropine; Child, Preschool; China; Coma; Female; Foodborne Diseases; Humans; Insecticides; Japan; Mi | 2008 |
Reduced midazolam clearance must be considered in prolonged coma.
Topics: Adult; Anesthetics, Intravenous; Antidotes; Cholinesterase Inhibitors; Coma; Flumazenil; Humans; Mal | 2008 |
Therapeutic hypothermia after cardiac arrest.
Topics: Analgesics; Coma; Fentanyl; Heart Arrest; Humans; Hypnotics and Sedatives; Hypothermia, Induced; Mid | 2011 |
Utility of bilateral Bispectral index (BIS) monitoring in a comatose patient with focal nonconvulsive status epilepticus.
Topics: Aged; Aneurysm, Ruptured; Coma; Consciousness Monitors; Deep Sedation; Electroencephalography; Femal | 2012 |
Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2013 |
Survival after treatment of rabies with induction of coma.
Topics: Adolescent; Amantadine; Anesthetics; Animals; Antiviral Agents; Athetosis; Benzodiazepines; Bites an | 2005 |
Recovery from rabies.
Topics: Amantadine; Anesthetics; Animals; Antiviral Agents; Bites and Stings; Chiroptera; Coma; Excitatory A | 2005 |
Pilot study of rapid infusion of 2 L of 4 degrees C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrest.
Topics: Adult; Cold Temperature; Coma; Heart Arrest; Humans; Hypnotics and Sedatives; Hypothermia, Induced; | 2005 |
[Physostigmine reversal of central anticholinergic syndrome induced by midazolam/fentanyl, benzoctamine/buprenorphine and etomidate/carticaine or by atropine/promethazine/pethidine for premedication? (author's transl)].
Topics: Adult; Aged; Anthracenes; Atropine; Benzodiazepines; Buprenorphine; Carticaine; Coma; Delirium; Etom | 1982 |
Prolonged sedation due to accumulation of conjugated metabolites of midazolam.
Topics: Aged; Aged, 80 and over; Animals; Coma; Electroencephalography; Female; Flumazenil; Glucuronates; Hu | 1995 |
Flumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient.
Topics: Aged; Bacterial Infections; Coma; Critical Illness; Diagnosis, Differential; Diazepam; Flumazenil; H | 1994 |
[Episodic depression in electroencephalography and midazolam].
Topics: Adult; Aged; Anti-Anxiety Agents; Brain; Coma; Female; Humans; Male; Midazolam; Middle Aged | 1996 |
[Acute overdose of Zolpidem (Stilnox)].
Topics: Adolescent; Adult; Aged; Antidotes; Coma; Drug Overdose; Female; Flumazenil; Humans; Hypnotics and S | 1996 |
First report of mirtazapine overdose.
Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Coma; Depressive Dis | 1996 |
Dynamics of MLAEP changes in midazolam-induced sedation.
Topics: Adult; Aged; Aged, 80 and over; Coma; Electroencephalography; Evoked Potentials, Auditory; Humans; H | 1997 |
Midazolam coma for refractory status epilepticus in children.
Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Child; Child, Preschool; Coma; Electroencephalogra | 1999 |
[A case of carbamazepine intoxication with alpha coma and status epilepticus].
Topics: Adolescent; Carbamazepine; Charcoal; Coma; Electroencephalography; Female; Gastric Lavage; Humans; M | 2001 |
Aminophylline reversal of midazolam sedation.
Topics: Aminophylline; Coma; Humans; Midazolam | 1990 |
[The efficacy of the benzodiazepine antagonist flumazenil (Ro 15-1788) based on the EEG of mechanically ventilated intensive care patients].
Topics: Adult; Aged; Arousal; Benzodiazepines; Coma; Critical Care; Electroencephalography; Flumazenil; Huma | 1989 |
The effects of midazolam reversal by RO 15-1788 on cerebral perfusion pressure in patients with severe head injury.
Topics: Adult; Cerebrovascular Circulation; Coma; Craniocerebral Trauma; Female; Flumazenil; Humans; Intracr | 1988 |